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Advanced nutritional and stem cells approaches to prevent equine metabolic syndrome.
Abstract: Horses metabolic disorders have become an important problem of modern veterinary medicine. Pathological obesity, insulin resistance and predisposition toward laminitis are associated with Equine Metabolic Syndrome (EMS). Based on pathogenesis of EMS, dietary and cell therapy management may significantly reduce development of this disorder. Special attention has been paid to the diet supplementation with highly bioavailable minerals and mesenchymal stem cells (MSC) which increase insulin sensitivity. In nutrition, there is a great interests in natural algae enriched via biosorption process with micro- and macroelements. In the case of cellular therapy, metabolic condition of engrafted cells may be crucial for the effectiveness of the therapy. Although, recent studies indicated on MSC deterioration in EMS individuals. Here, we described the combined nutritional and stem cells therapy for the EMS treatment. Moreover, we specified in details how EMS affects the adipose-derived stem cells (ASC) population. Presented here, combined kind of therapy- an innovative and cutting edge approach of metabolic disorders treatment may become a new gold standard in personalized veterinary medicine.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Publication Date: 2018-01-31 PubMed ID: 29421480DOI: 10.1016/j.rvsc.2018.01.015Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
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Summary
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This research article investigates the effectiveness of combining nutritional measures and stem cell approaches to prevent and treat Equine Metabolic Syndrome, a common metabolic disorder affecting horses.
Equine Metabolic Syndrome (EMS)
- The research paper begins by addressing Equine Metabolic Syndrome (EMS), a metabolic disorder now prevalent among horses, posing significant concerns to modern veterinary medicine. EMS in horses is characterized by obesity, insulin resistance, and a predisposition toward laminitis, a painful condition affecting the horse’s feet.
Nutritional and Stem Cell Therapies
- The paper suggests that diet modifications and stem cell therapy could potentially decrease the development of EMS. Horses diagnosed with EMS could benefit from diets fortified with highly bioavailable minerals and the administration of mesenchymal stem cells (MSCs), known to enhance insulin sensitivity.
- Nutrition-wise, the study particularly focuses on natural algae, enriched through a biosorption process with micro- and macroelements, which has garnered considerable interest.
Role of Cellular Therapy
- In the area of cell therapy, the metabolic state of the implanted cells can significantly impact the effectiveness of the treatment. However, recent research highlights that MSCs’ quality appears to deteriorate in EMS individuals, presenting possible challenges to the cellular therapy approach.
Effect of EMS on Adipose-derived Stem Cells
- The paper provides an in-depth discussion on how EMS impacts the adipose-derived stem cell (ASC) population in horses. This level of detail is crucial to understanding how EMS can alter stem cells and, in turn, affect the effectiveness of stem cell therapies.
Combined Therapy Approach
- The researchers propose a combined approach involving both nutritional and stem cell therapies to treat EMS. This innovative strategy could potentially pave the way for new treatment methods in personalized veterinary medicine, thereby setting a new standard for managing metabolic disorders.
Cite This Article
APA
Marycz K, Michalak I, Kornicka K.
(2018).
Advanced nutritional and stem cells approaches to prevent equine metabolic syndrome.
Res Vet Sci, 118, 115-125.
https://doi.org/10.1016/j.rvsc.2018.01.015 Publication
Researcher Affiliations
- Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, 50-630 Wrocław, Poland; Wroclaw Research Centre EIT+, 54-066 Wrocław, Poland.
- Department of Advanced Material Technologies, Faculty of Chemistry, Wrocław University of Science and Technology, Smoluchowskiego 25, 50-372 Wrocław, Poland.
- Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, 50-630 Wrocław, Poland; Wroclaw Research Centre EIT+, 54-066 Wrocław, Poland. Electronic address: katarzyna.kornicka@upwr.edu.pl.
MeSH Terms
- Animals
- Diet Therapy
- Horse Diseases / prevention & control
- Horse Diseases / therapy
- Horses
- Insulin Resistance
- Metabolic Syndrome / prevention & control
- Metabolic Syndrome / therapy
- Metabolic Syndrome / veterinary
- Obesity / veterinary
- Precision Medicine / veterinary
- Stem Cells / metabolism
Citations
This article has been cited 10 times.- Tomal A, Szłapka-Kosarzewska J, Mironiuk M, Michalak I, Marycz K. Arthrospira platensis enriched with Cr(III), Mg(II), and Mn(II) ions improves insulin sensitivity and reduces systemic inflammation in equine metabolic affected horses. Front Endocrinol (Lausanne) 2024;15:1382844.
- Ferreira-Baptista C, Ferreira R, Fernandes MH, Gomes PS, Colaço B. Influence of the Anatomical Site on Adipose Tissue-Derived Stromal Cells' Biological Profile and Osteogenic Potential in Companion Animals. Vet Sci 2023 Nov 24;10(12).
- Bourebaba L, Serwotka-Suszczak A, Bourebaba N, Zyzak M, Marycz K. The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity. Int J Inflam 2023;2023:3803056.
- Bourebaba N, Sikora M, Qasem B, Bourebaba L, Marycz K. Sex hormone-binding globulin (SHBG) mitigates ER stress and improves viability and insulin sensitivity in adipose-derived mesenchymal stem cells (ASC) of equine metabolic syndrome (EMS)-affected horses. Cell Commun Signal 2023 Sep 11;21(1):230.
- Cequier A, Sanz C, Rodellar C, Barrachina L. The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses. Animals (Basel) 2021 Mar 25;11(4).
- Bourebaba L, Kornicka-Garbowska K, Al Naem M, Röcken M, Łyczko J, Marycz K. MSI-1436 improves EMS adipose derived progenitor stem cells in the course of adipogenic differentiation through modulation of ER stress, apoptosis, and oxidative stress. Stem Cell Res Ther 2021 Feb 3;12(1):97.
- Marycz K, Szłapka-Kosarzewska J, Geburek F, Kornicka-Garbowska K. Systemic Administration of Rejuvenated Adipose-Derived Mesenchymal Stem Cells Improves Liver Metabolism in Equine Metabolic Syndrome (EMS)- New Approach in Veterinary Regenerative Medicine. Stem Cell Rev Rep 2019 Dec;15(6):842-850.
- Kornicka K, Szłapka-Kosarzewska J, Śmieszek A, Marycz K. 5-Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy. J Cell Mol Med 2019 Jan;23(1):237-259.
- Michalak I, Mironiuk M, Marycz K. A comprehensive analysis of biosorption of metal ions by macroalgae using ICP-OES, SEM-EDX and FTIR techniques. PLoS One 2018;13(10):e0205590.
- Kornicka K, Śmieszek A, Szłapka-Kosarzewska J, Irwin Houston JM, Roecken M, Marycz K. Characterization of Apoptosis, Autophagy and Oxidative Stress in Pancreatic Islets Cells and Intestinal Epithelial Cells Isolated from Equine Metabolic Syndrome (EMS) Horses. Int J Mol Sci 2018 Oct 8;19(10).
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