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Home / Equine Research Bank / Animals (Basel) / Age and Body Condition Influence the Post-Prandial Interleuk...
Animals : an open access journal from MDPI2021; 11(12); 3362; doi: 10.3390/ani11123362

Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses.

Abstract: Older horses and those prone to obesity may be at a higher risk for inflammation than younger and leaner counterparts. Previous research indicated a postprandial elevation in plasma concentrations of interleukin-1β (IL-1β), a pro-inflammatory cytokine, after consuming 1.2 g of non-structural carbohydrates/kilogram of body weight. However, these studies utilized horses of mixed age and body condition. The current study evaluated post-prandial IL-1β concentrations in horses specifically comparing lean to over-conditioned and middle aged to older. Our results suggest that at least two weeks of daily consumption of a high non-structural carbohydrate diet is required to induce a post-prandial increase in IL-1β concentrations in younger and leaner horses. In opposition to this, older and over-conditioned horses experience plasma increased on the first day of feeding and thereafter. Feeding management practices of older and over-conditioned individuals should emphasize lower non-structural carbohydrate intakes and further research should elucidate mechanisms of IL-1β activation.
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Publication Date: 2021-11-24 PubMed ID: 34944138PubMed Central: PMC8698138DOI: 10.3390/ani11123362Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates how age and body condition in horses influence their bodies’ inflammatory responses after consuming a high-starch meal. The findings suggest that older or overweight horses exhibit an immediate increase in plasma interleukin-1β (a substance related to inflammation) concentrations after starting this diet, while younger, leaner horses require at least two weeks of such meals to show the same response.

Introduction and Methodology

  • The researchers sought to investigate how factors like age and body condition in horses affect the body’s inflammatory responses, particularly levels of interleukin-1β (IL-1β) in the blood, after eating a high-starch diet.
  • Previous studies had shown that consuming a diet rich in non-structural carbohydrates could lead to a post-meal increase in IL-1β levels, but these studies encompassed horses of mixed ages and body conditions, which led to the current study’s more specific focus.
  • This study compared responses between lean and overweight horses, as well as between older and middling-aged horses, to see if these factors influenced the rise in IL-1β concentrations.

Findings

  • The study found that horses’ bodies respond differently to high non-structural carbohydrate meals depending on their age and body condition.
  • Younger, leaner horses require daily consumption of such a high-starch diet for at least two weeks before they demonstrate a noticeable post-meal increase in IL-1β levels.
  • In contrast, overweight and older horses exhibit an immediate (i.e., from the first day of the diet change) post-meal increase in IL-1β levels.

Implications

  • The research implies that older and overweight horses are at a higher risk of inflammation when fed a starch-rich diet, compared to their younger, leaner counterparts.
  • These findings suggest that feeding management practices for older and overweight horses should minimize non-structural carbohydrate intake to control inflammation levels.
  • Further research is suggested to understand the mechanisms through which the horse body activates IL-1β after consuming a high-starch diet, and how age and body condition factor into this process.

Cite This Article

APA
Suagee-Bedore J, Shost N, Miller C, Grado L, Bechelli J. (2021). Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses. Animals (Basel), 11(12), 3362. https://doi.org/10.3390/ani11123362

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 12
PII: 3362

Researcher Affiliations

Suagee-Bedore, Jessica
  • School of Agricultural Sciences, College of Science and Engineering Technology, Sam Houston State University, Huntsville, TX 77340, USA.
Shost, Nichola
  • School of Agricultural Sciences, College of Science and Engineering Technology, Sam Houston State University, Huntsville, TX 77340, USA.
Miller, Christian
  • Department of Biological Sciences, College of Science and Engineering Technology, Sam Houston State University, Huntsville, TX 77340, USA.
Grado, Luis
  • Department of Biological Sciences, College of Science and Engineering Technology, Sam Houston State University, Huntsville, TX 77340, USA.
Bechelli, Jeremy
  • Department of Biological Sciences, College of Science and Engineering Technology, Sam Houston State University, Huntsville, TX 77340, USA.

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 28 references
  1. Schroder K, Tschopp J. The inflammasomes.. Cell 2010 Mar 19;140(6):821-32.
    doi: 10.1016/j.cell.2010.01.040pubmed: 20303873google scholar: lookup
  2. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.. Mol Cell 2002 Aug;10(2):417-26.
    doi: 10.1016/S1097-2765(02)00599-3pubmed: 12191486google scholar: lookup
  3. Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.. J Immunol 2009 Jul 15;183(2):787-91.
    doi: 10.4049/jimmunol.0901363pmc: PMC2824855pubmed: 19570822google scholar: lookup
  4. Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. Cryopyrin activates the inflammasome in response to toxins and ATP.. Nature 2006 Mar 9;440(7081):228-32.
    doi: 10.1038/nature04515pubmed: 16407890google scholar: lookup
  5. He Y, Hara H, Núñez G. Mechanism and Regulation of NLRP3 Inflammasome Activation.. Trends Biochem Sci 2016 Dec;41(12):1012-1021.
    doi: 10.1016/j.tibs.2016.09.002pmc: PMC5123939pubmed: 27669650google scholar: lookup
  6. Ahn H, Kim J, Lee H, Lee E, Lee GS. Characterization of equine inflammasomes and their regulation.. Vet Res Commun 2020 May;44(2):51-59.
    doi: 10.1007/s11259-020-09772-1pubmed: 32297137google scholar: lookup
  7. Suagee JK, Splan RK, Swyers KL, Geor RJ, Corl BA. Effects of high-sugar and high-starch diets on postprandial inflammatory protein concentrations in horses.. J. Equine Vet. Sci. 2015;35:191–197.
    doi: 10.1016/j.jevs.2014.12.014google scholar: lookup
  8. Suagee-Bedore JK, Wagner AL, Girard ID. Validation of the postprandial interleukin-1β response in horses using equine-specific antibodies.. J. Equine Vet. Sci. 2017;48:69–72.
    doi: 10.1016/j.jevs.2016.08.014google scholar: lookup
  9. Suagee-Bedore JK, Wagner AL, Girard ID. Feeding DigestaWell Buffer to horses alters the effects of starch intake on blood pH, lipopolysaccharide, and interleukin-1β.. J. Equine Vet. Sci. 2018;61:36–45.
    doi: 10.1016/j.jevs.2017.11.006google scholar: lookup
  10. Adams AA, Katepalli MP, Kohler K, Reedy SE, Stilz JP, Vick MM, Fitzgerald BP, Lawrence LM, Horohov DW. Effect of body condition, body weight and adiposity on inflammatory cytokine responses in old horses.. Vet Immunol Immunopathol 2009 Feb 15;127(3-4):286-94.
    doi: 10.1016/j.vetimm.2008.10.323pubmed: 19097648google scholar: lookup
  11. Reynolds A, Keen JA, Fordham T, Morgan RA. Adipose tissue dysfunction in obese horses with equine metabolic syndrome.. Equine Vet J 2019 Nov;51(6):760-766.
    doi: 10.1111/evj.13097pmc: PMC6850304pubmed: 30866087google scholar: lookup
  12. De Fombelle A, Julliand V, Drogoul C, Jacotot E. Feeding and microbial disorders in horses: 1-effects of an abrupt incorporation of two levels of barley in a hay diet on microbial profile and activities.. J. Equine Vet. Sci. 2001;21:439–445.
    doi: 10.1016/S0737-0806(01)70018-4google scholar: lookup
  13. Khafipour E, Krause DO, Plaizier JC. A grain-based subacute ruminal acidosis challenge causes translocation of lipopolysaccharide and triggers inflammation.. J Dairy Sci 2009 Mar;92(3):1060-70.
    doi: 10.3168/jds.2008-1389pubmed: 19233799google scholar: lookup
  14. Henneke DR, Potter GD, Kreider JL, Yeates BF. Relationship between condition score, physical measurements and body fat percentage in mares.. Equine Vet J 1983 Oct;15(4):371-2.
    doi: 10.1111/j.2042-3306.1983.tb01826.xpubmed: 6641685google scholar: lookup
  15. Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity.. Am J Physiol Cell Physiol 2021 Mar 1;320(3):C375-C391.
    doi: 10.1152/ajpcell.00379.2020pmc: PMC8294624pubmed: 33356944google scholar: lookup
  16. Zak A, Siwinska N, Elzinga S, Barker VD, Stefaniak T, Schanbacher BJ, Place NJ, Niedzwiedz A, Adams AA. Effects of equine metabolic syndrome on inflammation and acute-phase markers in horses.. Domest Anim Endocrinol 2020 Jul;72:106448.
    doi: 10.1016/j.domaniend.2020.106448pubmed: 32247989google scholar: lookup
  17. Suagee JK, Corl BA, Crisman MV, Pleasant RS, Geor RJ, Thatcher CD. Relationships between inflammatory cytokines, body condition, and plasma insulin in light breed horses.. J. Equine Vet. Sci. 2011;31:251.
    doi: 10.1016/j.jevs.2011.03.055google scholar: lookup
  18. Jin C, Flavell RA. Molecular mechanism of NLRP3 inflammasome activation.. J Clin Immunol 2010 Sep;30(5):628-31.
    doi: 10.1007/s10875-010-9440-3pubmed: 20589420google scholar: lookup
  19. Ou Y, Zheng Z, Niu B, Su J, Su H. Different MAPK signal transduction pathways play different roles in the impairment of glucose‑stimulated insulin secretion in response to IL‑1β.. Mol Med Rep 2020 Oct;22(4):2973-2980.
    doi: 10.3892/mmr.2020.11366pubmed: 32945406google scholar: lookup
  20. Ahmed Alfar E, Kirova D, Konantz J, Birke S, Mansfeld J, Ninov N. Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity.. Sci Rep 2017 Jun 26;7(1):3994.
    doi: 10.1038/s41598-017-03873-9pmc: PMC5484671pubmed: 28652605google scholar: lookup
  21. Mooradian AD, Reed RL, Scuderi P. Serum levels of tumor necrosis factor alpha, interleukin-1 alpha and beta in healthy elderly subjects.. Age 1991;14:61–64.
    doi: 10.1007/BF02434091google scholar: lookup
  22. Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases.. Nat Rev Endocrinol 2018 Oct;14(10):576-590.
    doi: 10.1038/s41574-018-0059-4pubmed: 30046148google scholar: lookup
  23. Dixon LJ, Flask CA, Papouchado BG, Feldstein AE, Nagy LE. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis.. PLoS One 2013;8(2):e56100.
    doi: 10.1371/journal.pone.0056100pmc: PMC3567081pubmed: 23409132google scholar: lookup
  24. Brocker CN, Kim D, Melia T, Karri K, Velenosi TJ, Takahashi S, Aibara D, Bonzo JA, Levi M, Waxman DJ, Gonzalez FJ. Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting.. Nat Commun 2020 Nov 17;11(1):5847.
    doi: 10.1038/s41467-020-19554-7pmc: PMC7673042pubmed: 33203882google scholar: lookup
  25. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.. Cell Metab 2012 Aug 8;16(2):250-64.
    doi: 10.1016/j.cmet.2012.07.007pmc: PMC4014071pubmed: 22883233google scholar: lookup
  26. Spaner DE, Lee E, Shi Y, Wen F, Li Y, Tung S, McCaw L, Wong K, Gary-Gouy H, Dalloul A, Ceddia R, Gorzcynski R. PPAR-alpha is a therapeutic target for chronic lymphocytic leukemia.. Leukemia 2013 Apr;27(5):1090-9.
    doi: 10.1038/leu.2012.329pubmed: 23160450google scholar: lookup
  27. Suagee JK, Corl BA, Swyers KL, Smith TL, Flinn CD, Geor RJ. A 90-day adaptation to a high glycaemic diet alters postprandial lipid metabolism in non-obese horses without affecting peripheral insulin sensitivity.. J Anim Physiol Anim Nutr (Berl) 2013 Apr;97(2):245-54.
    doi: 10.1111/j.1439-0396.2011.01261.xpubmed: 22129443google scholar: lookup
  28. Vasanthan T, Bhatty RS. Enhancement of resistant starch (RS3) in amylomaize, barley, field pea and lentil starches.. Starch Stärke 1998;50:286–291.
    doi: 10.1002/(SICI)1521-379X(199807)50:7<286::AID-STAR286>3.0.CO;2-Ogoogle scholar: lookup

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