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Home / Equine Research Bank / PLoS One / An Adenoviral Vector Based Vaccine for Rhodococcus equi.
PloS one2016; 11(3); e0152149; doi: 10.1371/journal.pone.0152149

An Adenoviral Vector Based Vaccine for Rhodococcus equi.

Abstract: Rhodococcus equi is a respiratory pathogen which primarily infects foals and is endemic on farms around the world with 50% mortality and 80% morbidity in affected foals. Unless detected early and treated appropriately the disease can be fatal. Currently, there is no vaccine available to prevent this disease. For decades researchers have endeavoured to develop an effective vaccine to no avail. In this study a novel human adenoviral vector vaccine for R. equi was developed and tested in the mouse model. This vaccine generated a strong antibody and cytokine response and clearance of R. equi was demonstrated following challenge. These results show that this vaccine could potentially be developed further for use as a vaccine to prevent R. equi disease in foals.
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Publication Date: 2016-03-23 PubMed ID: 27008624PubMed Central: PMC4805240DOI: 10.1371/journal.pone.0152149Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research is about a newly developed vaccine for Rhodococcus equi, a fatal respiratory disease affecting foals. The vaccine revealed strong immune responses in the test subjects and successfully cleared the R. equi infection.

Introduction to Rhodococcus equi

  • Rhodococcus equi is a respiratory pathogen that primarily infects young horses (foals) and poses significant threats to equine farming worldwide.
  • The disease has a high mortality rate of 50% and a morbidity rate of 80%, making it a major concern for horse owners and vets.
  • To date, there has been no reliable vaccine for this disease despite numerous research attempts.

The Novel Vaccine

  • In this study, scientists have developed a novel vaccine using a human adenoviral vector, a common technique of using a virus as a transport medium to deliver the vaccine into the body.
  • The vaccine was tested in the mouse model, often used as the initial step in preclinical trials due to the genetic, biological and behavior characteristics mice share with humans.

Vaccine Efficacy

  • The results of the experiments were highly promising — the vaccine prompted a strong response in terms of antibodies and cytokines, proteins that play an important role in the immune response.
  • The test subjects were then able to effectively clear the R. equi infection following the challenge, demonstrating the vaccine’s potential efficacy.

Implications of the Study

  • The successful development of this vaccine has the potential to greatly reduce the losses in equine farming caused by R. equi infections.
  • The vaccine could significantly decrease the mortality rate of this deadly disease, posing a solution to a problem that persisted for decades.
  • However, further research and testing are needed before it can be used as a regular vaccine to prevent R. equi disease in foals.

Cite This Article

APA
Giles C, Ndi O, Barton MD, Vanniasinkam T. (2016). An Adenoviral Vector Based Vaccine for Rhodococcus equi. PLoS One, 11(3), e0152149. https://doi.org/10.1371/journal.pone.0152149

Publication

PloS one
ISSN: 1932-6203
NlmUniqueID: 101285081
Country: United States
Language: English
Volume: 11
Issue: 3
Pages: e0152149
PII: e0152149

Researcher Affiliations

Giles, Carla
  • School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia.
Ndi, Olasumbo
  • School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia.
Barton, Mary D
  • School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia.
Vanniasinkam, Thiru
  • School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.

MeSH Terms

  • Actinomycetales Infections / prevention & control
  • Actinomycetales Infections / veterinary
  • Animals
  • Antibodies, Bacterial / immunology
  • Bacterial Vaccines / immunology
  • Bacterial Vaccines / therapeutic use
  • Cytokines / metabolism
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Horse Diseases / microbiology
  • Horse Diseases / prevention & control
  • Horses
  • Lung / cytology
  • Lung / metabolism
  • Lung / microbiology
  • Mice
  • Mice, Inbred C3H
  • Rhodococcus equi / immunology

Conflict of Interest Statement

The authors have declared that no competing interests exist.

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Citations

This article has been cited 2 times.
  1. da Silveira BP, Cohen ND, Lawhon SD, Watson RO, Bordin AI. Protective immune response against Rhodococcus equi: An innate immunity-focused review. Equine Vet J 2025 May;57(3):563-586.
    doi: 10.1111/evj.14214pubmed: 39258739google scholar: lookup
  2. Liu L, Cai P, Gu W, Duan X, Gao S, Ma X, Ma Y, Ma S, Li G, Wang X, Cai K, Wang Y, Cai T, Zhao H. Evaluation of vaccine candidates against Rhodococcus equi in BALB/c mice infection model: cellular and humoral immune responses. BMC Microbiol 2024 Jul 8;24(1):249.
    doi: 10.1186/s12866-024-03408-zpubmed: 38977999google scholar: lookup
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