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Home / Equine Research Bank / Vet Parasitol / Anthelmintic resistance in important parasites of horses: do...
Veterinary parasitology2014; 201(1-2); 1-8; doi: 10.1016/j.vetpar.2014.01.004

Anthelmintic resistance in important parasites of horses: does it really matter?

Abstract: Parascaris equorum and cyathostomins are currently considered the most important parasites of horses and have traditionally been controlled with anthelmintics belonging to three drug classes: benzimidazoles, the tetrahydropyrimidine pyrantel, and macrocyclic lactones. Unfortunately, resistance to benzimidazoles, and to a lesser extent pyrantel, is widespread in cyathostomins around the world. Furthermore, resistance to macrocyclic lactones appears to be in the early stages of development in cyathostomins in multiple locations. In contrast, P. equorum populations have remained susceptible to the three anthelmintic drug classes for a considerably longer period of time. However, over the last 10 years, resistance to macrocyclic lactones has been described in multiple countries. In contrast, resistance to pyrantel has only been described in the USA; resistance to benzimidazoles has yet to be reported. Despite the large number of reports of anthelmintic resistance in both cyathostomins and P. equorum, there are presently no reports that definitively link anthelmintic resistance with clinical problems in horses. However, that generally appears to be due to a publication bias toward well managed horse farms and the lack of appropriate diagnostic methods for rapidly quantifying anthelmintic resistance in these parasites. Management-based, and other, reasons likely responsible for this apparent anomaly are also discussed. Finally, future research priorities in this area, identified from a discussion at the 9th International Conference on Equine Infectious Diseases, are summarized.
Copyright © 2014 Elsevier B.V. All rights reserved.
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Publication Date: 2014-01-15 PubMed ID: 24485565DOI: 10.1016/j.vetpar.2014.01.004Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The key focus of this research is the growing resistance of horse parasites, cyathostomins and Parascaris equorum, to three main anthelmintic drugs. The study also explores how this perceived resistance, despite its widespread documentation, has not been directly linked with clinical health issues in horses.

Background

  • The research focuses on the parasites P. equorum and cyathostomins, considered the most detrimental to horses. These parasites traditionally have been kept in check with three types of anthelmintic drugs: benzimidazoles, the tetrahydropyrimidine pyrantel, and macrocyclic lactones.
  • The study notes that there is increasing resistance to these drugs among the parasite populations, particularly towards benzimidazoles and pyrantel in cyathostomins.

Resistant Strains and Geographic Differences

  • The study observes that in the case of cyathostomins there is a global rise in resistance to benzimidazoles and somewhat to pyrantel. Early signs of resistance to macrocyclic lactones are also being detected in cyathostomins in several areas.
  • Interestingly, P. equorum has been prone to being treated successfully with all three drugs for a considerably longer period. However, over the past decade, they have begun showing resistance to macrocyclic lactones in various countries.
  • In contrast, resistance to pyrantel has only been reported in the USA and no cases of resistance to benzimidazoles has been observed yet.

Resistance and Clinical Problems in Horses

  • Despite ample evidence of anthelmintic resistance in both P. equorum and cyathostomins, no definitive association has been made yet between this resistance and health problems in horses.
  • The reason behind this paradox could be due to a publication bias towards reports from well-managed horse farms and the lack of efficient diagnostic methods to quantify anthelmintic resistance in these parasites speedily.

Management Factors and Future Prospects

  • The researchers suggest that other non-medical factors might be causing this disparity. A large part of the apparent anomaly could be the effect of different management practices across farms.
  • The study concludes by summarizing future research priorities in this field, drawing from discussions held during the 9th International Conference on Equine Infectious Diseases.

Cite This Article

APA
Peregrine AS, Molento MB, Kaplan RM, Nielsen MK. (2014). Anthelmintic resistance in important parasites of horses: does it really matter? Vet Parasitol, 201(1-2), 1-8. https://doi.org/10.1016/j.vetpar.2014.01.004

Publication

Veterinary parasitology
ISSN: 1873-2550
NlmUniqueID: 7602745
Country: Netherlands
Language: English
Volume: 201
Issue: 1-2
Pages: 1-8

Researcher Affiliations

Peregrine, Andrew S
  • Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Electronic address: aperegri@ovc.uoguelph.ca.
Molento, Marcelo Beltrão
  • Laboratory of Parasitic Diseases, Department of Veterinary Medicine, Federal University of Parana, Curitiba, PR, Brazil.
Kaplan, Ray M
  • Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Nielsen, Martin K
  • M.H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.

MeSH Terms

  • Animals
  • Anthelmintics / pharmacology
  • Anthelmintics / therapeutic use
  • Drug Resistance
  • Helminthiasis, Animal / drug therapy
  • Helminths / drug effects
  • Horse Diseases / drug therapy
  • Horse Diseases / parasitology
  • Horses
  • Research / trends

Citations

This article has been cited 67 times.
  1. Ullah A, Geng M, Chen W, Zhu Q, Shi L, Zhang X, Akhtar MF, Wang C, Khan MZ. Effect of Parasitic Infections on Hematological Profile, Reproductive and Productive Performance in Equines. Animals (Basel) 2025 Nov 14;15(22).
    doi: 10.3390/ani15223294pubmed: 41302002google scholar: lookup
  2. Wang T, Chen X, Yan X, Su Y, Gao W, Liu C, Wang W. Progress in serology and molecular biology of equine parasite diagnosis: sustainable control strategies. Front Vet Sci 2025;12:1663577.
    doi: 10.3389/fvets.2025.1663577pubmed: 40979365google scholar: lookup
  3. Stahel L, Bigler NA, Grimm F, Schnyder M, Oehm AW. Case report: The gastrointestinal nematode Strongylus vulgaris as a cause of hoof abscess in a donkey. BMC Vet Res 2025 Jul 10;21(1):454.
    doi: 10.1186/s12917-025-04492-7pubmed: 40640810google scholar: lookup
  4. Rodriguez Velazquez D, Forte L, Varela Guerrero JA, Díaz Alvarado T, Elghandour MMMY, Maggiolino A, De Palo P, Salem AZM. Could Mesquite (Prosopis juliflora) Help Control Gastrointestinal Parasites in Horses?. Animals (Basel) 2025 Apr 28;15(9).
    doi: 10.3390/ani15091245pubmed: 40362060google scholar: lookup
  5. do Carmo TA, Fonseca JDS, Braga FR, Paz-Silva A, de Soutello RVG, de Araújo JV. Exploring the Use of Helminthophagous Fungi in the Control of Helminthoses in Horses: A Review. Animals (Basel) 2025 Mar 18;15(6).
    doi: 10.3390/ani15060864pubmed: 40150393google scholar: lookup
  6. Fakheri A, Esmaeilnejad B, Akbari H, Molaei R. In vitro evaluation of anthelmintic activity of biocompatibile carbon quantum dot nanocomposite against egg and larval stages of equine strongyles. BMC Vet Res 2025 Jan 22;21(1):32.
    doi: 10.1186/s12917-025-04494-5pubmed: 39844158google scholar: lookup
  7. Whitlock F, van Dijk J, Hodgkinson JE, Grewar JD, Newton JR. Reasons to be fearful? Rising proportions of positive faecal worm egg counts among UK horses (2007-2023). Equine Vet J 2025 Nov;57(6):1572-1583.
    doi: 10.1111/evj.14478pubmed: 39840839google scholar: lookup
  8. Kritikos G, Monteith G, Weese JS, Bateman SW. Prevalence of enteropathogens and endoparasites in cats at an animal shelter in Ontario. Can Vet J 2025 Jan;66(1):70-78.
    pubmed: 39781414
  9. Hamad MH, Jitsamai W, Chinkangsadarn T, Ngangam TS, Wattanapornpilom T, Naraporn D, Ouisuwan S, Taweethavonsawat P. Prevalence, risk factors, and species diversity of strongylid nematodes in domesticated Thai horses: insights from ITS-2 rDNA metabarcoding. Parasitol Res 2024 Dec 17;123(12):410.
    doi: 10.1007/s00436-024-08438-0pubmed: 39688721google scholar: lookup
  10. Kuzmina TA, Königová A, Antipov A, Kuzmin Y, Kharchenko V, Syrota Y. Changes in equine strongylid communities after two decades of annual anthelmintic treatments at the farm level. Parasitol Res 2024 Nov 25;123(11):394.
    doi: 10.1007/s00436-024-08417-5pubmed: 39585485google scholar: lookup
  11. Elghryani N, Lawlor A, McOwan T, de Waal T. Unravelling the Effectiveness of Anthelmintic Treatments on Equine Strongyles on Irish Farms. Animals (Basel) 2024 Jul 2;14(13).
    doi: 10.3390/ani14131958pubmed: 38998069google scholar: lookup
  12. Samiei A, Tavassoli M, Esmaeilnejad B. Green synthesis and anthelmintic activity of silver nanoparticles using Morus Alba Fruit extract against different stages of equine strongyles. Vet Res Commun 2024 Aug;48(4):2083-2098.
    doi: 10.1007/s11259-024-10365-5pubmed: 38568387google scholar: lookup
  13. Hamad MH, Islam SI, Jitsamai W, Chinkangsadarn T, Naraporn D, Ouisuwan S, Taweethavonsawat P. Patterns of Equine Small Strongyle Species Infection after Ivermectin Intervention in Thailand: Egg Reappearance Period and Nemabiome Metabarcoding Approach. Animals (Basel) 2024 Feb 8;14(4).
    doi: 10.3390/ani14040574pubmed: 38396542google scholar: lookup
  14. Dube F, Delhomme N, Martin F, Hinas A, Åbrink M, Svärd S, Tydén E. Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure. PLoS One 2024;19(2):e0298039.
    doi: 10.1371/journal.pone.0298039pubmed: 38359071google scholar: lookup
  15. Elghryani N, McAloon C, Mincher C, McOwan T, de Waal T. Comparison of the Automated OvaCyte Telenostic Faecal Analyser versus the McMaster and Mini-FLOTAC Techniques in the Estimation of Helminth Faecal Egg Counts in Equine. Animals (Basel) 2023 Dec 16;13(24).
    doi: 10.3390/ani13243874pubmed: 38136911google scholar: lookup
  16. Onder Z, Yildirim A, Duzlu O, Ciloglu A, Yetismis G, Karabulut F, Inci A. Detection of SNPs and benzimidazole resistance in strongyle nematode eggs of horses by allele-specific PCR. Parasitol Res 2023 Sep;122(9):2037-2043.
    doi: 10.1007/s00436-023-07903-6pubmed: 37354256google scholar: lookup
  17. Buono F, Veneziano V, Veronesi F, Molento MB. Horse and donkey parasitology: differences and analogies for a correct diagnostic and management of major helminth infections. Parasitology 2023 Oct;150(12):1119-1138.
    doi: 10.1017/S0031182023000525pubmed: 37221816google scholar: lookup
  18. Elghandour MMMY, Maggiolino A, Vázquez-Mendoza P, Alvarado-Ramírez ER, Cedillo-Monroy J, De Palo P, Salem AZM. Moringa oleifera as a Natural Alternative for the Control of Gastrointestinal Parasites in Equines: A Review. Plants (Basel) 2023 May 8;12(9).
    doi: 10.3390/plants12091921pubmed: 37176979google scholar: lookup
  19. Courtot É, Boisseau M, Dhorne-Pollet S, Serreau D, Gesbert A, Reigner F, Basiaga M, Kuzmina T, Lluch J, Annonay G, Kuchly C, Diekmann I, Krücken J, von Samson-Himmelstjerna G, Mach N, Sallé G. Comparison of two molecular barcodes for the study of equine strongylid communities with amplicon sequencing. PeerJ 2023;11:e15124.
    doi: 10.7717/peerj.15124pubmed: 37070089google scholar: lookup
  20. Elghryani N, McOwan T, Mincher C, Duggan V, de Waal T. Estimating the Prevalence and Factors Affecting the Shedding of Helminth Eggs in Irish Equine Populations. Animals (Basel) 2023 Feb 7;13(4).
    doi: 10.3390/ani13040581pubmed: 36830368google scholar: lookup
  21. Boelow H, Krücken J, von Samson-Himmelstjerna G. Epidemiological study on factors influencing the occurrence of helminth eggs in horses in Germany based on sent-in diagnostic samples. Parasitol Res 2023 Mar;122(3):749-767.
    doi: 10.1007/s00436-022-07765-4pubmed: 36627515google scholar: lookup
  22. Jato J, Orman E, Duah Boakye Y, Oppong Bekoe E, Oppong Bekoe S, Asare-Nkansah S, Spiegler V, Hensel A, Liebau E, Agyare C. Anthelmintic Agents from African Medicinal Plants: Review and Prospects. Evid Based Complement Alternat Med 2022;2022:8023866.
    doi: 10.1155/2022/8023866pubmed: 36624864google scholar: lookup
  23. Macdonald SL, Abbas G, Ghafar A, Gauci CG, Bauquier J, El-Hage C, Tennent-Brown B, Wilkes EJA, Beasley A, Jacobson C, Cudmore L, Carrigan P, Hurley J, Beveridge I, Hughes KJ, Nielsen MK, Jabbar A. Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited. Int J Parasitol Drugs Drug Resist 2023 Apr;21:28-39.
    doi: 10.1016/j.ijpddr.2022.12.002pubmed: 36543048google scholar: lookup
  24. Nielsen MK. Anthelmintic resistance in equine nematodes: Current status and emerging trends. Int J Parasitol Drugs Drug Resist 2022 Dec;20:76-88.
    doi: 10.1016/j.ijpddr.2022.10.005pubmed: 36342004google scholar: lookup
  25. D'Anza E, Buono F, Albarella S, Castaldo E, Pugliano M, Iannuzzi A, Cascone I, Battista E, Peretti V, Ciotola F. Chromosome Instability in Pony of Esperia Breed Naturally Infected by Intestinal Strongylidae. Animals (Basel) 2022 Oct 18;12(20).
    doi: 10.3390/ani12202817pubmed: 36290203google scholar: lookup
  26. Baranova MV, Panova OA, Polukhina DN, Panova DS. Reduction of the nematode egg reappearance period in horses after anthelmintic therapy. Vet World 2022 Jun;15(6):1530-1534.
    doi: 10.14202/vetworld.2022.1530-1534pubmed: 35993067google scholar: lookup
  27. Malsa J, Courtot É, Boisseau M, Dumont B, Gombault P, Kuzmina TA, Basiaga M, Lluch J, Annonay G, Dhorne-Pollet S, Mach N, Sutra JF, Wimel L, Dubois C, Guégnard F, Serreau D, Lespine A, Sallé G, Fleurance G. Effect of sainfoin (Onobrychis viciifolia) on cyathostomin eggs excretion, larval development, larval community structure and efficacy of ivermectin treatment in horses. Parasitology 2022 Sep;149(11):1439-1449.
    doi: 10.1017/S0031182022000853pubmed: 35929352google scholar: lookup
  28. Jürgenschellert L, Krücken J, Bousquet E, Bartz J, Heyer N, Nielsen MK, von Samson-Himmelstjerna G. Occurrence of Strongylid Nematode Parasites on Horse Farms in Berlin and Brandenburg, Germany, With High Seroprevalence of Strongylus vulgaris Infection. Front Vet Sci 2022;9:892920.
    doi: 10.3389/fvets.2022.892920pubmed: 35754549google scholar: lookup
  29. Özben M, von Samson-Himmelstjerna G, Freiin von Streit MKB, Wilkes EJA, Hughes KJ, Krücken J. Absence of Polymorphisms in Codons 167, 198 and 200 of All Seven β-Tubulin Isotypes of Benzimidazole Susceptible and Resistant Parascaris spp. Specimens from Australia. Pathogens 2022 Apr 20;11(5).
    doi: 10.3390/pathogens11050490pubmed: 35631011google scholar: lookup
  30. Attia MM, Soliman SM, Salaeh NMK, Salem HM, Alkafafy M, Saad AM, El-Saadony MT, El-Gameel SM. Evaluation of immune responses and oxidative stress in donkeys: Immunological studies provoked by Parascaris equorum infection. Saudi J Biol Sci 2022 Apr;29(4):2173-2179.
    doi: 10.1016/j.sjbs.2021.11.044pubmed: 35531146google scholar: lookup
  31. Ghafar A, Abbas G, King J, Jacobson C, Hughes KJ, El-Hage C, Beasley A, Bauquier J, Wilkes EJA, Hurley J, Cudmore L, Carrigan P, Tennent-Brown B, Nielsen MK, Gauci CG, Beveridge I, Jabbar A. Comparative studies on faecal egg counting techniques used for the detection of gastrointestinal parasites of equines: A systematic review. Curr Res Parasitol Vector Borne Dis 2021;1:100046.
    doi: 10.1016/j.crpvbd.2021.100046pubmed: 35284858google scholar: lookup
  32. Steuer AE, Anderson HP, Shepherd T, Clark M, Scare JA, Gravatte HS, Nielsen MK. Parasite dynamics in untreated horses through one calendar year. Parasit Vectors 2022 Feb 8;15(1):50.
    doi: 10.1186/s13071-022-05168-zpubmed: 35135605google scholar: lookup
  33. Dauparaitė E, Kupčinskas T, Hoglund J, Petkevičius S. A Survey of Control Strategies for Equine Small Strongyles in Lithuania. Helminthologia 2021 Sep;58(3):225-232.
    doi: 10.2478/helm-2021-0031pubmed: 34934386google scholar: lookup
  34. Abbas G, Ghafar A, Hurley J, Bauquier J, Beasley A, Wilkes EJA, Jacobson C, El-Hage C, Cudmore L, Carrigan P, Tennent-Brown B, Gauci CG, Nielsen MK, Hughes KJ, Beveridge I, Jabbar A. Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses. Parasit Vectors 2021 Dec 4;14(1):597.
    doi: 10.1186/s13071-021-05103-8pubmed: 34863271google scholar: lookup
  35. Lamassiaude N, Courtot E, Corset A, Charvet CL, Neveu C. Pharmacological characterization of novel heteromeric GluCl subtypes from Caenorhabditis elegans and parasitic nematodes. Br J Pharmacol 2022 Mar;179(6):1264-1279.
    doi: 10.1111/bph.15703pubmed: 34623639google scholar: lookup
  36. Hu D, Yang J, Qi Y, Li B, Li K, Mok KM. Metagenomic Analysis of Fecal Archaea, Bacteria, Eukaryota, and Virus in Przewalski's Horses Following Anthelmintic Treatment. Front Vet Sci 2021;8:708512.
    doi: 10.3389/fvets.2021.708512pubmed: 34490397google scholar: lookup
  37. Sallé G, Canlet C, Cortet J, Koch C, Malsa J, Reigner F, Riou M, Perrot N, Blanchard A, Mach N. Integrative biology defines novel biomarkers of resistance to strongylid infection in horses. Sci Rep 2021 Jul 12;11(1):14278.
    doi: 10.1038/s41598-021-93468-2pubmed: 34253752google scholar: lookup
  38. Trailovic SM, Rajkovic M, Marjanovic DS, Neveu C, Charvet CL. Action of Carvacrol on Parascaris sp. and Antagonistic Effect on Nicotinic Acetylcholine Receptors. Pharmaceuticals (Basel) 2021 May 26;14(6).
    doi: 10.3390/ph14060505pubmed: 34073197google scholar: lookup
  39. Johnson ACB, Biddle AS. The Use of Molecular Profiling to Track Equine Reinfection Rates of Cyathostomin Species Following Anthelmintic Administration. Animals (Basel) 2021 May 9;11(5).
    doi: 10.3390/ani11051345pubmed: 34065099google scholar: lookup
  40. de Oliveira LDSSCB, Dias FGS, Melo ALT, de Carvalho LM, Silva EN, Araújo JV. Bioverm(®) in the Control of Nematodes in Beef Cattle Raised in the Central-West Region of Brazil. Pathogens 2021 May 1;10(5).
    doi: 10.3390/pathogens10050548pubmed: 34062798google scholar: lookup
  41. Scala A, Tamponi C, Sanna G, Predieri G, Meloni L, Knoll S, Sedda G, Dessì G, Cappai MG, Varcasia A. Parascaris spp. eggs in horses of Italy: a large-scale epidemiological analysis of the egg excretion and conditioning factors. Parasit Vectors 2021 May 8;14(1):246.
    doi: 10.1186/s13071-021-04747-wpubmed: 33964977google scholar: lookup
  42. Urban JF Jr, Nielsen MK, Gazzola D, Xie Y, Beshah E, Hu Y, Li H, Rus F, Flanagan K, Draper A, Vakalapudi S, Li RW, Ostroff GR, Aroian RV. An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals. One Health 2021 Jun;12:100241.
    doi: 10.1016/j.onehlt.2021.100241pubmed: 33889707google scholar: lookup
  43. Zanet S, Battisti E, Labate F, Oberto F, Ferroglio E. Reduced Efficacy of Fenbendazole and Pyrantel Pamoate Treatments against Intestinal Nematodes of Stud and Performance Horses. Vet Sci 2021 Mar 5;8(3).
    doi: 10.3390/vetsci8030042pubmed: 33807857google scholar: lookup
  44. Roelfstra L, Quartier M, Pfister K. Preliminary Data from Six Years of Selective Anthelmintic Treatment on Five Horse Farms in France and Switzerland. Animals (Basel) 2020 Dec 15;10(12).
    doi: 10.3390/ani10122395pubmed: 33333748google scholar: lookup
  45. Scala A, Tamponi C, Sanna G, Predieri G, Dessì G, Sedda G, Buono F, Cappai MG, Veneziano V, Varcasia A. Gastrointestinal Strongyles Egg Excretion in Relation to Age, Gender, and Management of Horses in Italy. Animals (Basel) 2020 Dec 3;10(12).
    doi: 10.3390/ani10122283pubmed: 33287298google scholar: lookup
  46. Arfuso F, Bazzano M, Brianti E, Gaglio G, Passantino A, Tesei B, Laus F. Nutritional Supplements Containing Cardus mariano, Eucalyptus globulus, Gentiana lutea, Urtica urens, and Mallotus philippinensis Extracts Are Effective in Reducing Egg Shedding in Dairy Jennies (Equus asinus) Naturally Infected by Cyathostomins. Front Vet Sci 2020;7:556270.
    doi: 10.3389/fvets.2020.556270pubmed: 33251253google scholar: lookup
  47. Bellaw JL, Nielsen MK. Meta-analysis of cyathostomin species-specific prevalence and relative abundance in domestic horses from 1975-2020: emphasis on geographical region and specimen collection method. Parasit Vectors 2020 Oct 12;13(1):509.
    doi: 10.1186/s13071-020-04396-5pubmed: 33046130google scholar: lookup
  48. Nielsen MK, Banahan M, Kaplan RM. Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm. Int J Parasitol Drugs Drug Resist 2020 Dec;14:99-104.
    doi: 10.1016/j.ijpddr.2020.09.004pubmed: 33022574google scholar: lookup
  49. Sauermann CW, Leathwick DM, Lieffering M, Nielsen MK. Climate change is likely to increase the development rate of anthelmintic resistance in equine cyathostomins in New Zealand. Int J Parasitol Drugs Drug Resist 2020 Dec;14:73-79.
    doi: 10.1016/j.ijpddr.2020.09.001pubmed: 32992276google scholar: lookup
  50. Tydén E, Enemark HL, Franko MA, Höglund J, Osterman-Lind E. Prevalence of Strongylus vulgaris in horses after ten years of prescription usage of anthelmintics in Sweden. Vet Parasitol X 2019 Nov;2:100013.
    doi: 10.1016/j.vpoa.2019.100013pubmed: 32904767google scholar: lookup
  51. Slusarewicz M, Slusarewicz P, Nielsen MK. The effect of counting duration on quantitative fecal egg count test performance. Vet Parasitol X 2019 Nov;2:100020.
    doi: 10.1016/j.vpoa.2019.100020pubmed: 32904743google scholar: lookup
  52. Barlaam A, Traversa D, Papini R, Giangaspero A. Habronematidosis in Equids: Current Status, Advances, Future Challenges. Front Vet Sci 2020;7:358.
    doi: 10.3389/fvets.2020.00358pubmed: 32719812google scholar: lookup
  53. Martin F, Dube F, Karlsson Lindsjö O, Eydal M, Höglund J, Bergström TF, Tydén E. Transcriptional responses in Parascaris univalens after in vitro exposure to ivermectin, pyrantel citrate and thiabendazole. Parasit Vectors 2020 Jul 9;13(1):342.
    doi: 10.1186/s13071-020-04212-0pubmed: 32646465google scholar: lookup
  54. Scare JA, Dini P, Norris JK, Steuer AE, Scoggin K, Gravatte HS, Howe DK, Slusarewicz P, Nielsen MK. Ascarids exposed: a method for in vitro drug exposure and gene expression analysis of anthelmintic naïve Parascaris spp. Parasitology 2020 May;147(6):659-666.
    doi: 10.1017/S0031182020000189pubmed: 32046800google scholar: lookup
  55. Scare JA, Leathwick DM, Sauermann CW, Lyons ET, Steuer AE, Jones BA, Clark M, Nielsen MK. Dealing with double trouble: Combination deworming against double-drug resistant cyathostomins. Int J Parasitol Drugs Drug Resist 2020 Apr;12:28-34.
    doi: 10.1016/j.ijpddr.2019.12.002pubmed: 31883485google scholar: lookup
  56. Leathwick DM, Sauermann CW, Nielsen MK. Managing anthelmintic resistance in cyathostomin parasites: Investigating the benefits of refugia-based strategies. Int J Parasitol Drugs Drug Resist 2019 Aug;10:118-124.
    doi: 10.1016/j.ijpddr.2019.08.008pubmed: 31491731google scholar: lookup
  57. Cain JL, Foulk D, Jedrzejewski E, Stofanak H, Nielsen MK. The importance of anthelmintic efficacy monitoring: results of an outreach effort. Parasitol Res 2019 Oct;118(10):2877-2883.
    doi: 10.1007/s00436-019-06423-6pubmed: 31422463google scholar: lookup
  58. Sanna G, Pipia AP, Tamponi C, Manca R, Varcasia A, Traversa D, Scala A. Anthelmintics efficacy against intestinal strongyles in horses of Sardinia, Italy. Parasite Epidemiol Control 2016 Jun;1(2):15-19.
    doi: 10.1016/j.parepi.2016.01.001pubmed: 29988184google scholar: lookup
  59. Hu Y, Miller M, Zhang B, Nguyen TT, Nielsen MK, Aroian RV. In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites. PLoS Negl Trop Dis 2018 May;12(5):e0006506.
    doi: 10.1371/journal.pntd.0006506pubmed: 29775454google scholar: lookup
  60. Peachey LE, Molena RA, Jenkins TP, Di Cesare A, Traversa D, Hodgkinson JE, Cantacessi C. The relationships between faecal egg counts and gut microbial composition in UK Thoroughbreds infected by cyathostomins. Int J Parasitol 2018 May;48(6):403-412.
    doi: 10.1016/j.ijpara.2017.11.003pubmed: 29432771google scholar: lookup
  61. Molena RA, Peachey LE, Di Cesare A, Traversa D, Cantacessi C. Cyathostomine egg reappearance period following ivermectin treatment in a cohort of UK Thoroughbreds. Parasit Vectors 2018 Jan 25;11(1):61.
    doi: 10.1186/s13071-018-2638-6pubmed: 29370872google scholar: lookup
  62. Sallé G, Cortet J, Bois I, Dubès C, Guyot-Sionest Q, Larrieu C, Landrin V, Majorel G, Wittreck S, Woringer E, Couroucé A, Guillot J, Jacquiet P, Guégnard F, Blanchard A, Leblond A. Risk factor analysis of equine strongyle resistance to anthelmintics. Int J Parasitol Drugs Drug Resist 2017 Dec;7(3):407-415.
    doi: 10.1016/j.ijpddr.2017.10.007pubmed: 29149701google scholar: lookup
  63. Peachey LE, Pinchbeck GL, Matthews JB, Burden FA, Lespine A, von Samson-Himmelstjerna G, Krücken J, Hodgkinson JE. P-glycoproteins play a role in ivermectin resistance in cyathostomins. Int J Parasitol Drugs Drug Resist 2017 Dec;7(3):388-398.
    doi: 10.1016/j.ijpddr.2017.10.006pubmed: 29121562google scholar: lookup
  64. Zak A, Siwinska N, Slowikowska M, Borowicz H, Kubiak K, Hildebrand J, Popiolek M, Niedzwiedz A. Searching for ivermectin resistance in a Strongylidae population of horses stabled in Poland. BMC Vet Res 2017 Jul 3;13(1):210.
    doi: 10.1186/s12917-017-1133-1pubmed: 28673347google scholar: lookup
  65. Kaspar A, Pfister K, Nielsen MK, Silaghi C, Fink H, Scheuerle MC. Detection of Strongylus vulgaris in equine faecal samples by real-time PCR and larval culture - method comparison and occurrence assessment. BMC Vet Res 2017 Jan 11;13(1):19.
    doi: 10.1186/s12917-016-0918-ypubmed: 28077153google scholar: lookup
  66. Sallé G, Cabaret J. A survey on parasite management by equine veterinarians highlights the need for a regulation change. Vet Rec Open 2015;2(2):e000104.
    doi: 10.1136/vetreco-2014-000104pubmed: 26421153google scholar: lookup
  67. Nielsen MK, Wang J, Davis R, Bellaw JL, Lyons ET, Lear TL, Goday C. Parascaris univalens--a victim of large-scale misidentification?. Parasitol Res 2014 Dec;113(12):4485-90.
    doi: 10.1007/s00436-014-4135-ypubmed: 25231078google scholar: lookup
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