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Anti-inflammatory and immunomodulatory activities of stem cells.
Abstract: The recent interest in equine stem cell biology and the rapid increase in experimental data highlight the growing attention that this topic has been receiving over the past few years. Within the field of stem cell biology, the relevance of immunobiology is of particular intrigue. It appears that optimal and effective stem cell therapy for equine patients will require a thorough analysis of the immune properties of stem cells as well as their response to immune mediators. The main goal of this review is to discuss the biology of adult mesenchymal stem cells in the context of immunology.
Published by Elsevier Inc.
Publication Date: 2011-08-30 PubMed ID: 21872763DOI: 10.1016/j.cveq.2011.06.003Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
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The research explores the immune properties of stem cells, particularly adult mesenchymal stem cells in horses, and their potential for effective therapy in these animals. The emphasis is on understanding the anti-inflammatory and immune-regulating abilities of these cells.
Overview of Stem Cell Biology & Immunology
- This research article delves deep into the biology of stem cell and immunobiology, pinpointing its growing relevance in the field of cell biology. Stem cells are undifferentiated cells that have the potential to develop into different cell types in the body, demonstrating a great potential for healing and regenerative therapies.
- Specifically, the study review focuses on adult mesenchymal stem cells which can be derived from a variety of tissues in the body and are recognized for their ability to home to sites of inflammation when introduced into the blood circulation.
Significance of Immunobiology
- Immunobiology is the study of the immune system in all organisms. It plays a critical role in the sphere of stem cell biology because it helps to understand how stem cells interact with the immune system. This has significant implications when it comes to employing stem cell therapy in a clinical setting because these interactions can determine the success or failure of the therapy.
- Proper assessment of the immune properties of stem cells and how they respond to immune mediators can therefore help to optimise and enhance the effectiveness of stem cell therapy.
Focus on Equine Patients
- The research paper has a specific emphasis on equine patients. Horse stem cell therapy has recently been gaining traction due to its potential for treating a variety of conditions ranging from injuries to certain degenerative diseases.
- However, for the therapy to be successful and efficient, a comprehensive understanding of the immune responses of stem cells in horses is necessary.
The Main Goal of the Review
- The primary objective of the review is to provide an in-depth discussion about adult mesenchymal stem cells, particularly their biology, in the context of immunology. This is central to advancing and fine-tuning stem cell therapies in equine medical treatments and potentially beyond.
Cite This Article
APA
Peroni JF, Borjesson DL.
(2011).
Anti-inflammatory and immunomodulatory activities of stem cells.
Vet Clin North Am Equine Pract, 27(2), 351-362.
https://doi.org/10.1016/j.cveq.2011.06.003 Publication
Researcher Affiliations
- Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, H-322, Athens, GA 30602, USA. jperoni@uga.edu
MeSH Terms
- Animals
- Humans
- Immunomodulation / physiology
- Inflammation / metabolism
- Mesenchymal Stem Cell Transplantation
- Mesenchymal Stem Cells / physiology
Citations
This article has been cited 23 times.- Jiang L, Lu J, Chen Y, Lyu K, Long L, Wang X, Liu T, Li S. Mesenchymal stem cells: An efficient cellu00a0therapy for tendon repair (Review).. Int J Mol Med 2023 Aug;52(2).
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