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Home / Equine Research Bank / Arch Gesamte Virusforsch / Antigenic drift of equine infectious anemia virus in chronic...
Archiv fur die gesamte Virusforschung1973; 41(1); 1-10; doi: 10.1007/BF01249923

Antigenic drift of equine infectious anemia virus in chronically infected horses.

Abstract: No abstract available
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Publication Date: 1973-01-01 PubMed ID: 4123810DOI: 10.1007/BF01249923Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates how constant exposure to equine infectious anemia virus (EIA) affects horses over time, focusing particularly on how the virus’s antigenic identity changes, possibly leading to repeated bouts of fever and increased virus levels in the blood.

Study Overview

  • The study involved horses that were experimentally infected with a laboratory-controlled version of the EIA virus.
  • These horses developed a chronic form of the disease, characterized by repeated periods of fever and increases in viremia (the presence of viruses in the blood).

Findings on Virus Variations

  • Different viruses isolated from the horses at various times during their febrile (fever) episodes demonstrated changes in their antigenic specificity, signifying that these viruses had undergone antigenic drift.
  • These evolved versions of the virus were distinct from each other, identified through their ability to be neutralized by certain antibodies, but not by others that trigger complement fixation or precipitation.
  • This evidence suggested changes in the viruses’ surface antigens but no change in overall infectivity among the variant viruses.

Hypotheses and Suggestions

  • The researchers put forward that the persistent presence of the virus in the infected horses’ blood could be due to ongoing cycles of the development of antigenically distinct virus populations.
  • These new virus populations would not be vulnerable to being neutralized by the antibodies previously produced in response to the virus, allowing the continual presence and proliferation of the virus within the host.
  • They suggest that the emergence and increase of such viral variants in the blood could be driving the bouts of fever experienced by the infected horses.

Cite This Article

APA
Kono Y, Kobayashi K, Fukunaga Y. (1973). Antigenic drift of equine infectious anemia virus in chronically infected horses. Arch Gesamte Virusforsch, 41(1), 1-10. https://doi.org/10.1007/BF01249923

Publication

Archiv fur die gesamte Virusforschung
ISSN: 0003-9012
NlmUniqueID: 7506868
Country: Austria
Language: English
Volume: 41
Issue: 1
Pages: 1-10

Researcher Affiliations

Kono, Y
    Kobayashi, K
      Fukunaga, Y

        MeSH Terms

        • Animals
        • Antibody Specificity
        • Clone Cells
        • Complement Fixation Tests
        • Cross Reactions
        • Epitopes
        • Equine Infectious Anemia / blood
        • Equine Infectious Anemia / immunology
        • Horses
        • Immunodiffusion
        • Infectious Anemia Virus, Equine / isolation & purification
        • Infectious Anemia Virus, Equine / pathogenicity
        • Leukocytes
        • Neutralization Tests
        • Precipitin Tests
        • Time Factors

        References

        This article includes 24 references
        1. Hyslop NS. Isolation of variant strains from foot-and-mouth disease virus propagated in cell cultures containing antiviral sera.. J Gen Microbiol 1965 Oct;41(1):135-42.
          pubmed: 4286959doi: 10.1099/00221287-41-1-135google scholar: lookup
        2. LIU OC, HENLE W. Studies on host-virus interactions in the chick embryo-influenza virus system. VII. Data concerning the significance of infectivity titration end-points and the separation of clones at limiting dilutions.. J Exp Med 1953 Jun;97(6):889-902.
          pubmed: 13069643doi: 10.1084/jem.97.6.889google scholar: lookup
        3. Lang DJ, Noren B. Cytomegaloviremia following congenital infection.. J Pediatr 1968 Dec;73(6):812-9.
          pubmed: 4301363doi: 10.1016/s0022-3476(68)80233-1google scholar: lookup
        4. Nakajima H, Ushimi C. Detection of precipitating antibody in equine infectious anemia by concentrated virus antigen.. Natl Inst Anim Health Q (Tokyo) 1972 Summer;12(2):47-53.
          pubmed: 4340682
        5. Meleney HE. RELAPSE PHENOMENA OF SPIRONEMA RECURRENTIS.. J Exp Med 1928 Jun 30;48(1):65-82.
          pubmed: 19869472doi: 10.1084/jem.48.1.65google scholar: lookup
        6. Kono Y, Kobayashi K, Fukunaga Y. Distribution of equine infectious anemia virus in horses infected with the virus.. Natl Inst Anim Health Q (Tokyo) 1971 Spring;11(1):11-20.
          pubmed: 4325551
        7. Notkins AL, Mahar S, Scheele C, Goffman J. Infectious virus-antibody complex in the blood of chronically infected mice.. J Exp Med 1966 Jul 1;124(1):81-97.
          pubmed: 5944351doi: 10.1084/jem.124.1.81google scholar: lookup
        8. ISHII S. EQUINE INFECTIOUS ANEMIA OR SWAMP FEVER.. Adv Vet Sci 1963;8:263-98.
          pubmed: 14272338
        9. Kono Y, Kobayashi K. Complement fixation test of equine infectious anemia. I. Specificity of the test.. Natl Inst Anim Health Q (Tokyo) 1966 Winter;6(4):194-203.
          pubmed: 4292231
        10. Kono Y, Kobayashi K, Fukunaga Y. Serological comparison among various strains of equine infectious anemia virus.. Arch Gesamte Virusforsch 1971;34(3):202-8.
          pubmed: 4330134doi: 10.1007/BF01242993google scholar: lookup
        11. Hyslop NS, Fagg RH. Isolation of variants during passage of a strain of foot-and-mouth disease virus in partly immunized cattle.. J Hyg (Lond) 1965 Sep;63(3):357-68.
          pubmed: 4283920doi: 10.1017/s0022172400045241google scholar: lookup
        12. Kobayashi K, Kono Y. Propagation and titration of equine infectious anemia virus in horse leukocyte culture.. Natl Inst Anim Health Q (Tokyo) 1967 Spring;7(1):8-20.
          pubmed: 4293214
        13. Brown IN, Brown KN, Hills LA. Immunity to malaria: the antibody response to antigenic variation by Plasmodium knowlesi.. Immunology 1968 Jan;14(1):127-38.
          pubmed: 4965829
        14. Kono Y, Kobayashi K. Changes in pathogenicity of equine infectious anemia virus during passages in horse leukocyte cultures.. Natl Inst Anim Health Q (Tokyo) 1970 Fall;10(3):106-12.
          pubmed: 4320651
        15. HOTCHIN J, WEIGAND H. Studies of lymphocytic choriomeningitis in mice. I. The relationship between age at inoculation and outcome of infection.. J Immunol 1961 Apr;86:392-400.
          pubmed: 13716107
        16. Nakajima H, Ushimi C. Immunodiffusion studies of purified equine infectious anemia virus.. Infect Immun 1971 Mar;3(3):373-7.
          pubmed: 16557982doi: 10.1128/iai.3.3.373-377.1971google scholar: lookup
        17. Nakajima H, Tanaka S, Ushimi C. Physicochemical studies of equine infectious anemia virus. IV. Determination of the nucleic acid type in the virus.. Arch Gesamte Virusforsch 1970;31(3):273-80.
          pubmed: 4321449doi: 10.1007/BF01253762google scholar: lookup
        18. Laver WG, Webster RG. Selection of antigenic mutants of influenza viruses. Isolation and peptide mapping of their hemagglutination proteins.. Virology 1968 Feb;34(2):193-202.
          pubmed: 5640817doi: 10.1016/0042-6822(68)90230-4google scholar: lookup
        19. Kono Y. Viremia and immunological responses in horses infected with equine infectious anemia virus.. Natl Inst Anim Health Q (Tokyo) 1969 Spring;9(1):1-9.
          pubmed: 4306393
        20. STEIN CD, MOTT LO, GATES DW. Some observations on carriers of equine infectious anemia.. J Am Vet Med Assoc 1955 Apr;126(937):277-86.
          pubmed: 14353779
        21. Kono Y, Kobayashi K, Fukunaga Y. Immunization of horses against equine infectious anemia (EIA) with an attenuated EIA virus.. Natl Inst Anim Health Q (Tokyo) 1970 Fall;10(3):113-22.
          pubmed: 4320652
        22. Kono Y. Characteristics of the complement-fixing antigen of equine infectious anemia virus.. Natl Inst Anim Health Q (Tokyo) 1968 Fall;8(3):117-21.
          pubmed: 4305805
        23. Kono Y, Kobayashi K. Specificity of assay of equine infectious anemia virus in horse leukocyte culture.. Natl Inst Anim Health Q (Tokyo) 1967 Fall;7(3):138-44.
          pubmed: 4295385
        24. RUBIN H. Conditions for establishing immuno logical tolerance to a tumor virus.. Nature 1962 Jul 28;195:342-5.
          pubmed: 14494906doi: 10.1038/195342a0google scholar: lookup

        Citations

        This article has been cited 61 times.
        1. Patel JR, Heldens JG, Bakonyi T, Rusvai M. Important mammalian veterinary viral immunodiseases and their control.. Vaccine 2012 Feb 27;30(10):1767-81.
          doi: 10.1016/j.vaccine.2012.01.014pubmed: 22261411google scholar: lookup
        2. Cappelli K, Capomaccio S, Cook FR, Felicetti M, Marenzoni ML, Coppola G, Verini-Supplizi A, Coletti M, Passamonti F. Molecular detection, epidemiology, and genetic characterization of novel European field isolates of equine infectious anemia virus.. J Clin Microbiol 2011 Jan;49(1):27-33.
          doi: 10.1128/JCM.01311-10pubmed: 21084503google scholar: lookup
        3. Chung C, Mealey RH, McGuire TC. Evaluation of high functional avidity CTL to Gag epitope clusters in EIAV carrier horses.. Virology 2005 Nov 25;342(2):228-39.
          doi: 10.1016/j.virol.2005.07.033pubmed: 16139857google scholar: lookup
        4. Fraser DG, Leib SR, Zhang BS, Mealey RH, Brown WC, McGuire TC. Lymphocyte proliferation responses induced to broadly reactive Th peptides did not protect against equine infectious anemia virus challenge.. Clin Diagn Lab Immunol 2005 Aug;12(8):983-93.
          doi: 10.1128/CDLI.12.8.983-993.2005pubmed: 16085917google scholar: lookup
        5. Chung C, Mealey RH, McGuire TC. CTL from EIAV carrier horses with diverse MHC class I alleles recognize epitope clusters in Gag matrix and capsid proteins.. Virology 2004 Sep 15;327(1):144-54.
          doi: 10.1016/j.virol.2004.06.035pubmed: 15327905google scholar: lookup
        6. Mealey RH, Leib SR, Pownder SL, McGuire TC. Adaptive immunity is the primary force driving selection of equine infectious anemia virus envelope SU variants during acute infection.. J Virol 2004 Sep;78(17):9295-305.
          doi: 10.1128/JVI.78.17.9295-9305.2004pubmed: 15308724google scholar: lookup
        7. Mealey RH, Zhang B, Leib SR, Littke MH, McGuire TC. Epitope specificity is critical for high and moderate avidity cytotoxic T lymphocytes associated with control of viral load and clinical disease in horses with equine infectious anemia virus.. Virology 2003 Sep 1;313(2):537-52.
          doi: 10.1016/s0042-6822(03)00344-1pubmed: 12954220google scholar: lookup
        8. Richman DD, Wrin T, Little SJ, Petropoulos CJ. Rapid evolution of the neutralizing antibody response to HIV type 1 infection.. Proc Natl Acad Sci U S A 2003 Apr 1;100(7):4144-9.
          doi: 10.1073/pnas.0630530100pubmed: 12644702google scholar: lookup
        9. Fraser DG, Oaks JL, Brown WC, McGuire TC. Identification of broadly recognized, T helper 1 lymphocyte epitopes in an equine lentivirus.. Immunology 2002 Mar;105(3):295-305.
          doi: 10.1046/j.0019-2805.2001.01370.xpubmed: 11918691google scholar: lookup
        10. Zhang W, Lonning SM, McGuire TC. Gag protein epitopes recognized by ELA-A-restricted cytotoxic T lymphocytes from horses with long-term equine infectious anemia virus infection.. J Virol 1998 Dec;72(12):9612-20.
          doi: 10.1128/JVI.72.12.9612-9620.1998pubmed: 9811694google scholar: lookup
        11. Park EJ, Vujcic LK, Anand R, Theodore TS, Quinnan GV Jr. Mutations in both gp120 and gp41 are responsible for the broad neutralization resistance of variant human immunodeficiency virus type 1 MN to antibodies directed at V3 and non-V3 epitopes.. J Virol 1998 Sep;72(9):7099-107.
          doi: 10.1128/JVI.72.9.7099-7107.1998pubmed: 9696803google scholar: lookup
        12. Leroux C, Issel CJ, Montelaro RC. Novel and dynamic evolution of equine infectious anemia virus genomic quasispecies associated with sequential disease cycles in an experimentally infected pony.. J Virol 1997 Dec;71(12):9627-39.
          doi: 10.1128/JVI.71.12.9627-9639.1997pubmed: 9371627google scholar: lookup
        13. Zheng YH, Sentsui H, Nakaya T, Kono Y, Ikuta K. In vivo dynamics of equine infectious anemia viruses emerging during febrile episodes: insertions/duplications at the principal neutralizing domain.. J Virol 1997 Jul;71(7):5031-9.
          doi: 10.1128/JVI.71.7.5031-5039.1997pubmed: 9188568google scholar: lookup
        14. Hammond SA, Cook SJ, Lichtenstein DL, Issel CJ, Montelaro RC. Maturation of the cellular and humoral immune responses to persistent infection in horses by equine infectious anemia virus is a complex and lengthy process.. J Virol 1997 May;71(5):3840-52.
          doi: 10.1128/JVI.71.5.3840-3852.1997pubmed: 9094660google scholar: lookup
        15. Clements JE, Zink MC. Molecular biology and pathogenesis of animal lentivirus infections.. Clin Microbiol Rev 1996 Jan;9(1):100-17.
          doi: 10.1128/CMR.9.1.100pubmed: 8665473google scholar: lookup
        16. Lichtenstein DL, Issel CJ, Montelaro RC. Genomic quasispecies associated with the initiation of infection and disease in ponies experimentally infected with equine infectious anemia virus.. J Virol 1996 Jun;70(6):3346-54.
          doi: 10.1128/JVI.70.6.3346-3354.1996pubmed: 8648664google scholar: lookup
        17. Burns DP, Collignon C, Desrosiers RC. Simian immunodeficiency virus mutants resistant to serum neutralization arise during persistent infection of rhesus monkeys.. J Virol 1993 Jul;67(7):4104-13.
          doi: 10.1128/JVI.67.7.4104-4113.1993pubmed: 8510218google scholar: lookup
        18. Carvalho M, Kirkland M, Derse D. Protein interactions with DNA elements in variant equine infectious anemia virus enhancers and their impact on transcriptional activity.. J Virol 1993 Nov;67(11):6586-95.
          doi: 10.1128/JVI.67.11.6586-6595.1993pubmed: 8411361google scholar: lookup
        19. Sellon DC. Equine infectious anemia.. Vet Clin North Am Equine Pract 1993 Aug;9(2):321-36.
          doi: 10.1016/s0749-0739(17)30399-1pubmed: 8395326google scholar: lookup
        20. McGuire TC, Tumas DB, Byrne KM, Hines MT, Leib SR, Brassfield AL, O'Rourke KI, Perryman LE. Major histocompatibility complex-restricted CD8+ cytotoxic T lymphocytes from horses with equine infectious anemia virus recognize Env and Gag/PR proteins.. J Virol 1994 Mar;68(3):1459-67.
          doi: 10.1128/JVI.68.3.1459-1467.1994pubmed: 8107209google scholar: lookup
        21. Sellon DC, Fuller FJ, McGuire TC. The immunopathogenesis of equine infectious anemia virus.. Virus Res 1994 May;32(2):111-38.
          doi: 10.1016/0168-1702(94)90038-8pubmed: 8067050google scholar: lookup
        22. Cook RF, Berger SL, Rushlow KE, McManus JM, Cook SJ, Harrold S, Raabe ML, Montelaro RC, Issel CJ. Enhanced sensitivity to neutralizing antibodies in a variant of equine infectious anemia virus is linked to amino acid substitutions in the surface unit envelope glycoprotein.. J Virol 1995 Mar;69(3):1493-9.
          doi: 10.1128/JVI.69.3.1493-1499.1995pubmed: 7853482google scholar: lookup
        23. Choi WS, Collignon C, Thiriart C, Burns DP, Stott EJ, Kent KA, Desrosiers RC. Effects of natural sequence variation on recognition by monoclonal antibodies neutralize simian immunodeficiency virus infectivity.. J Virol 1994 Sep;68(9):5395-402.
          doi: 10.1128/JVI.68.9.5395-5402.1994pubmed: 7520089google scholar: lookup
        24. Adams DS, Crawford TB, Klevjer-Anderson P. A pathogenetic study of the early connective tissue lesions of viral caprine arthritis-encephalitis.. Am J Pathol 1980 May;99(2):257-78.
          pubmed: 6990770
        25. Ahmed R, Salmi A, Butler LD, Chiller JM, Oldstone MB. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.. J Exp Med 1984 Aug 1;160(2):521-40.
          doi: 10.1084/jem.160.2.521pubmed: 6332167google scholar: lookup
        26. Johnson GC, Barbet AF, Klevjer-Anderson P, McGuire TC. Preferential immune response to virion surface glycoproteins by caprine arthritis-encephalitis virus-infected goats.. Infect Immun 1983 Aug;41(2):657-65.
          doi: 10.1128/iai.41.2.657-665.1983pubmed: 6307878google scholar: lookup
        27. Klevjer-Anderson P, McGuire TC. Neutralizing antibody response of rabbits and goats to caprine arthritis-encephalitis virus.. Infect Immun 1982 Nov;38(2):455-61.
          doi: 10.1128/iai.38.2.455-461.1982pubmed: 6292102google scholar: lookup
        28. Shively MA, Banks KL, Greenlee A, Klevjer-Anderson P. Antigenic stimulation of T lymphocytes in chronic nononcogenic retrovirus infection: equine infectious anemia.. Infect Immun 1982 Apr;36(1):38-46.
          doi: 10.1128/iai.36.1.38-46.1982pubmed: 6281191google scholar: lookup
        29. Sentsui H, Kono Y. Hemagglutination of several strains of equine infectious anemia virus.. Arch Virol 1981;67(1):75-84.
          doi: 10.1007/BF01314604pubmed: 6263225google scholar: lookup
        30. Anderson LW, Klevjer-Anderson P, McGuire TC. Immune rabbit sera do not recognize antigenic variants of caprine arthritis-encephalitis virus isolated during persistent infection.. Infect Immun 1983 Nov;42(2):845-7.
          doi: 10.1128/iai.42.2.845-847.1983pubmed: 6196294google scholar: lookup
        31. Montelaro RC, Lohrey N, Parekh B, Blakeney EW, Issel CJ. Isolation and comparative biochemical properties of the major internal polypeptides of equine infectious anemia virus.. J Virol 1982 Jun;42(3):1029-38.
          doi: 10.1128/JVI.42.3.1029-1038.1982pubmed: 6178843google scholar: lookup
        32. Mims CA. Interactions of viruses with the immune system.. Clin Exp Immunol 1986 Oct;66(1):1-16.
          pubmed: 3542314
        33. Ahmed R, Oldstone MB. Organ-specific selection of viral variants during chronic infection.. J Exp Med 1988 May 1;167(5):1719-24.
          doi: 10.1084/jem.167.5.1719pubmed: 3367096google scholar: lookup
        34. Sentsui H, Kono Y. Phagocytosis of horse erythrocytes treated with equine infectious anemia virus by cultivated horse leukocytes.. Arch Virol 1987;95(1-2):67-77.
          doi: 10.1007/BF01311335pubmed: 3036046google scholar: lookup
        35. Payne SL, Salinovich O, Nauman SM, Issel CJ, Montelaro RC. Course and extent of variation of equine infectious anemia virus during parallel persistent infections.. J Virol 1987 Apr;61(4):1266-70.
          doi: 10.1128/JVI.61.4.1266-1270.1987pubmed: 3029423google scholar: lookup
        36. Henderson LE, Sowder RC, Smythers GW, Oroszlan S. Chemical and immunological characterizations of equine infectious anemia virus gag-encoded proteins.. J Virol 1987 Apr;61(4):1116-24.
          doi: 10.1128/JVI.61.4.1116-1124.1987pubmed: 3029406google scholar: lookup
        37. Derse D, Dorn PL, Levy L, Stephens RM, Rice NR, Casey JW. Characterization of equine infectious anemia virus long terminal repeat.. J Virol 1987 Mar;61(3):743-7.
          doi: 10.1128/JVI.61.3.743-747.1987pubmed: 3027401google scholar: lookup
        38. Salinovich O, Payne SL, Montelaro RC, Hussain KA, Issel CJ, Schnorr KL. Rapid emergence of novel antigenic and genetic variants of equine infectious anemia virus during persistent infection.. J Virol 1986 Jan;57(1):71-80.
          doi: 10.1128/JVI.57.1.71-80.1986pubmed: 3001367google scholar: lookup
        39. Race RE, Chesebro B, Bloom ME, Aasted B, Wolfinbarger J. Monoclonal antibodies against Aleutian disease virus distinguish virus strains and differentiate sites of virus replication from sites of viral antigen sequestration.. J Virol 1986 Jan;57(1):285-93.
          doi: 10.1128/JVI.57.1.285-293.1986pubmed: 3001352google scholar: lookup
        40. Kono Y. Antigenic variation of equine infectious anemia virus as detected by virus neutralization. Brief report.. Arch Virol 1988;98(1-2):91-7.
          doi: 10.1007/BF01321009pubmed: 2829799google scholar: lookup
        41. McGuire TC, Norton LK, O'Rourke KI, Cheevers WP. Antigenic variation of neutralization-sensitive epitopes of caprine arthritis-encephalitis lentivirus during persistent arthritis.. J Virol 1988 Sep;62(9):3488-92.
          doi: 10.1128/JVI.62.9.3488-3492.1988pubmed: 2457116google scholar: lookup
        42. Carpenter S, Evans LH, Sevoian M, Chesebro B. Role of the host immune response in selection of equine infectious anemia virus variants.. J Virol 1987 Dec;61(12):3783-9.
          doi: 10.1128/JVI.61.12.3783-3789.1987pubmed: 2446008google scholar: lookup
        43. Ito Y, Tsurudome M, Hishiyama M. Effects of antibodies and interferon on mumps virus persistently infected L929 cells. Generation of variant viruses in the cells during incubation with monoclonal antibodies and interferon.. Arch Virol 1986;88(3-4):217-30.
          doi: 10.1007/BF01310876pubmed: 2423057google scholar: lookup
        44. Wilson C, Reitz MS Jr, Aldrich K, Klasse PJ, Blomberg J, Gallo RC, Robert-Guroff M. The site of an immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 does not constitute the neutralization epitope.. J Virol 1990 Jul;64(7):3240-8.
          doi: 10.1128/JVI.64.7.3240-3248.1990pubmed: 2352323google scholar: lookup
        45. Whetter L, Archambault D, Perry S, Gazit A, Coggins L, Yaniv A, Clabough D, Dahlberg J, Fuller F, Tronick S. Equine infectious anemia virus derived from a molecular clone persistently infects horses.. J Virol 1990 Dec;64(12):5750-6.
          doi: 10.1128/JVI.64.12.5750-5756.1990pubmed: 2173767google scholar: lookup
        46. Rwambo PM, Issel CJ, Adams WV Jr, Hussain KA, Miller M, Montelaro RC. Equine infectious anemia virus (EIAV) humoral responses of recipient ponies and antigenic variation during persistent infection.. Arch Virol 1990;111(3-4):199-212.
          doi: 10.1007/BF01311054pubmed: 2162160google scholar: lookup
        47. Narayan O. Lentiviruses are etiological agents of chronic diseases in animals and acquired immunodeficiency syndrome in humans.. Can J Vet Res 1990 Jan;54(1):42-8.
          pubmed: 2155049
        48. O'Rourke KI, Besola ML, McGuire TC. Proviral sequences detected by polymerase chain reaction in peripheral blood cells of horses with equine infectious anemia lentivirus.. Arch Virol 1991;117(1-2):109-19.
          doi: 10.1007/BF01310496pubmed: 1848747google scholar: lookup
        49. Perryman LE, O'Rourke KI, Mason PH, McGuire TC. Equine monoclonal antibodies recognize common epitopes on variants of equine infectious anaemia virus.. Immunology 1990 Dec;71(4):592-4.
          pubmed: 1703988
        50. Wolfs TF, de Jong JJ, Van den Berg H, Tijnagel JM, Krone WJ, Goudsmit J. Evolution of sequences encoding the principal neutralization epitope of human immunodeficiency virus 1 is host dependent, rapid, and continuous.. Proc Natl Acad Sci U S A 1990 Dec;87(24):9938-42.
          doi: 10.1073/pnas.87.24.9938pubmed: 1702224google scholar: lookup
        51. Alexandersen S, Carpenter S. Characterization of variable regions in the envelope and S3 open reading frame of equine infectious anemia virus.. J Virol 1991 Aug;65(8):4255-62.
          doi: 10.1128/JVI.65.8.4255-4262.1991pubmed: 1649329google scholar: lookup
        52. Ball JM, Rushlow KE, Issel CJ, Montelaro RC. Detailed mapping of the antigenicity of the surface unit glycoprotein of equine infectious anemia virus by using synthetic peptide strategies.. J Virol 1992 Feb;66(2):732-42.
          doi: 10.1128/JVI.66.2.732-742.1992pubmed: 1370556google scholar: lookup
        53. Monk RJ, Malik FG, Stokesberry D, Evans LH. Direct determination of the point mutation rate of a murine retrovirus.. J Virol 1992 Jun;66(6):3683-9.
          doi: 10.1128/JVI.66.6.3683-3689.1992pubmed: 1316475google scholar: lookup
        54. Issel CJ, Horohov DW, Lea DF, Adams WV Jr, Hagius SD, McManus JM, Allison AC, Montelaro RC. Efficacy of inactivated whole-virus and subunit vaccines in preventing infection and disease caused by equine infectious anemia virus.. J Virol 1992 Jun;66(6):3398-408.
          doi: 10.1128/JVI.66.6.3398-3408.1992pubmed: 1316455google scholar: lookup
        55. Chesebro B, Wehrly K, Doig D, Nishio J. Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.. Proc Natl Acad Sci U S A 1979 Nov;76(11):5784-8.
          doi: 10.1073/pnas.76.11.5784pubmed: 293683google scholar: lookup
        56. Chesebro B, Bloom M, Wehrly K, Nishio J. Persistence of infectious Friend virus in spleens of mice after spontaneous recovery from virus-induced erythroleukemia.. J Virol 1979 Dec;32(3):832-7.
          doi: 10.1128/JVI.32.3.832-837.1979pubmed: 292801google scholar: lookup
        57. Klevjer-Anderson P, Cheevers WP, Crawford TB. Characterization of the infection of equine fibroblasts by equine infectious anemia virus.. Arch Virol 1979;60(3-4):279-89.
          doi: 10.1007/BF01317499pubmed: 228638google scholar: lookup
        58. Fujimiya Y, Perryman LE, Crawford TB. Leukocyte cytotoxicity in a persistent virus infection: presence of direct cytotoxicity but absence of antibody-dependent cellular cytotoxicity in horses infected with equine infectious anemia virus.. Infect Immun 1979 Jun;24(3):628-36.
          doi: 10.1128/iai.24.3.628-636.1979pubmed: 223981google scholar: lookup
        59. Charman H, Long C, Coggins L. Specificity of response to viral proteins in horses infected with equine infectious anemia virus.. Infect Immun 1979 Feb;23(2):472-8.
          doi: 10.1128/iai.23.2.472-478.1979pubmed: 217831google scholar: lookup
        60. Archer BG, Crawford TB, McGuire TC, Frazier ME. RNA-dependent DNA polymerase associated with equine infectious anemia virus.. J Virol 1977 Apr;22(1):16-22.
          doi: 10.1128/JVI.22.1.16-22.1977pubmed: 67219google scholar: lookup
        61. Sentsui H, Kono Y. Hemagglutination by equine infectious anemia virus.. Infect Immun 1976 Aug;14(2):325-31.
          doi: 10.1128/iai.14.2.325-331.1976pubmed: 9361google scholar: lookup
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