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The Journal of experimental medicine1964; 119(4); 547-565; doi: 10.1084/jem.119.4.547

Antigenic Variants of Eastern Equine Encephalitis Virus.

Abstract: A study by hemagglutination-inhibition test showed that 19 strains of eastern equine encephalitis virus grouped themselves in two main types, which have been designated North American and South American. The former consists of ten strains from the eastern half of the United States, from Massachusetts to Florida; Jamaica, the Dominican Republic, and, subject to confirmation, Thailand. The South American type comprises nine strains from Panama, Trinidad, British Guiana, Brazil, and Argentina. The strains were isolated from different natural hosts over a period of 30 years.
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Publication Date: 1964-04-01 PubMed ID: 14151098PubMed Central: PMC2137852DOI: 10.1084/jem.119.4.547Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The researchers studied 19 strains of Eastern Equine Encephalitis virus and found that they can be grouped into two main types, North American and South American, based on a hemagglutination-inhibition test.

Research Background

In this research, the focus is on examining the antigenic characteristics of different strains of the Eastern Equine Encephalitis virus (EEEV), which is a significant cause of disease in horses and humans. This virus tends to exhibit variations in different geographical regions, and these variations can have significant implications relating to disease patterns and vaccine strategies.

Methodology

  • Scientists used a hemaglutination-inhibition test, a standard serology test which measures the ability of an individual’s antibodies to prevent red blood cells from sticking together (hemagglutinating) in the presence of specific viruses.
  • They studied a total of 19 strains of EEEV, which had been isolated from various natural hosts over a span of three decades.

Findings

  • The results indicated that these 19 strains could be classified into two main types based on the results of the hemagglutination-inhibition test.
  • These types were named as the ‘North American’ and the ‘South American’ based on the geographical location from where the strains were found.
  • The North American type consisted of strains isolated from parts of the United States, Jamaica, the Dominican Republic, and potentially Thailand. This covered areas from as far north as Massachusetts to as far south as Florida in the USA.
  • The South American type included strains collected from Panama, Trinidad, British Guiana, Brazil, and Argentina.

Implications

  • This study provides crucial information about the antigenic diversity of EEEV strains, which may impact the development of effective therapeutic and preventive strategies against different types of this virus.
  • The geographical differentiation could also help in identifying and predicting the movement and potential outbreak areas of this disease, enabling more targeted preventative measures.
  • Moreover, it could contribute to understanding the virus’s evolutionary process, host-pathogen interactions, and epidemiological patterns in different regions.

Cite This Article

APA
CASALS J. (1964). Antigenic Variants of Eastern Equine Encephalitis Virus. J Exp Med, 119(4), 547-565. https://doi.org/10.1084/jem.119.4.547

Publication

The Journal of experimental medicine
ISSN: 0022-1007
NlmUniqueID: 2985109R
Country: United States
Language: English
Volume: 119
Issue: 4
Pages: 547-565

Researcher Affiliations

CASALS, J

    MeSH Terms

    • Animals
    • Antigens
    • Encephalitis Virus, Eastern Equine
    • Encephalitis Viruses
    • Encephalomyelitis
    • Encephalomyelitis, Equine
    • Hemagglutination Inhibition Tests
    • Horses
    • United States

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    This article includes 6 references
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