FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Can Vet J / Antimicrobial resistance in bacteria isolated from horses fr...
The Canadian veterinary journal = La revue veterinaire canadienne2018; 59(9); 951-957;

Antimicrobial resistance in bacteria isolated from horses from the Atlantic Provinces, Canada (1994 to 2013).

Abstract: This study determined the antimicrobial susceptibility patterns and trends for selected bacteria isolated from horses using diagnostic data from the Atlantic Veterinary College Diagnostic Services Bacteriology Laboratory, Charlottetown, Prince Edward Island over a 20-year period. subsp. and were the most commonly isolated bacteria over the study period. Clinical samples were most frequently submitted from respiratory and reproductive systems. Most bacterial isolates were susceptible to ceftiofur. Resistance was most common in Gram-negative enteric bacteria, while streptococci were frequently susceptible to most of the antimicrobials tested including penicillin and trimethoprim-sulfamethoxazole. The antimicrobial resistance trends over the study period were relatively stable. Multi-drug resistance was observed in 9% of the bacterial isolates. Information provided in this study could be used to help guide rational, empirical antimicrobial treatment selection in equine practices in Atlantic Canada. Cette étude a déterminé les modèles et les tendances de susceptibilité antimicrobienne pour certaines bactéries isolées des chevaux en s’appuyant sur des données diagnostiques du Laboratoire de bactériologie des services diagnostiques de l’Atlantic Veterinary College à Charlottetown, à l’Île-du-Prince-Édouard, pendant une période de 20 ans. ssp. et ont été les bactéries les plus communément isolées pendant la période à l’étude. Des échantillons cliniques des systèmes respiratoires et reproducteurs étaient les plus fréquemment soumis. La plupart des isolats bactériens étaient susceptibles au ceftiofur. La résistance était la plus courante chez les bactéries entériques à Gram négatif, tandis que les streptocoques étaient fréquemment susceptibles à la plupart des antimicrobiens testés incluant la pénicilline et le triméthoprime-sulfaméthoxazole. Les tendances de résistance aux antimicrobiens pendant la période à l’étude étaient relativement stables. Une multirésistance aux médicaments a été observée dans 9 % des isolats bactériens. Les renseignements fournis dans cette étude pourraient servir à guider un choix rationnel et empirique pour les traitements antimicrobiens dans les pratiques équines des provinces de l’Atlantique.(Traduit par Isabelle Vallières).
Get Full Text
Publication Date: 2018-09-11 PubMed ID: 30197437PubMed Central: PMC6091118
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article studies the resistance patterns and trends of selected bacteria isolated from horses over a span of 20 years in the Atlantic Provinces, Canada.

Objective of Research

  • The main objective of the research was to understand the antimicrobial susceptibility patterns and trends of certain bacteria isolated from horses. This data was sourced from the Atlantic Veterinary College Diagnostic Services Bacteriology Laboratory in Charlottetown, Prince Edward Island, and spans over 20 years.

Findings of Study

  • The research reveals that Streptococci and Gram-negative enteric bacteria were the most common types of bacteria isolated over the 20 year study period.
  • The clinical samples that were analysed primarily came from the respiratory and reproductive systems of the horses.
  • The majority of these bacterial isolates were susceptible to the antibiotic, ceftiofur.
  • Resistance was eminent mostly in the Gram-negative enteric bacteria, while streptococci were susceptible to most of the antimicrobials that were tested. This includes penicillin and trimethoprim-sulfamethoxazole.
  • Over the course of the study, the antimicrobial resistance patterns were relatively stable.
  • The research also discovered that multi-drug resistance was present in about 9% of the bacterial isolates.

Significance of Research

  • In conclusion, the study is of significant value as it compiles information on the susceptibility and resistance patterns in bacteria found in horses from the Atlantic Provinces over a 20-year period.
  • This study provides crucial information that can aid in a more rational and empirical selection of antimicrobial treatments in equine practices within the Atlantic Provinces of Canada.

Cite This Article

APA
Awosile BB, Heider LC, Saab ME, McClure JT. (2018). Antimicrobial resistance in bacteria isolated from horses from the Atlantic Provinces, Canada (1994 to 2013). Can Vet J, 59(9), 951-957.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 59
Issue: 9
Pages: 951-957

Researcher Affiliations

Awosile, Babafela B
  • Department of Health Management (Awosile, Heider, Saab, McClure), Diagnostic Services (Saab), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3.
Heider, Luke C
  • Department of Health Management (Awosile, Heider, Saab, McClure), Diagnostic Services (Saab), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3.
Saab, Matthew E
  • Department of Health Management (Awosile, Heider, Saab, McClure), Diagnostic Services (Saab), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3.
McClure, J T
  • Department of Health Management (Awosile, Heider, Saab, McClure), Diagnostic Services (Saab), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3.

MeSH Terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects
  • Canada / epidemiology
  • Drug Resistance, Bacterial
  • Drug Resistance, Multiple
  • Horse Diseases / microbiology
  • Horses
  • Microbial Sensitivity Tests / veterinary
  • Retrospective Studies

References

This article includes 23 references
  1. Maddox TW, Clegg PD, Williams NJ, Pinchbeck GL. Antimicrobial resistance in bacteria from horses: Epidemiology of antimicrobial resistance.. Equine Vet J 2015 Nov;47(6):756-65.
    pubmed: 26084443doi: 10.1111/evj.12471google scholar: lookup
  2. Weese JS, Giguère S, Guardabassi L, Morley PS, Papich M, Ricciuto DR, Sykes JE. ACVIM consensus statement on therapeutic antimicrobial use in animals and antimicrobial resistance.. J Vet Intern Med 2015 Mar-Apr;29(2):487-98.
    pmc: PMC4895515pubmed: 25783842doi: 10.1111/jvim.12562google scholar: lookup
  3. Johns IC, Adams EL. Trends in antimicrobial resistance in equine bacterial isolates: 1999-2012.. Vet Rec 2015 Mar 28;176(13):334.
    pubmed: 25628448doi: 10.1136/vr.102708google scholar: lookup
  4. Weese JS. Antimicrobial use and antimicrobial resistance in horses.. Equine Vet J 2015 Nov;47(6):747-9.
    pubmed: 26475768doi: 10.1111/evj.12469google scholar: lookup
  5. Bonnet R, Caron F, Cavallo JD, et al. Comité de l’Antibiogramme de la Société Française de Microbiologie. Recomm 2012 [Internet] 2012. [Last accessed May 16, 2018]. [cited 2017 Jun 1]; Available from: https://www.resapath.anses.fr/resapath_uploadfiles/files/Documents/2013_CASFM.pdf.
  6. Leclercq R, Cantón R, Brown DF, Giske CG, Heisig P, MacGowan AP, Mouton JW, Nordmann P, Rodloff AC, Rossolini GM, Soussy CJ, Steinbakk M, Winstanley TG, Kahlmeter G. EUCAST expert rules in antimicrobial susceptibility testing.. Clin Microbiol Infect 2013 Feb;19(2):141-60.
    pubmed: 22117544doi: 10.1111/j.1469-0691.2011.03703.xgoogle scholar: lookup
  7. Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.. Clin Microbiol Infect 2012 Mar;18(3):268-81.
    pubmed: 21793988doi: 10.1111/j.1469-0691.2011.03570.xgoogle scholar: lookup
  8. Clark C, Greenwood S, Boison JO, Chirino-Trejo M, Dowling PM. Bacterial isolates from equine infections in western Canada (1998-2003).. Can Vet J 2008 Feb;49(2):153-60.
    pmc: PMC2216435pubmed: 18309745
  9. Russell CM, Axon JE, Blishen A, Begg AP. Blood culture isolates and antimicrobial sensitivities from 427 critically ill neonatal foals.. Aust Vet J 2008 Jul;86(7):266-71.
    pubmed: 18616477doi: 10.1111/j.1751-0813.2008.00311.xgoogle scholar: lookup
  10. Malo A, Cluzel C, Labrecque O, Beauchamp G, Lavoie JP, Leclere M. Evolution of in vitro antimicrobial resistance in an equine hospital over 3 decades.. Can Vet J 2016 Jul;57(7):747-51.
    pmc: PMC4904812pubmed: 27429463
  11. Erol E, Locke SJ, Donahoe JK, Mackin MA, Carter CN. Beta-hemolytic Streptococcus spp. from horses: a retrospective study (2000-2010).. J Vet Diagn Invest 2012 Jan;24(1):142-7.
    pubmed: 22362945doi: 10.1177/1040638711434138google scholar: lookup
  12. Stewart AJ, Hinchcliff KW, Saville WJ, Jose-Cunilleras E, Hardy J, Kohn CW, Reed SM, Kowalski JJ. Actinobacillus sp. bacteremia in foals: clinical signs and prognosis.. J Vet Intern Med 2002 Jul-Aug;16(4):464-71.
    pubmed: 12141310doi: 10.1892/0891-6640(2002)016<0464:sbifcs>2.3.co;2google scholar: lookup
  13. Marsh PS, Palmer JE. Bacterial isolates from blood and their susceptibility patterns in critically ill foals: 543 cases (1991-1998).. J Am Vet Med Assoc 2001 May 15;218(10):1608-10.
    pubmed: 11393374doi: 10.2460/javma.2001.218.1608google scholar: lookup
  14. Sweeney CR, Timoney JF, Newton JR, Hines MT. Streptococcus equi infections in horses: guidelines for treatment, control, and prevention of strangles.. J Vet Intern Med 2005 Jan-Feb;19(1):123-34.
    pubmed: 15715061
  15. Wilson WD. Rational selection of antimicrobials for use in horses. Proc AAEP 2001;pp. 75–93.
  16. Buckley T, McManamon E, Stanbridge S. Resistance studies of erythromycin and rifampin for Rhodococcus equi over a 10-year period.. Ir Vet J 2007 Dec 1;60(12):728-31.
    pmc: PMC3113830pubmed: 21851690doi: 10.1186/2046-0481-60-12-728google scholar: lookup
  17. Venner M, Credner N, Lämmer M, Giguère S. Comparison of tulathromycin, azithromycin and azithromycin-rifampin for the treatment of mild pneumonia associated with Rhodococcus equi.. Vet Rec 2013 Oct 26;173(16):397.
    pubmed: 24106244doi: 10.1136/vr.101867google scholar: lookup
  18. Cisek AA, Rzewuska M, Witkowski L, Binek M. Antimicrobial resistance in Rhodococcus equi.. Acta Biochim Pol 2014;61(4):633-8.
    pubmed: 25371917
  19. Oliver OE, Stämpfli H. Acute diarrhea in the adult horse: case example and review.. Vet Clin North Am Equine Pract 2006 Apr;22(1):73-84.
    pubmed: 16627106doi: 10.1016/j.cveq.2005.12.008google scholar: lookup
  20. Feary DJ, Hyatt D, Traub-Dargatz J, Roach S, Jones RL, Wu CC, Morley PS. Investigation of falsely reported resistance of Streptococcus equi subsp. zooepidemicus isolates from horses to trimethoprim-sulfamethoxazole.. J Vet Diagn Invest 2005 Sep;17(5):483-6.
    pubmed: 16312244doi: 10.1177/104063870501700515google scholar: lookup
  21. Maddox TW, Clegg PD, Diggle PJ, Wedley AL, Dawson S, Pinchbeck GL, Williams NJ. Cross-sectional study of antimicrobial-resistant bacteria in horses. Part 1: Prevalence of antimicrobial-resistant Escherichia coli and methicillin-resistant Staphylococcus aureus.. Equine Vet J 2012 May;44(3):289-96.
    pubmed: 21848534doi: 10.1111/j.2042-3306.2011.00441.xgoogle scholar: lookup
  22. Health Canada. Categorization of Antimicrobial Drugs Based on Importance in Human Medicine. 2009.
  23. Dunowska M, Morley PS, Traub-Dargatz JL, Hyatt DR, Dargatz DA. Impact of hospitalization and antimicrobial drug administration on antimicrobial susceptibility patterns of commensal Escherichia coli isolated from the feces of horses.. J Am Vet Med Assoc 2006 Jun 15;228(12):1909-17.
    pubmed: 16784384doi: 10.2460/javma.228.12.1909google scholar: lookup

Citations

This article has been cited 6 times.
  1. Lord J, Carter C, Smith J, Locke S, Phillips E, Odoi A. Antimicrobial resistance among Streptococcus equi subspecies zooepidemicus and Rhodococcus equi isolated from equine specimens submitted to a diagnostic laboratory in Kentucky, USA. PeerJ 2022;10:e13682.
    doi: 10.7717/peerj.13682pubmed: 36164606google scholar: lookup
  2. Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortazar Schmidt C, Herskin M, Michel V, Miranda Chueca MA, Padalino B, Pasquali P, Roberts HC, Sihvonen LH, Spoolder H, Stahl K, Velarde A, Viltrop A, Winckler C, Dewulf J, Guardabassi L, Hilbert F, Mader R, Baldinelli F, Alvarez J. Assessment of animal diseases caused by bacteria resistant to antimicrobials: Horses. EFSA J 2021 Dec;19(12):e07112.
    doi: 10.2903/j.efsa.2021.7112pubmed: 34987627google scholar: lookup
  3. Rossi GAM, Sellera FP, Ferraz CM, Carvalho RS, Oliveira APL, Marques CA, Fávaro EBR, Rosa RDS, Silva LAM, Cardozo MV, Stehling EG, Furlan JPR. Antimicrobial-Resistant Enteric Gram-Negative Bacteria Isolated from a Fatal Diarrhea in a Horse: Genomic Characterization of CTX-M-2-Producing Escherichia coli. Antibiotics (Basel) 2025 Nov 21;14(12).
    doi: 10.3390/antibiotics14121185pubmed: 41463689google scholar: lookup
  4. Hepworth-Warren KL, Love K. Survey of the approach to the diagnosis and management of bacterial pneumonia in adult horses by equine veterinarians. Front Vet Sci 2024;11:1484970.
    doi: 10.3389/fvets.2024.1484970pubmed: 39764370google scholar: lookup
  5. Kabir A, Lamichhane B, Habib T, Adams A, El-Sheikh Ali H, Slovis NM, Troedsson MHT, Helmy YA. Antimicrobial Resistance in Equines: A Growing Threat to Horse Health and Beyond-A Comprehensive Review. Antibiotics (Basel) 2024 Jul 29;13(8).
    doi: 10.3390/antibiotics13080713pubmed: 39200013google scholar: lookup
  6. Garcês A, Lopes R, Silva A, Sampaio F, Duque D, Brilhante-Simões P. Bacterial Isolates from Urinary Tract Infection in Dogs and Cats in Portugal, and Their Antibiotic Susceptibility Pattern: A Retrospective Study of 5 Years (2017-2021). Antibiotics (Basel) 2022 Oct 31;11(11).
    doi: 10.3390/antibiotics11111520pubmed: 36358175google scholar: lookup
Subscribe to our newsletter
Join 99,344 horse owners like you who receive our email updates on horse health and nutrition.