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The Veterinary clinics of North America. Equine practice2021; 37(2); 461-494; doi: 10.1016/j.cveq.2021.04.012

Antimicrobial Selection for the Equine Practitioner.

Abstract: Antimicrobial drugs play an important, often central, role in the therapeutic management of mature horses and foals with a variety of illnesses, including those requiring critical care. Antimicrobial use must be based on rational principles involving thorough patient evaluation and sound clinical judgment that indicate a high likelihood that the patient has a bacterial infection and that antimicrobials are indicated to promote recovery. The aim of antimicrobial treatment is to inflict an insult on infecting bacteria sufficient to kill the organism or render it susceptible to inactivation by natural host defenses or the local microenvironment without adversely affecting the patient.
Publication Date: 2021-07-11 PubMed ID: 34243881DOI: 10.1016/j.cveq.2021.04.012Google Scholar: Lookup
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Summary

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This study focuses on the best practices for the use of antimicrobial drugs in the treatment of horses and foals, particularly for bacterial infections. The research underscores the need for sound judgement and patient evaluation in the decision to use antimicrobials to assist in patient recovery without causing harm.

Antimicrobial Drugs and Horse Illnesses

  • The study centers on the role of antimicrobial drugs in the treatment of various illnesses in mature horses and foals. These medicines are especially important for treating critical conditions requiring swift and effective intervention.
  • The researchers examine the process through which clinicians choose to use antimicrobial drugs. They conclude that this decision should be based on rational principles, suggesting a carefully considered and scientific approach to antimicrobial usage.

Principle of Treatment

  • The principle behind using antimicrobial treatment, as identified by the research is two-fold. First, the drug must be potent enough to either kill the bacteria causing the illness or render it ineffective. This ultimately leads to the stoppage of the infection and consequent improvement in the patient’s health.
  • The second part of this principle is ensuring that the horse or foal being treated doesn’t experience any adverse effects from the treatment. Here, the study emphasises the importance of maintaining patient welfare while attempting to eradicate the infection.

Importance of Patient Evaluation

  • The study stresses the importance of thorough patient evaluation prior to the administration of antimicrobial drugs. This involves accurately diagnosing the presence of a bacterial infection in the patient and assessing the likelihood that the patient’s health will be improved by the administration of antimicrobials.
  • Such an evaluation requires sound clinical judgement. The researchers suggest that only when a clinician is highly confident in both their diagnosis of a bacterial infection and in the effectiveness of potential antimicrobial treatment should such drugs be used.

Cite This Article

APA
Wilson WD, Magdesian KG. (2021). Antimicrobial Selection for the Equine Practitioner. Vet Clin North Am Equine Pract, 37(2), 461-494. https://doi.org/10.1016/j.cveq.2021.04.012

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 37
Issue: 2
Pages: 461-494
PII: S0749-0739(21)00032-8

Researcher Affiliations

Wilson, W David
  • Department of Medicine (VM: VME), School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA. Electronic address: wdwilson@ucdavis.edu.
Magdesian, K Gary
  • Department of Medicine (VM: VME), School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA.

MeSH Terms

  • Animals
  • Anti-Infective Agents / therapeutic use
  • Antimicrobial Stewardship
  • Bacterial Infections / drug therapy
  • Bacterial Infections / microbiology
  • Bacterial Infections / veterinary
  • Drug Resistance, Bacterial
  • Horse Diseases / drug therapy
  • Horse Diseases / microbiology
  • Horses

Conflict of Interest Statement

Disclosure The authors have no affiliations or agreements that would constitute conflicts of interest.

Citations

This article has been cited 2 times.
  1. Pimenta J, Pinto AR, Saavedra MJ, Cotovio M. Equine Gram-Negative Oral Microbiota: An Antimicrobial Resistances Watcher?. Antibiotics (Basel) 2023 Apr 21;12(4).
    doi: 10.3390/antibiotics12040792pubmed: 37107153google scholar: lookup
  2. Tyrnenopoulou P, Fthenakis GC. Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids.. Antibiotics (Basel) 2023 Mar 28;12(4).
    doi: 10.3390/antibiotics12040664pubmed: 37107026google scholar: lookup