Antiviral agents against equid alphaherpesviruses: Current status and perspectives.
Abstract: Equid herpesvirus infections cause respiratory, neurological and reproductive syndromes. Despite preventive and control measures and the availability of vaccines and immunostimulants, herpesvirus infections still constitute a major threat to equine health and for the equine industry worldwide. Antiviral drugs, particularly nucleoside analogues and foscarnet, are successfully used for the treatment of human alphaherpesvirus infections. In equine medicine, the use of antiviral medications in alphaherpesvirus infections would decrease the excretion of virus and diminish the risk of contagion and the convalescent time in affected horses, and would also improve the clinical outcome of equine herpesvirus myeloencephalopathy. The combined use of antiviral compounds, along with vaccines, immune modulators, and effective preventive and control measures, might be beneficial in diminishing the negative impact of alphaherpesvirus infections in horses. The purpose of this review is to analyse the available information regarding the use of antiviral agents against alphaherpesviruses, with particular emphasis on equine alphaherpesvirus infections.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication Date: 2015-06-12 PubMed ID: 26654843DOI: 10.1016/j.tvjl.2015.06.010Google Scholar: Lookup
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Summary
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The research article discusses the use of antiviral agents in combating equid alphaherpesviruses, which cause severe respiratory, neurological, and reproductive diseases in horses. Despite the availability of vaccines and immunostimulants, these infections remain a concern for equine health and the horse industry.
Equid Alphaherpesviruses: An Overview
- The article mainly focuses on equid herpesviruses, which cause a variety of health issues in horses, including respiratory, neurological, and reproductive diseases. These infections are a significant threat to the health of horses globally, despite the existence of preventive measures, vaccines, and immunostimulants.
Antiviral Drugs in Combatting Equid Alphaherpesviruses
- The researchers discuss the potential of antiviral drugs, notably nucleoside analogues and foscarnet, in treating equid herpesvirus infections. These drugs have proven effective in treating human alphaherpesvirus infections.
- The research underscores that utilizing antiviral medications could decrease the excretion of the virus, reduce the risk of contagion and the recovery time in affected horses, and improve the clinical outcome of equine herpesvirus myeloencephalopathy, a severe and often fatal neurological disease in horses.
Combination Therapies for Equid Alphaherpesviruses
- The combination of antiviral drugs with preventive measures, vaccines, and immune modulators can help minimize the negative impacts of alphaherpesvirus infections in horses, according to the research.
Review and Analysis of Existing Information
- Lastly, the research contributes to knowledge by reviewing and analyzing currently available data on the use of antiviral agents against alphaherpesviruses, specifically in the context of equine alphaherpesvirus infections. This analysis can guide future research and serve as a reference for veterinarians and researchers in the field.
Cite This Article
APA
Vissani MA, Thiry E, Dal Pozzo F, Barrandeguy M.
(2015).
Antiviral agents against equid alphaherpesviruses: Current status and perspectives.
Vet J, 207, 38-44.
https://doi.org/10.1016/j.tvjl.2015.06.010 Publication
Researcher Affiliations
- Instituto de Virología, CICVyA, INTA, Las Cabañas y Los Reseros s/n, Castelar 1712, Argentina. Electronic address: vissani.aldana@inta.gob.ar.
- Veterinary Virology and Animal Viral Diseases and UREAR, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, B-4000 Liege, Belgium.
- Veterinary Virology and Animal Viral Diseases and UREAR, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, B-4000 Liege, Belgium.
- Instituto de Virología, CICVyA, INTA, Las Cabañas y Los Reseros s/n, Castelar 1712, Argentina; Carrera de Veterinaria, Universidad del Salvador, Champagnat 1599, Ruta Panamericana km 54.5 (B1630AHU), Pilar, Buenos Aires, Argentina.
MeSH Terms
- Alphaherpesvirinae
- Animals
- Antiviral Agents / therapeutic use
- Herpesviridae Infections / drug therapy
- Herpesviridae Infections / veterinary
- Herpesvirus 1, Equid
- Horse Diseases / therapy
- Horse Diseases / virology
- Horses
- Humans
Citations
This article has been cited 6 times.- Wang L, Unger L, Sharif H, Eriksson S, Gerber V, Rönnberg H. Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma. BMC Mol Cell Biol 2021 Dec 14;22(1):59.
- Alling CR, Liu CC, Langohr IM, Haque M, Carter RT, Baker RE, Lewin AC. Assessment of Cidofovir for Treatment of Ocular Bovine Herpesvirus-1 Infection in Cattle Using an Ex-Vivo Model. Viruses 2021 Oct 18;13(10).
- Andreu S, Ripa I, Bello-Morales R, López-Guerrero JA. Valproic Acid and Its Amidic Derivatives as New Antivirals against Alphaherpesviruses. Viruses 2020 Nov 26;12(12).
- Lecollinet S, Pronost S, Coulpier M, Beck C, Gonzalez G, Leblond A, Tritz P. Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe?. Viruses 2019 Dec 24;12(1).
- Shabani M, Nasr Esfahani B, Sadegh Ehdaei B, Moghim S, Mirzaei A, Sharifi M, Mouhebat L. Inhibition of herpes simplex virus type 1 replication by novel hsa-miR-7704 in vitro. Res Pharm Sci 2019 Apr;14(2):167-174.
- Lamote JAS, Kestens M, Van Waesberghe C, Delva J, De Pelsmaeker S, Devriendt B, Favoreel HW. The Pseudorabies Virus Glycoprotein gE/gI Complex Suppresses Type I Interferon Production by Plasmacytoid Dendritic Cells. J Virol 2017 Apr 1;91(7).
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