Assessment of animal diseases caused by bacteria resistant to antimicrobials: Horses.
Abstract: In this opinion, the antimicrobial-resistant bacteria responsible for transmissible diseases that constitute a threat to the health of horses have been assessed. The assessment has been performed following a methodology composed of information collected via an extensive literature review and expert judgement. Details on the methodology used for this assessment are explained in a separate opinion. A global state of play of antimicrobial-resistant spp. spp. and subsp and subsp. and subsp. has been provided. Among those bacteria, EFSA identified , and with more than 66% certainty as the most relevant antimicrobial-resistant bacteria in the EU, given their importance as causative agents of clinical disease in horses and the significant levels of resistance to clinically relevant antimicrobials. The animal health impact of these 'most relevant' bacteria as well as their eligibility of being listed and categorised within the animal health law framework will be assessed in separate scientific opinions.
© 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Publication Date: 2021-12-24 PubMed ID: 34987627PubMed Central: PMC8703245DOI: 10.2903/j.efsa.2021.7112Google Scholar: Lookup
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- Journal Article
Summary
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This research evaluates the impact of bacteria resistant to antimicrobials, which are harmful to horse health. The investigation involved an extensive literature review and expert judgement, identifying certain bacteria strains that are likely to be the most significant antimicrobial-resistant threats to horses in the EU.
Research methodology
- This research evaluated antimicrobial-resistant bacteria that cause diseases threatening the health of horses.
- The process involved collecting information through an extensive literature review and soliciting expert opinion. The specifics of the methodology used, however, are explained in a separate paper.
- A comprehensive review was given of antimicrobial-resistant strains such as spp. spp. and subsp, and variations of these bacteria.
Findings
- The research identified, with over 66% certainty, three types of bacteria which are the most relevant in the European Union due to their significant levels of resistance to clinically relevant antimicrobials. These bacteria are vital agents of clinical disease in horses.
- Unfortunately, the names of these bacteria strains have not been provided in the given abstract.
Future research
- The study concludes with a proposal for future scientific opinions to assess the animal health impact of the identified ‘most relevant’ bacteria.
- The authors suggest further investigation into whether these bacteria should be listed and categorised under the animal health law framework for better regulation and control.
Cite This Article
APA
Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortazar Schmidt C, Herskin M, Michel V, Miranda Chueca MA, Padalino B, Pasquali P, Roberts HC, Sihvonen LH, Spoolder H, Stahl K, Velarde A, Viltrop A, Winckler C, Dewulf J, Guardabassi L, Hilbert F, Mader R, Baldinelli F, Alvarez J.
(2021).
Assessment of animal diseases caused by bacteria resistant to antimicrobials: Horses.
EFSA J, 19(12), e07112.
https://doi.org/10.2903/j.efsa.2021.7112 Publication
Researcher Affiliations
References
This article includes 28 references
- Adams R, Smith J, Locke S, Phillips E, Erol E, Carter C, Odoi A. An epidemiologic study of antimicrobial resistance of Staphylococcus species isolated from equine samples submitted to a diagnostic laboratory.. BMC Vet Res 2018 Feb 5;14(1):42.
- Awosile BB, Heider LC, Saab ME, McClure JT. Antimicrobial resistance in bacteria isolated from horses from the Atlantic Provinces, Canada (1994 to 2013).. Can Vet J 2018 Sep;59(9):951-957.
- Berghaus LJ, Giguère S, Guldbech K, Warner E, Ugorji U, Berghaus RD. Comparison of Etest, disk diffusion, and broth macrodilution for in vitro susceptibility testing of Rhodococcus equi.. J Clin Microbiol 2015 Jan;53(1):314-8.
- Bortolami A, Zendri F, Maciuca EI, Wattret A, Ellis C, Schmidt V, Pinchbeck G, Timofte D. Diversity, Virulence, and Clinical Significance of Extended-Spectrum β-Lactamase- and pAmpC-Producing Escherichia coli From Companion Animals.. Front Microbiol 2019;10:1260.
- Bourély C, Cazeau G, Jarrige N, Haenni M, Gay E, Leblond A. Antimicrobial resistance in bacteria isolated from diseased horses in France.. Equine Vet J 2020 Jan;52(1):112-119.
- Davis HA, Stanton MB, Thungrat K, Boothe DM. Uterine bacterial isolates from mares and their resistance to antimicrobials: 8,296 cases (2003-2008).. J Am Vet Med Assoc 2013 Apr 1;242(7):977-83.
- Duchesne R, Castagnet S, Maillard K, Petry S, Cattoir V, Giard JC, Leon A. In vitro antimicrobial susceptibility of equine clinical isolates from France, 2006-2016.. J Glob Antimicrob Resist 2019 Dec;19:144-153.
- Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortazar Schmidt C, Herskin M, Michel V, Miranda Chueca MA, Padalino B, Pasquali P, Roberts HC, Sihvonen LH, Spoolder H, Stahl K, Velarde A, Viltrop A, Winckler C, Dewulf J, Guardabassi L, Hilbert F, Mader R, Smith P, Aznar I, Baldinelli F, Alvarez J. Ad hoc method for the assessment of animal diseases caused by bacteria resistant to antimicrobials.. EFSA J 2021 Jun;19(6):e06645.
- Elias L, Gillis DC, Gurrola-Rodriguez T, Jeon JH, Lee JH, Kim TY, Lee SH, Murray SA, Ohta N, Scott HM, Wu J, Rogovskyy AS. The Occurrence and Characterization of Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli Isolated from Clinical Diagnostic Specimens of Equine Origin.. Animals (Basel) 2019 Dec 21;10(1).
- Erol E, Locke SJ, Donahoe JK, Mackin MA, Carter CN. Beta-hemolytic Streptococcus spp. from horses: a retrospective study (2000-2010).. J Vet Diagn Invest 2012 Jan;24(1):142-7.
- Erol E, Locke S, Saied A, Cruz Penn MJ, Smith J, Fortner J, Carter C. Antimicrobial susceptibility patterns of Rhodococcus equi from necropsied foals with rhodococcosis.. Vet Microbiol 2020 Mar;242:108568.
- Estell KE, Young A, Kozikowski T, Swain EA, Byrne BA, Reilly CM, Kass PH, Aleman M. Pneumonia Caused by Klebsiella spp. in 46 Horses.. J Vet Intern Med 2016 Jan-Feb;30(1):314-21.
- EUCAST. EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and/or epidemiological importance. 2017 Version 2.0 Edition.
- Ewers C, Stamm I, Pfeifer Y, Wieler LH, Kopp PA, Schønning K, Prenger-Berninghoff E, Scheufen S, Stolle I, Günther S, Bethe A. Clonal spread of highly successful ST15-CTX-M-15 Klebsiella pneumoniae in companion animals and horses.. J Antimicrob Chemother 2014 Oct;69(10):2676-80.
- Fonseca JD, Mavrides DE, Morgan AL, Na JG, Graham PA, McHugh TD. Antibiotic resistance in bacteria associated with equine respiratory disease in the United Kingdom.. Vet Rec 2020 Sep 5;187(5):189.
- Giguère S, Berghaus LJ, Willingham-Lane JM. Antimicrobial Resistance in Rhodococcus equi.. Microbiol Spectr 2017 Oct;5(5).
- Guérin F, Fines-Guyon M, Meignen P, Delente G, Fondrinier C, Bourdon N, Cattoir V, Léon A. Nationwide molecular epidemiology of methicillin-resistant Staphylococcus aureus responsible for horse infections in France.. BMC Microbiol 2017 May 3;17(1):104.
- Haenni M, Targant H, Forest K, Sévin C, Tapprest J, Laugier C, Madec JY. Retrospective study of necropsy-associated coagulase-positive staphylococci in horses.. J Vet Diagn Invest 2010 Nov;22(6):953-6.
- Haenni M, Châtre P, Dupieux-Chabert C, Métayer V, Bes M, Madec JY, Laurent F. Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in Horses, Cats, and Dogs Over a 5-Year Period in France.. Front Microbiol 2017;8:2493.
- Johns IC, Adams EL. Trends in antimicrobial resistance in equine bacterial isolates: 1999-2012.. Vet Rec 2015 Mar 28;176(13):334.
- Léon A, Castagnet S, Maillard K, Paillot R, Giard JC. Evolution of In Vitro Antimicrobial Susceptibility of Equine Clinical Isolates in France between 2016 and 2019.. Animals (Basel) 2020 May 7;10(5).
- Mader R, Damborg P, Amat JP, Bengtsson B, Bourély C, Broens EM, Busani L, Crespo-Robledo P, Filippitzi ME, Fitzgerald W, Kaspar H, Madero CM, Norström M, Nykäsenoja S, Pedersen K, Pokludova L, Urdahl AM, Vatopoulos A, Zafeiridis C, Madec JY. Building the European Antimicrobial Resistance Surveillance network in veterinary medicine (EARS-Vet).. Euro Surveill 2021 Jan;26(4).
- Pisello L, Rampacci E, Stefanetti V, Beccati F, Hyatt DR, Coletti M, Passamonti F. Temporal efficacy of antimicrobials against aerobic bacteria isolated from equine endometritis: an Italian retrospective analysis (2010-2017).. Vet Rec 2019 Nov 16;185(19):598.
- nResapathn(ANSES). French surveillance network for antimicrobial resistance in bacteria from diseased animals 2018 annual report. 2020.
- Saputra S, Jordan D, Worthing KA, Norris JM, Wong HS, Abraham R, Trott DJ, Abraham S. Antimicrobial resistance in coagulase-positive staphylococci isolated from companion animals in Australia: A one year study.. PLoS One 2017;12(4):e0176379.
- van Spijk JN, Schmitt S, Fürst AE, Schoster A. A retrospective analysis of antimicrobial resistance in bacterial pathogens in an equine hospital (2012-2015).. Schweiz Arch Tierheilkd 2016 Jun;158(6):433-42.
- nSwedres‐Svarmn. Sales of antibiotics and occurrence of resistance in Sweden. 2018 ISSN 1650-6332, Solna/Uppsala.
- nSwedres‐Svarmn. Sales of antibiotics and occurrence of resistance in Sweden. 2019 1650-6332 Solna/Uppsala.
Citations
This article has been cited 4 times.- Tyrnenopoulou P, Fthenakis GC. Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids.. Antibiotics (Basel) 2023 Mar 28;12(4).
- Vereecke N, Vandekerckhove A, Theuns S, Haesebrouck F, Boyen F. Whole genome sequencing to study antimicrobial resistance and RTX virulence genes in equine Actinobacillus isolates.. Vet Res 2023 Apr 5;54(1):33.
- Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar C, Herskin M, Michel V, Miranda Chueca MÁ, Padalino B, Pasquali P, Roberts HC, Spoolder H, Ståhl K, Velarde A, Viltrop A, Winckler C, Baldinelli F, Broglia A, Kohnle L, Alvarez J. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Escherichia coli in dogs and cats, horses, swine, poultry, cattle, sheep and goats.. EFSA J 2022 May;20(5):e07311.
- Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar C, Herskin M, Michel V, Miranda Chueca MÁ, Padalino B, Pasquali P, Roberts HC, Spoolder H, Ståhl K, Velarde A, Viltrop A, Winckler C, Baldinelli F, Broglia A, Kohnle L, Alvarez J. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Staphylococcus aureus in cattle and horses.. EFSA J 2022 May;20(5):e07312.
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