Assessment of the application for renewal of authorisation of Yea-Sacc® (Saccharomyces cerevisiae) for horses.
Abstract: Yea-Sacc is an additive based on a live preparation of a strain of intended for use as a zootechnical additive (digestibility enhancer). The current assessment is performed in the context of the renewal of the authorisation of the feed additive; however, the applicant proposed also to lower (6.5 × 10 colony forming unit (CFU)/kg of complete feedingstuff) the minimum dose of the additive when used in feed for horses. The additive is produced in a powder (Yea-Sacc) and in a prills (Yea-Sacc_TS) forms. The Panel considered that the additive currently on the market complies with the existing conditions of authorisation. is considered by EFSA to be suitable for the qualified presumption of safety approach to safety assessment. As the identity of the production strain has been confirmed, safety for the target species, consumer and the environment were presumed. Both formulations are non-irritant to skin, Yea-Sacc_TS is non-irritant to the eye while Yea-Sacc is a moderate irritant. Both formulations should be considered skin sensitisers and because of their high proteinaceous nature, they should be considered as potential respiratory sensitisers. The applicant submitted two efficacy studies: the FEEDAP Panel concluded that in the first study inconsistent results were observed for the two lower doses which are considered microbiologically equivalent. The second study demonstrated that Yea-Sacc at the level of 7.5 × 10 resulted in a better digestion of organic matter which may be explained by increases in digestibility of the fibre. Based on the data provided, the FEEDAP Panel cannot conclude on the efficacy of Yea-sacc when used as a feed additive in horses at the proposed level (6.5 × 10 CFU/kg complete feed).
© 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Publication Date: 2019-12-19 PubMed ID: 32626206PubMed Central: PMC7008869DOI: 10.2903/j.efsa.2019.5918Google Scholar: Lookup
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Summary
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The research article assesses Yea-Sacc, a zootechnical additive for horse feed based on a strain of Saccharomyces cerevisiae, in the context of renewal of its authorization. It also proposes to lower its minimum dose when used in horse feed. Despite inconsistent results in the first study, it was concluded that Yea-Sacc improves digestion of organic matter in horses in the second study. However, the research panel couldn’t confirm its efficacy at the proposed level.
Background and Purpose of the Research
- The research focuses on Yea-Sacc, a zootechnical additive made from a live preparation of Saccharomyces cerevisiae. It is mainly used as a digestibility enhancer in animal feed, in this case, specifically horses.
- The context of this research revolves around the renewal of Yea-Sacc’s authorization. The researchers are also considering a proposal to lower the minimum dose of Yea-Sacc in horse feed.
- The two forms of Yea-Sacc studied are a powder and a prills (small, round pellets). Both types of the additive are currently available in the market and have complied with existing authorization conditions.
Safety Assessment and Findings
- The study assessed the safety of Yea-Sacc, with the European Food Safety Authority presuming it to be safe for the target species (horses), consumers, and the environment since the identity of the production strain was confirmed.
- However, there are certain aspects to consider. Whilst both forms of Yea-Sacc do not irritate the skin, the powdered form causes moderate irritation to the eyes. Additionally, both formulations proved to be potential skin sensitizers.
- Due to their high protein content, the study suggests that both types of Yea-Sacc should be classified as potential respiratory sensitizers as well.
Efficacy Studies and Conclusions
- The applicant conducted two efficacy studies for Yea-Sacc. In the first study, results were inconsistent for the two lower doses, which were considered microbiologically the same.
- On the other hand, the second study proved that Yea-Sacc led to improved digestion of organic matter. This improvement might be attributed to increases in the digestibility of fiber.
- In spite of these results, the two studies’ data could not conclusively establish the effectiveness of Yea-Sacc when used as a feed additive for horses at the proposed lower dose level.
Cite This Article
APA
Bampidis V, Azimonti G, de Lourdes Bastos M, Christensen H, Dusemund B, Kouba M, Kos Durjava M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Anguita M, Galobart J, Holczknecht O, Manini P, Tarrés-Call J, Pettenati E, Pizzo F.
(2019).
Assessment of the application for renewal of authorisation of Yea-Sacc® (Saccharomyces cerevisiae) for horses.
EFSA J, 17(12), e05918.
https://doi.org/10.2903/j.efsa.2019.5918 Publication
Researcher Affiliations
References
This article includes 6 references
- EFSA. Opinion of the Scientific Panel on additives and products or substances used in animal feed on the safety of the product Yea‐Sacc® for leisure horses. EFSA Journal 2003;2(3):7, 5 pp.
- EFSA. Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) on the safety and efficacy Yea‐Sacc1026® (Saccharomyces cerevisiae) for horses. EFSA Journal 2009;7(3):991, 15 pp.
- EFSA FEEDAP Panel. Guidance on the renewal of the authorisation of feed additives. EFSA Journal 2013;11(10):3431, 8 pp.
- EFSA FEEDAP Panel. Scientific opinion on the safety and efficacy of Yea‐Sacc® (Saccharomyces cerevisiae) as a feed additive for cattle for fattening, goats for fattening, dairy cows, dairy sheep, dairy goats and buffaloes. EFSA Journal 2014;12(5):3666, 15 pp.
- EFSA FEEDAP Panel. Guidance on the characterisation of microorganisms used as feed additives or as production organisms. EFSA Journal 2018;16(3):5206, 24 pp.
- EFSA FEEDAP Panel. Guidance on the assessment of the efficacy of feed additives. EFSA Journal 2018;16(5):5274, 25 pp.
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