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Animals : an open access journal from MDPI2020; 10(2); 332; doi: 10.3390/ani10020332

Broad-Spectrum Cephalosporin-Resistant Klebsiella spp. Isolated from Diseased Horses in Austria.

Abstract: The aim of the present study was to investigate the diversity of broad-spectrum cephalosporin-resistant spp. isolated from horses in Austria that originated from diseased horses. A total of seven non-repetitive cefotaxime-resistant sp. isolates were obtained during diagnostic activities from autumn 2012 to October 2019. Antimicrobial susceptibility testing was performed. The isolates were genotyped by whole-genome sequencing (WGS). Four out of seven isolates were identified as , two as and one as . All isolates displayed a multi-drug resistant phenotype. The detection of resistance genes reflected well the phenotypic resistance profiles of the respective isolates. All but one isolate displayed the extended-spectrum β-lactamases (ESBL) phenotype and carried CTX-M cefotaximases, whereas one isolate displayed an ESBL and AmpC phenotype and carried cephamycinase (CMY)-2 and sulfhydryl variable (SHV)-type b and Temoniera (TEM) β-lactamases. Among isolates, for different sequence types (ST) could be detected (ST147, ST307, ST1228, and a new ST4848). Besides resistance genes, a variety of virulence genes, including genes coding for yersiniabactin were detected. Considering the high proximity between horses and humans, our results undoubtedly identified a public health issue. This deserves to be also monitored in the years to come.
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Publication Date: 2020-02-20 PubMed ID: 32093201PubMed Central: PMC7070950DOI: 10.3390/ani10020332Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article focuses on investigating diverse strains of broad-spectrum cephalosporin-resistant Klebsiella species in sick horses in Austria.

Research Objective and Methods

According to the study:

  • The researchers aimed to study the variety of broad-spectrum cephalosporin-resistant Klebsiella species that originated from diseased horses in Austria.
  • For this purpose, they collected seven non-repetitive cefotaxime-resistant Klebsiella species isolates from diagnostic activities performed from Autumn 2012 until October 2019.
  • To assess the strains’ resistance to antibiotics, the researchers conducted Antimicrobial susceptibility testing.
  • The isolates collected were then genotyped using a method known as Whole-genome sequencing (WGS).

Research Findings

Several important observations were made in this study:

  • Out of the seven isolates collected, four were identified as Klebsiella pneumoniae, two as Klebsiella oxytoca and one as Klebsiella grimontii.
  • It was discovered that each strain showed signs of resistance to multiple drugs, a condition otherwise known as a multi-drug resistant phenotype.
  • The isolation of different resistance genes accurately represented the respective isolation strains’ resistance profiles.
  • All but one of the isolates exhibited an extended-spectrum β-lactamases (ESBL) phenotype and carried CTX-M agent cefotaximases, linked with resistance to antibiotics.
  • One isolate showcased an ESBL and AmpC phenotype, indicating the presence of enzymes degrading antibiotics, and carried cephamycinase (CMY)-2 and sulfhydryl variable (SHV)-type b and Temoniera (TEM) β-lactamases.
  • Four different sequence types (ST) were identified among the Klebsiella pneumoniae isolates: ST147, ST307, ST1228 and an unknown ST which was christened as ST4848.
  • In addition to the resistance genotypes, various virulence genes were spotted in the isolates, including those that code for yersiniabactin – a siderophore that steals iron from host cells and is crucial for bacterial infection in host organisms.

Significance of the Findings

The findings of this study have important implications:

  • The findings shine light on a potential health issue as there is close proximity between horses and humans, increasing the chances of these resistant strains causing infections in humans.
  • The researchers emphasize on the need for continued study and monitoring of these strains in the future.

Cite This Article

APA
Loncaric I, Cabal Rosel A, Szostak MP, Licka T, Allerberger F, Ruppitsch W, Spergser J. (2020). Broad-Spectrum Cephalosporin-Resistant Klebsiella spp. Isolated from Diseased Horses in Austria. Animals (Basel), 10(2), 332. https://doi.org/10.3390/ani10020332

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 10
Issue: 2
PII: 332

Researcher Affiliations

Loncaric, Igor
  • Institute of Microbiology, University of Veterinary Medicine, 1210 Vienna, Austria.
Cabal Rosel, Adriana
  • Institute of Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safety, 1090 Vienna, Austria.
Szostak, Michael P
  • Institute of Microbiology, University of Veterinary Medicine, 1210 Vienna, Austria.
Licka, Theresia
  • Clinical Unit of Equine Surgery, University of Veterinary Medicine, 1210 Vienna, Austria.
Allerberger, Franz
  • Institute of Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safety, 1090 Vienna, Austria.
Ruppitsch, Werner
  • Institute of Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safety, 1090 Vienna, Austria.
Spergser, Joachim
  • Institute of Microbiology, University of Veterinary Medicine, 1210 Vienna, Austria.

Grant Funding

  • H2020-SFS-2016-2017 (H2020-SFS-2017-1) / Framework Programme H2020

Conflict of Interest Statement

The authors declare no conflict of interest.

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