Case report: Use of penicillin G potassium in poloxamer 407 gel to aid in healing of an equine sublingual abscess.
Abstract: The use of poloxamer 407 gels have been reported in several studies to prolong the release of drugs at the injection site. Oral lesions unrelated to dental disease are rare but may result in ulceration and sequestration of bone. To date, there have been no reports on the use of penicillin G potassium poloxamer 407 gel and its effect on wound healing. The present case report describes the use of a penicillin G potassium poloxamer 407 gel for the treatment of a sublingual abscess involving the mandible in a 20 year old Arabian mare who initially presented with acute onset of dysphagia, hypersalivation, and a mass under the tongue. A presumptive diagnosis of lingual cellulitis was made, and a sublingual abscess ruptured on day 7 of hospitalization. In this case, poloxamer 407 gel was used to decrease wound contamination, protect the exposed mandible, and potentially prolong the release of penicillin G potassium into the wound.
Copyright © 2022 Larsen, Lack and Wassack.
Publication Date: 2022-07-29 PubMed ID: 35968007PubMed Central: PMC9372548DOI: 10.3389/fvets.2022.783753Google Scholar: Lookup
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Summary
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The research article is about a case study involving the use of penicillin G potassium in poloxamer 407 gel to aid in healing a sublingual abscess in a 20-year-old Arabian mare.
Research Overview
The research focuses on an uncommon case of a sublingual (beneath the tongue) abscess in an Arabian horse. The researchers used a unique treatment combination of penicillin G potassium and poloxamer 407 gel. The main hypothesis was that this combination could help heal the abscess by reducing wound contamination, protecting the exposed bone and possibly extending the release of penicillin into the wound.
Poloxamer 407 Gel and Penicillin G Potassium
- Poloxamer 407 gels have been recognized in multiple studies for their ability to prolong the release of drugs at the injection site.
- Penicillin G potassium is an antibiotic used to treat severe bacterial infections.
- In this case, the two were combined to make a unique medication. The hope was that the gel would prolong the release of the antibiotic, ensuring that it continues fighting off the infection over a longer period of time.
Case Presentation
- The horse, a 20-year-old Arabian mare, had an acute onset of dysphagia (difficulty swallowing), hypersalivation (excessive saliva), and a mass under its tongue.
- A preliminary diagnosis of lingual cellulitis (inflammation of the cells of the tongue) was given.
- A sublingual abscess (pus-filled swelling under the tongue) ruptured on the seventh day of the mare being hospitalized.
The Treatment
- The researchers chose to use the poloxamer 407 gel infused with penicillin G potassium to treat the abscess, with an intention to diminish wound contamination, shield the exposed mandible (horse’s jawbone), and possibly maintain the release of penicillin G potassium into the wound.
- This was an innovative approach, as there have been no previous reports on the use of penicillin G potassium poloxamer 407 gel and its effect on wound healing.
Cite This Article
APA
Larsen EA, Lack AC, Wassack E.
(2022).
Case report: Use of penicillin G potassium in poloxamer 407 gel to aid in healing of an equine sublingual abscess.
Front Vet Sci, 9, 783753.
https://doi.org/10.3389/fvets.2022.783753 Publication
Researcher Affiliations
- Oklahoma State University Veterinary Medical Hospital, Stillwater, OK, United States.
- Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University College of Veterinary Medicine, Mississippi State, MS, United States.
- Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University College of Veterinary Medicine, Mississippi State, MS, United States.
- Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
- Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University College of Veterinary Medicine, Mississippi State, MS, United States.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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