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Home / Equine Research Bank / J Vet Intern Med / Catheter-associated venous air embolism in hospitalized hors...
Journal of veterinary internal medicine2018; 32(2); 805-814; doi: 10.1111/jvim.15057

Catheter-associated venous air embolism in hospitalized horses: 32 cases.

Abstract: Venous air embolism is a potentially life-threatening complication of IV catheter use in horses. Despite widespread anecdotal reports of their occurrence, few cases have been reported in the literature and the prognosis is currently unknown. Objective: Our objective was to describe the surrounding circumstances, clinical signs, treatment, progression, and outcome of venous air embolism in hospitalized horses. Methods: Thirty-two horses with acute onset of compatible clinical signs associated with IV catheter disconnection or damage. Methods: Multicenter retrospective study. Data extracted from clinical records included signalment, presenting complaint, catheter details, clinical signs, treatments, and outcome. Results: Most cases resulted from extension set disconnection occurring within approximately 24 hours after catheter placement. In fewer horses, extension set damage was cited as a cause. Common clinical signs included tachycardia, tachypnea, recumbency, muscle fasciculations and agitation, with abnormal behavior including kicking and flank biting. Less commonly, pathological arrhythmias or more severe neurologic signs, including blindness and seizures, were noted. Progression was unpredictable, with some affected horses developing delayed-onset neurologic signs. Mortality was 6/32 (19%), including 2 cases of sudden death and other horses euthanized because of persistent neurologic deficits. Negative outcomes were more common in horses with recorded blindness, sweating or recumbency, but blindness resolved in 5/8 affected horses. Conclusions: The prognosis for resolution of clinical signs after air embolism is fair, but permanent neurologic deficits or pathologic cardiac arrhythmias can arise. Unpredictable progression warrants close monitoring. Systematic clinic-based surveillance could provide additional useful information to aid prevention.
Copyright © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2018-02-20 PubMed ID: 29460300PubMed Central: PMC5866986DOI: 10.1111/jvim.15057Google Scholar: Lookup
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  • Journal Article
  • Multicenter Study

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores air embolism cases associated with IV catheter use in hospitalized horses, detailing the circumstances, symptoms, treatment, progression, and outcome.

Objective and Methodology

  • The study aims to document cases of venous air embolism; a complication from IV catheter use in horses which is believed to be common but not often reported in literature, with the prognosis still unknown.
  • The method used in this research was a retrospective study of 32 horses that showed sudden compatible clinical signs related to the disconnection or damage of their IV catheter.
  • Data extracted from the subjects’ clinical records included their characteristics, presenting complaint, details about the catheter, symptoms, treatments received, and outcome.

Results

  • Most air embolism cases were due to a disconnection of the extension set from the catheter, typically within 24 hours after placement.
  • Less common were cases related to damage to the extension set.
  • Common symptoms observed in the horses included fast heart rate, fast breathing, collapse, muscle twitching, and agitation, alongside unusual behavior such as kicking and biting themselves.
  • Less frequent were more severe symptoms such as heart arrhythmias, blindness, and seizures.
  • The progression of the condition was not predictable, with delayed-onset neurological symptoms occurring in some horses.
  • The rate of mortality was 19%, with two cases of instantaneous death and other horses euthanized due to persistent neurological deficits.
  • Negative outcomes were more common in horses with noted symptoms of blindness, sweating, or collapse, but blindness was resolved in 5 of the 8 horses displaying it.

Conclusions

  • The study concludes that while the prognosis for resolution of symptoms after an air embolism is generally good, the condition can lead to permanent neurological deficits or pathological heart arrhythmias.
  • The unpredictable progression of the disease underscores the need for close monitoring of affected horses.
  • The researchers recommend systematic surveillance at clinics, which could provide more information to aid in prevention.

Cite This Article

APA
Parkinson NJ, McKenzie HC, Barton MH, Davis JL, Dunkel B, Johnson AL, MacDonald ES. (2018). Catheter-associated venous air embolism in hospitalized horses: 32 cases. J Vet Intern Med, 32(2), 805-814. https://doi.org/10.1111/jvim.15057

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 32
Issue: 2
Pages: 805-814

Researcher Affiliations

Parkinson, Nicholas J
  • Virginia Maryland College of Veterinary Medicine, Blacksburg, Virginia.
  • Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian, United Kingdom.
McKenzie, Harold C
  • Virginia Maryland College of Veterinary Medicine, Blacksburg, Virginia.
Barton, Michelle H
  • University of Georgia College of Veterinary Medicine, Athens, Georgia.
Davis, Jennifer L
  • Virginia Maryland College of Veterinary Medicine, Blacksburg, Virginia.
Dunkel, Bettina
  • The Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire, United Kingdom.
Johnson, Amy L
  • New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, Pennsylvania.
MacDonald, Elizabeth S
  • Marion duPont Scott Equine Medical Center, Virginia Maryland College of Veterinary Medicine, Leesburg, Virginia.

MeSH Terms

  • Animals
  • Arrhythmias, Cardiac / complications
  • Arrhythmias, Cardiac / veterinary
  • Blindness / complications
  • Blindness / veterinary
  • Embolism, Air / complications
  • Embolism, Air / etiology
  • Embolism, Air / mortality
  • Embolism, Air / veterinary
  • Horse Diseases / etiology
  • Horse Diseases / mortality
  • Horses
  • Nervous System Diseases / complications
  • Nervous System Diseases / veterinary
  • Retrospective Studies
  • Seizures / complications
  • Seizures / veterinary
  • Vascular Access Devices / adverse effects
  • Vascular Access Devices / veterinary

References

This article includes 29 references
  1. Gordy S, Rowell S. Vascular air embolism. Int J Crit Illness Injury Sci 2013;3:73–76.
    pmc: PMC3665124pubmed: 23724390
  2. Taylor PM. Suspected venous air embolism. Equine Vet Educ 2009;21:89–90.
  3. Souders JE. Pulmonary air embolism. J Clin Monit Comput 2000;16:375–383.
    pubmed: 12580220
  4. Pinho J, Amorim JM, Araujo JM. Cerebral gas embolism associated with central venous catheter: Systematic review. J Neurol Sci 2016;362:160–164.
    pubmed: 26944140
  5. Wosko J, Dabrowski W, Zadora P. Coronary air embolism during removal of a central venous catheter. Anaesthesiol Intens Therapy 2012;44:21–24.
    pubmed: 23801508
  6. Mushkat Y, Luxman D, Nachum Z. Gas embolism complicating obstetric or gynecologic procedures. Case reports and review of the literature. Eur J Obstet Gynecol Reprod Biol 1995;63:97–103.
    pubmed: 8674575
  7. Albin MS, Carroll RG, Maroon JC. Clinical considerations concerning detection of venous air embolism. Neurosurgery 1978;3:380–384.
    pubmed: 740137
  8. Bradbury LA, Archer DC, Dugdale AHA. Suspected venous air embolism in a horse. Vet Rec 2005;156:109–111.
    pubmed: 15704551
  9. Caporelli F, McGowan CM, Tulamo RM. Suspected venous air embolism in a Finnhorse. Equine Vet Educ 2009;21:85–88.
  10. Holbrook TC, Dechant JE, Crowson CL. Suspected air embolism associated with post‐anesthetic pulmonary edema and neurologic sequelae in a horse. Vet Anaesth Analg 2007;34:217–222.
    pubmed: 17444936
  11. Pellegrini‐Masini A, Rodriguez Hurtado I, Stewart AJ. Suspected venous air embolism in three horses. Equine Vet Educ 2009;21:79–84.
  12. Sacks M, Mosing M. Volumetric capnography to diagnose venous air embolism in an anaesthetised horse. Vet Anaesth Analg 2017;44:189–190.
    pubmed: 27174421
  13. Romagnoli N, Rinnovati R, Lukacs RM. Suspected venous air embolism during urinary tract endoscopy in a standing horse. Equine Vet Educ 2014;26:134–137.
  14. Lapolla L. Pathogenesis of air embolism. Clin Vet 1934;57:593–606.
  15. Yesilaras M, Atilla OD, Aksay E. Retrograde cerebral air embolism. Am J Emerg Med 2014;32:1562.e1–1562.e1562.
    pubmed: 24993685
  16. Flanagan JP, Gradisar IA, Gross RJ. Air embolus–a lethal complication of subclavian venipuncture. N Engl J Med 1969;281:488–489.
    pubmed: 5796967
  17. Albertine KH, Wiener‐Kronish JP, Koike K. Quantification of damage by air emboli to lung microvessels in anesthetized sheep. J Appl Physiol 1984;57:1360–1368.
    pubmed: 6520028
  18. Ohkuda K, Nakahara K, Binder A. Venous air emboli in sheep: reversible increase in lung microvascular permeability. J Appl Physiol 1981;51:887–894.
    pubmed: 7298434
  19. Wang D, Li MH, Hsu K. Air embolism‐induced lung injury in isolated rat lungs. J Appl Physiol 1992;72:1235–1242.
    pubmed: 1592709
  20. Nims M, Hallonquist H, Camann W. Coronary arterial air embolus occurring during cesarean delivery. Int J Obstet Anesth 2006;15:166–169.
    pubmed: 16431100
  21. Raposo N, Faiz F, Albucher JF. Embolie gazeuse cérébrale iatrogène d'origine veineuse sans signe respiratoire: un mécanisme rétrograde?. Revue Neurologique 2011;167:615–618.
    pubmed: 21190704
  22. Cheng CK, Chang TY, Liu CH. Presence of gyriform air predicts unfavorable outcome in venous catheter‐related cerebral air embolism. J Stroke Cerebrovasc Dis 2015;24:2189–2195.
    pubmed: 26219843
  23. Butler BD, Hills BA. Transpulmonary passage of venous air emboli. J Appl Physiol 1985;59:543–547.
    pubmed: 4030608
  24. Warren BA, Philp RB, Inwood MJ. The ultrastructural morphology of air embolism: platelet adhesion to the interface and endothelial damage. Br J Exp Pathol 1973;54:163–172.
    pmc: PMC2072572pubmed: 4121722
  25. Mitchell S, Gorman D. The pathophysiology of cerebral arterial gas embolism. J Extra Corpor Technol 2002;34:18–23.
    pubmed: 11911624
  26. van Hulst RA, Lameris TW, Hasan D. Effects of cerebral air embolism on brain metabolism in pigs. Acta Neurol Scand 2003;108:118–124.
    pubmed: 12859289
  27. Zuliani G, Cherubini A, Atti AR. Prescription of anti‐oedema agents and short‐term mortality in older patients with acute ischaemic stroke. Drugs Aging 2004;21:273–278.
    pubmed: 15012172
  28. Sundboll J, Horvath‐Puho E, Schmidt M. Preadmission use of glucocorticoids and 30‐day mortality after stroke. Stroke 2016;47:829–835.
    pubmed: 26903585
  29. Murphy BP, Harford FJ, Cramer FS. Cerebral air embolism resulting from invasive medical procedures. Treatment with hyperbaric oxygen. Ann Surg 1985;201:242–245.
    pmc: PMC1250649pubmed: 3918516

Citations

This article has been cited 3 times.
  1. Majcher AM, Troillet A, Gerlach K, Tönnies PR, Brehm W, Ulrich R. Postmortem diagnosis of venous air embolism in a Wielkopolski horse. J Vet Diagn Invest 2025 Nov;37(6):948-951.
    doi: 10.1177/10406387251362462pubmed: 40842091google scholar: lookup
  2. Vitale V, Velloso Álvarez A, de la Cuesta-Torrado M, Neira-Egea P, Vandecandelaere M, Tee E, Gimeno M, van Galen G. Can Acute Neurological Disease Cause Cardiomyopathy in Horses?. Animals (Basel) 2025 May 16;15(10).
    doi: 10.3390/ani15101447pubmed: 40427323google scholar: lookup
  3. Hussein HA, Ibrahim A. B-mode and color Doppler ultrasonography of normal external jugular vein in donkeys (Equus asinus). BMC Vet Res 2022 Sep 14;18(1):345.
    doi: 10.1186/s12917-022-03441-ypubmed: 36104788google scholar: lookup
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