Characterization and clinical application of mesenchymal stem cells from equine umbilical cord blood.
Abstract: Tendinitis of the superficial digital flexor tendon (SDFT) is a significant cause of lameness in horses; however, recent studies have shown that stem cells could be useful in veterinary regenerative medicine. Therefore, we isolated and characterized equine umbilical cord blood mesenchymal stem cells (eUCB-MSCs) from equine umbilical cord blood obtained from thoroughbred mares during the foaling period. Horses that had tendinitis of the SDFT were treated with eUCB-MSCs to confirm the therapeutic effect. After eUCB-MSCs transplantation, the core lesion in the SDFT was found to decrease. These results suggest that transplantation using eUCB-MSCs could be another source of cell treatment.
Publication Date: 2013-06-28 PubMed ID: 23820166PubMed Central: PMC3788164DOI: 10.4142/jvs.2013.14.3.367Google Scholar: Lookup
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- Case Reports
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The researchers explored the potential use of horse umbilical cord blood stem cells (eUCB-MSCs) to treat tendon inflammation in horses, observing a decrease in lesion size after treatment.
Introduction and Objectives
- The aim of this research was to investigate the therapeutic potential of mesenchymal stem cells from equine umbilical cord blood (eUCB-MSCs) in treating horse tendon inflammation.
- Tendinitis of the superficial digital flexor tendon (SDFT), a common cause of lameness in horses, was the specific condition targeted.
Methods
- The researchers collected equine umbilical cord blood from thoroughbred mares during foaling, from which they isolated the eUCB-MSCs.
- Horses suffering from SDFT tendinitis were then treated with these stem cells.
Results
- The results indicated that treatment of affected horses with eUCB-MSCs decreased the size of the core lesion in the SDFT.
- This suggests that the stem cell transplantation had a positive therapeutic effect on the inflammation.
Conclusion
- This study suggests that eUCB-MSCs could be a viable new source for cell treatment in veterinary medicine.
- The evidence of a decrease in lesion size within the affected SDFT post-treatment implies a potential for stem cell therapy in treating tendinitis.
Cite This Article
APA
Kang JG, Park SB, Seo MS, Kim HS, Chae JS, Kang KS.
(2013).
Characterization and clinical application of mesenchymal stem cells from equine umbilical cord blood.
J Vet Sci, 14(3), 367-371.
https://doi.org/10.4142/jvs.2013.14.3.367 Publication
Researcher Affiliations
- Department of Veterinary Internal Medicine,Department of Veterinary Public Health, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Korea.
MeSH Terms
- Animals
- Cord Blood Stem Cell Transplantation / veterinary
- Horse Diseases / surgery
- Horses
- Male
- Tendinopathy / surgery
- Tendinopathy / veterinary
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This article includes 20 references
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Citations
This article has been cited 8 times.- Cao M, Tong M, Pu Y, Lv X, Sun Y, Zhang H, Sheng R, Wang H, Gao Y, Dai G, Xiong F, Wang Q, Rui Y. Human Umbilical Cord-Derived Mesenchymal Stem Cells-Involved Strategies: Advancing Tendon Injuries Therapy Towards Clinical Translation. Stem Cell Rev Rep 2026 Apr;22(3):1177-1199.
- Zeng YN, Kang YB, Xu YA. [Research advances on skin sweat gland regeneration induced by stem cells and tissue engineering]. Zhonghua Shao Shang Za Zhi 2021 Sep 20;37(9):900-904.
- Al Naem M, Bourebaba L, Kucharczyk K, Röcken M, Marycz K. Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders. Stem Cell Rev Rep 2020 Apr;16(2):301-322.
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