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Veterinary journal (London, England : 1997)2019; 248; 95-100; doi: 10.1016/j.tvjl.2019.05.001

Clinical presentation, diagnostic findings, and outcome of adult horses with equine coronavirus infection at a veterinary teaching hospital: 33 cases (2012-2018).

Abstract: Equine coronavirus (ECoV) is a recently described enteric virus with worldwide outbreaks; however, there are little data available on clinical presentation, diagnosis, and outcome. The study objective was to document case management of ECoV in adult horses presented to a referral hospital and compare to a cohort of horses that tested negative for ECoV. A retrospective case series was performed based on positive real-time quantitative PCR results for ECoV on faeces from horses treated at the UC Davis Veterinary Medical Teaching Hospital from 1 March 2012 to 31 March 2018. Horses negative for ECoV were matched to the ECoV-positive group as controls. Data collected included signalment, history, exam findings, diagnostics, treatment, and follow-up. Thirty-three horses (median age, 11 years; range, 2-37 years) tested ECoV-positive, including three horses with co-infections. Presenting complaints for ECoV-infected horses included historic fevers (n = 25/30; 83%), anorexia (n = 14/30; 47%), and colic (n = 13/30; 43%). ECoV-positive horses had significantly lower white blood cell (median, 3.0 × 10/L; range, 0.68-16.2 × 10/L), neutrophil (median, 1.26 × 10/L; range, 0.15-14.4 × 10/L), and lymphocyte (median, 0.86 × 10/L; range, 0.42-3.47 × 10/L) counts than ECoV-negative horses. Electrolyte and metabolic derangements and scant faeces were common. Twenty-seven horses were hospitalised for a median of 5 days (range, 0.5-14 days), with 26/27 (96%) horses surviving to discharge. ECoV infection should be a differential diagnosis for adult horses with fever, colic, anorexia, and leukopenia. The disease has a low mortality rate, but horses may require intensive care to resolve severe leukopenia, systemic inflammation, and metabolic disturbances.
Copyright © 2019 Elsevier Ltd. All rights reserved.
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Publication Date: 2019-05-04 PubMed ID: 31113572PubMed Central: PMC7110482DOI: 10.1016/j.tvjl.2019.05.001Google Scholar: Lookup
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  • Journal Article
  • Multicenter Study

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research provides comprehensive data on the clinical presentation, diagnostic findings, and outcomes of adult horses infected with Equine Coronavirus (ECoV). The research employed a retrospective case series from the UC Davis Veterinary Medical Teaching Hospital, and findings indicate that the condition often presents with fever, anorexia, colic and leukopenia, with a relatively low mortality rate, but requiring intensive care in severe cases.

Objective and Methodology of the Study

  • The main objective of this study was to present detailed information on how Equine Coronavirus (ECoV) affects adult horses, by looking into case histories, diagnostic results, and outcomes of the disease.
  • A retrospective case series was employed, basically using past cases, to gather and analyze this data.
  • The cases considered were those that had been diagnosed with ECoV at the UC Davis Veterinary Medical Teaching Hospital over a six year period from March 2012 to March 2018.
  • A control group was also followed. These were horses who tested negative for ECoV. The purpose of this group was to provide a comparison basis for the ECoV-positive horses.

Findings from the Study

  • The research identified a total of 33 horses that tested positive for ECoV, with ages ranging from 2 to 37 years old.
  • The most common symptoms were history of fevers, anorexia, and colic.
  • In comparison with ECoV-negative horses, ECoV-positive horses had significantly lower counts of white blood cells, neutrophils, and lymphocytes. This state is also known as leukopenia.
  • Other common findings in ECoV-positive horses included electrolyte and metabolic imbalances and scant faeces or a decrease in faecal elimination.
  • The majority of the horses hospitalized (27 out of 33) required intensive care due to the severity of the leukopenia, systemic inflammation, and metabolic disturbances. Hospital stays ranged from half a day to two weeks.
  • A significantly high number of the hospitalised horses (26 out of 27), equivalent to 96%, survived and were discharged, indicating relatively low fatality rates.

Implications of the Study

  • The findings suggest that ECoV must be considered as a potential diagnosis in adult horses presenting with fever, colic, anorexia, and leukopenia.
  • While the condition has a relatively low mortality rate, the high incidence of hospitalizations indicates it can have severe impact requiring intensive care.
  • The study arms veterinarians and other medical practitioners with information for diagnosing, treating and managing ECoV in horses, which could assist in controlling future outbreaks and ensuring horse health.

Cite This Article

APA
Berryhill EH, Magdesian KG, Aleman M, Pusterla N. (2019). Clinical presentation, diagnostic findings, and outcome of adult horses with equine coronavirus infection at a veterinary teaching hospital: 33 cases (2012-2018). Vet J, 248, 95-100. https://doi.org/10.1016/j.tvjl.2019.05.001

Publication

Veterinary journal (London, England : 1997)
ISSN: 1532-2971
NlmUniqueID: 9706281
Country: England
Language: English
Volume: 248
Pages: 95-100
PII: S1090-0233(18)30328-9

Researcher Affiliations

Berryhill, E H
  • Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Ave., Davis, CA, 95616, USA. Electronic address: ehberryhill@vmth.ucdavis.edu.
Magdesian, K G
  • Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Ave., Davis, CA, 95616, USA.
Aleman, M
  • Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Ave., Davis, CA, 95616, USA.
Pusterla, N
  • Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Ave., Davis, CA, 95616, USA.

MeSH Terms

  • Animals
  • Betacoronavirus 1 / isolation & purification
  • California / epidemiology
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / veterinary
  • Disease Outbreaks / veterinary
  • Female
  • Horse Diseases / epidemiology
  • Horse Diseases / etiology
  • Horses
  • Hospitals, Animal
  • Male
  • Records / veterinary

References

This article includes 13 references
  1. Barsnick RJ, Hurcombe SD, Dembek K, Frazer ML, Slovis NM, Saville WJ, Toribio RE. Somatotropic axis resistance and ghrelin in critically ill foals.. Equine Vet J 2014 Jan;46(1):45-9.
    pubmed: 23663031doi: 10.1111/evj.12086google scholar: lookup
  2. Fielding CL, Higgins JK, Higgins JC, McIntosh S, Scott E, Giannitti F, Mete A, Pusterla N. Disease associated with equine coronavirus infection and high case fatality rate.. J Vet Intern Med 2015 Jan;29(1):307-10.
    pmc: PMC4858071pubmed: 25319406doi: 10.1111/jvim.12480google scholar: lookup
  3. Holm S. A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics 1979;2:65–70.
  4. Kooijman LJ, Mapes SM, Pusterla N. Development of an equine coronavirus-specific enzyme-linked immunosorbent assay to determine serologic responses in naturally infected horses.. J Vet Diagn Invest 2016 Jul;28(4):414-8.
    pubmed: 27216723doi: 10.1177/1040638716649643google scholar: lookup
  5. Kooijman LJ, James K, Mapes SM, Theelen MJ, Pusterla N. Seroprevalence and risk factors for infection with equine coronavirus in healthy horses in the USA.. Vet J 2017 Feb;220:91-94.
    pmc: PMC7110631pubmed: 28190504doi: 10.1016/j.tvjl.2017.01.007google scholar: lookup
  6. Miszczak F, Tesson V, Kin N, Dina J, Balasuriya UB, Pronost S, Vabret A. First detection of equine coronavirus (ECoV) in Europe.. Vet Microbiol 2014 Jun 25;171(1-2):206-9.
    pmc: PMC7117151pubmed: 24768449doi: 10.1016/j.vetmic.2014.03.031google scholar: lookup
  7. Nemoto M, Oue Y, Morita Y, Kanno T, Kinoshita Y, Niwa H, Ueno T, Katayama Y, Bannai H, Tsujimura K, Yamanaka T, Kondo T. Experimental inoculation of equine coronavirus into Japanese draft horses.. Arch Virol 2014 Dec;159(12):3329-34.
    pmc: PMC7087042pubmed: 25139547doi: 10.1007/s00705-014-2205-1google scholar: lookup
  8. Nemoto M, Morita Y, Niwa H, Bannai H, Tsujimura K, Yamanaka T, Kondo T. Rapid detection of equine coronavirus by reverse transcription loop-mediated isothermal amplification.. J Virol Methods 2015 Apr;215-216:13-6.
    pmc: PMC7113660pubmed: 25682750doi: 10.1016/j.jviromet.2015.02.001google scholar: lookup
  9. Oue Y, Morita Y, Kondo T, Nemoto M. Epidemic of equine coronavirus at Obihiro Racecourse, Hokkaido, Japan in 2012.. J Vet Med Sci 2013;75(9):1261-5.
    pubmed: 23648375doi: 10.1292/jvms.13-0056google scholar: lookup
  10. Pusterla N, Mapes S, Wademan C, White A, Ball R, Sapp K, Burns P, Ormond C, Butterworth K, Bartol J, Magdesian KG. Emerging outbreaks associated with equine coronavirus in adult horses.. Vet Microbiol 2013 Feb 22;162(1):228-31.
    pmc: PMC7117461pubmed: 23123176doi: 10.1016/j.vetmic.2012.10.014google scholar: lookup
  11. Pusterla N, Vin R, Leutenegger CM, Mittel LD, Divers TJ. Enteric coronavirus infection in adult horses.. Vet J 2018 Jan;231:13-18.
    pmc: PMC7110460pubmed: 29429482doi: 10.1016/j.tvjl.2017.11.004google scholar: lookup
  12. Schaefer E, Harms C, Viner M, Barnum S, Pusterla N. Investigation of an experimental infection model of equine coronavirus in adult horses.. J Vet Intern Med 2018 Nov;32(6):2099-2104.
    pmc: PMC6271284pubmed: 30353949doi: 10.1111/jvim.15318google scholar: lookup
  13. Slovis NM, Elam J, Estrada M, Leutenegger CM. Infectious agents associated with diarrhoea in neonatal foals in central Kentucky: a comprehensive molecular study.. Equine Vet J 2014 May;46(3):311-6.
    pmc: PMC7163618pubmed: 23773143doi: 10.1111/evj.12119google scholar: lookup

Citations

This article has been cited 15 times.
  1. Stummer M, Frisch V, Glitz F, Hinney B, Spergser J, Krücken J, Diekmann I, Dimmel K, Riedel C, Cavalleri JV, Rümenapf T, Joachim A, Lyrakis M, Auer A. Presence of Equine and Bovine Coronaviruses, Endoparasites, and Bacteria in Fecal Samples of Horses with Colic. Pathogens 2023 Aug 15;12(8).
    doi: 10.3390/pathogens12081043pubmed: 37624003google scholar: lookup
  2. Hepworth-Warren KL, Erwin SJ, Moore CB, Talbot JR, Young KAS, Neault MJ, Haugland JC, Robertson JB, Blikslager AT. Risk factors associated with an outbreak of equine coronavirus at a large farm in North Carolina. Front Vet Sci 2023;10:1060759.
    doi: 10.3389/fvets.2023.1060759pubmed: 36937023google scholar: lookup
  3. Ayoub C, Arroyo LG, MacNicol JL, Renaud D, Weese JS, Gomez DE. Fecal microbiota of horses with colitis and its association with laminitis and survival during hospitalization. J Vet Intern Med 2022 Nov;36(6):2213-2223.
    doi: 10.1111/jvim.16562pubmed: 36271677google scholar: lookup
  4. Gomez DE, Leclere M, Arroyo LG, Li L, John E, Afonso T, Payette F, Darby S. Acute diarrhea in horses: A multicenter Canadian retrospective study (2015 to 2019). Can Vet J 2022 Oct;63(10):1033-1042.
    pubmed: 36185796
  5. Korath ADJ, Janda J, Untersmayr E, Sokolowska M, Feleszko W, Agache I, Adel Seida A, Hartmann K, Jensen-Jarolim E, Pali-Schöll I. One Health: EAACI Position Paper on coronaviruses at the human-animal interface, with a specific focus on comparative and zoonotic aspects of SARS-CoV-2. Allergy 2022 Jan;77(1):55-71.
    doi: 10.1111/all.14991pubmed: 34180546google scholar: lookup
  6. Luethy D, Feldman R, Stefanovski D, Aitken MR. Risk factors for laminitis and nonsurvival in acute colitis: Retrospective study of 85 hospitalized horses (2011-2019). J Vet Intern Med 2021 Jul;35(4):2019-2025.
    doi: 10.1111/jvim.16147pubmed: 33938584google scholar: lookup
  7. Gryseels S, De Bruyn L, Gyselings R, Calvignac-Spencer S, Leendertz FH, Leirs H. Risk of human-to-wildlife transmission of SARS-CoV-2. Mamm Rev 2021 Apr;51(2):272-292.
    doi: 10.1111/mam.12225pubmed: 33230363google scholar: lookup
  8. Mattei DN, Kopper JJ, Sanz MG. Equine Coronavirus-Associated Colitis in Horses: A Retrospective Study. J Equine Vet Sci 2020 Apr;87:102906.
    doi: 10.1016/j.jevs.2019.102906pubmed: 32172908google scholar: lookup
  9. Zhao S, Smits C, Schuurman N, Barnum S, Pusterla N, Kuppeveld FV, Bosch BJ, Maanen KV, Egberink H. Development and Validation of a S1 Protein-Based ELISA for the Specific Detection of Antibodies against Equine Coronavirus. Viruses 2019 Nov 30;11(12).
    doi: 10.3390/v11121109pubmed: 31801275google scholar: lookup
  10. Kouadria W, Poder SL, van Maanen K, Seuberlich T, Dawson KLD, Zientara S, Laabassi F. First serological evidence of equine coronavirus and severe acute respiratory syndrome coronavirus 2 in horses in North Africa. Vet Res Commun 2025 Oct 4;49(6):347.
    doi: 10.1007/s11259-025-10928-0pubmed: 41045398google scholar: lookup
  11. Ricci I, Rosone F, Pacchiarotti G, Manna G, Cersini A, Carvelli A, La Rocca D, Cammalleri E, Giordani R, Tofani S, Conti R, Rombolà P, Nardini R, Minniti CA, Caforio R, Linardi B, Scicluna MT. Pegiviruses and Coronavirus: Biomolecular Prevalence and Phylogenetic Analysis of Strains Detected in Italian Horse Populations. Viruses 2025 Aug 2;17(8).
    doi: 10.3390/v17081076pubmed: 40872790google scholar: lookup
  12. Pinn-Woodcock TL, Aprea MS, Lejeune M, Tomlinson JE. Molecular detection of pathogens in an equine fever diagnostic panel: 2019-2023. Equine Vet J 2026 Mar;58(2):486-496.
    doi: 10.1111/evj.14527pubmed: 40384355google scholar: lookup
  13. de la Cuesta-Torrado M, Vitale V, Velloso Alvarez A, Neira-Egea P, Diss C, Cuervo-Arango J. The Effect of Vaccination Status on Total Lymphocyte Count in Horses Affected by Equine Herpes Virus-1 Myeloencephalopathy. Animals (Basel) 2025 Apr 1;15(7).
    doi: 10.3390/ani15071019pubmed: 40218411google scholar: lookup
  14. Haywood LMB, Sheahan BJ. A Review of Epithelial Ion Transporters and Their Roles in Equine Infectious Colitis. Vet Sci 2024 Oct 7;11(10).
    doi: 10.3390/vetsci11100480pubmed: 39453072google scholar: lookup
  15. Pusterla N, Lawton K, Barnum S. Investigation of the seroprevalence to equine coronavirus and SARS-CoV-2 in healthy adult horses recently imported to the United States. Vet Q 2024 Dec;44(1):1-6.
    doi: 10.1080/01652176.2023.2288876pubmed: 38010292google scholar: lookup
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