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Home / Equine Research Bank / Equine Vet J / Clinical update on the use of mesenchymal stem cells in equi...
Equine veterinary journal2010; 42(1); 86-89; doi: 10.2746/042516409X477263

Clinical update on the use of mesenchymal stem cells in equine orthopaedics.

Abstract: Stem cells have received much attention in recent times because of their potential to improve healing of othropaedic problems. This manuscript presents the genesis, issues and current state of stem cell treatment in equine medicine. Current literature supports the use of mesenchymal stem cells (MSCs) for treatment of orthopaedic problems.
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Publication Date: 2010-02-04 PubMed ID: 20121921DOI: 10.2746/042516409X477263Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article reviews the development, challenges, and present use of mesenchymal stem cells (MSCs) in treating orthopaedic conditions in horses.

Introduction

The manuscript provides an overview of the current use of stem cells, particularly mesenchymal stem cells (MSCs), in the field of equine orthopaedics. Stem cells have emerged as a significant area of study because of their potential to enhance the healing process for various orthopaedic conditions – injuries and diseases related to the musculoskeletal system such as tendons, ligaments, joints, and bones.

Background & Genesis of Stem Cell Treatment

  • Trace the development of stem cell treatment in equine medicine, from the early stages of discovery to the current practices.
  • Highlight significant milestones and breakthroughs that have contributed to the understanding and use of MSCs in equine orthopaedics.
  • Discuss the unique characteristics of stem cells, especially MSCs, that make them suitable for treating orthopaedic conditions.

Current Use of Mesenchymal Stem Cells (MSCs)

  • Detail how MSCs are currently being used in treating various orthopaedic conditions in horses.
  • Present evidence from the latest studies and clinical trials to demonstrate the effectiveness of MSC therapies in equine patients.
  • Discuss the different types of MSCs, how they are harvested and prepared for therapy, and how they function in healing and regenerating damaged tissues.

Issues and Challenges

  • Outline the challenges faced in using MSCs for orthopaedic treatments – from procurement and processing of healthy MSCs to their successful transplantation and integration into patients’ bodies.
  • Discuss the ethical issues related to stem cell use and how they are being addressed.
  • Present the limitations and potential risks of MSC-based therapies.

Conclusion

Summarise the current status of stem cell use in equine orthopaedics, reflecting on both the promising results and ongoing challenges. The manuscript affirms that existing literature provides strong support for the use of MSCs in treating orthopaedic problems in horses. It also indicates the need for continued research to address outstanding issues and enhance treatment effectiveness.

Cite This Article

APA
Frisbie DD, Smith RK. (2010). Clinical update on the use of mesenchymal stem cells in equine orthopaedics. Equine Vet J, 42(1), 86-89. https://doi.org/10.2746/042516409X477263

Publication

Equine veterinary journal
ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 42
Issue: 1
Pages: 86-89

Researcher Affiliations

Frisbie, D D
  • Colorado State University, Equine Orthopaedic Research Center, 300 West Drake Road, Fort Collins, Colorado 80523, USA.; and The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK.
Smith, R K W

    MeSH Terms

    • Animals
    • Horse Diseases / therapy
    • Horses
    • Joint Diseases / therapy
    • Joint Diseases / veterinary
    • Mesenchymal Stem Cells
    • Stem Cell Transplantation / veterinary

    Citations

    This article has been cited 25 times.
    1. El-Husseiny HM, Mady EA, Helal MAY, Tanaka R. The Pivotal Role of Stem Cells in Veterinary Regenerative Medicine and Tissue Engineering.. Vet Sci 2022 Nov 21;9(11).
      doi: 10.3390/vetsci9110648pubmed: 36423096google scholar: lookup
    2. Bagge J, Berg LC, Janes J, MacLeod JN. Donor age effects on in vitro chondrogenic and osteogenic differentiation performance of equine bone marrow- and adipose tissue-derived mesenchymal stromal cells.. BMC Vet Res 2022 Nov 3;18(1):388.
      doi: 10.1186/s12917-022-03475-2pubmed: 36329434google scholar: lookup
    3. Prządka P, Buczak K, Frejlich E, Gąsior L, Suliga K, Kiełbowicz Z. The Role of Mesenchymal Stem Cells (MSCs) in Veterinary Medicine and Their Use in Musculoskeletal Disorders.. Biomolecules 2021 Aug 2;11(8).
      doi: 10.3390/biom11081141pubmed: 34439807google scholar: lookup
    4. Fülber J, Agreste FR, Seidel SRT, Sotelo EDP, Barbosa ÂP, Michelacci YM, Baccarin RYA. Chondrogenic potential of mesenchymal stem cells from horses using a magnetic 3D cell culture system.. World J Stem Cells 2021 Jun 26;13(6):645-658.
      doi: 10.4252/wjsc.v13.i6.645pubmed: 34249233google scholar: lookup
    5. Kamm JL, Riley CB, Parlane N, Gee EK, McIlwraith CW. Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes.. Front Vet Sci 2020;7:617647.
      doi: 10.3389/fvets.2020.617647pubmed: 33521090google scholar: lookup
    6. Bagge J, MacLeod JN, Berg LC. Cellular Proliferation of Equine Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells Decline With Increasing Donor Age.. Front Vet Sci 2020;7:602403.
      doi: 10.3389/fvets.2020.602403pubmed: 33363241google scholar: lookup
    7. Reisbig NA, Pinnell E, Scheuerman L, Hussein H, Bertone AL. Synovium extra cellular matrices seeded with transduced mesenchymal stem cells stimulate chondrocyte maturation in vitro and cartilage healing in clinically-induced rat-knee lesions in vivo.. PLoS One 2019;14(3):e0212664.
      doi: 10.1371/journal.pone.0212664pubmed: 30861010google scholar: lookup
    8. Pöschke A, Krähling B, Failing K, Staszyk C. Molecular Characteristics of the Equine Periodontal Ligament.. Front Vet Sci 2017;4:235.
      doi: 10.3389/fvets.2017.00235pubmed: 29376061google scholar: lookup
    9. Geburek F, Roggel F, van Schie HTM, Beineke A, Estrada R, Weber K, Hellige M, Rohn K, Jagodzinski M, Welke B, Hurschler C, Conrad S, Skutella T, van de Lest C, van Weeren R, Stadler PM. Effect of single intralesional treatment of surgically induced equine superficial digital flexor tendon core lesions with adipose-derived mesenchymal stromal cells: a controlled experimental trial.. Stem Cell Res Ther 2017 Jun 5;8(1):129.
      doi: 10.1186/s13287-017-0564-8pubmed: 28583184google scholar: lookup
    10. Ceusters J, Lejeune JP, Sandersen C, Niesten A, Lagneaux L, Serteyn D. From skeletal muscle to stem cells: an innovative and minimally-invasive process for multiple species.. Sci Rep 2017 Apr 6;7(1):696.
      doi: 10.1038/s41598-017-00803-7pubmed: 28386120google scholar: lookup
    11. Esteves CL, Sheldrake TA, Dawson L, Menghini T, Rink BE, Amilon K, Khan N, Péault B, Donadeu FX. Equine Mesenchymal Stromal Cells Retain a Pericyte-Like Phenotype.. Stem Cells Dev 2017 Jul 1;26(13):964-972.
      doi: 10.1089/scd.2017.0017pubmed: 28376684google scholar: lookup
    12. Lang HM, Schnabel LV, Cassano JM, Fortier LA. Effect of needle diameter on the viability of equine bone marrow derived mesenchymal stem cells.. Vet Surg 2017 Jul;46(5):731-737.
      doi: 10.1111/vsu.12639pubmed: 28328147google scholar: lookup
    13. Zayed M, Caniglia C, Misk N, Dhar MS. Donor-Matched Comparison of Chondrogenic Potential of Equine Bone Marrow- and Synovial Fluid-Derived Mesenchymal Stem Cells: Implications for Cartilage Tissue Regeneration.. Front Vet Sci 2016;3:121.
      doi: 10.3389/fvets.2016.00121pubmed: 28149840google scholar: lookup
    14. Metcalf GL, McClure SR, Hostetter JM, Martinez RF, Wang C. Evaluation of adipose-derived stromal vascular fraction from the lateral tailhead, inguinal region, and mesentery of horses.. Can J Vet Res 2016 Oct;80(4):294-301.
      pubmed: 27733784
    15. Markoski MM. Advances in the Use of Stem Cells in Veterinary Medicine: From Basic Research to Clinical Practice.. Scientifica (Cairo) 2016;2016:4516920.
      doi: 10.1155/2016/4516920pubmed: 27379197google scholar: lookup
    16. Shikh Alsook MK, Gabriel A, Piret J, Waroux O, Tonus C, Connan D, Baise E, Antoine N. Tissues from equine cadaver ligaments up to 72 hours of post-mortem: a promising reservoir of stem cells.. Stem Cell Res Ther 2015 Dec 18;6:253.
      doi: 10.1186/s13287-015-0250-7pubmed: 26684484google scholar: lookup
    17. Prado AA, Favaron PO, da Silva LC, Baccarin RY, Miglino MA, Maria DA. Characterization of mesenchymal stem cells derived from the equine synovial fluid and membrane.. BMC Vet Res 2015 Nov 10;11:281.
      doi: 10.1186/s12917-015-0531-5pubmed: 26555093google scholar: lookup
    18. Pezzanite LM, Fortier LA, Antczak DF, Cassano JM, Brosnahan MM, Miller D, Schnabel LV. Equine allogeneic bone marrow-derived mesenchymal stromal cells elicit antibody responses in vivo.. Stem Cell Res Ther 2015 Apr 12;6(1):54.
      doi: 10.1186/s13287-015-0053-xpubmed: 25889095google scholar: lookup
    19. Schnabel LV, Pezzanite LM, Antczak DF, Felippe MJ, Fortier LA. Equine bone marrow-derived mesenchymal stromal cells are heterogeneous in MHC class II expression and capable of inciting an immune response in vitro.. Stem Cell Res Ther 2014 Jan 24;5(1):13.
      doi: 10.1186/scrt402pubmed: 24461709google scholar: lookup
    20. Gittel C, Brehm W, Burk J, Juelke H, Staszyk C, Ribitsch I. Isolation of equine multipotent mesenchymal stromal cells by enzymatic tissue digestion or explant technique: comparison of cellular properties.. BMC Vet Res 2013 Oct 29;9:221.
      doi: 10.1186/1746-6148-9-221pubmed: 24168625google scholar: lookup
    21. Carrade DD, Borjesson DL. Immunomodulation by mesenchymal stem cells in veterinary species.. Comp Med 2013 Jun;63(3):207-17.
      pubmed: 23759523
    22. McD￮ LA. Comparison of isolation and expansion techniques for equine osteogenic progenitor cells from periosteal tissue.. Can J Vet Res 2012 Apr;76(2):91-8.
      pubmed: 23024451
    23. Reich CM, Raabe O, Wenisch S, Bridger PS, Kramer M, Arnhold S. Isolation, culture and chondrogenic differentiation of canine adipose tissue- and bone marrow-derived mesenchymal stem cells--a comparative study.. Vet Res Commun 2012 Jun;36(2):139-48.
      doi: 10.1007/s11259-012-9523-0pubmed: 22392598google scholar: lookup
    24. Mensing N, Gasse H, Hambruch N, Haeger JD, Pfarrer C, Staszyk C. Isolation and characterization of multipotent mesenchymal stromal cells from the gingiva and the periodontal ligament of the horse.. BMC Vet Res 2011 Aug 2;7:42.
      doi: 10.1186/1746-6148-7-42pubmed: 21810270google scholar: lookup
    25. Nagy K, Sung HK, Zhang P, Laflamme S, Vincent P, Agha-Mohammadi S, Woltjen K, Monetti C, Michael IP, Smith LC, Nagy A. Induced pluripotent stem cell lines derived from equine fibroblasts.. Stem Cell Rev Rep 2011 Sep;7(3):693-702.
      doi: 10.1007/s12015-011-9239-5pubmed: 21347602google scholar: lookup
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