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Clinicopathologic evidence of disseminated intravascular coagulation in horses with acute colitis.
Abstract: To detect subclinical disseminated intravascular coagulation (DIC) in horses with colitis and to determine any association between the diagnosis of subclinical DIC and outcome or occurrence of complications in horses with colitis. Methods: Prospective study. Methods: 37 horses admitted to a veterinary teaching hospital for treatment of acute colitis. Methods: Coagulation profiles were obtained on each horse 0, 24, and 48 hours after admission. Six tests were performed: platelet count, plasma fibrinogen concentration, prothrombin time, activated partial thromboplastin time, antithrombin activity, and serum fibrin degradation products concentration. Results: A clinicopathologic diagnosis of subclinical DIC was made if 3 of the 6 tests had abnormal results at any 1 sample period. No horse had clinical signs of DIC at the time of sampling. Twelve of 37 (32%) horses met the criteria for diagnosis of subclinical DIC within a 1-year period. Outcome was defined as survival or nonsurvival. Five of 12 horses with subclinical DIC and 2 of 25 horses without subclinical DIC did not survive. Crude odds ratio analysis revealed a horse with acute colitis was 8 times as likely to die or be euthanatized if a diagnosis of subclinical DIC was made. Conclusions: Clinicopathologic evidence of DIC is common and is significantly associated with a poor outcome in horses with acute colitis. Treatment of subclinical DIC may influence outcome in horses with acute colitis.
Publication Date: 2002-11-08 PubMed ID: 12420783DOI: 10.2460/javma.2002.220.1034Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research evaluates the presence of subclinical Disseminated Intravascular Coagulation (DIC) in horses affected by acute colitis. The study reveals that there is a substantial correlation between the diagnosis of subclinical DIC and the poor outcome or complication occurrence in horses suffering from acute colitis.
Objective and Methods
- The research was conducted to identify the presence of subclinical DIC (a condition affecting the blood’s ability to clot) in horses suffering from acute colitis (inflammation of the colon).
- A total of 37 horses with acute colitis, admitted to a veterinary teaching hospital, were enlisted for the study.
- The researchers performed six tests on each horse at three different intervals: at admission, 24 hours after admission, and 48 hours after admission.
- The six tests included measuring platelet count, plasma fibrinogen concentration, prothrombin time, activated partial thromboplastin time, antithrombin activity, and serum fibrin degradation products concentration.
Results and Conclusions
- The researchers diagnosed subclinical DIC in a horse if three of the six tests showed abnormal results during any single sample period. None of the horses showed visible signs of DIC during sampling.
- Of the 37 horses, 12 (approximately 32%) met the criteria for subclinical DIC diagnosis over the period of a year.
- The outcome was defined as survival or non-survival. Out of the 12 horses diagnosed with subclinical DIC, five didn’t survive. In contrast, only 2 out of the 25 horses without the subclinical DIC diagnosis didn’t survive.
- The calculated odds ratio suggested that a horse with acute colitis was eight times more likely to face death or euthanasia if diagnosed with subclinical DIC.
- Based on their findings, the researchers concluded that clinical pathological evidence of DIC is quite common and is noticeably associated with poor outcomes in horses with acute colitis.
- They suggested that treating subclinical DIC could possibly influence the eventual outcome in horses with acute colitis.
Cite This Article
APA
Dolente BA, Wilkins PA, Boston RC.
(2002).
Clinicopathologic evidence of disseminated intravascular coagulation in horses with acute colitis.
J Am Vet Med Assoc, 220(7), 1034-1038.
https://doi.org/10.2460/javma.2002.220.1034 Publication
Researcher Affiliations
- Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348, USA.
MeSH Terms
- Acute Disease
- Animals
- Colitis / blood
- Colitis / complications
- Colitis / mortality
- Colitis / veterinary
- Disseminated Intravascular Coagulation / blood
- Disseminated Intravascular Coagulation / diagnosis
- Disseminated Intravascular Coagulation / etiology
- Disseminated Intravascular Coagulation / veterinary
- Fibrin Fibrinogen Degradation Products / analysis
- Fibrinogen / analysis
- Horse Diseases / blood
- Horse Diseases / diagnosis
- Horse Diseases / etiology
- Horse Diseases / mortality
- Horses
- Odds Ratio
- Partial Thromboplastin Time / veterinary
- Platelet Count / veterinary
- Prognosis
- Prospective Studies
- Prothrombin Time / veterinary
- Survival Analysis
- Thrombin Time / veterinary
Citations
This article has been cited 12 times.- Macleod BM, Wilkins PA, McCoy AM, Bishop RC. Integration of machine learning and viscoelastic testing to improve survival prediction in horses experiencing acute abdominal pain at a veterinary teaching hospital. Equine Vet J 2026 Jan;58(1):105-114.
- Mersich I, Bishop RC, Diaz Yucupicio S, Nobrega AD, Austin SM, Barger AM, Fick ME, Wilkins PA. Decreased Circulating Red Cell Mass Induced by Intravenous Acepromazine Administration Alters Viscoelastic and Traditional Plasma Coagulation Testing Results in Healthy Horses. Animals (Basel) 2024 Oct 28;14(21).
- Haywood LMB, Sheahan BJ. A Review of Epithelial Ion Transporters and Their Roles in Equine Infectious Colitis. Vet Sci 2024 Oct 7;11(10).
- Brown JE, Noormohammadi AH, Courtman NF. Immunoreactivity of canine, feline, and equine D-dimer with antibodies to human D-dimer. J Vet Intern Med 2024 Jan-Feb;38(1):187-196.
- Mendonça FS, Navarro MA, Uzal FA. The comparative pathology of enterocolitis caused by Clostridium perfringens type C, Clostridioides difficile, Paeniclostridium sordellii, Salmonella enterica subspecies enterica serovar Typhimurium, and nonsteroidal anti-inflammatory drugs in horses. J Vet Diagn Invest 2022 May;34(3):412-420.
- Satué K, Gardon JC, Muñoz A. Clinical and laboratorial description of the differential diagnoses of hemostatic disorders in the horse. Iran J Vet Res 2020 Winter;21(1):1-8.
- Lambertini C, Bombardi C, Zannoni A, Bernardini C, Dondi F, Morini M, Rinnovati R, Spadari A, Romagnoli N. Proteinase Activated Receptor 4 in the Jejunum of Healthy Horses and of Horses With Epiploic Hernia. Front Vet Sci 2020;7:158.
- Kopper JJ, Kogan CJ, Cook VL, Schott HC 2nd. Outcome of horses with enterocolitis receiving oncotic fluid support with either plasma or hetastarch. Can Vet J 2019 Nov;60(11):1207-1212.
- Serpa PBS, Brooks MB, Divers T, Ness S, Birschmann I, Papich MG, Stokol T. Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration. Front Vet Sci 2018;5:304.
- Nomura M, Mizobe F, Kato T, Kuroda T, Urayama S, Muranaka M. Evaluating continuous blood coagulopathy in assessing the severity of acute colitis in Thoroughbred racehorses. J Equine Sci 2018 Sep;29(3):79-85.
- McConachie E, Giguère S, Barton MH. Scoring System for Multiple Organ Dysfunction in Adult Horses with Acute Surgical Gastrointestinal Disease. J Vet Intern Med 2016 Jul;30(4):1276-83.
- Cesarini C, Cotovio M, Ríos J, Armengou L, Jose-Cunilleras E. Association Between Necropsy Evidence of Disseminated Intravascular Coagulation and Hemostatic Variables Before Death in Horses With Colic. J Vet Intern Med 2016 Jan-Feb;30(1):269-75.
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