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Home / Equine Research Bank / J Biomed Mater Res B Appl Biomater / Comparative in vitro biomechanical evaluation of two soft ti...
Journal of biomedical materials research. Part B, Applied biomaterials2007; doi: 10.1002/jbm.b.30816

Comparative in vitro biomechanical evaluation of two soft tissue defect products.

Abstract: A soft tissue defect is often an unavoidable consequence of various surgical procedures or a result of trauma. Recently, intraoperative use of xenograft as a patch to the soft tissue defect has become popular with various products available in the market. In this study, mechanical properties of the OrthADAPTtrade mark Bioimplants (Pegasus Biologics, Irvine, CA), new xenograft products composed of collagen from equine pericardium, were evaluated individually and against an existing bioimplant product. The OrthADAPTtrade mark Bioimplants have three subtypes which differ in the degree of crosslinking of collagen strands. The three products are named as FX, PX, and MX in the order of the degree of collagen crosslinking and likely durability in vivo, with FX most dense in crosslinking and hence most durable. The three subtypes underwent three destructive mechanical tests: tensile strength, suture pull-out strength, and burst strength test. In tensile strength and suture pull-out strength tests, the three products were compared with CuffPatchtrade mark, a similar collagen-based xenograft product from a competing manufacturer. In the burst strength test, the three products were compared with untreated equine pericardium tissue. In tensile strength and suture pull-out strength tests, the products FX and MX were shown to have mechanical properties that were comparable with CuffPatch, while the mechanical strength of PX was significantly inferior to FX and CuffPatch in tensile strength test. In burst strength test, there were no differences in mechanical properties among the three OrthADAPT Bioimplants. This study demonstrates the biomechanical equivalence of OrthADAPT with CuffPatch. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007.
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Publication Date: 2007-04-05 PubMed ID: 17415772DOI: 10.1002/jbm.b.30816Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigates the mechanical properties of a new tissue defect patch product derived from horse heart (pericardium), OrthADAPT, and compares it with an existing product, CuffPatch. The study shows the new product has similar characteristics to its competitor, making it a viable option in the market.

Details of the Abstract

In this study, they compared the mechanical characteristics of a new xenograft product against an existing competing xenograft product. Specifically:

  • OrthADAPT Bioimplants, the new xenograft product. OrthADAPT was derived from equine pericardium, the sac that surrounds a horse’s heart. It comes in three types, having different degrees of collagen crosslinking namely: FX, PX, and MX. FX has the most dense crosslinking, which makes it the most durable.
  • The existing bioimplant product is called CuffPatch, which is also a xenograft product based on collagen.

Investigative Tests and Comparisons

To assess the quality of these products, they conducted three mechanical tests:

  • Tensile strength, which measures the resistance of a material to breaking under tension.
  • Suture pull-out strength, which determines the amount of force required to pull a suture out of the material.
  • Burst strength, which tests the pressure at which the product bursts.

In these tests, the products FX and MX (OrthADAPT subtypes) were found to have similar mechanical properties with CuffPatch, while the PX was found to be significantly less strong in the tensile strength test. In the burst strength test, however, there was no discernible difference among the three OrthADAPT variants.

Conclusions from the Study

The findings of this study prove that OrthADAPT products (specifically, the FX and MX variants) have equivalent biomechanical properties with the existing CuffPatch product. Thus, these new products should prove as operative substitutes to CuffPatch in relevant clinical applications.

Cite This Article

APA
Johnson W, Inamasu J, Yantzer B, Papangelou C, Guiot B. (2007). Comparative in vitro biomechanical evaluation of two soft tissue defect products. J Biomed Mater Res B Appl Biomater. https://doi.org/10.1002/jbm.b.30816

Publication

Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
NlmUniqueID: 101234238
Country: United States
Language: English

Researcher Affiliations

Johnson, Wesley
  • Spine Biomechanics Laboratory, Department of Neurosurgery, University of South Florida College of Medicine, Tampa, Florida.
Inamasu, Joji
    Yantzer, Brenda
      Papangelou, Christopher
        Guiot, Bernard

          Citations

          This article has been cited 1 times.
          1. Yoder JH, Elliott DM. Nonlinear and anisotropic tensile properties of graft materials used in soft tissue applications.. Clin Biomech (Bristol, Avon) 2010 May;25(4):378-82.
            doi: 10.1016/j.clinbiomech.2010.01.004pubmed: 20129728google scholar: lookup
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