Complete Genome Sequencing of Two Equine Influenza A(H3N8) Virus Strains Isolated in Kazakhstan.
Abstract: Here, we report the complete genome sequencing of strains A/equine/Kostanay/9/2012(H3N8) and A/equine/LKZ/9/2012(H3N8) of the equine influenza virus belonging to Florida sublineage, clade 2. The strains were isolated in 2012 in the northern and southern regions of Kazakhstan, respectively.
Copyright © 2018 Burashev et al.
Publication Date: 2018-06-28 PubMed ID: 29954896PubMed Central: PMC6025920DOI: 10.1128/genomeA.00574-18Google Scholar: Lookup
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- Journal Article
Summary
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This study details the full genome sequencing of two strains of the equine influenza virus, A/equine/Kostanay/9/2012(H3N8) and A/equine/LKZ/9/2012(H3N8), which were isolated in Kazakhstan in 2012 and are part of the Florida sublineage, clade 2.
Objective and Methodology of the Research
- The researchers aimed to sequence the full genomes of two strains of the equine influenza virus A(H3N8) – A/equine/Kostanay/9/2012(H3N8) and A/equine/LKZ/9/2012(H3N8).
- These strains were isolated from viral samples taken from cases of equine influenza in the northern and southern regions of Kazakhstan in 2012. They belong to Florida sublineage, clade 2.
- Complete genome sequencing would allow an in-depth understanding of the genetic makeup of these viruses, which can further contribute to the study of their biology.
Relevance and Importance of the Study
- Equine influenza is a highly contagious respiratory disease among horses. It is caused by strains of the influenza virus that primarily affect equines.
- New strains can emerge due to antigenic shift and drift, which can prove detrimental if not detected and studied in time. Hence, constant surveillance and characterization of circulating strains are crucial.
- By sequencing the full genomes of these two strains, the researchers provide valuable genetic information that can inform vaccine development, contribute to epidemiological studies, and aid in disease management strategies.
Contribution to Broader Scientific and Medical Communities
- The complete genome sequencing of any virus strain is a significant contribution to virology as it adds to the comprehensive database of virus genetic material, improving the understanding of virus evolution and diversity.
- Specifically for equine health, this research provides important insights about the equine influenza virus circulating in Kazakhstan in 2012. It can help prepare for possible future outbreaks by informing vaccination programs and antiviral treatments.
- This knowledge may also be used in comparative studies, enabling scientists to track the evolution of the virus over time and across different geographical regions.
Cite This Article
APA
Burashev Y, Strochkov V, Sultankulova K, Orynbayev M, Sansyzbay A, Sandybayev N, Nurabayev S, Savitskaya I, Rock DL, Tulman ER.
(2018).
Complete Genome Sequencing of Two Equine Influenza A(H3N8) Virus Strains Isolated in Kazakhstan.
Genome Announc, 6(26), e00574-18.
https://doi.org/10.1128/genomeA.00574-18 Publication
Researcher Affiliations
- Research Institute for Biological Safety Problems (RIBSP), Gvardeyskiy, Kazakhstan.
- Research Institute for Biological Safety Problems (RIBSP), Gvardeyskiy, Kazakhstan.
- Research Institute for Biological Safety Problems (RIBSP), Gvardeyskiy, Kazakhstan.
- Research Institute for Biological Safety Problems (RIBSP), Gvardeyskiy, Kazakhstan.
- Research Institute for Biological Safety Problems (RIBSP), Gvardeyskiy, Kazakhstan.
- Research Institute for Biological Safety Problems (RIBSP), Gvardeyskiy, Kazakhstan.
- Research Institute for Biological Safety Problems (RIBSP), Gvardeyskiy, Kazakhstan.
- Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
- Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
- Department of Pathobiology and Veterinary Science and Center of Excellence for Vaccine Research, University of Connecticut, Storrs, Connecticut, USA edan.tulman@uconn.edu.
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This article includes 9 references
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Citations
This article has been cited 5 times.- Alaql FA, Alhafufi AN, Kasem S, Alhammad YMO, Albaqshi H, Alyousaf A, Alsubaie FM, Alghamdi AN, Abdel-Moneim AS, Alharbi SA. Full-Length Genome of the Equine Influenza A Virus Subtype H3N8 from 2019 Outbreak in Saudi Arabia.. Animals (Basel) 2022 Oct 10;12(19).
- Burashev Y, Orynbayev M, Zakarya K, Abduraimov Y, Kassenov M, Strochkov V, Kozhabergenov N, Usserbayev B, Melisbek A, Shirinbekov M, Sypatay N, Sultankulova K. Complete Coding Genome Sequence of an Influenza A/H3N8 Equine Virus Isolated in Kazakhstan in 2007.. Microbiol Resour Announc 2022 Oct 20;11(10):e0114721.
- Oladunni FS, Oseni SO, Martinez-Sobrido L, Chambers TM. Equine Influenza Virus and Vaccines.. Viruses 2021 Aug 20;13(8).
- Yongfeng Y, Xiaobo S, Nan X, Jingwen Z, Wenqiang L. Detection of the epidemic of the H3N8 subtype of the equine influenza virus in large-scale donkey farms.. Int J Vet Sci Med 2020;8(1):26-30.
- Singh RK, Dhama K, Karthik K, Khandia R, Munjal A, Khurana SK, Chakraborty S, Malik YS, Virmani N, Singh R, Tripathi BN, Munir M, van der Kolk JH. A Comprehensive Review on Equine Influenza Virus: Etiology, Epidemiology, Pathobiology, Advances in Developing Diagnostics, Vaccines, and Control Strategies.. Front Microbiol 2018;9:1941.
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