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Home / Equine Research Bank / Vet World / Cryptic etiopathological conditions of equine nervous system...
Veterinary world2017; 10(12); 1427-1438; doi: 10.14202/vetworld.2017.1427-1438

Cryptic etiopathological conditions of equine nervous system with special emphasis on viral diseases.

Abstract: The importance of horse (Equus caballus) to equine practitioners and researchers cannot be ignored. An unevenly distributed population of equids harbors numerous diseases, which can affect horses of any age and breed. Among these, the affections of nervous system are potent reason for death and euthanasia in equids. Many episodes associated with the emergence of equine encephalitic conditions have also pose a threat to human population as well, which signifies their pathogenic zoonotic potential. Intensification of most of the arboviruses is associated with sophisticated interaction between vectors and hosts, which supports their transmission. The alphaviruses, bunyaviruses, and flaviviruses are the major implicated groups of viruses involved with equines/humans epizootic/epidemic. In recent years, many outbreaks of deadly zoonotic diseases such as Nipah virus, Hendra virus, and Japanese encephalitis in many parts of the globe addresses their alarming significance. The equine encephalitic viruses differ in their global distribution, transmission and main vector species involved, as discussed in this article. The current review summarizes the status, pathogenesis, pathology, and impact of equine neuro-invasive conditions of viral origin. A greater understanding of these aspects might be able to provide development of advances in neuro-protective strategies in equine population.
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Publication Date: 2017-12-10 PubMed ID: 29391683PubMed Central: PMC5771167DOI: 10.14202/vetworld.2017.1427-1438Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses diseases that affect the nervous system of horses, with particular emphasis on those caused by viruses and their implications to both equine and human populations.

Objective of the Research

  • The primary objective of the study is to delve into the numerous diseases that can afflict horses, focusing on affections of the nervous system. The research places special emphasis on the role that viruses play in these diseases.

Key Findings

  • The research indicates that diseases of the nervous system in horses are often significant reasons for death and euthanasia in the animals.
  • The study also underscores the potential health danger these equine diseases can pose to the human population due to their zoonotic potential. These diseases can make the jump from animals to humans and create significant public health issues.
  • The article stresses on three specific groups of viruses – alphaviruses, bunyaviruses, and flaviviruses – as the major culprits involved in horse-human disease transmission.
  • The research further points to the role that vectors (organisms that transmit infectious disease) and hosts play in the spread of these viruses.

Discussion on Specific Viral Diseases

  • The research specifically discusses outbreaks of deadly zoonotic diseases such as Nipah virus, Hendra virus, and Japanese encephalitis. These viral diseases emphasize the importance and urgency of studying horse nervous system diseases due to their potential risks toward human lives.
  • These equine encephalitic viruses have different distributions, transmission methods, and main vector species involved worldwide. The differences among these viruses and their geographic-specific factors are explored in this article.

Impact of the Research

  • The study aims to promote better understanding of viral diseases of the equine nervous system, in terms of their status, pathogenesis, pathology, and overall impact. This enhanced knowledge could contribute to the development of advanced neuro-protective strategies for horses.
  • By discussing the zoonotic potential of these diseases, the research could help shape measures to protect public health and curb the spread of such viruses from animals to humans.

Cite This Article

APA
Kumar R, Patil RD. (2017). Cryptic etiopathological conditions of equine nervous system with special emphasis on viral diseases. Vet World, 10(12), 1427-1438. https://doi.org/10.14202/vetworld.2017.1427-1438

Publication

Veterinary world
ISSN: 0972-8988
NlmUniqueID: 101504872
Country: India
Language: English
Volume: 10
Issue: 12
Pages: 1427-1438

Researcher Affiliations

Kumar, Rakesh
  • Department of Veterinary Pathology, Dr. G.C. Negi College of Veterinary and Animal Sciences, CSK Himachal Pradesh Agricultural University, Palampur - 176 062, Himachal Pradesh, India.
Patil, Rajendra D
  • Department of Veterinary Pathology, Dr. G.C. Negi College of Veterinary and Animal Sciences, CSK Himachal Pradesh Agricultural University, Palampur - 176 062, Himachal Pradesh, India.

References

This article includes 121 references
  1. Outram A.K, Stear N.A, Bendrey R, Olsen S, Kasparov A, Zaibert V, Thorpe N, Evershed R.P. The earliest horse harnessing and milking.. Science 2009;323:1332–1335.
    pubmed: 19265018
  2. Orlando L, Ginolhac A, Zhang G, Froese D, Albrechtsen A, Stiller M, Schubert M, Cappellini E, Petersen B, Moltke I, Johnson P.L, Fumagalli M, Vilstrup J.T, Raghavan M, Korneliussen T, Malaspinas A.S, Vogt J, Szklarczyk D, Kelstrup C.D, Vinther J, Dolocan A, Stenderup J, Velazquez A.M, Cahill J, Rasmussen M, Wang X, Min J, Zazula G.D, Seguin-Orlando A, Mortensen C, Magnussen K, Thompson J.F, Weinstock J, Gregersen K, Roed K.H, Eisenmann V, Rubin C.J, Miller D.C, Antczak D.F, Bertelsen M.F, Brunak S, Al-Rasheid K.A, Ryder O, Andersson L, Mundy J, Krogh A, Gilbert M.T, Kjaer K, Sicheritz-Ponten T, Jensen L.J, Olsen J.V, Hofreiter M, Nielsen R, Shapiro B, Wang J, Willerslev E. Recalibrating equus evolution using the genome sequence of an early middle pleistocene horse.. Nature 2013;499:74–78.
    pubmed: 23803765
  3. Jesús F, Martin B, Alonso A.A, Rivera M.G, Tamayo E, Eiros J.M, Almansa R. Postbooster antibodies from humans as source of diphtheria antitoxin.. Emerg. Infect. Dis. 2016;22:7.
    pmc: PMC4918160pubmed: 27314309
  4. Guidlolin R.G, Marcelino R.M, Gondo H.H, Morais J.F, Ferreira R.A, Silva C.L, Kipnis T.L, Silva J.A, Fafetine J, da Silva W.D. Polyvalent horse F(Ab`)2 snake antivenom:Development of process to produce polyvalent horse F(Ab`)2 antibodies anti-African snake venom.. Afr. J. Biotechnol. 2010;9(16):2446–2455.
  5. Horohov D.W. The equine immune responses to infectious and allergic disease:A model for humans?. Mol. Immunol. 2015;66:89–96.
    pubmed: 25457878
  6. Rech R, Barros C. Neurologic diseases in horses.. Clin. Equine. 2015;31:281–306.
    pubmed: 26210953
  7. Vandevelde M, Higgins R.J, Oevermann A. Metabolic encephalopathy.. Veterinary Neuropathology. Essentials of Theory and Practice Oxford (United Kingdom): Wiley-Blackwell; 2012. pp. 22–124.
  8. Elliott C.R.B, McCowan C.I. Nigropallidal encephalomalacia in horses grazing Rhaponticum repens(creeping knapweed). Aust. Vet. J. 2012;90(4):151–154.
    pubmed: 22443332
  9. Long M.T. West Nile virus and equine encephalitis viruses:New perspectives.. Vet. Clin. North Am. Equine Pract. 2014;30:523–542.
    pubmed: 25441112
  10. Boone A.C, Susta L, Rech R.R. Pathology in practice:Poliomyelitis with intraneuronal negri bodies.. J. Am. Vet. Med. Assoc. 2010;237:277–279.
    pubmed: 20673107
  11. Dubey J.P, Lindsay D.S, Saville W.J.A, Reed S.M, Granstrom D.E, Speer C.A. A review of Sarcocystis neurona and equine protozoal myeloencephalitis (EPM). Vet. Parasitol. 2001;95:89–131.
    pubmed: 11223193
  12. Zacchary J.F. Cervical stenotic myelopathy.. Pathologic Basis of Veterinary Disease 5th ed. St Louis (MO): Elsevier; 2012. pp. 833–835.
  13. Hahn C. Equine reflex hypertonia.. Equine Neurology 2nd ed. Oxford (United Kingdom): Blackwell Publishing; 2008. pp. 366–367.
  14. Chalmers H.J, Yeager A.E, Cheetham J. Diagnostic sensitivity of subjective and quantitative laryngeal ultrasonography for recurrent laryngeal neuropathy in horses.. Vet. Radiol. Ultrasound. 2012;53(6):660–666.
    pubmed: 22985286
  15. Musso D, Cao-Lormeau V.M, Gubler D.J. Zika virus:Following the path of dengue and chikungunya?. Lancet 2015;386:243–244.
    pubmed: 26194519
  16. Garcia M.D.F, Mazzon M, Jacobs M, Amara A. Pathogenesis of Flavivirus infections:Using and abusing the host cell.. Cell Host Microbe. 2009;5(4):318–328.
    pubmed: 19380111
  17. Singha H, Gulati B.R, Kumar P, Singh B.K, Virmani N, Singh R.K. Complete genome sequence analysis of Japanese encephalitis virus isolated from a horse in India.. Arch, Virol. 2013;158(1):113–122.
    pubmed: 23001697
  18. Mann B.R, McMullen A.R, Swetnam D.M, Salvato V, Reyna M, Guzman H.R.B, Jr, Dennett J.A, Tesh R.B, Barrett A.D.T. Continued evolution of West Nile virus, Houston, Texas, USA, 2002-2012.. Emerg. Infect. Dis. 2013;19(9):1418–1427.
    pmc: PMC3810927pubmed: 23965756
  19. Taylor K.G, Paessler S. Pathogenesis of Venezuelan equine encephalitis.. Vet. Microbiol. 2013;167(1-2):145–150.
    pubmed: 23968890
  20. Blitvich B.J, Firth A.E. Insect-specific flaviviruses:A systematic review of their discovery, host range, mode of trans-mission, super infection exclusion potential and genomic organization.. Viruses 2015;7:1927–1959.
    pmc: PMC4411683pubmed: 25866904
  21. Asnis D.S, Conetta R, Teixeira A.A, Waldman G, Sampson B.A. The West Nile virus outbreak of 1999 in New York:The flushing hospital experience.. Clin. Infect. Dis. 2000;30:413–418.
    pubmed: 10722421
  22. Platonov A.E, Shipulin G.A, Shipulina O.Y, Tyutyunnik E.N, Frolochkina T.I, Lanciotti R.S. Outbreak of west Nile Infection, Volgograd region, Russia, 1999.. Emerg. Infect. Dis. 2001;7:128–132.
    pmc: PMC2631674pubmed: 11266303
  23. Paramasivan R, Mishra A.C, Mourya D.T. West Nile virus:The Indian Scenario.. Indian J. Med. Res. 2003;118:101–108.
    pubmed: 14700342
  24. Pattan S.R, Dighe N.S, Bhawar S.B, Gaware V.M, Hole M.B, Musmade D.S, Bhosale M.S. West Nile Fever:An overview.. J. Biomed. Sci. Res. 2009;1(1):33–48.
  25. Banker D.D. Preliminary observations on antibody patterns against certain viruses among inhabitants of Bombay city.. Indian J. Med. Sci. 1952;6:733–746.
  26. Murgue B, Murri S, Zientara S, Durand B, Durand J, Zeller H. West Nile outbreak in horses in Southern France, 2000:The return after 35 years.. Emerg. Infect. Dis. 2001;7:692–696.
    pmc: PMC2631744pubmed: 11585534
  27. Komar N. West Nile viral encephalitis.. Rev. Sci. Tech. 2000;19:166–176.
    pubmed: 11189714
  28. George S, Gourie-Devi M, Rao J.A, Prasad S.R, Pavri K.M. Isolation of West Nile virus from the brains of children who had died of encephalitis.. Bull. World Health Organ. 1984;62:879–882.
    pmc: PMC2536262pubmed: 6099760
  29. Geevarghese G, Shaikh B.H, Jacob P.G, Bhat H.R, Pavri K.M. Domestic pigs as sentinels to monitor the activity of Japanese encephalitis and West Nile viruses in Kolar District, Karnataka.. Indian J. Med. Res. 1987;86:413–418.
    pubmed: 2832323
  30. Ilkal M.A, Prasanna Y, Jacob P.G, Geevarghese G, Banerjee K. Experimental studies on the susceptibility of domestic pigs to West Nile virus followed by Japanese encephalitis virus infection and vice-versa.. Acta. Virol. 1994;38:157–161.
    pubmed: 7817897
  31. Ziegler U, Angenvoort J, Fischer D, Fast C, Eiden M, Rodriguez A.V, Fernandez S.R, Nowotny N, de la Fuente J.C, Lierz M, Groschup M.H. Pathogenesis of West Nile virus lineage 1 and 2 in experimentally infected large falcons.. Vet. Microbiol. 2013;161:263–273.
    pubmed: 22909991
  32. Monaco F, Savini G, Calistri P, Polci A, Pinoni C, Bruno R, Lelli R. 2009 West Nile disease epidemic in Italy:First evidence of overwintering in Western Europe?. Res. Vet. Sci. 2011;91(2):321–326.
    pubmed: 21334703
  33. Bakonyi T, Ivanics E, Erde´lyi K, Ursu K, Ferenczi E, Weissenbo¨ck H, Nowotny N. Lineage 1 and 2 strains of encephalitic West Nile virus, central Europe.. Emerg. Infect. Dis. 2006;12:618–623.
    pmc: PMC3294705pubmed: 16704810
  34. Wodak E, Richter S, Bago Z, Revilla-Ferna´ndez S, Weissenbo¨ck H, Nowotny N, Winter P. Detection and molecular analysis of West Nile virus infections in birds of prey in the eastern part of Austria in 2008 and 2009.. Vet. Microbiol. 2011;149:358–366.
    pubmed: 21276665
  35. Papa A, Bakonyi T, Xanthopoulou K, Vazquez A, Tenorio A, Nowotny N. Genetic characterization of West Nile virus lineage 2 Greece, 2010.. Emerg. Infect. Dis. 2011a;17:920–922.
    pmc: PMC3321789pubmed: 21529413
  36. Papa A, Xanthopoulou K, Gewehr S, Mourelatos S. Detection of West Nile virus lineage 2 in mosquitoes during a human outbreak in Greece.. Clin. Microbiol. Infect. 2011b;17:1176–1180.
    pubmed: 21781205
  37. Valiakos G, Touloudi A, Lacovakis C, Athanasiou L, Birtsas P, Spyrou V, Billinis C. Molecular detection and phylogenetic analysis of West Nile virus lineage 2 in sedentary wild birds (Eurasian magpie) Greece, 2010.. Euro Surveill. 2011;16(18):19862.
    pubmed: 21586266
  38. Anukumar B, Sapkalb G.N, Tandaleb B.V, Balasubramaniana R, Gangaleb D. West Nile encephalitis outbreak in Kerala, India.. J. Clin. Virol. 2014;61:152–155.
    pubmed: 24985196
  39. McMullen A.R, Albayrak H, May F.J. Molecular evolution of lineage 2 West Nile virus.. J. Gen. Virol. 2013;94:318–325.
    pmc: PMC3709619pubmed: 23136360
  40. Chaintoutis S.C, Chaskopoulou A, Chassalevris T. West Nile virus lineage 2 strain in Greece, 2012.. Emerg. Infect. Dis. 2013;19:827–829.
    pmc: PMC3647506pubmed: 23697609
  41. Centers for Disease Control and Prevention (CDC). West Nile virus and other arboviral diseases-United States, 2012.. MMWR Morb. Mortal. Wkly. Rep. 2013;62:513–517.
    pmc: PMC4604949pubmed: 23803959
  42. De F.M, Ulbert S, Diamond M, Sanders N.N. Recent progress in West Nile virus diagnosis and vaccination.. Vet. Res. 2012;43(1):16.
    pmc: PMC3311072pubmed: 22380523
  43. Nemeth N, Gould D, Bowen R, Komar N. Natural and experimental West Nile virus infection in five raptor species.. J. Wildl. Dis. 2006;42:1–13.
    pubmed: 16699143
  44. Nazmi A, Dutta K, Hazra B, Basu A. Role of pattern recognition receptors in flavivirus infections.. Virus. Res. 2014;185:32–40.
    pubmed: 24657789
  45. Basumatary L.J, Raja D, Bhuyan D, Das M, Goswami M, Kayal A.K. Clinical and radiological spectrum of Japanese encephalitis.. J. Neurol. Sci. 2013;325:15–21.
    pubmed: 23260319
  46. Sudeep A.B, Ghodke Y.S, Gokhale M.D, George R.P, Dhaigude S.D, Bondre V.P. Replication potential and different modes of transmission of West Nile virus in an Indian strain of Culex gelidus Theobald (Diptera Culicidae) mosquitoes.. J. Vector Borne Dis. 2014;51:333–338.
    pubmed: 25540967
  47. Arunachalam N, Murty U.S, Narahari D, Balasubramanian A, Samuel P.P, Thenmozhi V. Longitudinal studies of Japanese encephalitis virus infection in vector mosquitoes in Kurnool district, Andhra Pradesh, South India.. J. Med. Entomol. 2009;46:633–639.
    pubmed: 19496437
  48. Murty U.S, Rao M.S, Arunachalam N. The effects of climatic factors on the distribution and abundance of Japanese encephalitis vectors in Kurnool district of Andhra Pradesh, India.. J. Vector Borne Dis. 2010;47:26–32.
    pubmed: 20231770
  49. Sudeep A.B, Ghodke Y.S, George R.P, Ingale V.S, Dhaigude S.D, Gokhale M.D. Vectorial capacity of Culex gelidus(Theobald) mosquitoes to certain viruses of public health importance in India.. J. Vector Borne Dis. 2015;52:153–158.
    pubmed: 26119548
  50. Avabratha K.S, Sulochana P, Nirmala G, Vishwanath B, Veerashankar M, Bhagyalakshmi K. Japanese encephalitis in children in Bellary Karnataka:Clinical profile and sequelae.. Int. J. Biotechnol. Res. 2012;3(2):100–105.
  51. Terry R.L, Getts D.R, Deffrasnes C, van Vreden C, Campbell I.L, King N.J. Inflammatory monocytes and the pathogenesis of viral encephalitis.. J. Neuroinflammation. 2012;9:270.
    pmc: PMC3560265pubmed: 23244217
  52. Miner J.J, Daniels B.P, Shrestha B, Proenca-Modena J.L, Lew E.D, Lazear H.M, Gorman M.J, Lemke G, Klein R.S, Diamond M.S. The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.. Nat. Med. 2015;21:1464–1472.
    pmc: PMC4674389pubmed: 26523970
  53. Marchiando A.M, Graham W.V, Turner J.R. Epithelial barriers in homeostasis and disease.. Annu. Rev. Pathol. 2010;5:119–144.
    pubmed: 20078218
  54. Persidsky Y, Heilman D, Haorah J, Zelivyanskaya M, Persidsky R, Weber G.A, Shimokawa H, Kaibuchi K, Ikezu T. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood. 2006;107:4770–4780.
    pmc: PMC1895810pubmed: 16478881
  55. Agrawal T, Sharvani V, Nair D, Medigeshi G.R. Japanese encephalitis virus disrupts cell–cell junctions and affects the epithelial permeability barrier functions.. PLoS One. 2013;8(7):e69465.
    pmc: PMC3722119pubmed: 23894488
  56. Ghoshal A, Das S, Ghosh S, Mishra M.K, Sharma V, Koli P, Sen E, Basu A. Pro inflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis.. Glia. 2007;55:483–496.
    pubmed: 17203475
  57. Lewis N.D, Hill J.D, Juchem K.W, Stefanopoulos D.E, Modis L.K. RNA sequencing of microglia and monocyte-derived macrophages from mice with experimenal autoimmune encephalomyelitis illustrates a changing phenotype with disease course.. J. Neuroimmuol. 2014;277:26–38.
    pubmed: 25270668
  58. Kim J.H, Choi J.Y, Kim S.B, Uyangaa E, Patil A.M, Han Y.W, Park S.Y, Lee J.H, Kim K, Eo S.K. CD11c (hi) dendritic cells regulate Ly-6C (hi) monocyte differentiation to preserve immune-privileged CNS in lethal neuroinflammation.. Sci. Rep. 2015;5:17548.
    pmc: PMC4667186pubmed: 26626303
  59. Winter P.M, Dung N.M, Loan H.T, Kneen R, Wills B, Thule T, House D, White N.J, Farrar J.J, Hart C.A, Solomon T. Pro inflammatory cytokines and chemokines in human with Japanese encephalitis.. J. Infect. Dis. 2004;190:1618–1626.
    pubmed: 15478067
  60. Das S, Mishra M.K, Ghosh J, Basu A. Japanese encephalitis virus infection induces IL-18 and IL-1b in microglia and astrocytes:Correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death.. J. Neuroimmunol. 2008;195:60–72.
    pubmed: 18374991
  61. Chen C.J, Liao S.L, Kuo M.D, Wang Y.M. Astrocytic alteration induced by Japanese encephalitis virus infection.. Neuroreport. 2000;11:1933–1937.
    pubmed: 10884046
  62. Chen C.J, Ou Y.C, Lin S.Y, Raung S.L, Liao S.L, Lai C.Y, Chen S.Y, Chen J.H. Glial activation involvement in neuronal death by Japanese encephalitis virus infection.. J Gen. Virol. 2010a;91:1028–1037.
    pubmed: 20007359
  63. Chen C.J, Ou Y.C, Chang C.Y, Pan H.C, Liao S.L, Raung S.L, Chen S.Y. TNFa and IL-1b mediate Japanese encephalitis virus-induced RANTES gene expression in astrocytes.. Neurochem. Int. 2010b;58(2):234–242.
    pubmed: 21167894
  64. Swarup V, Ghosh J, Das S, Basu A. Tumor necrosis factor receptor associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis.. Neurochem. Int. 2008;52:1310–1321.
    pubmed: 18325634
  65. Chua K.B, Bellini W.J, Rota P.A, Harcourt B.H, Tamin A, Lam S.K, Ksiazek T.G, Rollin P.E, Zaki S.R, Shieh W, Goldsmith C.S, Gubler D.J, Roehrig J.T, Eaton B, Gould A.R, Olson J, Field H, Daniels P, Ling A.E, Peters C.J, Anderson L.J, Mahy B.W. Nipah virus:A recently emergent deadly paramyxovirus.. Science 2000;288:1432–1435.
    pubmed: 10827955
  66. Harcourt B.H, Tamin A, Halpin K, Ksiazek T.G, Rollin P.E, Bellini W.J, Rota P.A. Molecular characterization of the polymerase gene and genomic termini of nipah virus.. Virology 2001;287:192–201.
    pubmed: 11504554
  67. Li M, Embury-Hyatt C, Weingart H.M. Experimental inoculation study indicates swine as a potential lhost for hendra virus.. Vet. Res. 2010;41:33.
    pmc: PMC2826093pubmed: 20167195
  68. Marsh G.A, Haining J, Hancock T.J, Robinson R, Foord A.J, Barr J.A, Riddell S, Heine H.G, White J.R, Crameri G, Field H.E, Wang L.F, Middleton D. Experimental infection of horses with hendra virus/Australia/horse/2008/Redlands.. Emerg. Infect. Dis. 2011;17:2232–2238.
    pmc: PMC3311212pubmed: 22172152
  69. Chua K.B, Koh C.L, Hooi P.S, Wee K.F, Khong J.H, Chua B.H, Chan Y.P, Lim M.E, Lam S.K. Isolation of nipah virus from Malaysian Island flying-foxes.. Microb. Infect. 2002;4:145–151.
    pubmed: 11880045
  70. Halpin K, Mungall B.A. Recent progress in henipavirus research.. Comp. Immunol. Microbiol. Infect. Dis. 2007;30:287–307.
    pubmed: 17629946
  71. Broder C.C, Weir D.L, Reid P.A. Hendra virus and nipah virus animal vaccines.. Vaccine 2016;34:3525–3534.
    pmc: PMC4933500pubmed: 27154393
  72. Satterfield B.A, Dawes B.E, Milligana G.N. Status of vaccine research and development of vaccines for nipah virus.. Vaccine 2016;34:2971–2975.
    pubmed: 26973068
  73. Chua K.B, Goh K.J, Wong K.T, Kamarulzaman A, Tan P.S, Ksiazek T.G, Zaki S.R, Paul G, Lam S.K, Tan C.T. Fatal encephalitis due to nipah virus among pig-farmers in Malaysia.. Lancet 1999;354:1257–1259.
    pubmed: 10520635
  74. Mohd N.M.N, Gan C.H, Ong B.L. Nipah virus infection of pigs in peninsular Malaysia.. Rev. Sci. Tech. 2000;19:160–165.
    pubmed: 11189713
  75. Hossain M.J, Gurley E.S, Montgomery J.M, Bell M, Carroll D.S, Hsu V.P. Clinical presentation of nipah virus infection in Bangladesh.. Clin. Infect. Dis. 2008;46:977–984.
    pubmed: 18444812
  76. Murray K, Rogers R, Selvey L, Selleck P, Hyatt A, Gould A, Gleeson L, Hooper P, Westbury H. A novel Morbillivirus pneumonia of horses and its transmission to humans.. Emerg. Infect. Dis. 1995;1:31–33.
    pmc: PMC2626820pubmed: 8903153
  77. Hanna J.N, McBride W.J, Brookes D.L, Shield J, Taylor C.T, Smith I.L, Craig S.B, Smith G.A. Hendra virus infection in a veterinarian.. Med. J. Aust. 2006;185:562–564.
    pmc: PMC7168387pubmed: 17115969
  78. Paterson D.L, Murray P.K, McCormack J.G. Zoonotic disease in Australia caused by a novel member of the Paramyxoviridae.. Clin. Infect. Dis. 1998;27:112–118.
    pubmed: 9675464
  79. Weingart H.M, Berhane Y, Czub M. Animal models of henipavirus infection:A review.. Vet. J. 2009;181:211–220.
    pubmed: 19084436
  80. Lamb R.A, Paterson R.G, Jardetzky T.S. Paramyxovirus membrane fusion:Lessons from the F and HN atomic structures.. Virology 2006;344:30–37.
    pmc: PMC7172328pubmed: 16364733
  81. Luque L.E, Russell C.J. Spring-loaded heptad repeat residues regulate the expression and activation of paramyxovirus fusion protein.. J. Virol. 2007;81:3130–3141.
    pmc: PMC1866055pubmed: 17251293
  82. Steele K.E, Twenhafel N.A. Pathology of animal models of Alphavirus encephalitis.. Vet. Pathol. 2010;47(5):790–805.
    pubmed: 20551475
  83. Scott T.W, Weaver S.C. Eastern equine encephalomyelitis virus:Epidemiology and evolution of mosquito transmission.. Adv. Virus Res. 1989;37:277–328.
    pubmed: 2574935
  84. Silva M.L, Galiza G.J, Dantas A.F, Oliveira R.N, Iamamoto K, Achkar S.M, Riet-Correa F. Outbreaks of eastern equine encephalitis in north eastern Brazil.. J. Vet. Diagn. Invest. 2011;23(3):570–575.
    pubmed: 21908293
  85. Estep L.K, McClure C.J, Burkett-Cadena N.D, Estep L.K. A multi-year study of mosquito feeding patterns on avian hosts in a southeastern focus of eastern equine encephalitis virus.. Am. J. Trop. Med. Hyg. 2011;84(5):718–726.
    pmc: PMC3083738pubmed: 21540380
  86. Molaei G, Andreadis T.G, Armstrong P.M, Thomas M.C, Deschamps T, Cuebas-Incle E. Vector-host interactions and epizootiology of eastern equine encephalitis virus in Massachusetts.. Vector Borne Zoonotic Dis. 2013;13:312–323.
    pubmed: 23473221
  87. Molaei G, Armstrong P.M, Graham A.C, Kramer L.D, Andreadis T.G. Insights into the recent emergence and expansion of eastern equine encephalitis virus in a new focus in the Northern New England USA.. Parasit Vectors. 2015;8:516.
    pmc: PMC4600208pubmed: 26453283
  88. Armstrong P.M, Andreadis T.G, Anderson J.F, Stull J.W, Mores C.N. Tracking eastern equine encephalitis virus perpetuation in the northeastern United States by phylogenetic analysis.. Am. J. Trop. Med. Hyg. 2008;79:291–296.
    pubmed: 18689638
  89. Zacks M.A, Paessler S. Encephalitic Alphaviruses.. Vet. Microbiol. 2010;140:3–4.
    pmc: PMC2814892pubmed: 19775836
  90. Arrigo N.C, Adams A.P, Watts D.M, Newman P.C, Weaver S.C. Cotton rats and house sparrows as hosts for North and South American strains of Eastern equine encephalitis virus.. Emerg. Infect. Dis. 2010;16(9):1373–1380.
    pmc: PMC3294987pubmed: 20735920
  91. Morrison A.C, Forshey B.M, Notyce D, Astete H, Lopez V, Rocha C, Carrion R, Carey C, Eza D, Montgomery J.M, Kochel T.J. Venezuelan equine encephalitis virus in Iquitos, Peru:Urban transmission of a sylvatic strain.. PLoS Negl. Trop. Dis. 2008;2:e349.
    pmc: PMC2593782pubmed: 19079600
  92. Vogel P, Abplanalp D, Kell W, Ibrahim M.S, Downs M.B, Pratt W.D, Davis K.J. Venezuelan equine encephalitis in BALB/c mice:Kinetic analysis of central nervous system infection following aerosol or subcutaneous inoculation.. Arch. Pathol. Lab. Med. 1996;120:164–172.
    pubmed: 8712896
  93. Steele K.E, Davis K.J, Stephan K, Kell W, Vogel P, Hart M.K. Comparative neurovirulence and tissue tropism of wild-type and attenuated strains of Venezuelan equine encephalitis virus administered by aerosol in C3H/HeN and BALB/c mice.. Vet. Pathol. 1998;35:386–397.
    pubmed: 9754544
  94. Paessler S, Ni H, Petrakova O, Fayzulin R.Z, Yun N, Anishchenko M, Weaver S.C, Frolov I. Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses.. J. Virol. 2006;80:2784–2796.
    pmc: PMC1395430pubmed: 16501087
  95. Wang Y, Kawamura N, Schmelzer J.D, Schmeichel A.M, Low P.A. Decreased peripheral nerve damage after ischemia–reperfusion injury in mice lacking TNF-alpha.. J. Neurol. Sci. 2008;267:107–111.
    pmc: PMC2329795pubmed: 18028959
  96. Barabe N.D, Rayner G.A, Christopher M.E, Nagata L.P, Wu J.Q. Single-dose, fast-acting vaccine candidate against western equine encephalitis virus completely protects mice from intranasal challenge with different strains of the virus.. Vaccine 2007;25:6271–6276.
    pubmed: 17630056
  97. Anishchenko M, Bowen R.A, Paessler S, Austgen L, Greene I.P, Weaver S.C. Venezuelan encephalitis emergence mediated by a phylogenetic ally predicted viral mutation.. Proc. Natl. Acad. Sci. U S A. 2006;103:4994–4999.
    pmc: PMC1458783pubmed: 16549790
  98. Hu W.G, Phelps A.L, Jager S, Chau D, Hu C.C, O'Brien L.M, Perkins S.D, Gates A.J, Phillpotts R.J, Nagata L.P. A recombinant humanized monoclonal antibody completely protects mice against lethal challenge with Venezuelan equine encephalitis virus.. Vaccine 2010;28:5558–5564.
    pubmed: 20600509
  99. O'Brien L.M, Goodchild S.A, Phillpotts R.J, Perkins S.D. A humanised murine monoclonal antibody protects mice from Venezuelan equine encephalitis virus everglades virus and mucambo virus when administered up to 48 h after airborne challenge.. Virology 2012;426:100–105.
    pubmed: 22341308
  100. Dupuy L.C, Richards M.J, Ellefsen B, Chau L, Luxembourg A, Hannaman D, Livingston B.D, Schmaljohn C.S. A DNA vaccine for Venezuelan equine encephalitis virus delivered by intramuscular electroporation elicits high levels of neutralizing antibodies in multiple animal models and provides protective immunity to mice and nonhuman primates.. Clin. Vaccine Immunol. 2011;18:707–716.
    pmc: PMC3122536pubmed: 21450977
  101. Tretyakova I, Lukashevich I.S, Glass P, Wang E, Weaver S, Pushko P. Novel vaccine against Venezuelan equine encephalitis combines advantages of DNA immunization and a live attenuated vaccine.. Vaccine 2013;31:1019–1025.
    pmc: PMC3556218pubmed: 23287629
  102. Lunn D.P, Davis-Poynter N, Flaminio M.J, Horohov D.W, Osterrieder K, Pusterla N, Townsend H.G. Equine herpesvirus–1 consensus statement.. J. Vet. Intern. Med. 2009;23:450–461.
    pubmed: 19645832
  103. Kapoor S, Sharma H, Singh M, Kumar P, Ranjan K, Kumari A, Khirbat R. Equine herpesviruses:A brief review.. Adv. Anim. Vet. Sci. 2014;2(2S):46–54.
  104. El-Habashi N, El-Nahass E.S, Namihira Y, Hagiwara H, Fukushi H, Narita M, Hirata A, Sakai H, Yanai T. Neuropathogenicity of equine herpesvirus 9 in cattle.. J. Equine Vet. Sci. 2011;31(2):72–77.
  105. Schrenzel M.D, Tucker T.A, Donovan T.A, Busch M.D, Wise A.G, Maes R.K, Kiupel M. New hosts for equine herpesvirus 9.. Emerg. Infect. Dis. 2008;14:1616–1619.
    pmc: PMC2609862pubmed: 18826828
  106. Kasem S, Yamada S, Kiupel M, Woodruff M, Ohya K, Fukushi H. Equine herpesvirus Type 9 in giraffe with encephalitis.. Emerg. Infect. Dis. 2008;14(12):1948.
    pmc: PMC2634639pubmed: 19046530
  107. Greenwood A.D, Tsangaras K, Ho S.Y, Szentiks C.A, Nikolin V.M, Ma G, Damiani A, East M.L, Lawrenz A, Hofer H, Osterrieder N. A potentially fatal mix of herpes in zoos.. Curr. Biol. 2012;22:1727–1731.
    pubmed: 22902751
  108. Hebia I, Fieni F, Duchamp G, Destrumelle S, Pellerin J.L, Zientara S, Vautherot J.F, Bruyas J.F. Potential risk of Equine herpesvirus 1(EHV–1) transmission by equine embryo transfer.. Theriogenology. 2007;67(9):1485–1491.
    pubmed: 17459463
  109. Allen G.P, Kydd J.H, Slater J.D, Smith K.C. Advances in Understanding of the Pathogenesis, Epidemiology and Immunological Control of Equine herpesvirus Abortion.. Proceedings 8th International Conference on Equine Infectious Diseases Dubai; 1998. pp. 129–146.
  110. Gosztony G, Borchers K, Ludwig H. Pathogenesis of Equine herpesvirus-1 infection in the mouse model.. APMIS. 2009;117:10–21.
    pubmed: 19161532
  111. Henninger R.W, Reed S.M, Saville W.J, Allen G.P, Hass G.F, Kohn C.W, Sofaly C. Outbreak of neurologic disease caused by Equine herpesvirus–1 at a university equestrian center.. J Vet. Intern. Med. 2007;21:157–165.
    pubmed: 17338164
  112. El-Habashi N, El-Shaymaa E.N, Fukushi H, Hibi D, Sakai H, Sasseville V, Yanai T. Experimental intranasal infection of Equine herpesvirus9 (EHV-9) in suckling hamsters:Kinetics of viral transmission and inflammation in the nasal cavity and brain.. J. Neurovirol. 2010;16:242–248.
    pubmed: 20500017
  113. Goehring L.S, van Maanen C, van Oldruitenborgh–Oosterbaan M.M.S. Neurological syndromes among horses in the Netherlands:A 5 year retrospective survey (1999-2004). Vet. Q. 2005;27:11–20.
    pubmed: 15835280
  114. Easton C, Fuentealba N.A, Paullier C, Alonzo P, Carluccio J, Galosi C.M. Immunohistochemical and molecular detection of Equine herpesvirus 1 in uruguay.. Rev. Sci. Tech. 2009;28(3):1085–1090.
    pubmed: 20462167
  115. Sáenz J.R, Góez Y, Herrera A.L. Equine herpesvirus 1 and 4 DNA detection in peripheral blood mononuclear cells and trigeminal ganglion of equines:Infection, latency and approximation to neuropathogenesis of the strain.. Rev. Colomb. Cienc. Pecuarias. 2008;21(3):372–386.
  116. Sharma P, Rastogi A, Narwal P.S. Detection of equine herpesvirus infection:sensitivity assay of polymerase chain reaction.. J. Biol. Agric. Healthc. 2012;8(2):106–108.
  117. Sarani A, Mohammadi G, Mayameei A, Akbari M. Investigation of Equine herpesvirus-1 and 4 infections in equine population of Iran by real-time PCR.. HVM. 2013;5(1):29–33.
  118. Allen G.P. Development of a real–time polymerase chain reaction assay for rapid diagnosis of neuropathogenic strains of Equine herpesvirus-1.. J. Vet. Diagn. Invest. 2007;19:69–72.
    pubmed: 17459834
  119. Smith K.L, Li Y, Breheny P, Cook R.F, Henney P.J, Sells S, Pronost S, Lu Z, Crossley B.M, Timoney P.J, Balasuriya U.B.R. New real–time PCR assay using allelic discrimination for detection and differentiation of Equine herpesvirus–1 strains with A2254 and G2254 polymorphisms.. J. Clin. Microbiol. 2012;50(6):1981–1988.
    pmc: PMC3372139pubmed: 22493339
  120. Kapoor S, Dhama K, Pawaiya R.V.S, Mathew T, Thankam M. Equine herpesvirus.. Tropical Viral Diseases of Large Animals Part 1 West Orange, New Jersey, USA: Thajema Publishers; 2010. pp. 110–132.
  121. Stein L.T, Rech R.R, Harrison L, Brown C.C. Immunohistochemical study of rabies virus within the central nervous system of domestic and wildlife species.. Vet. Pathol. 2010;47(4):630–633.
    pubmed: 20484176
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