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Home / Equine Research Bank / Sci Rep / Development of the equine gut microbiota.
Scientific reports2019; 9(1); 14427; doi: 10.1038/s41598-019-50563-9

Development of the equine gut microbiota.

Abstract: Shortly after birth the mammalian gut is colonized, by a transient microbiota, highly susceptible to environment and diet, that eventually stabilizes and becomes the resident gut microbiota. In a window of opportunity during the colonization, oral tolerance is established towards resident bacteria. In this study, the development of the equine gut microbiota was investigated in ten foals from parturition until post weaning. We found great differences in the core species of the gut microbiota composition between time-matched samples on Day 7 and 20 post-partum. Between day 20 and Day 50 post-partum, we saw the gut microbiota became increasingly dominated by fiber fermenting species. After Day 50, no significant changes in species abundance were observed. Gene expression analysis of pro- and anti-inflammatory cytokines in the blood revealed no significant changes before and after weaning. In summary, relative stability of the gut microbiota was reached within 50 days post-partum and, weaning did not have a major impact on the microbial composition.
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Publication Date: 2019-10-08 PubMed ID: 31594971PubMed Central: PMC6783416DOI: 10.1038/s41598-019-50563-9Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study explores the development of the equine gut microbiota, or the community of microorganisms in the horse’s digestive tract, from birth to post weaning. The researchers found that the composition of the gut microbiota changed a lot in the first 20 days but became increasingly stable by day 50, with weaning having little effect on this composition.

Objective of the Research

  • The research aimed to investigate the development of the equine gut microbiota—the community of microorganisms residing in the horse’s digestive tract. Starting from birth (parturition) right through to after weaning, the researchers tracked and compared the composition and stability of the gut microbiota in foals.

Methodology

  • Researchers selected a group of ten foals and began collecting data from the day of parturition until post-weaning.
  • The focus was on the core species of the gut microbiota and their abundance at different times.
  • Specific days—Day 7, Day 20, and Day 50 post-partum—were chosen to identify any changes or evolution in the microbiota composition.
  • Gene expression analysis was also carried out to observe any significant changes in pro- and anti-inflammatory cytokines in the blood before and after weaning.

Findings

  • There were significant differences in the gut microbiota composition on day 7 and day 20 after birth.
  • From Day 20 to Day 50 post-birth, the researchers found that the microbiota population became mostly composed of fiber fermenting species.
  • After Day 50, there were no significant changes observed in terms of species abundance.
  • The gene expression analysis showed no significant changes in the level of pro- and anti-inflammatory cytokines before and after weaning.

Conclusion

  • Based on their findings, the researchers concluded that relative stability in the gut microbiota of horses is typically reached within 50 days after birth.
  • They also found that the process of weaning does not majorly impact or dramatically alter the microbial composition in the gut.

Cite This Article

APA
Lindenberg F, Krych L, Kot W, Fielden J, Frøkiær H, van Galen G, Nielsen DS, Hansen AK. (2019). Development of the equine gut microbiota. Sci Rep, 9(1), 14427. https://doi.org/10.1038/s41598-019-50563-9

Publication

Scientific reports
ISSN: 2045-2322
NlmUniqueID: 101563288
Country: England
Language: English
Volume: 9
Issue: 1
Pages: 14427
PII: 14427

Researcher Affiliations

Lindenberg, F
  • Brogaarden Aps, Copenhagen, Denmark. frederikke@lindenberg.dk.
  • Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark. frederikke@lindenberg.dk.
Krych, L
  • Faculty of Sciences, Department of Food Science, University of Copenhagen, Copenhagen, Denmark.
Kot, W
  • Department of Environmental Sciences, Aarhus University, København, Denmark.
Fielden, J
  • Brogaarden Aps, Copenhagen, Denmark.
Frøkiær, H
  • Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
van Galen, G
  • Faculty of Health and Medical Sciences, Department of Veterinary Clinical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nielsen, D S
  • Faculty of Sciences, Department of Food Science, University of Copenhagen, Copenhagen, Denmark.
Hansen, A K
  • Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.

MeSH Terms

  • Animals
  • Bacteria / classification
  • Bacteria / genetics
  • Bacteria / isolation & purification
  • Cytokines
  • Diet / adverse effects
  • Gastrointestinal Microbiome / genetics
  • Gastrointestinal Tract / growth & development
  • Gastrointestinal Tract / microbiology
  • Horses / growth & development
  • Horses / microbiology
  • Microbiota / genetics
  • Phylogeny
  • Weaning

Conflict of Interest Statement

The authors declare no competing interests.

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