Dietary Supplements of Vitamins E, C, and β-Carotene to Reduce Oxidative Stress in Horses: An Overview.
Abstract: Oxidative stress is the excess generation of free radicals and/or a decrease in the response of the antioxidant system. It is known to cause damage to the equine health by unbalancing the stable molecules. The dietary supplementation of vitamins E, C, and β-carotene cause beneficial effect on horses' health. These supplements could transform free radicals into the stable radicals, thereby showing importance in the prevention of diseases associated with oxidative stress. Adding vitamins E, C, and β-carotene to the horses' diets in stressful conditions could decrease the production of free radicals that cause inflammation and tissue damage, the typical characteristics that have been associated with oxidative stress. This review spotlights the available evidence of the benefits of dietary supplements of vitamins E, C, and β-carotene towards the reduction of oxidative stress in horses.
Copyright © 2022. Published by Elsevier Inc.
Publication Date: 2022-01-10 PubMed ID: 35017039DOI: 10.1016/j.jevs.2022.103863Google Scholar: Lookup
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Summary
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This research article discusses the positive effects of supplementing horses’ diets with vitamins E, C, and β-carotene in order to combat oxidative stress, which can lead to inflammation and tissue damage.
Underlying Concepts
- The study is focused on oxidative stress in horses, a condition that is characterized by an overproduction of harmful free radicals or a weakening of the antioxidant system. This imbalance can adversely impact the health of horses by destabilizing their molecular structures.
- Elements known as free radicals are potentially damaging as they contain unpaired electrons, making them highly reactive and capable of causing harm to cells and tissues.
- The research emphasizes the importance of vitamins E, C, and β-carotene as dietary supplements for horses. These vitamins function as powerful antioxidants, which are substances that can neutralize harmful free radicals by transforming them into stable molecules.
- The use of these supplements is crucial in preventing diseases linked to oxidative stress.
- The paper suggests that in conditions of stress, supplementing a horse’s diet with vitamins E, C, and β-carotene can potentially lower the production of free radicals. This, in turn, reduces inflammation and tissue damage, which are the typical outcomes of oxidative stress.
- The article reviews a variety of existing studies and evidence demonstrating the benefits of using supplements of vitamins E, C, and β-carotene in reducing oxidative stress in horses.
- By reviewing and synthesizing this evidence, the authors create a comprehensive overview of the current understanding of the role of these vitamins in the management of oxidative stress in horses.
Role of Vitamins E, C, and β-carotene
Dietary Management of Oxidative Stress
Review of Available Evidence
Cite This Article
APA
Garcia EIC, Elghandour MMMY, Khusro A, Alcala-Canto Y, Tirado-González DN, Barbabosa-Pliego A, Salem AZM.
(2022).
Dietary Supplements of Vitamins E, C, and β-Carotene to Reduce Oxidative Stress in Horses: An Overview.
J Equine Vet Sci, 110, 103863.
https://doi.org/10.1016/j.jevs.2022.103863 Publication
Researcher Affiliations
- Facultad de Ciencias, Universidad Autónoma del Estado de México, Estado de México, México.
- Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Estado de México, México.
- Research Department of Plant Biology and Biotechnology, Loyola College, Chennai, Tamil Nadu, India.
- Departamento de Parasitologia, Facultad de Medicina Veterinaria y Zootecnia. Universidad Nacional Autonoma de Mexico, Mexico.
- CENID Agricultura Familiar/INIFAP, Jalisco, México.
- Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Estado de México, México.
- Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Estado de México, México. Electronic address: asalem70@yahoo.com.
MeSH Terms
- Animals
- Ascorbic Acid
- Dietary Supplements
- Horses
- Oxidative Stress
- Vitamin E / pharmacology
- Vitamins / pharmacology
- beta Carotene / pharmacology
Citations
This article has been cited 9 times.- Culhuac EB, Maggiolino A, Elghandour MMMY, De Palo P, Salem AZM. Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the Yucca Genus. Antioxidants (Basel) 2023 Feb 24;12(3).
- Li RQ, Lu TY, Wang J, Zhang WS, Du J, Jin YL, Kan JT, Lam TH, Cheng KK, Huang EY, Xu L. Construction and validation of a novel nutrient-based index for risk of aging using an interpretable machine learning framework: results from two population-based studies. Nutr J 2025 Dec 29;24(1):189.
- Shahidi F, Samarasinghe A. How to assess antioxidant activity? Advances, limitations, and applications of in vitro, in vivo, and ex vivo approaches. Food Prod Process Nutr 2025;7(1):50.
- James C, Lloyd EM, Arthur PG. The Level of Thiol-Oxidised Plasma Albumin Is Elevated Following a Race in Australian Thoroughbred Horses. Vet Med Sci 2025 Jul;11(4):e70487.
- Loos C, Castelein A, Vanzant E, Adam E, McLeod KR. Nutraceutical Supplement Mitigates Insulin Resistance in Horses with a History of Insulin Dysregulation During a Challenge with a High-Starch Diet. Animals (Basel) 2024 Nov 25;14(23).
- Munteanu C, Mârza SM, Papuc I. The immunomodulatory effects of vitamins in cancer. Front Immunol 2024;15:1464329.
- Del Prete C, Vastolo A, Pasolini MP, Cocchia N, Montano C, Cutrignelli MI. Effects of maternal dietary supplementation with antioxidants on clinical status of mares and their foal. BMC Vet Res 2024 Sep 11;20(1):404.
- Jin H, Liu J, Wang D. Antioxidant Potential of Exosomes in Animal Nutrition. Antioxidants (Basel) 2024 Aug 8;13(8).
- Zhang X, Geng A, Cao D, Dugarjaviin M. Identification of mulberry leaf flavonoids and evaluating their protective effects on H(2)O(2)-induced oxidative damage in equine skeletal muscle satellite cells. Front Mol Biosci 2024;11:1353387.
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