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Home / Equine Research Bank / J Anat / Does subchondral bone of the equine proximal phalanx adapt t...
Journal of anatomy2016; 229(1); 104-113; doi: 10.1111/joa.12478

Does subchondral bone of the equine proximal phalanx adapt to race training?

Abstract: Sagittal fractures of the first phalanx are a common, potentially catastrophic injury in racehorses. These fractures are often linked to an acute, one time, biomechanical event; however, recent evidence implies that chronic exposure to stress can lead to the accumulation of bony changes that affect the structural integrity of the bone and increase the likelihood of fracture. The aim of the study was to compare variations of two common metrics of bone adaptation - subchondral bone density and thickness across the proximal articular surface of the first phalanx in Thoroughbred horses that (1) raced but never experienced a first phalanx fracture (Raced Control); (2) raced and had experienced fracture of the contralateral first phalanx (Contralateral to Fracture); (3) had never raced or experienced a first phalanx fracture (Unraced Control). A total of 22 first phalangeal bones were sampled post-mortem and imaged using micro-computed tomography calibrated for mineral density measures. Measurements of volumetric subchondral bone mineral density and thickness were taken from images at five sites from medial to lateral, in three coronal planes (25, 50 and 75% dorsal-palmar). At each of the 15 sites, measurements were repeated and averaged across 10 adjacent micro-computed tomography slices of bone, spanning 0.75 mm. The magnitude and variance of these measurements were compared between sites and between cohorts with non-parametric statistical tests. Across the proximal osteochondral surface of the first phalanx, the pattern of subchondral bone volumetric bone mineral density and thickness varied with each coronal section studied. The subchondral bone thickness was greater for the central and dorsal coronal sections, compared with the palmar section. For the race-fit groups (Raced Control and Contralateral to Fracture), the highest volumetric bone mineral density was in the central sagittal groove. The volumetric bone mineral density was significantly greater in the sagittal groove in the central coronal section in the raced than the unraced group. The Contralateral to Fracture group demonstrated significantly greater variance of volumetric bone mineral density compared with the Raced Control and Unraced Control (P < 0.0001), with no difference in variance noted between the Raced Control and Unraced Control groups. There was a small (R rank = 0.3) but significant correlation between subchondral bone volumetric bone mineral density and thickness in the Contralateral to Fracture group (P = 0.005). The findings demonstrate that differences exist in subchondral bone volumetric bone mineral density and thickness across the proximal osteochondral surface of the equine first phalanx in horses with different training histories. The findings also demonstrate that the subchondral bone of the sagittal groove of the equine first phalanx adapts to race-training in the race-fit groups (Raced Control and Contralateral to Fracture) with an increase in volumetric bone mineral density relative to unraced controls. Within the race-trained groups, the Contralateral to Fracture bones had a greater variance of volumetric bone mineral density, suggesting that stress-induced bone adaptation had become more erratic, potentially contributing to the aetiology of sagittal fractures of the first phalanx in the Thoroughbred racehorse.
© 2016 Anatomical Society.
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Publication Date: 2016-04-14 PubMed ID: 27075139PubMed Central: PMC5341590DOI: 10.1111/joa.12478Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper explores the impact of race training on the subchondral bone, particularly the first phalanx, of Thoroughbred horses. It suggests that race training could cause stress-induced changes to the subchondral bone that may boost its density and thickness, possibly raising the risk of sagittal fractures in these horses.

Objective and Sample Collection

  • The study aimed to analyze the variations in metrics of bone adaptation – specifically, subchondral bone density and thickness – across the articulary surface of the first phalanx in racehorses.
  • Horses that had taken part in races without ever experiencing a first phalanx fracture, horses that raced and had suffered a fracture, and horses that neither raced nor experienced a fracture were compared in the study.
  • 22 first phalangeal bones were gathered post-mortem and imaged using micro-computed tomography.

Methodology

  • Using these images, measurements of volumetric subchondral bone mineral density and thickness were extracted at five sites across three coronal planes.
  • These measurements were repeated and averaged over 10 adjacent micro-computed tomography slices of bone, spanning 0.75mm.
  • The differences and similarities in these measurements were compared between the sites and the cohorts using non-parametric statistical tests.

Results and Interpretation

  • The patterns of subchondral bone volumetric bone mineral density and thickness varied across the osteochondral surface of the first phalanx, changing with each coronal section studied.
  • The central and dorsal coronal sections had thicker subchondral bone than the palmar section.
  • Among the race-fit groups, the highest volumetric bone mineral density was located in the central sagittal groove.
  • The volumetric bone mineral density was significantly higher in the central coronal section’s sagittal groove in the raced group than in the unraced group.
  • The Contralateral to Fracture group displayed significantly more variation in volumetric bone mineral density than both the Raced Control and Unraced Control groups.
  • A minor but significant correlation between subchondral bone volumetric bone mineral density and thickness was observed in the Contralateral to Fracture group.
  • It’s concluded that different training histories lead to differences in subchondral bone volumetric bone mineral density and thickness across the equine first phalanx.

Conclusion

  • The subchondral bone of the equine first phalanx is found to adapt to race training in race-fit groups (Raced Control and Contralateral to Fracture) with increases in volumetric bone mineral density compared to unraced controls.
  • Within the race-trained groups, Contralateral to Fracture bones demonstrated a greater variation in volumetric bone mineral density, implying irregular stress-induced bone adaptation, potentially contributing to sagittal fractures of the first phalanx in Thoroughbred racehorses.

Cite This Article

APA
Noble P, Singer ER, Jeffery NS. (2016). Does subchondral bone of the equine proximal phalanx adapt to race training? J Anat, 229(1), 104-113. https://doi.org/10.1111/joa.12478

Publication

Journal of anatomy
ISSN: 1469-7580
NlmUniqueID: 0137162
Country: England
Language: English
Volume: 229
Issue: 1
Pages: 104-113

Researcher Affiliations

Noble, Phillipa
  • School of Veterinary Science, University of Liverpool, Liverpool, UK.
Singer, Ellen R
  • Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, Neston, UK.
Jeffery, Nathan S
  • Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, Neston, UK.
  • Human Anatomy Resource Centre, University of Liverpool, Liverpool, UK.

MeSH Terms

  • Adaptation, Physiological
  • Animals
  • Horses / anatomy & histology
  • Horses / physiology
  • Physical Conditioning, Animal / physiology
  • Toe Phalanges / anatomy & histology
  • Toe Phalanges / physiology

Grant Funding

  • Wellcome Trust

References

This article includes 54 references
  1. Anthenill LA, Gardner IA, Pool RR, Garcia TC, Stover SM. Comparison of macrostructural and microstructural bone features in Thoroughbred racehorses with and without midbody fracture of the proximal sesamoid bone.. Am J Vet Res 2010 Jul;71(7):755-65.
    pubmed: 20594077doi: 10.2460/ajvr.71.7.755google scholar: lookup
  2. Barr ED, Pinchbeck GL, Clegg PD, Boyde A, Riggs CM. Post mortem evaluation of palmar osteochondral disease (traumatic osteochondrosis) of the metacarpo/metatarsophalangeal joint in Thoroughbred racehorses.. Equine Vet J 2009 Apr;41(4):366-71.
    pubmed: 19562898doi: 10.2746/042516409x368372google scholar: lookup
  3. Beccati F, Pepe M, Di Meo A, Davanzo S, Moriconi F. Radiographic evaluation of changes in the proximal phalanx of Thoroughbreds in race training.. Am J Vet Res 2011 Nov;72(11):1482-8.
    pubmed: 22023126doi: 10.2460/ajvr.72.11.1482google scholar: lookup
  4. Brama PA, Karssenberg D, Barneveld A, van Weeren PR. Contact areas and pressure distribution on the proximal articular surface of the proximal phalanx under sagittal plane loading.. Equine Vet J 2001 Jan;33(1):26-32.
    pubmed: 11191606doi: 10.2746/042516401776767377google scholar: lookup
  5. Brama PA, TeKoppele JM, Bank RA, Barneveld A, van Weeren PR. Biochemical development of subchondral bone from birth until age eleven months and the influence of physical activity.. Equine Vet J 2002 Mar;34(2):143-9.
    pubmed: 11905435doi: 10.2746/042516402776767150google scholar: lookup
  6. Brama PA, Firth EC, van Weeren PR, Tuukkanen J, Holopainen J, Helminen HJ, Hyttinen MM. Influence of intensity and changes of physical activity on bone mineral density of immature equine subchondral bone.. Equine Vet J 2009 Jul;41(6):564-71.
    pubmed: 19803052doi: 10.2746/042516409x429437google scholar: lookup
  7. Brunishloz H, Hagan R, Fuerst AE. Computer tomographic configuration of incomplete proximal fractures of the proximal phalanx in horses not used for racing. Proceedings of the Annual European College of Veterinary Surgeons Congress 2014, 22.
  8. Chateau H, Degueurce C, Denoix JM. Three-dimensional kinematics of the distal forelimb in horses trotting on a treadmill and effects of elevation of heel and toe.. Equine Vet J 2006 Mar;38(2):164-9.
    pubmed: 16536387doi: 10.2746/042516406776563260google scholar: lookup
  9. Clayton HM, Sha D, Stick J, Elvin N. 3D kinematics of the equine metacarpophalangeal joint at walk and trot.. Vet Comp Orthop Traumatol 2007;20(2):86-91.
    pubmed: 17546207doi: 10.1160/vcot-07-01-0011google scholar: lookup
  10. Denoix J. Functional anatomy of the equine interphalangeal joints. Proc Am Ass equine Practnrs 1999;17:4–177.
  11. Donnelly SM, Kramer A. Testing for multiple species in fossil samples: an evaluation and comparison of tests for equal relative variation.. Am J Phys Anthropol 1999 Apr;108(4):507-29.
    pubmed: 10229391doi: 10.1002/(sici)1096-8644(199904)108:4<507::aid-ajpa8>3.0.co;2-0google scholar: lookup
  12. Dyson S, Nagy A, Murray R. Clinical and diagnostic imaging findings in horses with subchondral bone trauma of the sagittal groove of the proximal phalanx.. Vet Radiol Ultrasound 2011 Nov-Dec;52(6):596-604.
    pubmed: 21831247doi: 10.1111/j.1740-8261.2011.01852.xgoogle scholar: lookup
  13. Easton KL, Kawcak CE. Evaluation of increased subchondral bone density in areas of contact in the metacarpophalangeal joint during joint loading in horses.. Am J Vet Res 2007 Aug;68(8):816-21.
    pubmed: 17669020doi: 10.2460/ajvr.68.8.816google scholar: lookup
  14. Eckstein F, Jacobs CR, Merz BR. Mechanobiological adaptation of subchondral bone as a function of joint incongruity and loading.. Med Eng Phys 1997 Dec;19(8):720-8.
    pubmed: 9450256doi: 10.1016/s1350-4533(97)00031-3google scholar: lookup
  15. Ellis DR, Simpson DJ, Greenwood RE, Crowhurst JS. Observations and management of fractures of the proximal phalanx in young Thoroughbreds.. Equine Vet J 1987 Jan;19(1):43-9.
    pubmed: 3691459doi: 10.1111/j.2042-3306.1987.tb02579.xgoogle scholar: lookup
  16. Ely ER, Avella CS, Price JS, Smith RK, Wood JL, Verheyen KL. Descriptive epidemiology of fracture, tendon and suspensory ligament injuries in National Hunt racehorses in training.. Equine Vet J 2009 Apr;41(4):372-8.
    pubmed: 19562899doi: 10.2746/042516409x371224google scholar: lookup
  17. Firth EC, Rogers CW. Musculoskeletal responses of 2-year-old Thoroughbred horses to early training. 7. Bone and articular cartilage response in the carpus.. N Z Vet J 2005 Apr;53(2):113-22.
    pubmed: 15846395doi: 10.1080/00480169.2005.36488google scholar: lookup
  18. Firth EC, Rogers CW. Musculoskeletal responses of 2-year-old Thoroughbred horses to early training. Conclusions.. N Z Vet J 2005 Dec;53(6):377-83.
    pubmed: 16317437doi: 10.1080/00480169.2005.36581google scholar: lookup
  19. Firth EC, Delahunt J, Wichtel JW, Birch HL, Goodship AE. Galloping exercise induces regional changes in bone density within the third and radial carpal bones of Thoroughbred horses.. Equine Vet J 1999 Mar;31(2):111-5.
    pubmed: 10213422doi: 10.1111/j.2042-3306.1999.tb03802.xgoogle scholar: lookup
  20. Hammer Ø, Harper DAT, Ryan PD. PAST: paleontological statistics software package for education and data analysis. Palaeontol Electron 2001;4:9 pp.
  21. Den Hartog SM, Back W, Brommer H, van Weeren PR. In vitro evaluation of metacarpophalangeal joint loading during simulated walk.. Equine Vet J 2009 Mar;41(3):214-7.
    pubmed: 19469223doi: 10.2746/042516409x395570google scholar: lookup
  22. Holcombe SJ, Schneider RK, Bramlage LR, Gabel AA, Bertone AL, Beard WL. Lag screw fixation of noncomminuted sagittal fractures of the proximal phalanx in racehorses: 59 cases (1973-1991).. J Am Vet Med Assoc 1995 Apr 15;206(8):1195-9.
    pubmed: 7768743
  23. Holopainen JT, Brama PA, Halmesmäki E, Harjula T, Tuukkanen J, van Weeren PR, Helminen HJ, Hyttinen MM. Changes in subchondral bone mineral density and collagen matrix organization in growing horses.. Bone 2008 Dec;43(6):1108-14.
    pubmed: 18757048doi: 10.1016/j.bone.2008.07.254google scholar: lookup
  24. De Laet CE, van Hout BA, Burger H, Hofman A, Pols HA. Bone density and risk of hip fracture in men and women: cross sectional analysis.. BMJ 1997 Jul 26;315(7102):221-5.
    pmc: PMC2127146pubmed: 9253270doi: 10.1136/bmj.315.7102.221google scholar: lookup
  25. Lanyon LE. Functional strain as a determinant for bone remodeling.. Calcif Tissue Int 1984;36 Suppl 1:S56-61.
    pubmed: 6430523doi: 10.1007/bf02406134google scholar: lookup
  26. Madry H, van Dijk CN, Mueller-Gerbl M. The basic science of the subchondral bone.. Knee Surg Sports Traumatol Arthrosc 2010 Apr;18(4):419-33.
    pubmed: 20119671doi: 10.1007/s00167-010-1054-zgoogle scholar: lookup
  27. Markel MD, Richardson DW. Noncomminuted fractures of the proximal phalanx in 69 horses.. J Am Vet Med Assoc 1985 Mar 15;186(6):573-9.
    pubmed: 3988589
  28. Martin RB, Gibson VA, Stover SM, Gibeling JC, Griffin LV. Residual strength of equine bone is not reduced by intense fatigue loading: implications for stress fracture.. J Biomech 1997 Feb;30(2):109-14.
    pubmed: 9001930doi: 10.1016/s0021-9290(96)00113-3google scholar: lookup
  29. Melton LJ 3rd, Khosla S, Atkinson EJ, O'Fallon WM, Riggs BL. Relationship of bone turnover to bone density and fractures.. J Bone Miner Res 1997 Jul;12(7):1083-91.
    pubmed: 9200008doi: 10.1359/jbmr.1997.12.7.1083google scholar: lookup
  30. Murray RC, Birch HL, Lakhani K, Goodship AE. Biochemical composition of equine carpal articular cartilage is influenced by short-term exercise in a site-specific manner.. Osteoarthritis Cartilage 2001 Oct;9(7):625-32.
    pubmed: 11597175doi: 10.1053/joca.2001.0462google scholar: lookup
  31. Murray RC, Vedi S, Birch HL, Lakhani KH, Goodship AE. Subchondral bone thickness, hardness and remodelling are influenced by short-term exercise in a site-specific manner.. J Orthop Res 2001 Nov;19(6):1035-42.
    pubmed: 11781002doi: 10.1016/s0736-0266(01)00027-4google scholar: lookup
  32. van Oers RF, van Rietbergen B, Ito K, Huiskes R, Hilbers PA. Simulations of trabecular remodeling and fatigue: is remodeling helpful or harmful?. Bone 2011 May 1;48(5):1210-5.
    pubmed: 21256994doi: 10.1016/j.bone.2011.01.011google scholar: lookup
  33. O'Hare LM, Cox PG, Jeffery N, Singer ER. Finite element analysis of stress in the equine proximal phalanx.. Equine Vet J 2013 May;45(3):273-7.
    pubmed: 22943561doi: 10.1111/j.2042-3306.2012.00635.xgoogle scholar: lookup
  34. Parkin TD, Clegg PD, French NP, Proudman CJ, Riggs CM, Singer ER, Webbon PM, Morgan KL. Risk of fatal distal limb fractures among Thoroughbreds involved in the five types of racing in the United Kingdom.. Vet Rec 2004 Apr 17;154(16):493-7.
    pubmed: 15130054doi: 10.1136/vr.154.16.493google scholar: lookup
  35. Ramzan PH, Palmer L. Musculoskeletal injuries in Thoroughbred racehorses: a study of three large training yards in Newmarket, UK (2005-2007).. Vet J 2011 Mar;187(3):325-9.
    pubmed: 20089426doi: 10.1016/j.tvjl.2009.12.019google scholar: lookup
  36. Ramzan PH, Powell SE. Clinical and imaging features of suspected prodromal fracture of the proximal phalanx in three Thoroughbred racehorses.. Equine Vet J 2010 Mar;42(2):164-9.
    pubmed: 20156254doi: 10.2746/042516409x478695google scholar: lookup
  37. Riggs CM. Aetiopathogenesis of parasagittal fractures of the distal condyles of the third metacarpal and third metatarsal bones--review of the literature.. Equine Vet J 1999 Mar;31(2):116-20.
    pubmed: 10213423doi: 10.1111/j.2042-3306.1999.tb03803.xgoogle scholar: lookup
  38. Riggs CM, Boyde A. Effect of exercise on bone density in distal regions of the equine third metacarpal bone in 2-year-old thoroughbreds.. Equine Vet J Suppl 1999 Jul;(30):555-60.
    pubmed: 10659317doi: 10.1111/j.2042-3306.1999.tb05283.xgoogle scholar: lookup
  39. Riggs CM, Whitehouse GH, Boyde A. Structural variation of the distal condyles of the third metacarpal and third metatarsal bones in the horse.. Equine Vet J 1999 Mar;31(2):130-9.
    pubmed: 10213425doi: 10.1111/j.2042-3306.1999.tb03806.xgoogle scholar: lookup
  40. Rubin CT. Skeletal strain and the functional significance of bone architecture.. Calcif Tissue Int 1984;36 Suppl 1:S11-8.
    pubmed: 6430509doi: 10.1007/bf02406128google scholar: lookup
  41. Rubio-Martínez LM, Cruz AM, Gordon K, Hurtig MB. Mechanical properties of subchondral bone in the distal aspect of third metacarpal bones from Thoroughbred racehorses.. Am J Vet Res 2008 Nov;69(11):1423-33.
    pubmed: 18980424doi: 10.2460/ajvr.69.11.1423google scholar: lookup
  42. Rubio-Martínez LM, Cruz AM, Gordon K, Hurtig MB. Structural characterization of subchondral bone in the distal aspect of third metacarpal bones from Thoroughbred racehorses via micro--computed tomography.. Am J Vet Res 2008 Nov;69(11):1413-22.
    pubmed: 18980423doi: 10.2460/ajvr.69.11.1413google scholar: lookup
  43. Rubio-Martínez LM, Cruz AM, Inglis D, Hurtig MB. Analysis of the subchondral microarchitecture of the distopalmar aspect of the third metacarpal bone in racing Thoroughbreds.. Am J Vet Res 2010 Oct;71(10):1148-53.
    pubmed: 20919900doi: 10.2460/ajvr.71.10.1148google scholar: lookup
  44. Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis.. Nat Methods 2012 Jul;9(7):671-5.
    pmc: PMC5554542pubmed: 22930834doi: 10.1038/nmeth.2089google scholar: lookup
  45. Singer E, Garcia T, Stover S. How do metacarpophalangeal joint extension, collateromotion and axial rotation influence dorsal surface strains of the equine proximal phalanx at different loads in vitro?. J Biomech 2013 Feb 22;46(4):738-44.
    pubmed: 23246042doi: 10.1016/j.jbiomech.2012.11.028google scholar: lookup
  46. Smith MR, Wright IM. Are there radiologically identifiable prodromal changes in Thoroughbred racehorses with parasagittal fractures of the proximal phalanx?. Equine Vet J 2014 Jan;46(1):88-91.
    pubmed: 23663185doi: 10.1111/evj.12093google scholar: lookup
  47. Stover SM. The epidemiology of Thoroughbred racehorse injuries. Clin Tech Equine Practice 2003;2:312–322.
  48. Stover SM, Murray A. The California Postmortem Program: leading the way.. Vet Clin North Am Equine Pract 2008 Apr;24(1):21-36.
    pubmed: 18314034doi: 10.1016/j.cveq.2007.11.009google scholar: lookup
  49. Tidswell HK, Innes JF, Avery NC, Clegg PD, Barr AR, Vaughan-Thomas A, Wakley G, Tarlton JF. High-intensity exercise induces structural, compositional and metabolic changes in cuboidal bones--findings from an equine athlete model.. Bone 2008 Oct;43(4):724-33.
    pubmed: 18619567doi: 10.1016/j.bone.2008.06.003google scholar: lookup
  50. Tranquille CA, Parkin TD, Murray RC. Magnetic resonance imaging-detected adaptation and pathology in the distal condyles of the third metacarpus, associated with lateral condylar fracture in Thoroughbred racehorses.. Equine Vet J 2012 Nov;44(6):699-706.
    pubmed: 22256885doi: 10.1111/j.2042-3306.2011.00535.xgoogle scholar: lookup
  51. Vallance SA, Spriet M, Stover SM. Catastrophic scapular fractures in Californian racehorses: pathology, morphometry and bone density.. Equine Vet J 2011 Nov;43(6):676-85.
    pubmed: 21883414doi: 10.1111/j.2042-3306.2010.00346.xgoogle scholar: lookup
  52. Vickerton P, Jarvis JC, Gallagher JA, Akhtar R, Sutherland H, Jeffery N. Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle.. Proc Biol Sci 2014 Aug 7;281(1788):20140786.
    pmc: PMC4083794pubmed: 24966314doi: 10.1098/rspb.2014.0786google scholar: lookup
  53. Whitton RC, Trope GD, Ghasem-Zadeh A, Anderson GA, Parkin TD, Mackie EJ, Seeman E. Third metacarpal condylar fatigue fractures in equine athletes occur within previously modelled subchondral bone.. Bone 2010 Oct;47(4):826-31.
    pubmed: 20659599doi: 10.1016/j.bone.2010.07.019google scholar: lookup
  54. Young DR, Richardson DW, Markel MD, Nunamaker DM. Mechanical and morphometric analysis of the third carpal bone of Thoroughbreds.. Am J Vet Res 1991 Mar;52(3):402-9.
    pubmed: 2035913

Citations

This article has been cited 8 times.
  1. Noordwijk KJ, Chen L, Ruspi BD, Schurer S, Papa B, Fasanello DC, McDonough SP, Palmer SE, Porter IR, Basran PS, Donnelly E, Reesink HL. Metacarpophalangeal Joint Pathology and Bone Mineral Density Increase with Exercise but Not with Incidence of Proximal Sesamoid Bone Fracture in Thoroughbred Racehorses. Animals (Basel) 2023 Feb 24;13(5).
    doi: 10.3390/ani13050827pubmed: 36899684google scholar: lookup
  2. Mizobe F, Nomura M, Ueno T, Yamada K. Bone marrow oedema-type signal in the proximal phalanx of Thoroughbred racehorses. J Vet Med Sci 2019 Apr 16;81(4):593-597.
    doi: 10.1292/jvms.18-0530pubmed: 30828037google scholar: lookup
  3. Lipreri G, Bladon BM, Giorio ME, Singer ER. Conservative versus surgical treatment of 21 sports horses with osseous trauma in the proximal phalangeal sagittal groove diagnosed by low-field MRI. Vet Surg 2018 Oct;47(7):908-915.
    doi: 10.1111/vsu.12936pubmed: 30216476google scholar: lookup
  4. Zhang Z, Li J, Mai Z, Yang Y, Fu H, Cao X, Li T, Guo Q, Ma Y. Clinical study on the effect of low-intensity pulsed ultrasound on healing of proximal sesamoid bone fractures in Yili horses. Sci Rep 2025 Aug 28;15(1):31697.
    doi: 10.1038/s41598-025-17424-0pubmed: 40877380google scholar: lookup
  5. Lin ST, Foote AK, Bolas NM, Sargan DR, Murray RC. Histological and Histopathological Features of the Third Metacarpal/Tarsal Parasagittal Groove and Proximal Phalanx Sagittal Groove in Thoroughbred Horses with Racing History. Animals (Basel) 2024 Jun 30;14(13).
    doi: 10.3390/ani14131942pubmed: 38998057google scholar: lookup
  6. Schiavo S, Beccati F, Pokora R, Lin ST, Milmine RC, Bak L, Peter VG, Murray RC. Lesion Distribution in the Metacarpophalangeal and Metatarsophalangeal Region of 341 Horses Using Standing Magnetic Resonance Imaging. Animals (Basel) 2024 Jun 25;14(13).
    doi: 10.3390/ani14131866pubmed: 38997978google scholar: lookup
  7. Steiner J, Richter H, Kaufmann R, Ohlerth S. Characterization of Normal Bone in the Equine Distal Limb with Effective Atomic Number and Electron Density Determined with Single-Source Dual Energy and Detector-Based Spectral Computed Tomography. Animals (Basel) 2024 Mar 30;14(7).
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  8. Faulkner JE, Joostens Z, Broeckx BJG, Hauspie S, Mariën T, Vanderperren K. Follow-Up Magnetic Resonance Imaging of Sagittal Groove Disease of the Equine Proximal Phalanx Using a Classification System in 29 Non-Racing Sports Horses. Animals (Basel) 2023 Dec 21;14(1).
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