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Home / Equine Research Bank / Artif Organs / Donkey pericardium compares favorably with commercial xenope...
Artificial organs2019; 43(10); 976-987; doi: 10.1111/aor.13503

Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcatheter heart valves.

Abstract: Transcatheter aortic valve implantation (TAVI) has gained considerable acceptance in the past decade due to its lower risks than conventional open-heart surgery. However, the deformation and delamination of the leaflets during the crimping procedure have raised questions about the durability and long-term serviceability of the pericardium tissue from which the leaflets are made. The collagen architecture, wall thickness and mechanical properties of donkey pericardium were investigated to assess its suitability as an alternative material for the manufacture of heart valves. Coupons sampled from different locations of donkey pericardium were investigated. Bovine, equine, and porcine pericardium specimens served as controls. The donkey pericardium had a similar surface morphology to that of the control pericardia except for the wavy topology on both the fibrous and serous sides. The average thickness of donkey pericardium (ca. 120 µm) was significantly lower than that from bovine (375 µm) and equine (410 µm), but slightly higher than that from porcine (99 µm) specimens. The interlaced wavy collagen bundles in the pericardium were composed of collagen fibers about 100 nm in diameter. This unique structure ensures that the donkey pericardium has a comparable ultimate tensile strength (UTS) and a much higher failure strain than the commercial pericardia used for the manufacture of heart valves. The donkey pericardium has an organized wavy collagen bundle architecture similar to that of bovine pericardium and has a satisfactory UTS and high failure strain. The thin and strong donkey pericardium might be a good candidate valve leaflet material for TAVI.
© 2019 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
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Publication Date: 2019-07-03 PubMed ID: 31140630DOI: 10.1111/aor.13503Google Scholar: Lookup
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  • Comparative Study
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the use of donkey pericardium as a reliable alternative to commercial xenopericardia in the manufacture of transcatheter heart valves due to its comparable tensile strength and higher failure strain.

Background of the Research

  • Transcatheter aortic valve implantation (TAVI) is a surgical procedure that has gained popularity over the years due to lower risks compared to conventional open-heart surgery.
  • The durability and long-term performance of the pericardium tissue used in TAVIs, however, have been questioned because of its susceptibility to deformation and delamination during crimping.
  • This led to the investigation of donkey pericardium as an alternative material, examining its collagen structure, wall thickness, and mechanical properties.

Research Methodology

  • Researchers sampled coupons from different locations of the donkey pericardium and analysed them alongside control samples from bovine, equine, and porcine pericardia.
  • The team looked into the surface morphology, average thickness, and collagen fiber architecture of the pericardium of each species.

Research Findings

  • The donkey pericardium’s surface was nearly identical to the control pericardia, except it had a distinctive wavy topology on both the fibrous and serous sides.
  • The thickness of donkey pericardium was significantly lower than that of bovine and equine but slightly higher than the porcine samples.
  • The collagen fibers within the donkey pericardium were particularly robust, about 100 nm in diameter, and interlaced in a wavy pattern which contributed to the donkey pericardium’s excellent stress-bearing ability.
  • When it came to ultimate tensile strength (UTS), the donkey pericardium performed comparably well, yet demonstrated a much higher failure strain than the commercial pericardia used for valve production.
  • The characteristics of the donkey pericardium indicate a potential to outperform commercial pericardia in the manufacture of heart valves.

Conclusion

  • The unique collagen structure, thickness, and mechanical properties of donkey pericardium make it a formidable candidate for use in transcatheter heart valve production.

Cite This Article

APA
Mao J, Rassoli A, Tong Y, Rouse EN, Le-Bel G, How D, Germain L, Fatouraee N, Zhang Z, Reed RR, Guidoin R. (2019). Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcatheter heart valves. Artif Organs, 43(10), 976-987. https://doi.org/10.1111/aor.13503

Publication

Artificial organs
ISSN: 1525-1594
NlmUniqueID: 7802778
Country: United States
Language: English
Volume: 43
Issue: 10
Pages: 976-987

Researcher Affiliations

Mao, Jifu
  • Department of Surgery, Faculty of Medicine, Université Laval, Québec, QC, Canada.
  • Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec, Québec, QC, Canada.
Rassoli, Aisa
  • Department of Surgery, Faculty of Medicine, Université Laval, Québec, QC, Canada.
  • Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec, Québec, QC, Canada.
  • Biological Fluid Mechanics Research Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
Tong, Yiwei
  • Department of Surgery, Faculty of Medicine, Université Laval, Québec, QC, Canada.
  • Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec, Québec, QC, Canada.
Rouse, Elizabeth Nicole
  • Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, Knoxville, Tennessee.
Le-Bel, Gaёtan
  • Department of Surgery, Faculty of Medicine, Université Laval, Québec, QC, Canada.
  • Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec, Québec, QC, Canada.
How, Daniel
  • Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Germain, Lucie
  • Department of Surgery, Faculty of Medicine, Université Laval, Québec, QC, Canada.
  • Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec, Québec, QC, Canada.
Fatouraee, Nasser
  • Biological Fluid Mechanics Research Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
Zhang, Ze
  • Department of Surgery, Faculty of Medicine, Université Laval, Québec, QC, Canada.
  • Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec, Québec, QC, Canada.
Reed, Robert R
  • Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, Knoxville, Tennessee.
Guidoin, Robert
  • Department of Surgery, Faculty of Medicine, Université Laval, Québec, QC, Canada.
  • Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec, Québec, QC, Canada.

MeSH Terms

  • Animals
  • Aortic Valve / surgery
  • Biocompatible Materials / chemistry
  • Biomechanical Phenomena
  • Bioprosthesis
  • Cattle
  • Collagen / analysis
  • Elasticity
  • Equidae
  • Heart Valve Prosthesis
  • Heart Valves / surgery
  • Horses
  • Materials Testing
  • Pericardium / chemistry
  • Pericardium / ultrastructure
  • Swine
  • Tensile Strength
  • Transcatheter Aortic Valve Replacement

Grant Funding

  • MOP 106555 / CIHR
  • Fonds de Recherche en Chirurgie Vasculaire of the CHU de Quu00e9bec
  • Bourses de la Fondation du CHU de Quebec aux Etudiants
  • 262258-2011 / Natural Sciences and Engineering Research Council of Canada
  • Health Research

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Citations

This article has been cited 1 times.
  1. Schlachtenberger G, Doerr F, Brezina A, Menghesha H, Heldwein MB, Bennink G, Menger MD, Moussavian M, Hekmat K, Wahlers T. Perigraft reaction and incorporation of porcine and bovine pericardial patches.. Interact Cardiovasc Thorac Surg 2021 Apr 19;32(4):638-647.
    doi: 10.1093/icvts/ivaa308pubmed: 33313856google scholar: lookup
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