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Trends in parasitology2004; 20(10); 477-481; doi: 10.1016/j.pt.2004.08.001

Drug resistance in nematodes of veterinary importance: a status report.

Abstract: Reports of drug resistance have been made in every livestock host and to every anthelmintic class. In some regions of world, the extremely high prevalence of multi-drug resistance (MDR) in nematodes of sheep and goats threatens the viability of small-ruminant industries. Resistance in nematodes of horses and cattle has not yet reached the levels seen in small ruminants, but evidence suggests that the problems of resistance, including MDR worms, are also increasing in these hosts. There is an urgent need to develop both novel non-chemical approaches for parasite control and molecular assays capable of detecting resistant worms.
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Publication Date: 2004-09-15 PubMed ID: 15363441DOI: 10.1016/j.pt.2004.08.001Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article centers on the problem of drug resistance in nematodes that affect livestock, specifically in Sheep, Goats, Horses, and Cattle. It discusses the prevalence of multi-drug resistance in regions worldwide that pose a threat to small-ruminant industries and the developing resistance in horse and cattle nematodes. The article calls for an urgent need to develop non-chemical approaches for parasite control and molecular assays that can detect drug-resistant worms.

Objective of the Research

  • The research aims to provide a status report on the resistance of nematodes to drugs utilized in veterinary settings. Nematodes, affecting every livestock host, have been reported to resist every class of anthelmintics – drugs that serve to treat infections caused by parasitic worms – which can have significant impacts on livestock management and production.

Drug Resistance in Various Species

  • The study underlines the severe problem of multi-drug resistance (MDR) in nematodes that affect sheep and goats, particularly in certain global regions. This level of resistance threatens the survival and the overall economic viability of small-ruminant industries, i.e., industries that primarily raise and manage sheep and goats.
  • Although drug resistance in nematodes affecting horses and cattle hasn’t reached the levels observed in sheep and goats, the article suggests that resistance is increasing in these livestock too – implying a potentially larger and more severe scope of the problem.

Need for Novel Approaches and Molecular Assays

  • The researchers stress upon the urgency to develop non-chemical means to control these parasites. This approach will aim to circumvent the current resistance demonstrated by the nematodes towards the generally employed drugs.
  • Another crucial aspect highlighted by the researchers is that of creating molecular assays or laboratory tests which can detect worms that are resistant to drugs. This would allow for more efficient management, treatment, and control of parasitic infections in livestock.

Cite This Article

APA
Kaplan RM. (2004). Drug resistance in nematodes of veterinary importance: a status report. Trends Parasitol, 20(10), 477-481. https://doi.org/10.1016/j.pt.2004.08.001

Publication

Trends in parasitology
ISSN: 1471-4922
NlmUniqueID: 100966034
Country: England
Language: English
Volume: 20
Issue: 10
Pages: 477-481

Researcher Affiliations

Kaplan, Ray M
  • Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA. rkaplan@vet.uga.edu

MeSH Terms

  • Animals
  • Animals, Domestic / parasitology
  • Antinematodal Agents / pharmacology
  • Antinematodal Agents / therapeutic use
  • Drug Resistance
  • Drug Resistance, Multiple
  • Humans
  • Nematoda / drug effects
  • Nematoda / genetics
  • Nematode Infections / drug therapy
  • Nematode Infections / veterinary
  • Parasitic Sensitivity Tests / veterinary

Citations

This article has been cited 345 times.
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