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Home / Equine Research Bank / Acta Vet Scand / Effect of 19-norandrostenololylaurate on serum testosterone ...
Acta veterinaria Scandinavica1997; 38(1); 59-67; doi: 10.1186/BF03548508

Effect of 19-norandrostenololylaurate on serum testosterone concentration, libido, and closure of distal radial growth plate in colts.

Abstract: The long-term effect of anabolic steroid was investigated in 3 experiments. In experiment I, 500 mg of 19-norandrostenololylaurate was given to 5 colts and a dose of 100 mg to another 5 colts every 3rd week. Six colts served as untreated controls. The animals were 12-16 months old at the start, and 24 months at the end of treatment. In experiment II, a dose of 1 mg/kg was given every 3rd week to 4 colts and 0.3 mg/kg every week to another 4 colts. Six colts served as controls. The colts were treated from 7 months to 12 months of age. In experiment III, 1 mg/kg of steroid was given every 3rd week to 3 foals between 3 and 8 months of age. Three foals were used as controls. Libido and hCG-induced serum testosterone concentrations were studied after the cessation of treatments, up to 3 or 4 years of age. Closure of the right distal radial growth plate was determined between 21 and 36 months of age. Treated colts had lower testosterone levels 4.5 months after cessation of treatment in experiment I (p < 0.001) and experiment II (p < 0.05) when compared with the corresponding control groups. Two years after treatments in experiment I, hCG-induced testosterone levels were higher in treated colts than in untreated controls, but the difference was not statistically significant. The treatments had no effect on libido. The anabolic steroid treatment did not cause premature closure of epiphyseal growth plates in any of the experiments, but closure appeared to be delayed. It was concluded that anabolic steroids have long term effects on reproduction. Their influence on serum testosterone can last for years after cessation of treatment, and they can delay the closure of growth plates which can cause increased susceptibility to cartilage injury during exercise.
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Publication Date: 1997-01-01 PubMed ID: 9129347PubMed Central: PMC8057044DOI: 10.1186/BF03548508Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the long-term effects of an anabolic steroid on colts’ testosterone levels, libido and bone growth. The researchers found that the drug lowered testosterone, but did not affect libido and seemed to delay closure of the growth plates in the bones.

Study Design

  • The research was conducted in three different experiments, each varying slightly in design
  • Experiment I involved giving doses of the anabolic steroid 19-norandrostenololylaurate to colts, with some serving as untreated controls. The colts were aged between 12 to 16 months old at the start of treatment, and 24 months old at its end. The study compared testosterone levels, libido, and bone plate closure between the treated and untreated colts
  • Experiment II followed a similar process but with different dosages, given to colts aged 7 to 12 months
  • Experiment III gave the steroid to foals between 3 and 8 months old. Testosterone levels, libido and bone plate closure periods were observed in treated foals and compared with controls

Results of the Study

  • Following steroid treatment, colts in both experiment I and II showed lower testosterone levels when compared to controls
  • Interestingly, experiment I showed higher hCG-induced testosterone levels in treated colts two years after treatment, although this was not statistically significant
  • The treatments had no effect on the libido of the colts
  • Anabolic steroid treatment did not hasten the closure of distal radial growth plates in the colts, rather it seemed to delay the process

Conclusion

  • Anabolic steroids have observable long-term effects on colts, particularly influencing their testosterone levels
  • The effects can persist years after completion of treatment
  • The steroids delay the closure of growth plates, which could increase the risk of cartilage injury during exercise in the future

Cite This Article

APA
Koskinen E, Katila T. (1997). Effect of 19-norandrostenololylaurate on serum testosterone concentration, libido, and closure of distal radial growth plate in colts. Acta Vet Scand, 38(1), 59-67. https://doi.org/10.1186/BF03548508

Publication

Acta veterinaria Scandinavica
ISSN: 0044-605X
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 38
Issue: 1
Pages: 59-67

Researcher Affiliations

Koskinen, E
  • Agricultural Research Centre, Ypäjä, Finland. erkki.koskinen@mtt.fi
Katila, T

    MeSH Terms

    • Analysis of Variance
    • Animals
    • Growth Plate / drug effects
    • Growth Plate / growth & development
    • Horses
    • Laurates / pharmacology
    • Libido / drug effects
    • Male
    • Nandrolone / analogs & derivatives
    • Nandrolone / pharmacology
    • Radius
    • Reference Values
    • Testosterone / pharmacology

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    This article includes 16 references
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    Citations

    This article has been cited 4 times.
    1. Van Cauter R, Serteyn D, Lejeune JP, Rousset A, Caudron I. Evaluation of the appearance of osteochondrosis lesions by two radiographic examinations in sport horses aged from 12 to 36 months. PLoS One 2023;18(5):e0286213.
      doi: 10.1371/journal.pone.0286213pubmed: 37220101google scholar: lookup
    2. Rogers CW, Gee EK, Dittmer KE. Growth and Bone Development in the Horse: When Is a Horse Skeletally Mature?. Animals (Basel) 2021 Nov 29;11(12).
      doi: 10.3390/ani11123402pubmed: 34944179google scholar: lookup
    3. Hoffman JR, Ratamess NA. Medical issues associated with anabolic steroid use: are they exaggerated?. J Sports Sci Med 2006;5(2):182-93.
      pubmed: 24259990
    4. Strand E, Braathen LC, Hellsten MC, Huse-Olsen L, Bjornsdottir S. Radiographic closure time of appendicular growth plates in the Icelandic horse. Acta Vet Scand 2007 Jul 17;49(1):19.
      doi: 10.1186/1751-0147-49-19pubmed: 17640333google scholar: lookup
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