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Home / Equine Research Bank / J Vet Intern Med / Effect of Dexamethasone and Fluticasone on Airway Hyperrespo...
Journal of veterinary internal medicine2017; 31(4); 1193-1201; doi: 10.1111/jvim.14740

Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease.

Abstract: Airway hyperresponsiveness (AWHR), expressed as hypersensitivity (PC R ) or hyperreactivity (slope of the histamine dose-response curve), is a feature of inflammatory airway disease (IAD) or mild equine asthma in horses. Glucocorticoids are used empirically to treat IAD. Objective: To determine whether dexamethasone (DEX) (0.05 mg/kg IM q24h) and inhaled fluticasone (FLUT) (3,000 μg q12h) administered by inhalation are effective in decreasing AWHR, lung inflammation, and clinical signs in horses with IAD. Methods: A randomized crossover study design was used. Eight horses with IAD were assigned to a treatment group with either DEX or FLUT. Measured outcomes included lung mechanics during bronchoprovocative challenges, bronchoalveolar lavage fluid (BALF) cytology, and scoring of clinical signs during exercise. Results: Dexamethasone and FLUT abolished the increase in R by 75% at any histamine bronchoprovocative dose in all horses after the first week of treatment. However, after 2 weeks of FLUT treatment, 1 horse redeveloped hypersensitivity. There was a significant decrease in the number of lymphocytes after treatment with both DEX and FLUT (P = .039 for both) but no significant differences in other BALF cell types or total cell counts (P > .05). There was no difference in the scoring of the clinical signs during each treatment and washout period (P > .05). Conclusions: Both DEX and FLUT treatments significantly inhibit airway hypersensitivity and hyperreactivity in horses with IAD. There are no significant effects on the clinical signs or the number of inflammatory cells (except lymphocytes) in BALF. The treatments have no residual effect 3 weeks after discontinuation.
Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2017-05-31 PubMed ID: 28568169PubMed Central: PMC5508307DOI: 10.1111/jvim.14740Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates how dexamethasone and fluticasone treatments affect horses with Inflammatory Airway Disease, particularly looking at their impact on airway hypersensitivity and inflammation in the lungs.

Objective and Methodology

  • The study sought to determine the effectiveness of dexamethasone, an injectable steroid, and fluticasone, an inhaled steroid, in reducing airway hyper-responsiveness (AWHR), lung inflammation, and clinical symptoms in horses diagnosed with Inflammatory Airway Disease (IAD).
  • The researchers adopted a randomized crossover study design, involving eight horses suffering from IAD.
  • Each horse received either dexamethasone or fluticasone. During the course of the treatment, the researchers monitored changes in lung mechanics, brochoalveolar lavage fluid (BALF) cytology – the examination of cells in the fluid collected from the airways and lungs, and clinical signs during exercise.

Findings

  • Both dexamethasone and fluticasone treatments effectively halted the increase in airway hypersensitivity by 75% at any dosage in all horses after one week of treatment.
  • However, one horse treated with fluticasone exhibited a recurrence of hypersensitivity post two weeks of treatment.
  • A significant reduction in the number of lymphocytes, a type of white blood cell, was observable after treatment with both dexamethasone and fluticasone. No significant variation was seen in other BALF cell types or total cell counts.
  • The study also found no notable difference in the clinical signs during each treatment and washout phase – a period of discontinuation to eliminate the drug from the body before another treatment commences.

Conclusions

  • Dexamethasone and fluticasone treatments effectively inhibit airway hypersensitivity and hyperreactivity in horses with IAD.
  • However, these treatments do not significantly affect clinical signs or the number of inflammatory cells, except lymphocytes, in the bronchoalveolar lavage fluid.
  • The therapeutic effects of both treatments tend not to linger three weeks following their discontinuation.

Cite This Article

APA
Léguillette R, Tohver T, Bond SL, Nicol JA, McDonald KJ. (2017). Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease. J Vet Intern Med, 31(4), 1193-1201. https://doi.org/10.1111/jvim.14740

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 31
Issue: 4
Pages: 1193-1201

Researcher Affiliations

Léguillette, R
  • Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Tohver, T
  • Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Bond, S L
  • Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Nicol, J A
  • Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
McDonald, K J
  • Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.

MeSH Terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Asthma / drug therapy
  • Asthma / veterinary
  • Bronchial Provocation Tests / veterinary
  • Bronchoalveolar Lavage Fluid / cytology
  • Cross-Over Studies
  • Dexamethasone / therapeutic use
  • Female
  • Fluticasone / therapeutic use
  • Horse Diseases / drug therapy
  • Horses
  • Male
  • Respiratory Function Tests / veterinary
  • Respiratory Hypersensitivity / drug therapy
  • Respiratory Hypersensitivity / veterinary

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Citations

This article has been cited 17 times.
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