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Home / Equine Research Bank / Can Vet J / Effects of ketanserin on hypergranulation tissue formation, ...
The Canadian veterinary journal = La revue veterinaire canadienne2004; 45(2); 144-149;

Effects of ketanserin on hypergranulation tissue formation, infection, and healing of equine lower limb wounds.

Abstract: The objective of this multicentre, randomized, controlled field study was to determine the efficacy of ketanserin gel in preventing exuberant granulation tissue formation (hypergranulation) and infection in equine lower limb wounds. Horses and ponies (n = 481) with naturally occurring wounds were randomized to either topical treatment with ketanserin gel (n = 242) or a positive control (Belgium, Germany: ethacridin lactate solution, n = 120; France, United Kingdom: malic, benzoic, and salicylic acid [MBS] cream, n = 119). Treatment continued until the wound healed (success), formed hypergranulation tissue (failure), or became infected (failure). Treatment was terminated after 6 months in all remaining animals. Ketanserin was successful in 88% of cases. Wounds treated with ketanserin were 2 and 5 times more likely to heal successfully than were those treated with MBS or ethacridin lactate, respectively. Ketanserin gel is thus more effective than these standard treatments in preventing hypergranulation tissue and infection of equine lower limb wounds. Résumé — Les effets d’un gel de kétanserin sur la guérison de plaies situées à l’aspect distal du membre équin. L’objectif de cette étude de terrain multicentrique, était de déterminer l’efficacité d’un gel de kétanserin dans la prévention de l’hypergranulation et l’infection de plaies appendiculaires équines. Des chevaux et des poneys (n = 481) ayant des plaies traumatiques furent placés de façon aléatoire dans deux groupes. Les animaux du premier groupe reçurent un traitement topique de gel de kétanserin (n = 242) alors que ceux du deuxième groupe reçurent un contrôle positif (Belgique, Allemagne : solution lactate d’éthacridine, n = 120; France, Royaume Uni : onguent d’acides malique, benzoïque et salicylique [MBS], n = 119). Le traitement fut poursuivi jusqu’à guérison (succès), hypergranulation (échec), ou infection (échec) de la plaie. Le gel de kétanserin fut un succès dans 88 % des cas. Les plaies soignées avec ce traitement topique furent 2 et 5 fois plus aptes à guérir de façon convenable que celles recevant le MBS ou le lactate d’éthacridine. Il est donc apparent que le gel de kétanserin est un traitement efficace pour la prévention d’hypergranulation et d’infection de plaies à l’aspect distal du membre équin. (Traduit par Docteure Christine Théorêt)
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Publication Date: 2004-03-18 PubMed ID: 15025151PubMed Central: PMC548604
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  • Clinical Trial
  • Journal Article
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper presents an equine study that analyzes the effectiveness of ketanserin gel in the prevention of excessive granulation tissue formation, commonly known as hypergranulation, and infection in lower limb wounds in horses. The study determined that ketanserin gel is more effective than the standard treatments.

Research Method

  • The researchers conducted a randomized-controlled study across multiple locations to gauge the efficiency of ketanserin gel in preventing hypergranulation and infection in equine lower limb wounds.
  • A total of 481 horses and ponies with naturally occurring wounds were used in this study. The animals were randomly assigned to receive either ketanserin gel (242 in number) or a positive control treatment (239 in number). The positive control treatment varied according to the country in which it was administered: ethacridin lactate solution in Belgium and Germany (120 horses), and malic, benzoic, and salicylic acid (MBS) cream in France and the United Kingdom (119 horses).
  • Treatment was continued until the wound healed successfully (designated as success), formed hypergranulation tissue (designated as failure), or became infected (also designated as failure). Treatment was concluded after 6 months for all remaining animals in the study that had not met any of these conditions.

Results

  • Ketanserin gel treatment was found to be successful in 88% of the cases involved in this study.
  • The study also showed that wounds treated with ketanserin were 2 and 5 times more likely to heal successfully than those treated with MBS cream or ethacridin lactate solution, respectively.

Conclusions

  • Based on the results, the researchers concluded that ketanserin gel is more effective than the standard treatments (MBS cream or ethacridin lactate solution) in preventing the formation of hypergranulation tissue and infection in equine lower limb wounds.

Cite This Article

APA
Engelen M, Besche B, Lefay MP, Hare J, Vlaminck K. (2004). Effects of ketanserin on hypergranulation tissue formation, infection, and healing of equine lower limb wounds. Can Vet J, 45(2), 144-149.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 45
Issue: 2
Pages: 144-149

Researcher Affiliations

Engelen, Marc
  • Janssen Animal Health BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium. mengelen@janbe.jnj.com
Besche, Béatrice
    Lefay, Marie-Paul
      Hare, Jonathan
        Vlaminck, Kathleen

          MeSH Terms

          • Administration, Topical
          • Animals
          • Female
          • Gels
          • Granulation Tissue / drug effects
          • Granulation Tissue / pathology
          • Horse Diseases / drug therapy
          • Horses / injuries
          • Infection Control
          • Ketanserin / administration & dosage
          • Ketanserin / pharmacology
          • Male
          • Platelet Aggregation Inhibitors / administration & dosage
          • Platelet Aggregation Inhibitors / pharmacology
          • Treatment Outcome
          • Wound Healing / drug effects
          • Wounds and Injuries / drug therapy
          • Wounds and Injuries / veterinary

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          Citations

          This article has been cited 1 times.
          1. Ribeiro G, Carvalho L, Borges J, Prazeres J. The Best Protocol to Treat Equine Skin Wounds by Second Intention Healing: A Scoping Review of the Literature. Animals (Basel) 2024 May 18;14(10).
            doi: 10.3390/ani14101500pubmed: 38791717google scholar: lookup
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