FREE SHIPPING over $40
OVER 10000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
The Canadian veterinary journal = La revue veterinaire canadienne2004; 45(2); 144-149;

Effects of ketanserin on hypergranulation tissue formation, infection, and healing of equine lower limb wounds.

Abstract: The objective of this multicentre, randomized, controlled field study was to determine the efficacy of ketanserin gel in preventing exuberant granulation tissue formation (hypergranulation) and infection in equine lower limb wounds. Horses and ponies (n = 481) with naturally occurring wounds were randomized to either topical treatment with ketanserin gel (n = 242) or a positive control (Belgium, Germany: ethacridin lactate solution, n = 120; France, United Kingdom: malic, benzoic, and salicylic acid [MBS] cream, n = 119). Treatment continued until the wound healed (success), formed hypergranulation tissue (failure), or became infected (failure). Treatment was terminated after 6 months in all remaining animals. Ketanserin was successful in 88% of cases. Wounds treated with ketanserin were 2 and 5 times more likely to heal successfully than were those treated with MBS or ethacridin lactate, respectively. Ketanserin gel is thus more effective than these standard treatments in preventing hypergranulation tissue and infection of equine lower limb wounds. Résumé — Les effets d’un gel de kétanserin sur la guérison de plaies situées à l’aspect distal du membre équin. L’objectif de cette étude de terrain multicentrique, était de déterminer l’efficacité d’un gel de kétanserin dans la prévention de l’hypergranulation et l’infection de plaies appendiculaires équines. Des chevaux et des poneys (n = 481) ayant des plaies traumatiques furent placés de façon aléatoire dans deux groupes. Les animaux du premier groupe reçurent un traitement topique de gel de kétanserin (n = 242) alors que ceux du deuxième groupe reçurent un contrôle positif (Belgique, Allemagne : solution lactate d’éthacridine, n = 120; France, Royaume Uni : onguent d’acides malique, benzoïque et salicylique [MBS], n = 119). Le traitement fut poursuivi jusqu’à guérison (succès), hypergranulation (échec), ou infection (échec) de la plaie. Le gel de kétanserin fut un succès dans 88 % des cas. Les plaies soignées avec ce traitement topique furent 2 et 5 fois plus aptes à guérir de façon convenable que celles recevant le MBS ou le lactate d’éthacridine. Il est donc apparent que le gel de kétanserin est un traitement efficace pour la prévention d’hypergranulation et d’infection de plaies à l’aspect distal du membre équin. (Traduit par Docteure Christine Théorêt)
Get Full Text
Publication Date: 2004-03-18 PubMed ID: 15025151PubMed Central: PMC548604
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Clinical Trial
  • Journal Article
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper presents an equine study that analyzes the effectiveness of ketanserin gel in the prevention of excessive granulation tissue formation, commonly known as hypergranulation, and infection in lower limb wounds in horses. The study determined that ketanserin gel is more effective than the standard treatments.

Research Method

  • The researchers conducted a randomized-controlled study across multiple locations to gauge the efficiency of ketanserin gel in preventing hypergranulation and infection in equine lower limb wounds.
  • A total of 481 horses and ponies with naturally occurring wounds were used in this study. The animals were randomly assigned to receive either ketanserin gel (242 in number) or a positive control treatment (239 in number). The positive control treatment varied according to the country in which it was administered: ethacridin lactate solution in Belgium and Germany (120 horses), and malic, benzoic, and salicylic acid (MBS) cream in France and the United Kingdom (119 horses).
  • Treatment was continued until the wound healed successfully (designated as success), formed hypergranulation tissue (designated as failure), or became infected (also designated as failure). Treatment was concluded after 6 months for all remaining animals in the study that had not met any of these conditions.

Results

  • Ketanserin gel treatment was found to be successful in 88% of the cases involved in this study.
  • The study also showed that wounds treated with ketanserin were 2 and 5 times more likely to heal successfully than those treated with MBS cream or ethacridin lactate solution, respectively.

Conclusions

  • Based on the results, the researchers concluded that ketanserin gel is more effective than the standard treatments (MBS cream or ethacridin lactate solution) in preventing the formation of hypergranulation tissue and infection in equine lower limb wounds.

Cite This Article

APA
Engelen M, Besche B, Lefay MP, Hare J, Vlaminck K. (2004). Effects of ketanserin on hypergranulation tissue formation, infection, and healing of equine lower limb wounds. Can Vet J, 45(2), 144-149.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 45
Issue: 2
Pages: 144-149

Researcher Affiliations

Engelen, Marc
  • Janssen Animal Health BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium. mengelen@janbe.jnj.com
Besche, Béatrice
    Lefay, Marie-Paul
      Hare, Jonathan
        Vlaminck, Kathleen

          MeSH Terms

          • Administration, Topical
          • Animals
          • Female
          • Gels
          • Granulation Tissue / drug effects
          • Granulation Tissue / pathology
          • Horse Diseases / drug therapy
          • Horses / injuries
          • Infection Control
          • Ketanserin / administration & dosage
          • Ketanserin / pharmacology
          • Male
          • Platelet Aggregation Inhibitors / administration & dosage
          • Platelet Aggregation Inhibitors / pharmacology
          • Treatment Outcome
          • Wound Healing / drug effects
          • Wounds and Injuries / drug therapy
          • Wounds and Injuries / veterinary

          References

          This article includes 27 references
          1. Bertone AL. Principles of wound healing.. Vet Clin North Am Equine Pract 1989;5:449–463.
            pubmed: 2691024
          2. Bertone AL. Management of exuberant granulation tissue.. Vet Clin North Am Equine Pract 1989;5:551–562.
            pubmed: 2691030
          3. Miller CB, Wilson DA, Keegan KG, Kreeger JM, Adelstein EH, Ganjam VK. Growth characteristics of fibroblasts isolated from the trunk and distal aspect of the limb of horses and ponies.. Vet Surg 2000;29:1–7.
            pubmed: 10653489
          4. Wilmink JM, Nederbragt H, van Weeren PR, Stolk PW, Barneveld A. Differences in wound contraction between horses and ponies: the in vitro contraction capacity of fibroblasts.. Equine Vet J 2001;33:499–505.
            pubmed: 11558746
          5. Theoret CL, Barber SM, Moyana TN, Gordon JR. Expression of transforming growth factor beta(1), beta(3), and basic fibroblast growth factor in full-thickness skin wounds of equine limbs and thorax.. Vet Surg 2001;30:269–277.
            pubmed: 11340559
          6. Theoret CL, Barber SM, Moyana TN, Gordon JR. Preliminary observations on expression of transforming growth factors beta 1 and beta 3 in equine full-thickness skin wounds healing normally or with exuberant granulation tissue.. Vet Surg 2002;31:266–273.
            pubmed: 11994855
          7. Theoret CL, Barber SM, Gordon JR. Temporal localization of immunoreactive transforming growth factor beta1 in normal equine skin and in full-thickness dermal wounds.. Vet Surg 2002;31:274–280.
            pubmed: 11994856
          8. Stashak TS. Principles of wound healing.. Equine Wound Management 1991:1–18.
          9. Steel CM, Robertson ID, Thomas J, Yovich JV. Effect of topical rh-TGF-beta 1 on second intention wound healing in horses.. Aust Vet J 1999;77:734–737.
            pubmed: 10685169
          10. Dart AJ, Cries L, Jeffcott LB, Hodgson DR, Rose RJ. Effects of 25% propylene glycol hydrogel (Solugel) on second intention wound healing in horses.. Vet Surg 2002;31:309–313.
            pubmed: 12094343
          11. Dart AJ, Cries L, Jeffcott LB, Hodgson DR, Rose RJ. The effect of equine recombinant growth hormone on second intention wound healing in horses.. Vet Surg 2002;31:314–319.
            pubmed: 12094344
          12. Rooman RP, Janssen H. Ketanserin promotes wound healing: clinical and preclinical results.. Proc 3rd Int Symp Tissue Repair 1991:115–128.
            pubmed: 1862126
          13. Symoens J. Ketanserin: a novel cardiovascular drug.. Blood Coagul Fibrinolysis 1990;1:219–224.
            pubmed: 2130934
          14. Janssen PAJ, Janssen H, Cauwenbergh G. Use of topical ketanserin in the treatment of skin ulcers: A double-blind study.. J Am Acad Dermatol 1989;21:85–90.
            pubmed: 2663937
          15. Roelens P. Double-blind placebo-controlled study with topical 2% ketanserin ointment in the treatment of venous ulcers.. Dermatologica 1989;178:98–102.
            pubmed: 2647535
          16. Apelqvist J, Castenfors J, Larsson J, Stenström A, Persson G. Ketanserin in the treatment of diabetic foot ulcer with severe peripheral vascular disease.. Int Angiol 1990;9:120–124.
            pubmed: 2254674
          17. Martinez-de Jesus FR, Morales-Guzman M, Castañeda M, Perez- Morales A, Garcia-Alonso J, Mendiola-Segura I. Randomized single-blind trial of topical ketanserin for healing acceleration of diabetic foot ulcers.. Arch Med Res 1996;27:95–99.
            pubmed: 9078595
          18. Ooms LAA, Vlaminck K, Dony J, Desplenter L, Marsboom R. Wound healing in horses: Experience with ketanserin, an S2 antagonist.. Proc 4th Congr Europ Assoc Vet Pharmacol Toxicol 1988:239–243.
          19. Bertone AL, Sullins KE, Stashak TS, Norrdin RW. Effect of wound location and the use of topical collagen gel on exuberant granulation tissue formation and wound healing in the horse and pony.. Am J Vet Res 1985;46:1438–1444.
            pubmed: 4026023
          20. Woollen N, DeBowes RM, Leipold HW, Schneider LA. A comparison of four types of therapy for the treatment of full-thickness skin wounds of the horse.. Proc Am Assoc Equine Pract 1987;33:569–576.
          21. Sternberg EM, Trial J, Parker CW. Effect of serotonin on murine macrophages: suppression of Ia expression by serotonin and its reversal by 5-HT2 serotonergic receptor antagonists.. J Immunol 1986;137:276–282.
            pubmed: 2423604
          22. Bottaro D, Shepro D, Peterson S, Hechtman HB. Serotonin, histamine, and norepinephrine mediation of endothelial and vascular smooth muscle cell movement.. Am J Physiol 1985;248:C252–257.
            pubmed: 2983565
          23. Beele H, Thierens H, de Ridder L. Direct effects of serotonin and ketanserin on the functional morphology of embryonic chick skin in vitro.. In Vitro Cell Dev Biol Anim 1989;25:923–933.
            pubmed: 2808224
          24. Richter K, Kohn B, Hermanns W, Brunnberg L. Antiseptische Wundbehandlung Ein Vergleich der Wirksamkeit von Lavasept®, Rivanol® und Wasser.. Kleintierpraxis 1998;43:271–287.
          25. Young TW. The place of Aserbine in the healing of ulcerative disorders.. Clin Trials J 1966:579–589.
          26. de Kock M, van der Merwe AE. A study to assess the effects of a new Betadine cream formulation compared to a standard topical treatment regimen for burns.. Burns, including thermal injury 1987;13:69–74.
            pubmed: 3828858
          27. Stashak TS. Principles of wound management and selection of approaches to wound closure.. Equine Wound Management 1991:36–51.

          Citations

          This article has been cited 1 times.
          1. Ribeiro G, Carvalho L, Borges J, Prazeres J. The Best Protocol to Treat Equine Skin Wounds by Second Intention Healing: A Scoping Review of the Literature. Animals (Basel) 2024 May 18;14(10).
            doi: 10.3390/ani14101500pubmed: 38791717google scholar: lookup
          Subscribe to our newsletter
          Join 99,780 horse owners like you who receive our email updates on horse health and nutrition.