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Research in veterinary science2012; 93(3); 1439-1440; doi: 10.1016/j.rvsc.2012.04.008

Effects of mesenchymal stem cells isolated from amniotic fluid and platelet-rich plasma gel on severe decubitus ulcers in a septic neonatal foal.

Abstract: This paper documents the treatment of severe decubitus ulcers with amniotic fluid mesenchymal stem cells and platelets rich plasma (PRP) gel in a septic neonatal foal. The colt needed 25 days of hospitalization: during this period ulcers were treated for 15 days with mesenchymal stem cells (MSCs) plus PRP, PRP gel alone, or aloe gel. Healing was faster using MSCs+PRP, and at 7 months an ulcer treated with aloe gel was still not completely healed.
Copyright © 2012 Elsevier Ltd. All rights reserved.
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Publication Date: 2012-05-09 PubMed ID: 22579411DOI: 10.1016/j.rvsc.2012.04.008Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study focuses on the therapeutic effect of using mesenchymal stem cells, sourced from amniotic fluid, and platelet-rich plasma gel to treat severe decubitus ulcers in a newborn foal suffering from sepsis.

Treatment Methodology Overview

  • The researchers treated a neonatal foal suffering from severe decubitus ulcers and sepsis.
  • The treatment period extended over 25 days as the foal stayed in the hospital.
  • A range of treatments were used in an attempt to heal the ulcers, these were: a combination of mesenchymal stem cells (MSCs) plus platelet-rich plasma (PRP), PRP gel alone, or aloe gel.
  • The mesenchymal stem cells used for this study were isolated from amniotic fluid.

Treatment Results

  • The fastest healing was observed in the ulcers treated with the blend of MSCs and PRP.
  • The treatment using aloe gel had the slowest healing rate. One of the ulcers treated with this method was not completely healed until after 7 months.

Implications of the Study

  • The researchers concluded that the combination of MSCs and PRP resulted in quicker healing of decubitus ulcers.
  • The relatively slow healing of the ulcer treated with aloe gel emphasizes the potential advantage of the MSCs and PRP treatment method in severe cases.
  • These findings support the potential use of mesenchymal stem cells in regenerative medicine, in particular for the treatment of severe decubitus ulcers.
  • This research might spark further studies to explore the benefits and limitations of using MSCs from amniotic fluid and PRP in different therapeutic scenarios, including human medicine.

Cite This Article

APA
Iacono E, Merlo B, Pirrone A, Antonelli C, Brunori L, Romagnoli N, Castagnetti C. (2012). Effects of mesenchymal stem cells isolated from amniotic fluid and platelet-rich plasma gel on severe decubitus ulcers in a septic neonatal foal. Res Vet Sci, 93(3), 1439-1440. https://doi.org/10.1016/j.rvsc.2012.04.008

Publication

Research in veterinary science
ISSN: 1532-2661
NlmUniqueID: 0401300
Country: England
Language: English
Volume: 93
Issue: 3
Pages: 1439-1440

Researcher Affiliations

Iacono, E
  • Department of Veterinary Medical Sciences, Faculty of Veterinary Medicine, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell'Emilia, Bologna, Italy. eleonora.iacono2@unibo.it
Merlo, B
    Pirrone, A
      Antonelli, C
        Brunori, L
          Romagnoli, N
            Castagnetti, C

              MeSH Terms

              • Animals
              • Animals, Newborn
              • Gels
              • Horse Diseases / therapy
              • Horses
              • Male
              • Mesenchymal Stem Cell Transplantation / veterinary
              • Platelet-Rich Plasma
              • Pressure Ulcer / complications
              • Pressure Ulcer / therapy
              • Pressure Ulcer / veterinary
              • Sepsis / complications
              • Sepsis / veterinary
              • Time Factors
              • Wound Healing / drug effects

              Citations

              This article has been cited 17 times.
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              8. Merlo B, Baldassarro VA, Flagelli A, Marcoccia R, Giraldi V, Focarete ML, Giacomini D, Iacono E. Peptide Mediated Adhesion to Beta-Lactam Ring of Equine Mesenchymal Stem Cells: A Pilot Study. Animals (Basel) 2022 Mar 15;12(6).
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