Elimination of schistosomiasis japonica from formerly endemic areas in mountainous regions of southern China using a praziquantel regimen.
Abstract: Schistosomiasis japonica is a major public health problem in China. Domestic animals play a major role in the transmission of Schistosoma japonicum to humans. To better understand the epidemiology of schistosomiasis japonica in domestic animals in the mountainous areas of China, we performed a 5-year longitudinal study of schistosomiasis in cattle and horses in Yunnan Province from 2009 to 2013. We also performed a concurrent drug-based intervention study in three settlement groups in Yunnan Province aimed at developing an effective means of controlling transmission in this region. The prevalence of infection in cattle fluctuated between 1.67% and 3.05% from 2009 to 2011, and monthly treatments of schistosome-positive animals reduced the prevalence to 0% (P<0.05) from 2012 to 2013. Prior to the intervention, we found that schistosomiasis was prevalent from May to October, with the highest prevalence observed in June (10.00%). We surveyed for environmental schistosome contamination, and 94.29% of the miracidia found were from cattle. Our study showed that it is possible to eliminate schistosomiasis in domestic animals in the mountainous regions of China by monthly treating cattle and horses from schistosome-positive households from May to October.
Copyright © 2014 Elsevier B.V. All rights reserved.
Publication Date: 2014-12-31 PubMed ID: 25591407DOI: 10.1016/j.vetpar.2014.12.031Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
- Disease control
- Disease Diagnosis
- Disease Etiology
- Disease Management
- Disease Outbreaks
- Disease Prevalence
- Disease Surveillance
- Disease Transmission
- Disease Treatment
- Domestic Animals
- Epidemiology
- Equine Health
- Horses
- Infection
- Infectious Disease
- Longitudinal Study
- Public Health
- Veterinary Care
- Veterinary Medicine
- Veterinary Research
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article is about a successful effort to eliminate Schistosomiasis japonica, a major public health issue in China, from previously endemic regions in Yunnan Province using a drug called praziquantel.
Introduction and Background
- Schistosomiasis japonica is a significant public health concern in China. The disease caused by parasitic worms, is transmitted to humans primarily from domestic animals, highlighting the vital role these animals play in the disease’s epidemiology.
- This research was conducted to understand more about the transmission of Schistosomiasis japonica in domestic animals, particularly in China’s mountainous regions.
Methodology
- The research comprised a 5-year longitudinal study conducted from 2009 to 2013. It investigated Schistosomiasis in cattle and horses in Yunnan Province, which is known to be a difficult region for controlling the transmission of this disease.
- Alongside the longitudinal study, a drug-based intervention study was also carried out in three settlement groups in Yunnan Province. The aim was to develop an effective means of controlling transmission.
Results and Findings
- The infection prevalence in cattle fluctuated between 1.67% and 3.05% from 2009 to 2011. Nonetheless, through monthly treatments of schistosome-positive animals, the prevalence was reduced to 0% from 2012 to 2013, indicating a successful methodology.
- The researchers found that the disease was most prevalent from May to October, with the highest infection rate observed in June (10.00%). Also, investigations into environmental schistosome contamination revealed that an overwhelming 94.29% of the miracidia found originated from cattle.
Conclusion
- The results derived from the study indicate that it is possible to eliminate Schistosomiasis in domestic animals by frequently treating cattle and horses from May to October, specifically in the schistosome-positive households.
- By doing so, the potential for transmission of the disease to humans can also be significantly reduced, thereby improving public health conditions in these regions.
Cite This Article
APA
Li H, Dong GD, Liu JM, Gao JX, Shi YJ, Zhang YG, Jin YM, Lu K, Cheng GF, Lin JJ.
(2014).
Elimination of schistosomiasis japonica from formerly endemic areas in mountainous regions of southern China using a praziquantel regimen.
Vet Parasitol, 208(3-4), 254-258.
https://doi.org/10.1016/j.vetpar.2014.12.031 Publication
Researcher Affiliations
- National Laboratory of Animal Schistosomiasis Control/Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, P.R. China.
- Yunnan Center for Animal Disease Control and Prevention, Kunming 650051, Yunnan, P.R. China.
- National Laboratory of Animal Schistosomiasis Control/Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, P.R. China. Electronic address: jimyliu@shvri.ac.cn.
- Weishan County Center for Animal Disease Control and Prevention, Weishan 672400, Yunnan, P.R. China.
- National Laboratory of Animal Schistosomiasis Control/Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, P.R. China.
- Yunnan Center for Animal Disease Control and Prevention, Kunming 650051, Yunnan, P.R. China.
- National Laboratory of Animal Schistosomiasis Control/Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, P.R. China.
- National Laboratory of Animal Schistosomiasis Control/Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, P.R. China.
- National Laboratory of Animal Schistosomiasis Control/Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, P.R. China.
- National Laboratory of Animal Schistosomiasis Control/Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, P.R. China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, P.R. China.
MeSH Terms
- Animals
- Anthelmintics / therapeutic use
- Cattle
- Cattle Diseases / drug therapy
- Cattle Diseases / epidemiology
- Cattle Diseases / parasitology
- China / epidemiology
- Endemic Diseases / prevention & control
- Endemic Diseases / veterinary
- Female
- Humans
- Male
- Praziquantel / therapeutic use
- Schistosomiasis japonica / drug therapy
- Schistosomiasis japonica / epidemiology
- Schistosomiasis japonica / veterinary
- Seasons
Citations
This article has been cited 7 times.- Grover E, Paull S, Kechris K, Buchwald A, James K, Liu Y, Carlton EJ. Predictors of bovine Schistosoma japonicum infection in rural Sichuan, China.. Int J Parasitol 2022 Jul;52(8):485-496.
- Zhou X, Hong Y, Shang Z, Abuzeid AMI, Lin J, Li G. The Potential Role of MicroRNA-124-3p in Growth, Development, and Reproduction of Schistosoma japonicum.. Front Cell Infect Microbiol 2022;12:862496.
- Wu HW, Fu ZQ, Lu K, Pond-Tor S, Meng R, Hong Y, Chu K, Li H, Jiz M, Liu JM, Hou M, Park S, Lin JJ, Kurtis JD. Vaccination with recombinant paramyosin in Montanide ISA206 protects against Schistosoma japonicum infection in water buffalo.. Vaccine 2017 Jun 8;35(26):3409-3415.
- Liu Y, Zhong B, Wu ZS, Liang S, Qiu DC, Ma X. Interruption of schistosomiasis transmission in mountainous and hilly regions with an integrated strategy: a longitudinal case study in Sichuan, China.. Infect Dis Poverty 2017 Apr 7;6(1):79.
- Sun LP, Wang W, Zuo YP, Zhang ZQ, Hong QB, Yang GJ, Zhu HR, Liang YS, Yang HT. An integrated environmental improvement of marshlands: impact on control and elimination of schistosomiasis in marshland regions along the Yangtze River, China.. Infect Dis Poverty 2017 Mar 22;6(1):72.
- Sun LP, Wang W, Zuo YP, Hong QB, Du GL, Ma YC, Wang J, Yang GJ, Zhu DJ, Liang YS. A multidisciplinary, integrated approach for the elimination of schistosomiasis: a longitudinal study in a historically hyper-endemic region in the lower reaches of the Yangtze River, China from 2005 to 2014.. Infect Dis Poverty 2017 Mar 14;6(1):56.
- Huang Y, Li W, Liu K, Xiong C, Cao P, Tao J. New detection method in experimental mice for schistosomiasis: ClinProTool and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.. Parasitol Res 2016 Nov;115(11):4173-4181.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
