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The Veterinary clinics of North America. Equine practice2011; 27(2); 233-242; doi: 10.1016/j.cveq.2011.04.003

Embryonic stem cells and iPS cells: sources and characteristics.

Abstract: The field of regenerative medicine research is rapidly expanding. One area of interest to equine researchers is the possibility of isolating or generating pluripotent cells, capable of producing differentiated cell types derived from all 3 primary germ layers. Reports of equine embryonic stem-like (ES) cell isolation can be found in the literature. Other groups are working to produce equine-induced pluripotent stem (iPS) cells. This article summarizes the essential features needed to characterize a cell type as pluripotent, specific challenges in using the horse as a model organism for pluripotent cell generation, and current and upcoming clinical trials using ES/iPS cells.
Copyright © 2011 Elsevier Inc. All rights reserved.
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Publication Date: 2011-06-16 PubMed ID: 21872756PubMed Central: PMC3479634DOI: 10.1016/j.cveq.2011.04.003Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the progress and challenges in the field of equine regenerative medicine, specifically focusing on the isolation or creation of pluripotent cells – cells which can evolve into a variety of differentiated cells originating from all three primary germ layers.

Characterizing Pluripotent Cells

The article first describes the key features required to define a cell type as pluripotent:

  • Pluripotent cells are capable of giving rise to all different cell types of an organism.
  • These cells can self-renew indefinitely and therefore hold promising potential for regenerative medicine.

Horses as Model Organisms

Detailed in the article are the specific challenges of using horses as model organisms for pluripotent cell generation:

  • Due to differences in physiology and size compared to frequently used model organisms like mice, horses present unique obstacles in regenerative medicine research.
  • There are also logistical and ethical considerations unique to horses that make them challenging to work with.

Equine Embryonic Stem-like Cells and Induced Pluripotent Stem Cells

The research outlines the progress in isolating equine embryonic stem-like (ES) cells and the creation of equine-induced pluripotent stem (iPS) cells:

  • Equine ES cells have been found and isolated, as stated in several research reports.
  • Many research groups are actively working on generating equine iPS cells.

Current and Upcoming Clinical Trials

Finally, the review summarizes the conducted and forthcoming clinical trials utilizing pluripotent stem cells:

  • It discusses the goals and strategies of these trials as they strive to develop regenerative therapies.
  • The importance of these clinical trials to advance the field of regenerative medicine and to potentially provide new disease treatments is also emphasized.

Cite This Article

APA
Hackett CH, Fortier LA. (2011). Embryonic stem cells and iPS cells: sources and characteristics. Vet Clin North Am Equine Pract, 27(2), 233-242. https://doi.org/10.1016/j.cveq.2011.04.003

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 27
Issue: 2
Pages: 233-242

Researcher Affiliations

Hackett, Catherine H
  • Department of Clinical Sciences, Box 32, Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Fortier, Lisa A

    MeSH Terms

    • Animals
    • Cell Culture Techniques
    • Clinical Trials as Topic
    • Embryonic Stem Cells / cytology
    • Embryonic Stem Cells / physiology
    • Embryonic Stem Cells / transplantation
    • Horses
    • Humans
    • Induced Pluripotent Stem Cells / cytology
    • Induced Pluripotent Stem Cells / physiology
    • Induced Pluripotent Stem Cells / transplantation
    • Mice
    • Stem Cell Research

    Grant Funding

    • F32 AR056187 / NIAMS NIH HHS

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