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The Veterinary clinics of North America. Equine practice2026; S0749-0739(26)00055-6; doi: 10.1016/j.cveq.2026.07.008

Endocrine Disorders and Their Effect on Equine Reproduction.

Abstract: Continuing the reproductive potential of aged horses is a request many equine practitioners may receive. Reproductive performance may be impacted by a host of age-related comorbidities such as the endocrinopathies, pituitary pars intermedia dysfunction, and equine metabolic syndrome. While limited information is known, reproductive effects described may include irregular estrous cycles, development of anovulatory follicles, increased incidence of uterine infection, or generalized infertility. Accurate diagnosis, management strategies, and monitoring remain critical for improving quality of life and potentially continued reproductive success.
Publication Date: 2026-09-16 PubMed ID: 42749574DOI: 10.1016/j.cveq.2026.07.008Google Scholar: Lookup
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Summary

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Overview

  • This research article explores how endocrine disorders, especially those related to aging, affect the reproductive capabilities of horses.
  • The study focuses on specific conditions like pituitary pars intermedia dysfunction and equine metabolic syndrome, highlighting their impact on fertility and reproductive health.

Introduction to the Topic

  • Equine practitioners often face requests to assist aged horses in maintaining their reproductive potential.
  • Reproductive performance in older horses can decline due to various age-associated health issues.
  • The paper identifies endocrine disorders as key contributors to deteriorating reproductive health in aging horses.

Key Endocrine Disorders Discussed

  • Pituitary Pars Intermedia Dysfunction (PPID):
    • A common age-related endocrine disorder in horses.
    • Can disrupt hormonal balance affecting reproductive cycles.
  • Equine Metabolic Syndrome (EMS):
    • Metabolic disorder linked with obesity and insulin resistance.
    • May impair reproductive function due to hormonal imbalances.

Impact on Reproductive Performance

  • Endocrine dysfunctions can lead to irregular estrous cycles, making it difficult to predict or manage breeding times.
  • Development of anovulatory follicles, meaning follicles develop but do not release an egg, which impairs fertility.
  • Increased risk of uterine infections, potentially due to compromised immune responses or hormonal disturbances.
  • Overall decline in fertility rates, with some cases resulting in generalized infertility.

Diagnosis and Management

  • Accurate diagnosis of these endocrine disorders is essential to properly address reproductive issues.
  • Management strategies may include hormonal treatments, metabolic control, and supportive reproductive care.
  • Regular monitoring of endocrine status and reproductive health is crucial to adjust treatments and improve outcomes.
  • These clinical interventions aim to enhance quality of life for the horse and potentially allow continued breeding success despite aging.

Conclusion

  • Understanding the relationship between endocrine disorders and reproductive health is vital for managing aged equine patients.
  • Although research is limited, recognizing signs and applying targeted treatment can positively influence reproductive longevity.
  • This area highlights the importance of integrating endocrine health into equine reproductive management practices.

Cite This Article

APA
Beachler TM. (2026). Endocrine Disorders and Their Effect on Equine Reproduction. Vet Clin North Am Equine Pract, S0749-0739(26)00055-6. https://doi.org/10.1016/j.cveq.2026.07.008

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
PII: S0749-0739(26)00055-6

Researcher Affiliations

Beachler, Theresa M
  • Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, College of Veterinary Medicine, 1809 South Riverside Drive, Ames, IA 50011, USA. Electronic address: beachler@iastate.edu.

Conflict of Interest Statement

Disclosures The author has nothing to disclose.

Citations

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