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Home / Equine Research Bank / Acta Neuropathol / Eosinophilic cytoplasmic inclusions in sporadic equine motor...
Acta neuropathologica1993; 85(3); 291-297; doi: 10.1007/BF00227725

Eosinophilic cytoplasmic inclusions in sporadic equine motor neuron disease: an electron microscopic study.

Abstract: Equine motor neuron disease (EMND) is a sporadic, progressive neurodegenerative disorder that has been identified recently in horses of different breeds in North America. The cause is unknown. Pathologic changes which occur in spinal and certain brain stem motor neurons include chromatolysis, swelling, neurofilamentous accumulation, and development of eosinophilic cytoplasmic inclusions. Punctate eosinophilic inclusions, the type usually encountered in degenerating neurons, resembled Bunina bodies at the light microscopic level, but differed in their ultrastructural composition. These and less common but larger juxtanuclear inclusions appeared to be aggregated vesicular residues of membranous organelle degradation. The third kind of eosinophilic inclusion was a marginated derivative of endoplasmic reticulum and consisted of large membrane-bound accumulations of finely granular material. It was concluded that, although the distribution and nature of the lesions in EMND appeared similar to those of human motor neuron disease, none of the equine eosinophilic inclusions duplicated the ultrastructure of Bunina bodies.
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Publication Date: 1993-01-01 PubMed ID: 8384774DOI: 10.1007/BF00227725Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Research Support
  • U.S. Gov't
  • P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the neurological disorder equine motor neuron disease (EMND) in horses, detailing the peculiarities of pathological changes in certain neurons and emphasizing the difference of EMND’s eosinophilic inclusions from the Bunina bodies usually found in degenerating neurons.

A deeper look into Equine Motor Neuron Disease (EMND)

  • EMND is defined as a sporadic neurodegenerative disorder that progressively affects horses across different breeds in North America. While the exact cause hasn’t been discovered yet, the disease introduces significant pathologic changes to spinal and brain stem motor neurons.

Pathological Transformations in Neurons

  • The disease incites several changes in the neurons’ structure and behavior. Among these changes are chromatolysis (the dissolution of the Nissl bodies in a neuron), swelling, and neurofilamentous accumulation.
  • One of the most distinctive features of EMND is the development of eosinophilic cytoplasmic inclusions, identifiable as particular spots in degenerating neurons.

Particularities of Eosinophilic Inclusions

  • These inclusions resemble Bunina bodies (often found in degenerating neurons) when viewed through a light microscope. However, upon careful examination, researchers discovered significant differences in their ultrastructural composition.
  • Other larger inclusions were found situated near the nucleus and looked like aggregated vesicular residues coming from the degradation of membranous organelles.
  • The third kind of eosinophilic inclusion was a grouped derivative of endoplasmic reticulum, comprising large accumulations of finely granular material enclosed in a membrane.

Comparing EMND and Human Motor Neuron Disease

  • While the characteristics of lesions in EMND might seem similar to those occurring in human motor neuron disease, the research concluded none of the eosinophilic inclusions in EMND exactly reproduced the ultrastructure of Bunina bodies, implying significant distinctions between the two conditions.

Cite This Article

APA
Cummings JF, de Lahunta A, Summers BA, Mohammed HO, Divers TJ, Valentine BA, Trembicki-Graves K. (1993). Eosinophilic cytoplasmic inclusions in sporadic equine motor neuron disease: an electron microscopic study. Acta Neuropathol, 85(3), 291-297. https://doi.org/10.1007/BF00227725

Publication

Acta neuropathologica
ISSN: 0001-6322
NlmUniqueID: 0412041
Country: Germany
Language: English
Volume: 85
Issue: 3
Pages: 291-297

Researcher Affiliations

Cummings, J F
  • College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401.
de Lahunta, A
    Summers, B A
      Mohammed, H O
        Divers, T J
          Valentine, B A
            Trembicki-Graves, K

              MeSH Terms

              • Animals
              • Brain / pathology
              • Cytoplasm / ultrastructure
              • Eosinophils / ultrastructure
              • Horse Diseases / pathology
              • Horses
              • Inclusion Bodies / ultrastructure
              • Microscopy, Electron
              • Motor Neuron Disease / pathology
              • Motor Neuron Disease / veterinary
              • Spinal Cord / pathology

              Grant Funding

              • IR 29NS 29674-0181 / NINDS NIH HHS

              References

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              Citations

              This article has been cited 2 times.
              1. Mohammed HO, Starkey SR, Stipetic K, Divers TJ, Summers BA, de Lahunta A. The role of dietary antioxidant insufficiency on the permeability of the blood-brain barrier. J Neuropathol Exp Neurol 2008 Dec;67(12):1187-93.
                doi: 10.1097/NEN.0b013e31818f8f51pubmed: 19018244google scholar: lookup
              2. Cummings JF, de Lahunta A, Mohammed HO, Divers TJ, Summers BA, Valentine BA, Jackson CA. Endothelial lipopigment as an indicator of alpha-tocopherol deficiency in two equine neurodegenerative diseases. Acta Neuropathol 1995;90(3):266-72.
                doi: 10.1007/BF00296510pubmed: 8525800google scholar: lookup
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