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Home / Equine Research Bank / Front Vet Sci / Equine Dental Pulp Connective Tissue Particles Reduced Lamen...
Frontiers in veterinary science2017; 4; 31; doi: 10.3389/fvets.2017.00031

Equine Dental Pulp Connective Tissue Particles Reduced Lameness in Horses in a Controlled Clinical Trial.

Abstract: To assess if injection of allogeneic dental pulp tissue particles would improve lameness in horses with naturally occurring osteoarthritis (OA) or soft tissue (ST) injury. Methods: Prospective, randomized, blinded, and controlled clinical trial and client survey assessment. Methods: Forty lame client-owned horses. Methods: Sterile dental pulp, recovered from otherwise healthy foals that perish during dystocia, was processed under good manufacturing processing to produce mechanically manipulated, unexpanded pulp tissue particles containing viable cells surrounded in extracellular matrix. Forty lame client-owned horses with confirmed OA ( = 20), or ST injury (desmitis or tendonitis) received a 2 mL intra-articular ( = 20 OA) or intra-lesional ( = 20) injection of control transport vehicle ( = 20) or 10 × 10 dental pulp tissue particles ( = 20). Acclimatized horses had baseline measurements performed and were then injected on day 0. Horses were treadmill exercised for 2 weeks, evaluated by clinical parameters, lameness score, edema (score and circumference), pain on flexion (OA) or pressure (ST), and clients' scores for pain and discomfort before and through 45 days after pulp injection. Twenty horses were available for >2.5-year follow-up. Results: Pulp-treated horses showed decrease in lameness compared to baseline ( < 0.009) or placebo controls ( < 0.013) for at least 2 weeks. Client assessments of comfort were improved between before and 45 days after pulp injection ( < 0.001). Clinical improvement with ST injury was significantly greater than OA ( 2.5-year follow-up, at least 10 horses were in work. Conclusions: Dental pulp tissue particles can be considered as a treatment option for equine lameness due to OA, desmitis, or tendonitis.
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Publication Date: 2017-03-10 PubMed ID: 28344975PubMed Central: PMC5344919DOI: 10.3389/fvets.2017.00031Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article confirms the beneficial effect of allogeneic dental pulp tissue particle injections in reducing lameness in horses with osteoarthritis (OA) or soft tissue injuries.

Research Methods

  • The research was a prospective, randomized, blinded, and controlled clinical trial that involved a client survey assessment. It included forty lame client-owned horses as subjects.
  • The horses used were those diagnosed with either OA or soft tissue injuries (desmitis or tendonitis). This meant that there were two distinct groups in the study.
  • Researchers used sterile dental pulp from foals that had died due to dystocia. The pulp was mechanically manipulated to produce unexpanded pulp tissue particles containing viable cells encapsulated within an extracellular matrix.
  • The horses were given two types of injections: a transport vehicle (control) or dental pulp tissue particles. This helped establish a direct comparison between the effects of the dental pulp tissue particles and the control.
  • After the injections, the horses were treadmill exercised for two weeks and their progress was evaluated using various parameters: clinical parameters, lameness score, edema (score and circumference), pain on flexion (OA) or pressure (ST), and client assessments of pain and discomfort. These assessments were conducted both before and after the pulp injection for a period of 45 days.
  • The study also included a long-term follow-up of over two and a half years after the treatment.

Results and Conclusion

  • The results showed significant improvement in the condition of the horses that received the pulp tissue particle injections. The lameness decreased in comparison to the baseline or the placebo controls.
  • The clients also reported an improved comfort level for the horses at the end of the 45-day period after the pulp injection.
  • Interestingly, the study found that horses with soft tissue injuries showed significantly greater clinical improvement than those with OA. This suggests that the treatment may be particularly effective for soft tissue injuries.
  • At the time of the long-term follow-up, at least 10 horses were back to work, signifying the sustained effect of the treatment.
  • The study concluded that dental pulp tissue particles could be considered as a treatment option for equine lameness due to OA, desmites, or tendonitis.

Cite This Article

APA
Bertone AL, Reisbig NA, Kilborne AH, Kaido M, Salmanzadeh N, Lovasz R, Sizemore JL, Scheuermann L, Kopp RJ, Zekas LJ, Brokken MT. (2017). Equine Dental Pulp Connective Tissue Particles Reduced Lameness in Horses in a Controlled Clinical Trial. Front Vet Sci, 4, 31. https://doi.org/10.3389/fvets.2017.00031

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 4
Pages: 31
PII: 31

Researcher Affiliations

Bertone, Alicia L
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Reisbig, Nathalie A
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Kilborne, Allison H
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Kaido, Mari
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Salmanzadeh, Navid
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Lovasz, Rebecca
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Sizemore, Joy L
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Scheuermann, Logan
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Kopp, Rosalind J
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Zekas, Lisa J
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Brokken, Matthew T
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.

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Citations

This article has been cited 1 times.
  1. Heilen LB, Roßgardt J, Dern-Wieloch J, Vogelsberg J, Staszyk C. Isolation and cultivation as well as in situ identification of MSCs from equine dental pulp and periodontal ligament.. Front Vet Sci 2023;10:1116671.
    doi: 10.3389/fvets.2023.1116671pubmed: 36968463google scholar: lookup
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