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Equine Granulocytic Anaplasmosis 28 years later.
Abstract: Equine granulocytic anaplasmosis (EGA) is an important tick borne disease of equines that is caused by Anaplasma phagocytophilum (A. phagocytophilum). The etiological agent has veterinary as well as public health importance because of its zoonotic nature. A. phagocytophilum causes an acute illness in equines with loss of appetite, lethargy, hemorrhages and lameness. Clinically, EGA is diagnosed upon examination of morulae within neutrophils especially granulocytes in the blood. The best diagnostic tool for the detection of EGA is Polymerase chain reaction (PCR). Previous studies suggested that EGA is a self-limiting disease and tetracycline therapy is considered as a best treatment regimen. There is no comprehensive summary on the occurrence and distribution of the infection at global level. Therefore, we intended to provide a comprehensive summary on the prevalence and epidemiology of EGA in different areas of the world. It includes mapping the global distribution of EGA in different areas of the world to identify the endemic regions which may be a source of potential disease outbreak. For this purpose, the published data from 1990 to 2018 on EGA was reviewed and collected by electronic literature search of five databases including Google, Google Scholar, Science Direct, PubMed and Web of Science.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Publication Date: 2018-04-04 PubMed ID: 29626656DOI: 10.1016/j.micpath.2018.04.001Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
- Diagnosis
- Diagnostic Technique
- Disease control
- Disease Diagnosis
- Disease Management
- Disease Outbreaks
- Disease Prevalence
- Disease Surveillance
- Disease Treatment
- Epidemiology
- Equine Diseases
- Equine Health
- Equine Science
- Infection
- Polymerase Chain Reaction
- Public Health
- Tick-Borne Diseases
- Veterinary Medicine
- Veterinary Research
- Veterinary Science
- Zoonotic Diseases
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article provides a comprehensive view on equine granulocytic anaplasmosis (EGA), an important tick borne disease in horses, with a main focus on its occurrence, prevalence, and distribution globally based on literature review from 1990 to 2018.
About Equine Granulocytic Anaplasmosis (EGA)
- The paper explores EGA, a significant illness in horses brought about by the Anaplasma phagocytophilum (A. phagocytophilum) parasite, passed on by ticks.
- EGA not only affects veterinary health but can also affect human health due to its zoonotic characteristics, meaning it can be transmitted from animals to humans.
- The disease typically presents as an acute illness in horses, with signs such as loss of appetite, lethargy, hemorrhages, and lameness.
- EGA is commonly diagnosed through a clinical examination of the blood for morulae, particularly within neutrophils and granulocytes.
- The most effective detection tool for EGA, as stated in the paper, is the Polymerase Chain Reaction (PCR).
- Previous research pointed out that EGA is a self-limiting disease, with the tetracycline therapy deemed as the most suitable treatment regimen.
Epidemiology and Prevalence of EGA
- This study aimed to provide a thorough summary of the prevalence and epidemiology of EGA across the globe, which was identified as missing in previous research.
- The research included representation of the global distribution of EGA, aiding in pinpointing the endemic regions that may serve as a source for potential disease outbreaks.
- The study’s data derived from a comprehensive review of published materials on EGA spanning from 1990 to 2018.
- Five databases were utilized for the literature search, including Google, Google Scholar, Science Direct, PubMed, and Web of Science.
Cite This Article
APA
Saleem S, Ijaz M, Farooqi SH, Ghaffar A, Ali A, Iqbal K, Mehmood K, Zhang H.
(2018).
Equine Granulocytic Anaplasmosis 28 years later.
Microb Pathog, 119, 1-8.
https://doi.org/10.1016/j.micpath.2018.04.001 Publication
Researcher Affiliations
- Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, 54600, Pakistan.
- Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, 54600, Pakistan. Electronic address: mijaz@uvas.edu.pk.
- Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, 54600, Pakistan.
- Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, 54600, Pakistan.
- Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, 54600, Pakistan.
- Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, 54600, Pakistan.
- University College of Veterinary and Animal Sciences, Islamia University of Bahawalpur, Pakistan. Electronic address: khalid.mehmood@iub.edu.pk.
- College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address: dahuilang@webmail.hzau.edu.cn.
MeSH Terms
- Anaplasma phagocytophilum / pathogenicity
- Anaplasmosis / drug therapy
- Anaplasmosis / epidemiology
- Anaplasmosis / microbiology
- Anaplasmosis / transmission
- Animals
- Anti-Bacterial Agents / therapeutic use
- Databases, Factual
- Disease Outbreaks
- Disease Transmission, Infectious
- Granulocytes / microbiology
- Horse Diseases / drug therapy
- Horse Diseases / epidemiology
- Horse Diseases / microbiology
- Horse Diseases / transmission
- Horses
- Prevalence
- Tetracycline / therapeutic use
- Tick-Borne Diseases / drug therapy
- Tick-Borne Diseases / epidemiology
- Tick-Borne Diseases / transmission
- Tick-Borne Diseases / veterinary
- Ticks / microbiology
- Zoonoses / drug therapy
- Zoonoses / epidemiology
- Zoonoses / microbiology
- Zoonoses / transmission
Citations
This article has been cited 16 times.- Dahmani A, Salhi O, Nabi M, Boucif A, Mekroud M, Touhami NAK, Ouchene N. Abortive diseases in horses and donkeys in Algeria: a systematic review. Trop Anim Health Prod 2026 Jan 5;58(1):30.
- Hacilarlioglu S, Bilgic HB, Karagenc T, Aydin HB, Toker H, Kanlioglu H, Pekagirbas M, Bakirci S. Molecular Detection and Prevalence of Equine Piroplasmosis and Other Blood Parasites in Equids of Western Aegean Türkiye. Vet Sci 2025 Aug 27;12(9).
- Ireland HM, Ruxton GD. Zebra stripes: the questions raised by the answers. Biol Rev Camb Philos Soc 2025 Dec;100(6):2660-2680.
- Akin I, Ozcan O, Ozturan YA. Parasites and lameness in domestic animals. Vet Res Commun 2025 Apr 30;49(3):181.
- de Albuquerque CV, da Silva Andrade M, de Freitas MS, Paulino PG, Santos HA, de Tarso Landgraf Botteon P. Significance of Anaplasma phagocytophilum, Babesia caballi, and Theileria equi as etiologic agents in horses with clinical manifestations from the metropolitan area of Rio De Janeiro, Brazil. Trop Anim Health Prod 2024 Sep 21;56(8):268.
- Choi KS, Hwang S, Kim MC, Cho HC, Park YJ, Ji MJ, Han SW, Chae JS. Molecular surveillance of zoonotic pathogens from wild rodents in the Republic of Korea. PLoS Negl Trop Dis 2024 Jul;18(7):e0012306.
- Kruppenbacher AS, Müller E, Aardema ML, Schäfer I, von Loewenich FD. Granulocytic anaplasmosis in cats from central Europe and molecular characterization of feline Anaplasma phagocytophilum strains by ankA gene, groEL gene and multilocus sequence typing. Parasit Vectors 2023 Oct 6;16(1):348.
- Athanasiou LV, Katsogiannou EG, Tyrnenopoulou P, Gougoulis D, Apostolidis KN, Papadakis SM, Kokkinaki KCG, Papatsiros VG, Tsokana CN. Evidence of Horse Exposure to Anaplasma phagocytophilum, Borrelia burgdorferi, and Leishmania infantum in Greece through the Detection of IgG Antibodies in Serum and in an Alternative Diagnostic Sample-The Saliva. Biomolecules 2023 Sep 11;13(9).
- Traversa D, Milillo P, Maggi R, Simonato G, Di Cesare A, Pezzuto C, Grillini M, Morelli S, Colombo M, Passarelli A, Grassano A, Serio P, Losurdo M, Brueckmann R. Seroexposure to Zoonotic Anaplasma and Borrelia in Dogs and Horses That Are in Contact with Vulnerable People in Italy. Pathogens 2023 Mar 16;12(3).
- Zhang J, Ma H, Ai J, Qi T, Kang M, Li J, Sun Y. Serological Analysis of IgG and IgM Antibodies against Anaplasma spp. in Various Animal Species of the Qinghai-Tibetan Plateau. Animals (Basel) 2022 Oct 10;12(19).
- Galon EM, Macalanda AM, Garcia MM, Ibasco CJ, Garvida A, Ji S, Zafar I, Hasegawa Y, Liu M, Ybañez RH, Umemiya-Shirafuji R, Ybañez A, Claveria F, Xuan X. Molecular Identification of Selected Tick-Borne Protozoan and Bacterial Pathogens in Thoroughbred Racehorses in Cavite, Philippines. Pathogens 2021 Oct 13;10(10).
- Seo HJ, Truong AT, Kim KH, Lim JY, Min S, Kim HC, Yoo MS, Yoon SS, Klein TA, Cho YS. Molecular Detection and Phylogenetic Analysis of Tick-Borne Pathogens in Ticks Collected from Horses in the Republic of Korea. Pathogens 2021 Aug 24;10(9).
- Müller BJ, Westheider A, Birkner K, Seelig B, Kirschnek S, Bogdan C, von Loewenich FD. Anaplasma phagocytophilum Induces TLR- and MyD88-Dependent Signaling in In Vitro Generated Murine Neutrophils. Front Cell Infect Microbiol 2021;11:627630.
- Springer A, Glass A, Topp AK, Strube C. Zoonotic Tick-Borne Pathogens in Temperate and Cold Regions of Europe-A Review on the Prevalence in Domestic Animals. Front Vet Sci 2020;7:604910.
- Laamari A, Azzag N, Tennah S, Derdour SY, China B, Bouabdallah R, Ghalmi F. Seroprevalence of Antibodies Against Anaplasma Phagocytophilum and Borrelia Burgdorferi in Horses (Equus Caballus) from Northern Algeria. J Vet Res 2020 Sep;64(3):413-419.
- Langenwalder DB, Schmidt S, Silaghi C, Skuballa J, Pantchev N, Matei IA, Mihalca AD, Gilli U, Zajkowska J, Ganter M, Hoffman T, Salaneck E, Petrovec M, von Loewenich FD. The absence of the drhm gene is not a marker for human-pathogenicity in European Anaplasma phagocytophilum strains. Parasit Vectors 2020 May 7;13(1):238.
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