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PLoS pathogens2026; 22(8); e1014551; doi: 10.1371/journal.ppat.1014551

Equine influenza virus at 70: What horses taught us about flu.

Abstract: No abstract available
Publication Date: 2026-08-28 PubMed ID: 42664214PubMed Central: PMC13524233DOI: 10.1371/journal.ppat.1014551Google Scholar: Lookup
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  • Journal Article

Cite This Article

APA
Mojsiejczuk L, Chambers TM, Murcia PR. (2026). Equine influenza virus at 70: What horses taught us about flu. PLoS Pathog, 22(8), e1014551. https://doi.org/10.1371/journal.ppat.1014551

Publication

ISSN: 1553-7374
NlmUniqueID: 101238921
Country: United States
Language: English
Volume: 22
Issue: 8
Pages: e1014551
PII: e1014551

Researcher Affiliations

Mojsiejczuk, Laura
  • MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
Chambers, Thomas M
  • Department of Veterinary Science, Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, United States of America.
Murcia, Pablo R
  • MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.

Conflict of Interest Statement

The authors have declared that no competing interests exist.

References

This article includes 20 references
  1. Sovinova O, Tumova B, Pouska F, Nemec J. Isolation of a virus causing respiratory disease in horses.. Acta Virol 1958;2(1):52–61.
    pubmed: 13533033
  2. Morens DM, Taubenberger JK. Historical thoughts on influenza viral ecosystems, or behold a pale horse, dead dogs, failing fowl, and sick swine.. Influenza Other Respir Viruses 2010;4(6):327–37.
  3. Furmanski M, Murcia PR. Did horses act as intermediate hosts that facilitated the emergence of 1918 pandemic influenza?. J Infect Dis 2025;232(3):521–4.
    doi: 10.1093/infdis/jiaf197pubmed: 40261008google scholar: lookup
  4. Waddell GH, Teigland MB, Sigel MM. A new influenza virus associated with equine respiratory disease.. J Am Vet Med Assoc 1963;143:587–90.
    pubmed: 14077956
  5. Minuse E, Mcqueen JL, Davenport FM, Francis T Jr. Studies of antibodies to 1956 and 1963 equine influenza viruses in horses and man.. J Immunol 1965;94:563–6.
    doi: 10.4049/jimmunol.94.4.563pubmed: 14299031google scholar: lookup
  6. Lauring AS. Within-host viral diversity: a window into viral evolution.. Annu Rev Virol 2020;7(1):63–81.
  7. Murcia PR, Baillie GJ, Daly J, Elton D, Jervis C, Mumford JA. Intra- and interhost evolutionary dynamics of equine influenza virus.. J Virol 2010;84(14):6943–54.
    doi: 10.1128/JVI.00112-10pmc: PMC2898244pubmed: 20444896google scholar: lookup
  8. Hughes J, Allen RC, Baguelin M, Hampson K, Baillie GJ, Elton D. Transmission of equine influenza virus during an outbreak is characterized by frequent mixed infections and loose transmission bottlenecks.. PLoS Pathog 2012;8(12):e1003081.
  9. Russell CA, Fonville JM, Brown AEX, Burke DF, Smith DL, James SL. The potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host.. Science 2012;336(6088):1541–7.
    doi: 10.1126/science.1222526pmc: PMC3426314pubmed: 22723414google scholar: lookup
  10. McCrone JT, Woods RJ, Martin ET, Malosh RE, Monto AS, Lauring AS. Stochastic processes constrain the within and between host evolution of influenza virus.. Elife 2018;7:e35962.
    doi: 10.7554/eLife.35962pmc: PMC5933925pubmed: 29683424google scholar: lookup
  11. Grenfell BT, Pybus OG, Gog JR, Wood JLN, Daly JM, Mumford JA. Unifying the epidemiological and evolutionary dynamics of pathogens.. Science 2004;303(5656):327–32.
    doi: 10.1126/science.1090727pubmed: 14726583google scholar: lookup
  12. . Epidemiological and evolutionary dynamics of pathogens in time and space.. 2024.
  13. Worobey M, Han G-Z, Rambaut A. A synchronized global sweep of the internal genes of modern avian influenza virus.. Nature 2014;508(7495):254–7.
    doi: 10.1038/nature13016pmc: PMC4098125pubmed: 24531761google scholar: lookup
  14. Crawford PC, Dubovi EJ, Castleman WL, Stephenson I, Gibbs EPJ, Chen L. Transmission of equine influenza virus to dogs.. Science 2005;310(5747):482–5.
    doi: 10.1126/science.1117950pubmed: 16186182google scholar: lookup
  15. Wasik BR, Rothschild E, Voorhees IEH, Reedy SE, Murcia PR, Pusterla N. Understanding the divergent evolution and epidemiology of H3N8 influenza viruses in dogs and horses.. Virus Evol 2023;9(2):vead052.
    doi: 10.1093/ve/vead052pmc: PMC10484056pubmed: 37692894google scholar: lookup
  16. Murcia PR, Wood JLN, Holmes EC. Genome-scale evolution and phylodynamics of equine H3N8 influenza A virus. J Virol 2011;85(11):5312–22.
    doi: 10.1128/JVI.02619-10pmc: PMC3094979pubmed: 21430049google scholar: lookup
  17. Park AW, Daly JM, Lewis NS, Smith DJ, Wood JLN, Grenfell BT. Quantifying the impact of immune escape on transmission dynamics of influenza. Science 2009;326(5953):726–8.
    doi: 10.1126/science.1175980pmc: PMC3800096pubmed: 19900931google scholar: lookup
  18. Garner MG, Scanlan WA, Cowled BD, Carroll A. Regaining Australia’s equine influenza-free status: a national perspective. Aust Vet J 2011;89 Suppl 1:169–73.
  19. Mojsiejczuk L, Whitlock F, Chen H, Magill C, Aranday-Cortes E, Bone J. Multiple introductions of equine influenza virus into the United Kingdom resulted in widespread outbreaks and lineage replacement. PLoS Pathog 2025;21(6):e1013227.
  20. O’Kennedy MM, Reedy SE, Abolnik C, Khan A, Smith T, du Preez I. Protective efficacy of a bivalent equine influenza H3N8 virus-like particle vaccine in horses. Vaccine 2025;50:126861.
    doi: 10.1016/j.vaccine.2025.126861pubmed: 39938315google scholar: lookup

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