Equine motor neuron disease.
Abstract: This article reviews the subject of equine motor neuron disease, a neurodegenerative disease of horses. The authors discuss various topics, including epidemiology, pathophysiology, clinical signs, laboratory findings, diagnosis, and treatment.
Publication Date: 1997-04-01 PubMed ID: 9106346DOI: 10.1016/s0749-0739(17)30258-4Google Scholar: Lookup
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- Journal Article
- Review
Summary
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The article presents a comprehensive review of Equine Motor Neuron Disease (EMND), a neurodegenerative disease chiefly affecting horses. It offers insights into various aspects like its epidemiology, pathophysiology, symptomatic developments, notable laboratory findings, methodologies for diagnosis, and possibilities for treatment.
Epidemiology of Equine Motor Neuron Disease
- The study discusses the prevalence of EMND. While the disease can affect horses of all ages, it primarily affects adult horses.
- The distribution and frequency of the disease, specifics about demographic characteristics of the affected population, and any known risk factors associated with the disease are explored.
Pathophysiology of Equine Motor Neuron Disease
- The authors delve into understanding the disease processes, from origin to progression, or pathophysiology, of EMND.
- They present detailed information on the physiological alterations in the neurons of horses suffering from EMND and how this leads to the observed clinical signs.
Clinical Signs of Equine Motor Neuron Disease
- The researchers provide a comprehensive discussion of various clinical signs that veterinarians should look for.
- Typical signs may include weight loss, muscle weakness, or tremors. A comprehensive list would assist in the early detection of this disease.
Lab Findings for Equine Motor Neuron Disease
- The authors review any specific laboratory findings that may be indicative of a horse suffering from EMND.
- These might include specific bio-markers, blood test results, or image analysis results, which could contribute to a more precise diagnosis.
Diagnosis of Equine Motor Neuron Disease
- A thorough overview of various diagnostic methods is provided, discussing their efficacy and applicability.
- These methods could involve analysis of clinical signs, lab findings, and imaging studies, possibly combined with the horse’s medical history.
Treatment of Equine Motor Neuron Disease
- Finally, the paper explores potential treatment options available for EMND.
- These might involve medical interventions, supportive care, or therapy, and the research indicates the potential effectiveness of these treatment options.
Cite This Article
APA
Divers TJ, Mohammed HO, Cummings JF.
(1997).
Equine motor neuron disease.
Vet Clin North Am Equine Pract, 13(1), 97-105.
https://doi.org/10.1016/s0749-0739(17)30258-4 Publication
Researcher Affiliations
- Department of Clinical Science, Cornell University College of Veterinary Medicine, Ithaca, New York, USA.
MeSH Terms
- Animals
- Horse Diseases / diagnosis
- Horse Diseases / drug therapy
- Horse Diseases / physiopathology
- Horses
- Motor Neuron Disease / diagnosis
- Motor Neuron Disease / physiopathology
- Motor Neuron Disease / veterinary
- Vitamin E / blood
- Vitamin E / therapeutic use
Citations
This article has been cited 7 times.- Gellman K, Ruina A. Standing horse posture: a longer stance is more stable.. Biol Open 2022 Apr 15;11(4).
- Fernández-Ruiz J. The biomedical challenge of neurodegenerative disorders: an opportunity for cannabinoid-based therapies to improve on the poor current therapeutic outcomes.. Br J Pharmacol 2019 May;176(10):1370-1383.
- Husulak ML, Lohmann KL, Gabadage K, Wojnarowicz C, Marqués FJ. Equine motor neuron disease in 2 horses from Saskatchewan.. Can Vet J 2016 Jul;57(7):771-6.
- Díez de Castro E, Zafra R, Acevedo LM, Pérez J, Acosta I, Rivero JL, Aguilera-Tejero E. Eosinophilic Enteritis in Horses with Motor Neuron Disease.. J Vet Intern Med 2016 May;30(3):873-9.
- Luján L, Pérez M, Salazar E, Álvarez N, Gimeno M, Pinczowski P, Irusta S, Santamaría J, Insausti N, Cortés Y, Figueras L, Cuartielles I, Vila M, Fantova E, Chapullé JL. Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep.. Immunol Res 2013 Jul;56(2-3):317-24.
- Delguste C, de Moffarts B, Kirschvink N, Art T, Pincemail J, Defraigne JO, Amory H, Lekeux P. Change in blood antioxidant status of horses moved from a stable following diagnosis of equine motor neuron disease.. Can Vet J 2007 Nov;48(11):1165-7.
- Mohammed HO, Divers TJ, Summers BA, de Lahunta A. Vitamin E deficiency and risk of equine motor neuron disease.. Acta Vet Scand 2007 Jul 2;49(1):17.
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