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Home / Equine Research Bank / Vet Clin North Am Equine Pract / Equine pituitary pars intermedia dysfunction.
The Veterinary clinics of North America. Equine practice2011; 27(1); 93-113; doi: 10.1016/j.cveq.2010.12.007

Equine pituitary pars intermedia dysfunction.

Abstract: Equine pituitary pars intermedia dysfunction (PPID), also known as equine Cushing's syndrome, is a widely recognized disease of aged horses. Over the past two decades, the aged horse population has expanded significantly and in addition, client awareness of PPID has increased. As a result, there has been an increase in both diagnostic testing and treatment of the disease. This review focuses on the pathophysiology and clinical syndrome, as well as advances in diagnostic testing and treatment of PPID, with an emphasis on those findings that are new since the excellent comprehensive review by Schott in 2002.
Copyright © 2011 Elsevier Inc. All rights reserved.
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Publication Date: 2011-03-12 PubMed ID: 21392656DOI: 10.1016/j.cveq.2010.12.007Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research mainly focuses on the prevalent disease in aged horses: equine pituitary pars intermedia dysfunction (PPID), or equine Cushing’s syndrome. The researchers have observed a surge in diagnosis and treatment due to the rise in an aged horse population and increased awareness about PPID.

Introduction to Equine Pituitary Pars Intermedia Dysfunction

  • Equine pituitary pars intermedia dysfunction (PPID), commonly referred to as equine Cushing’s syndrome, represents a significant illness affecting elderly horses. It is a hormonal disorder caused by an increase in the size and activity of the middle lobe of the equine pituitary gland.
  • Over the past twenty years, not only has the aged horse population increased, but horse owners’ awareness about equine PPID has also soared. This has given rise to a higher number of diagnostic tests being conducted and treatments being administered to tackle this disease.

Pathophysiology and Clinical Syndrome of PPID

  • The paper discusses the pathophysiology and the clinical syndrome of PPID. This implies studying the dysfunction of the pituitary gland, leading to the disease, and the subsequent clinical presentations in horses.
  • PPID is typically characterized by an overgrowth or adenoma of the pituitary gland, causing an excess production of certain hormones leading to various symptoms. The most common signs include abnormal hair growth, weight loss, laminitis, increased thirst and urination, among others.

Advancements in Diagnostic Testing and Treatment

  • A highlight of the research lies in covering the developments in diagnostic testing and treatments for PPID since Schott’s detailed review in 2002.
  • The study underscores the importance of early diagnosis and effective treatments to curb the progression of the disease and maintain the horse’s quality of life.
  • While traditional methods like visual observation of physical signs and endocrine testing are still in use, newer methods, possibly including Plasmatic ACTH concentration measurement, might be discussed since their release post Schott’s review.
  • Appropriate treatments typically involve medication, dietary management, and treating secondary conditions. The advancements in these could be crucial in managing the disease more effectively.

Cite This Article

APA
McFarlane D. (2011). Equine pituitary pars intermedia dysfunction. Vet Clin North Am Equine Pract, 27(1), 93-113. https://doi.org/10.1016/j.cveq.2010.12.007

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 27
Issue: 1
Pages: 93-113

Researcher Affiliations

McFarlane, Dianne
  • Department of Physiological Sciences, 264 McElroy Hall, Oklahoma State University, Stillwater, OK 74078, USA. diannem@okstate.edu

MeSH Terms

  • Aging
  • Animals
  • Diet / veterinary
  • Dopamine Agonists / therapeutic use
  • Female
  • Horse Diseases / diagnosis
  • Horse Diseases / therapy
  • Horses
  • Male
  • Pergolide / therapeutic use
  • Pituitary Diseases / diagnosis
  • Pituitary Diseases / therapy
  • Pituitary Diseases / veterinary
  • Pituitary Gland, Intermediate / anatomy & histology
  • Pituitary Gland, Intermediate / physiopathology

Citations

This article has been cited 36 times.
  1. Zapf AM, Fey K, Büttner K, Gröf M, Staszyk C. Periodontal structures in horses with pituitary pars intermedia dysfunction: A histological evaluation. Front Vet Sci 2023;10:1114445.
    doi: 10.3389/fvets.2023.1114445pubmed: 36733635google scholar: lookup
  2. Kirkwood NC, Hughes KJ, Stewart AJ. Prospective Case Series of Clinical Signs and Adrenocorticotrophin (ACTH) Concentrations in Seven Horses Transitioning to Pituitary Pars Intermedia Dysfunction (PPID). Vet Sci 2022 Oct 17;9(10).
    doi: 10.3390/vetsci9100572pubmed: 36288186google scholar: lookup
  3. Kirkwood NC, Hughes KJ, Stewart AJ. Pituitary Pars Intermedia Dysfunction (PPID) in Horses. Vet Sci 2022 Oct 10;9(10).
    doi: 10.3390/vetsci9100556pubmed: 36288169google scholar: lookup
  4. Humphreys S, Kass PH, Magdesian KG, Goodrich E, Berryhill E. Seasonal variation of endogenous adrenocorticotropic hormone concentrations in healthy non-geriatric donkeys in Northern California. Front Vet Sci 2022;9:981920.
    doi: 10.3389/fvets.2022.981920pubmed: 36032308google scholar: lookup
  5. Desanti-Consoli H, Bouillon J, Chapuis RJJ. Equids' Core Vaccines Guidelines in North America: Considerations and Prospective. Vaccines (Basel) 2022 Mar 4;10(3).
    doi: 10.3390/vaccines10030398pubmed: 35335029google scholar: lookup
  6. Nitzsche AM, Fey K, Büttner K, Gröf M, Staszyk C. The Gingiva of Horses With Pituitary Pars Intermedia Dysfunction: A Macroscopic Anatomical Evaluation. Front Vet Sci 2021;8:786971.
    doi: 10.3389/fvets.2021.786971pubmed: 35146012google scholar: lookup
  7. Sillence M, Meier A, de Laat M, Klee R, Reiche D. Demographic, morphologic, hormonal and metabolic factors associated with the rate of improvement from equine hyperinsulinaemia-associated laminitis. BMC Vet Res 2022 Jan 18;18(1):49.
    doi: 10.1186/s12917-022-03149-zpubmed: 35042535google scholar: lookup
  8. Kam YN, McKenzie K, Coyle M, Bertin FR. Repeatability of a thyrotropin-releasing hormone stimulation test for diagnosis of pituitary pars intermedia dysfunction in mature horses. J Vet Intern Med 2021 Nov;35(6):2885-2890.
    doi: 10.1111/jvim.16281pubmed: 34642962google scholar: lookup
  9. Gehlen H, Fisch J, Merle R, Trachsel DS. Preliminary study on the effects of pergolide on left ventricular function in the horses with pituitary pars intermedia dysfunction. J Vet Sci 2021 Sep;22(5):e64.
    doi: 10.4142/jvs.2021.22.e64pubmed: 34553515google scholar: lookup
  10. Dunkel B, Knowles EJ, Chang YM, Menzies-Gow NJ. Influence of endocrine disease on l-lactate concentrations in blood of ponies. J Vet Intern Med 2021 May;35(3):1582-1588.
    doi: 10.1111/jvim.16079pubmed: 34043845google scholar: lookup
  11. Hicks GR, Fraser NS, Bertin FR. Changes Associated with the Peri-Ovulatory Period, Age and Pregnancy in ACTH, Cortisol, Glucose and Insulin Concentrations in Mares. Animals (Basel) 2021 Mar 20;11(3).
    doi: 10.3390/ani11030891pubmed: 33804751google scholar: lookup
  12. Satué K, Fazio E, Muñoz A, Medica P. Endocrine and Electrolyte Balances during Periovulatory Period in Cycling Mares. Animals (Basel) 2021 Feb 17;11(2).
    doi: 10.3390/ani11020520pubmed: 33671405google scholar: lookup
  13. Tatum RC, McGowan CM, Dean RS, Ireland JL. Equine pituitary pars intermedia dysfunction: Identifying research priorities for diagnosis, treatment and prognosis through a priority setting partnership. PLoS One 2021;16(1):e0244784.
    doi: 10.1371/journal.pone.0244784pubmed: 33395695google scholar: lookup
  14. Gehlen H, Schwarz B, Bartmann C, Gernhardt J, Stöckle SD. Pituitary Pars Intermedia Dysfunction and Metabolic Syndrome in Donkeys. Animals (Basel) 2020 Dec 8;10(12).
    doi: 10.3390/ani10122335pubmed: 33302557google scholar: lookup
  15. Rahnama S, Vathsangam N, Spence R, Medina-Torres CE, Pollitt CC, de Laat MA, Bailey SR, Sillence MN. Effects of an anti-IGF-1 receptor monoclonal antibody on laminitis induced by prolonged hyperinsulinaemia in Standardbred horses. PLoS One 2020;15(9):e0239261.
    doi: 10.1371/journal.pone.0239261pubmed: 32991593google scholar: lookup
  16. Fortin JS, Benskey MJ, Lookingland KJ, Patterson JS, Howey EB, Goudreau JL, Schott HC 2nd. Restoring pars intermedia dopamine concentrations and tyrosine hydroxylase expression levels with pergolide: evidence from horses with pituitary pars intermedia dysfunction. BMC Vet Res 2020 Sep 25;16(1):356.
    doi: 10.1186/s12917-020-02565-3pubmed: 32977825google scholar: lookup
  17. Gehlen H, Jaburg N, Merle R, Winter J. Can Endocrine Dysfunction Be Reliably Tested in Aged Horses That Are Experiencing Pain?. Animals (Basel) 2020 Aug 14;10(8).
    doi: 10.3390/ani10081426pubmed: 32824027google scholar: lookup
  18. Żak A, Siwińska N, Chełmecka E, Bażanów B, Romuk E, Adams A, Niedźwiedź A, Stygar D. Effects of Advanced Age, Pituitary Pars Intermedia Dysfunction and Insulin Dysregulation on Serum Antioxidant Markers in Horses. Antioxidants (Basel) 2020 May 21;9(5).
    doi: 10.3390/antiox9050444pubmed: 32455574google scholar: lookup
  19. Hu K, Stewart AJ, Yuen KY, Hinrichsen S, Dryburgh EL, Bertin FR. The effect of freeze-thaw cycles on determination of immunoreactive plasma adrenocorticotrophic hormone concentrations in horses. J Vet Intern Med 2020 May;34(3):1350-1356.
    doi: 10.1111/jvim.15771pubmed: 32255541google scholar: lookup
  20. Horn R, Bertin FR. Evaluation of combined testing to simultaneously diagnose pituitary pars intermedia dysfunction and insulin dysregulation in horses. J Vet Intern Med 2019 Sep;33(5):2249-2256.
    doi: 10.1111/jvim.15617pubmed: 31498947google scholar: lookup
  21. Shepard KN, Haffner JC, Neal DL, Grubbs ST, Pearce GL. Effect of delayed plasma centrifugation on equine adrenocorticotropic hormone concentration. J Vet Diagn Invest 2019 Jul;31(4):585-587.
    doi: 10.1177/1040638719860877pubmed: 31246158google scholar: lookup
  22. de Laat MA, Sillence MN, Reiche DB. Phenotypic, hormonal, and clinical characteristics of equine endocrinopathic laminitis. J Vet Intern Med 2019 May;33(3):1456-1463.
    doi: 10.1111/jvim.15419pubmed: 30697823google scholar: lookup
  23. Spelta CW. Equine pituitary pars intermedia dysfunction: current perspectives on diagnosis and management. Vet Med (Auckl) 2015;6:293-300.
    doi: 10.2147/VMRR.S74191pubmed: 30101114google scholar: lookup
  24. Lewis SL, Holl HM, Long MT, Mallicote MF, Brooks SA. Use of principle component analysis to quantitatively score the equine metabolic syndrome phenotype in an Arabian horse population. PLoS One 2018;13(7):e0200583.
    doi: 10.1371/journal.pone.0200583pubmed: 30001422google scholar: lookup
  25. Bertin FR, Ruffin-Taylor D, Stewart AJ. Insulin dysregulation in horses with systemic inflammatory response syndrome. J Vet Intern Med 2018 Jul;32(4):1420-1427.
    doi: 10.1111/jvim.15138pubmed: 29749643google scholar: lookup
  26. Warnken T, Delarocque J, Schumacher S, Huber K, Feige K. Retrospective analysis of insulin responses to standard dosed oral glucose tests (OGTs) via naso-gastric tubing towards definition of an objective cut-off value. Acta Vet Scand 2018 Jan 19;60(1):4.
    doi: 10.1186/s13028-018-0358-8pubmed: 29351765google scholar: lookup
  27. Banse HE, Schultz N, McCue M, Geor R, McFarlane D. Comparison of two methods for measurement of equine adrenocorticotropin. J Vet Diagn Invest 2018 Mar;30(2):233-237.
    doi: 10.1177/1040638717752216pubmed: 29284383google scholar: lookup
  28. Carmalt JL, Scansen BA. Development of two surgical approaches to the pituitary gland in the Horse. Vet Q 2018 Dec;38(1):21-27.
    doi: 10.1080/01652176.2017.1415488pubmed: 29219746google scholar: lookup
  29. Hart KA, Wochele DM, Norton NA, McFarlane D, Wooldridge AA, Frank N. Effect of Age, Season, Body Condition, and Endocrine Status on Serum Free Cortisol Fraction and Insulin Concentration in Horses. J Vet Intern Med 2016 Mar-Apr;30(2):653-63.
    doi: 10.1111/jvim.13839pubmed: 26860336google scholar: lookup
  30. Ohmes CM, Davis EG, Beard LA, Vander Werf KA, Bianco AW, Giger U. Transient Fanconi syndrome in Quarter horses. Can Vet J 2014 Feb;55(2):147-51.
    pubmed: 24489393
  31. Radin MJ, Yu MJ, Stoedkilde L, Miller RL, Hoffert JD, Frokiaer J, Pisitkun T, Knepper MA. Aquaporin-2 regulation in health and disease. Vet Clin Pathol 2012 Dec;41(4):455-70.
    doi: 10.1111/j.1939-165x.2012.00488.xpubmed: 23130944google scholar: lookup
  32. Parmantier S, Kyriazopoulou P, McClendon M, Adams A, Murphy BA. Influence of Extended Photoperiod Using Blue Light Masks on Hypertrichosis, Coat Condition and General Health Parameters in Horses with Pituitary Pars Intermedia Dysfunction. Animals (Basel) 2025 Oct 5;15(19).
    doi: 10.3390/ani15192905pubmed: 41096500google scholar: lookup
  33. Schott HC 2nd, Strachota JR, Marteniuk JV, Refsal KR. Long-Term Response of Equids With Pituitary Pars Intermedia Dysfunction to Treatment With Pergolide. J Vet Intern Med 2025 May-Jun;39(3):e70109.
    doi: 10.1111/jvim.70109pubmed: 40317948google scholar: lookup
  34. Vaughn SA, Lemons MB, Hart KA. The Effect of Season and Breed on Hypothalamic-Pituitary-Adrenal Axis Hormones, Metabolic Hormones, and Oxidative Markers in Ponies and Horses. J Vet Intern Med 2025 Mar-Apr;39(2):e70047.
    doi: 10.1111/jvim.70047pubmed: 40048369google scholar: lookup
  35. Sundra T, Kelty E, Rossi G, Rendle D. Retrospective assessment of the use of extended-release cabergoline in the management of equine pituitary pars intermedia dysfunction. Front Vet Sci 2024;11:1332337.
    doi: 10.3389/fvets.2024.1332337pubmed: 38511195google scholar: lookup
  36. Takahashi N, Chambers JK, Ota K, Toda K, Yoshimoto Y, Miyajima U, Uchida K. Pituitary pars intermedia dysfunction with pituitary gland melanotroph adenoma in a Grevy's zebra (Equus grevyi). J Vet Med Sci 2024 Jan 10;86(1):71-76.
    doi: 10.1292/jvms.23-0177pubmed: 37981318google scholar: lookup
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