Equine recurrent uveitis: new methods of management.
Abstract: Equine recurrent uveitis (ERU) is one of the most common causes of blindness in horses. Until recently, treatment of this condition consisted only of symptomatic therapy, typically with steroidal and nonsteroidal medications. A better understanding of the disease process(es) has permitted new medical and surgical therapies that have recently been described. This article highlights clinical features of ERU, the causes of ERU, and new management and treatment options for horses with ERU.
Publication Date: 2004-07-24 PubMed ID: 15271431DOI: 10.1016/j.cveq.2004.04.010Google Scholar: Lookup
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Summary
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This research article focuses on equine recurrent uveitis (ERU), a common cause of blindness in horses. The paper reviews improved understanding of the disease and the new treatment and management strategies that have emerged as a result.
Understanding Equine Recurrent Uveitis (ERU)
- The initial part of the research paper delves into equine recurrent uveitis, a medical condition in horses that repeatedly inflames their uvea. This is a significant issue in equine health since it is a leading cause of blindness.
Previous Treatment Approaches
- The article discusses the past treatment methods for ERU. Formerly, the treatment was primarily aimed at managing symptoms, as the disease’s cause and progression were not fully understood.
- Typical treatments included both steroidal and nonsteroidal medications. These drugs were intended to alleviate inflammation and pain associated with ERU but did not address the root cause.
New Insights into Disease Processes
- The paper sheds light on research that has led to a better comprehension of the disease processes involved in ERU. These insights have facilitated development of more targeted and effective treatment strategies.
New Treatments and Management Methods
- Rather than simply managing symptoms, the new approach to ERU treatment considers the whole disease process. This includes addressing the root causes of the inflammation to prevent recurring episodes.
- The article underscores the introduction of new medical and surgical therapies for ERU. The specifics of these treatment options are not outlined in the abstract, but the mention implies that these advances have been significant.
- This research paper is particularly valuable for veterinarians and horse owners alike, as it provides an updated overview of strategies for managing and treating ERU.
Cite This Article
APA
Gilger BC, Michau TM.
(2004).
Equine recurrent uveitis: new methods of management.
Vet Clin North Am Equine Pract, 20(2), 417-vii.
https://doi.org/10.1016/j.cveq.2004.04.010 Publication
Researcher Affiliations
- Department of Ophthalmology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. Brian_Gilger@ncsu.edu
MeSH Terms
- Animals
- Blindness / etiology
- Blindness / veterinary
- Horse Diseases / pathology
- Horse Diseases / surgery
- Horse Diseases / therapy
- Horses
- Recurrence
- Uveitis / pathology
- Uveitis / surgery
- Uveitis / therapy
- Uveitis / veterinary
- Vitrectomy / veterinary
References
This article includes 22 references
Citations
This article has been cited 16 times.- Sprenzel CJ, Amann B, Deeg CA, Degroote RL. Glycan Signatures on Neutrophils in an Equine Model for Autoimmune Uveitis. Biomolecules 2025 Oct 12;15(10).
- Stafford LS, Plummer CE, Smith WC, Gibson DJ, Sharma J, Vicuna V, Diakite S, Larkin J 3rd. A peptide mimic of SOCS1 modulates equine peripheral immune cells in vitro and ocular effector functions in vivo: implications for recurrent uveitis. Front Immunol 2024;15:1513157.
- Söth R, Hoffmann ALC, Deeg CA. Enhanced ROS Production and Mitochondrial Metabolic Shifts in CD4(+) T Cells of an Autoimmune Uveitis Model. Int J Mol Sci 2024 Oct 26;25(21).
- Morén S, Kallberg M, Strom L. Equine uveitis: Outcome and adverse effects after one or two intravitreal low-dose gentamicin injections. Equine Vet J 2025 Jan;57(1):160-168.
- Degroote RL, Schmalen A, Hauck SM, Deeg CA. Unveiling Differential Responses of Granulocytes to Distinct Immunostimulants with Implications in Autoimmune Uveitis. Biomedicines 2023 Dec 20;12(1).
- Padjasek M, Qasem B, Cisło-Pakuluk A, Marycz K. Cyclosporine A Delivery Platform for Veterinary Ophthalmology-A New Concept for Advanced Ophthalmology. Biomolecules 2022 Oct 20;12(10).
- Hoffmann ALC, Hauck SM, Deeg CA, Degroote RL. Pre-Activated Granulocytes from an Autoimmune Uveitis Model Show Divergent Pathway Activation Profiles upon IL8 Stimulation In Vitro. Int J Mol Sci 2022 Aug 23;23(17).
- Plummer CE, Polk T, Sharma J, Bae SS, Barr O, Jones A, Kitchen H, Wilhelmy M, Devin K, Clay Smith W, Kolaczkowski BD, Larkin J 3rd. Open label safety and efficacy pilot to study mitigation of equine recurrent uveitis through topical suppressor of cytokine signaling-1 mimetic peptide. Sci Rep 2022 May 3;12(1):7177.
- Hermans H, van den Berg EMH, Slenter IJM, Vendrig DJC, de Nijs-Tjon LJL, Vernooij JCM, Brommer H, Boevé MH, Gehring R. Penetration of topically administered dexamethasone disodium phosphate and prednisolone acetate into the normal equine ocular fluids. Equine Vet J 2022 Sep;54(5):965-972.
- MacDonald ES, Barrett JG. The Potential of Mesenchymal Stem Cells to Treat Systemic Inflammation in Horses. Front Vet Sci 2019;6:507.
- Fischer BM, McMullen RJ Jr, Reese S, Brehm W. Intravitreal injection of low-dose gentamicin for the treatment of recurrent or persistent uveitis in horses: Preliminary results. BMC Vet Res 2019 Jan 16;15(1):29.
- Schauer M, Kleinwort KJH, Degroote RL, Wiedemann C, Kremmer E, Hauck SM, Deeg CA. Interaction of septin 7 and DOCK8 in equine lymphocytes reveals novel insights into signaling pathways associated with autoimmunity. Sci Rep 2018 Aug 17;8(1):12332.
- Degroote RL, Hauck SM, Amann B, Hirmer S, Ueffing M, Deeg CA. Unraveling the equine lymphocyte proteome: differential septin 7 expression associates with immune cells in equine recurrent uveitis. PLoS One 2014;9(3):e91684.
- Sandmeyer LS, Bauer BS, Grahn BH. Diagnostic ophthalmology. Anterior uveitis of the right eye. Can Vet J 2013 Sep;54(9):897-8.
- Verma A, Kumar P, Babb K, Timoney JF, Stevenson B. Cross-reactivity of antibodies against leptospiral recurrent uveitis-associated proteins A and B (LruA and LruB) with eye proteins. PLoS Negl Trop Dis 2010 Aug 3;4(8):e778.
- Verma A, Artiushin S, Matsunaga J, Haake DA, Timoney JF. LruA and LruB, novel lipoproteins of pathogenic Leptospira interrogans associated with equine recurrent uveitis. Infect Immun 2005 Nov;73(11):7259-66.
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