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Home / Equine Research Bank / Toxins (Basel) / Evaluation of Inner Exposure of Horses to Zearalenone (ZEN),...
Toxins2021; 13(8); 588; doi: 10.3390/toxins13080588

Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits.

Abstract: Mycotoxin contaminated feed has been associated with colic of horses caused by intestinal disorders. Whether such disease conditions alter the intestinal toxin metabolism and transfer across a compromised mucosal barrier is unknown. A screening approach was used to relate blood residue levels of DON, ZEN and their metabolites to the status of the horses (sick vs. healthy). A total of 55 clinically healthy horses from 6 different farms with varying feeding background served as control for sick horses (N = 102) hospitalized due to colic. ZEN, alpha-zearalenol (ZEL), beta-ZEL and DON were detectable in peripheral blood as indicators for the inner exposure with significant farm effects for alpha- and beta-ZEL. However, the levels in sick horses were similar to all farms. Moreover, the proportion of beta-ZEL of all detected ZEN metabolites as an indicator for the degree of metabolism of ZEN was not different for sick horses but differed amongst the control farms. Although the incidence of DON in blood was generally low and not significantly different amongst healthy and sick horses, the positive samples were nearly exclusively found in sick horses suggesting either a higher toxin transfer, an association of DON with the development of colic or a different feeding background.
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Publication Date: 2021-08-23 PubMed ID: 34437459PubMed Central: PMC8402592DOI: 10.3390/toxins13080588Google Scholar: Lookup
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  • Comparative Study
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the relationship between mycotoxin-contaminated feed and colic in horses. The study compared the presence of certain toxins in the blood between healthy horses and those suffering from colic.

Study Design and Population

  • The research employed a screening approach to investigate the difference in toxin levels between healthy and unhealthy horses.
  • The study looked at 55 clinically healthy horses from six different farms with varied feeding backgrounds, using them as a control group. These were contrasted with a group of 102 sick horses which were hospitalized because of colic.

Toxins Detected in Peripheral Blood

  • The toxins evaluated were Zearalenone (ZEN), Deoxynivalenol (DON) and their metabolites including alpha-zearalenol (ZEL) and beta-ZEL.
  • These toxins were detectable in the peripheral blood of the horses in the study, which served as indicators of the internal exposure of the horses to these toxins.
  • Significant farm effects were found for alpha- and beta-ZEL, but the sick horses had similar levels to those from every farm.

Degree of Metabolism of ZEN

  • The proportion of beta-ZEL of all detected ZEN metabolites, as an indicator for the degree of metabolism of ZEN, was not different for sick horses, but it varied amongst the farms used for the control group.

Incidence of DON in Blood

  • The incidence of DON present in the blood was generally low and there was no significant difference between healthy and sick horses.
  • However, of the samples that were positive for DON, nearly all came from sick horses.
  • The researchers propose that this might suggest a higher toxin transfer or an association of DON with the development of colic or a different feeding background.

Cite This Article

APA
(2021). Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits. Toxins (Basel), 13(8), 588. https://doi.org/10.3390/toxins13080588

Publication

Toxins
ISSN: 2072-6651
NlmUniqueID: 101530765
Country: Switzerland
Language: English
Volume: 13
Issue: 8
PII: 588

Researcher Affiliations

MeSH Terms

  • Animal Feed / analysis
  • Animal Feed / microbiology
  • Animals
  • Blood Chemical Analysis
  • Colic / chemically induced
  • Horses
  • Mycotoxins / blood
  • Mycotoxins / metabolism
  • Mycotoxins / toxicity
  • Trichothecenes / blood
  • Trichothecenes / metabolism
  • Trichothecenes / toxicity
  • Zearalenone / blood
  • Zearalenone / metabolism
  • Zearalenone / toxicity

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 1 times.
  1. Satué K, Miguel-Pastor L, Chicharro D, Gardón JC. Hepatic Enzyme Profile in Horses.. Animals (Basel) 2022 Mar 29;12(7).
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