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Animals : an open access journal from MDPI2024; 14(22); 3308; doi: 10.3390/ani14223308

Evaluation of Recovery Time and Quality After Two Different Post-Operative Doses of Medetomidine in Spanish Purebred Horses Anaesthetized with Medetomidine-Isoflurane Partial Intravenous Anaesthesia.

Abstract: Recovery from general anaesthesia is risky in horses. Alpha-agonist administration after anaesthesia enhances the quality of recovery but may prolong this phase. Recovery time and quality were investigated after medetomidine administration at the end of general anaesthesia in a prospective, randomised, masked and clinical study. Horses underwent medetomidine-isoflurane partial intravenous anaesthesia. Medetomidine (0.5 or 1 µg/kg) IV was administered just after isoflurane was discontinued. The duration of different recovery phases and the number of attempts were recorded. A composite scale (from 1-excellent to 6-accident) was used for quality assessment. Mann-Whitney U-test was performed ( < 0.05). Twenty-seven horses per group were included. Results for 0.5 and 1 µg/kg groups were as follows: lateral recumbency time: 35 (24-45) and 43 (35-55) minutes; sternal recumbency time: 6 (3-15) and 5 (2-15) minutes; total recovery time: 47 (40-59) and 49 (42-62) minutes; number of attempts to sternal: 1 (1-1) and 1 (1-2) and to standing: 1 (1-3) and 1 (1-2); and, quality: 2 (1-2) and 2 (1-2), respectively. No significant differences between the groups were found. Medetomidine 0.5 µg/kg dose did not decrease the recovery time but maintained the recovery quality.
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Publication Date: 2024-11-18 PubMed ID: 39595360PubMed Central: PMC11591359DOI: 10.3390/ani14223308Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores the effectiveness of two different doses of medetomidine in aiding recovery after anesthesia in horses. The study finds that a lower dose of medetomidine does not shorten the recovery time but maintains the quality of recovery.

Study Design and Execution

  • The research was a prospective, randomized, and clinically supervised study.
  • The team used horses undergoing medetomidine-isoflurane partial intravenous anesthesia.
  • After discontinuation of isoflurane, medetomidine was administered intravenously at two different doses: 0.5 µg/kg and 1 µg/kg.
  • The duration of different recovery phases and the number of attempts to reach a full standing position was closely monitored and recorded.

Assessment Methods

  • The researchers used a composite scale to assess the quality of recovery. The scale ranged from 1 (excellent) to 6 (accident).
  • Mann-Whitney U-test, a statistical method for comparing independent data samples, was utilized to analyze the results (P < 0.05).
  • The sample included 27 horses for each dosage group.

Key Findings

  • According to the results, the 0.5 µg/kg dosage group experienced 35 (24-45) minutes of lateral recumbency time, 6 (3-15) minutes of sternal recumbency time, and 47 (40-59) minutes total recovery time.
  • On the other hand, the 1 µg/kg group had a lateral recumbency time of 43 (35-55) minutes, sternal recumbency time of 5 (2-15) minutes, and total recovery time of 49 (42-62) minutes.
  • The number of attempts it took for the horse to reach a sternal and standing position also did not significantly differ between the two groups.
  • When using the composite scale, both dosage groups yielded a score of 2, indicating a high-quality recovery.
  • There were no significant differences between the two groups with regards to recovery durations or the quality of recovery.

Conclusion

  • The study concluded that a dose of 0.5 µg/kg of medetomidine does not decrease the recovery time when compared to a 1 µg/kg dose.
  • Importantly, the administration of the lower dosage maintained the quality of the horses’ recovery, making it a viable option in post-operative care.

Cite This Article

APA
Medina-Bautista F, Morgaz J, Domínguez JM, Navarrete-Calvo R, Sánchez de Medina A, Quirós-Carmona S, Granados MDM. (2024). Evaluation of Recovery Time and Quality After Two Different Post-Operative Doses of Medetomidine in Spanish Purebred Horses Anaesthetized with Medetomidine-Isoflurane Partial Intravenous Anaesthesia. Animals (Basel), 14(22), 3308. https://doi.org/10.3390/ani14223308

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 14
Issue: 22
PII: 3308

Researcher Affiliations

Medina-Bautista, Francisco
  • Section Anaesthesiology, Department of Animal Medicine and Surgery, Veterinary Teaching Hospital, University of Córdoba, 14014 Córdoba, Spain.
Morgaz, Juan
  • Section Anaesthesiology, Department of Animal Medicine and Surgery, Veterinary Teaching Hospital, University of Córdoba, 14014 Córdoba, Spain.
Domínguez, Juan Manuel
  • Section Anaesthesiology, Department of Animal Medicine and Surgery, Veterinary Teaching Hospital, University of Córdoba, 14014 Córdoba, Spain.
Navarrete-Calvo, Rocío
  • Section Anaesthesiology, Department of Animal Medicine and Surgery, Veterinary Teaching Hospital, University of Córdoba, 14014 Córdoba, Spain.
Sánchez de Medina, Antonia
  • Section Anaesthesiology, Department of Animal Medicine and Surgery, Veterinary Teaching Hospital, University of Córdoba, 14014 Córdoba, Spain.
Quirós-Carmona, Setefilla
  • Section Anaesthesiology, Department of Animal Medicine and Surgery, Veterinary Teaching Hospital, University of Córdoba, 14014 Córdoba, Spain.
Granados, María Del Mar
  • Section Anaesthesiology, Department of Animal Medicine and Surgery, Veterinary Teaching Hospital, University of Córdoba, 14014 Córdoba, Spain.

Conflict of Interest Statement

The authors declare no conflicts of interest.

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