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Home / Equine Research Bank / Equine Vet J Suppl / Evidence of an association between inflammatory airway disea...
Equine veterinary journal. Supplement2002; (34); 417-424; doi: 10.1111/j.2042-3306.2002.tb05459.x

Evidence of an association between inflammatory airway disease and EIPH in young Thoroughbreds during training.

Abstract: In an epidemiological study of risk factors for exercise-induced pulmonary haemorrhage (EIPH) in young Thoroughbreds in the UK, in which 148 horses contributed 1614 horse-months of data, there were 64 (4%) episodes of endoscopically visible tracheal bleeding and 824 (51%) episodes of increased quantities of haemosiderophages in tracheal washes. There were increases in prevalence and risk of EIPH by both definitions with age from or = 4 years, season of sampling from winter (Nov-Jan) to autumn (Aug-Oct) and several different measures of airway inflammation, including tracheal mucus, neutrophil proportion, inflammation score and fungal material in tracheal washes. There was considerable variability in the prevalence of EIPH between trainers. EIPH in the preceding month significantly increased the risk of the condition the following month. There was no evidence that EIPH was associated with infection of the airways with even large numbers of Streptococcus zooepidemicus or Pasteurella-like spp., which are significantly associated with airway inflammation in younger racehorses. Multiple logistic regression modelling that took account of random variability between horses and the effects of each trainer and an episode the preceding month, confirmed that after controlling for the other risk factors, EIPH was still significantly associated with increasing age, different seasons, airway inflammation and evidence of airway fungal material.
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Publication Date: 2002-10-31 PubMed ID: 12405727DOI: 10.1111/j.2042-3306.2002.tb05459.xGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The paper investigates the link between inflammatory airway disease and exercise-induced pulmonary haemorrhage (EIPH) in young Thoroughbreds. It suggests an increased prevalence and risk of EIPH with age, season, and different measures of airway inflammation.

Study Participants and Data Collected

  • 148 young Thoroughbred horses contributed to the study, providing 1614 horse-months of data.
  • A total of 64 instances of visible tracheal bleeding were recorded, representing 4% of the cases.
  • Increased quantities of haemosiderophages were found in tracheal washes in 824 occasions, which accounted for 51% of the cases.

Prevalence and Risk of EIPH

  • The findings indicated an increased prevalence and risk of EIPH as horses aged from 2 to 4 years.
  • The season was also found to impact the prevalence of EIPH, increasing from winter to autumn.
  • Several measures of airway inflammation including mucus, neutrophil proportion, inflammation score, and the presence of fungal material in tracheal washes were linked to the increase of EIPH risks.

Inter-horse and Inter-trainer Differences

  • The study revealed significant variation in the prevalence of EIPH among different trainers.
  • Horses that had EIPH in the preceding month were found to have significantly increased risks of experiencing the condition in the following month.

Associations with Infections

  • The study found no evidence linking EIPH with airway infections caused by Streptococcus zooepidemicus or Pasteurella-like spp., which are known to cause airway inflammation in younger racehorses.

Multivariate analysis

  • After adjusting for random variability among horses and the impacts of different trainers and preceding month episodes, multivariate logistic regression confirmed that age, season, airway inflammation, and airway fungal material are associated significantly with EIPH.

Cite This Article

APA
Newton JR, Wood JL. (2002). Evidence of an association between inflammatory airway disease and EIPH in young Thoroughbreds during training. Equine Vet J Suppl(34), 417-424. https://doi.org/10.1111/j.2042-3306.2002.tb05459.x

Publication

Equine veterinary journal. Supplement
NlmUniqueID: 9614088
Country: United States
Language: English
Issue: 34
Pages: 417-424

Researcher Affiliations

Newton, J R
  • Epidemiology Unit, Animal Health Trust, Newmarket, Suffolk.
Wood, J L N

    MeSH Terms

    • Age Factors
    • Animal Husbandry / methods
    • Animals
    • Female
    • Hemorrhage / epidemiology
    • Hemorrhage / etiology
    • Hemorrhage / veterinary
    • Horse Diseases / epidemiology
    • Horse Diseases / etiology
    • Horse Diseases / microbiology
    • Horses
    • Logistic Models
    • Longitudinal Studies
    • Male
    • Mycoses / complications
    • Mycoses / epidemiology
    • Mycoses / veterinary
    • Physical Conditioning, Animal / adverse effects
    • Prevalence
    • Respiratory Tract Infections / complications
    • Respiratory Tract Infections / epidemiology
    • Respiratory Tract Infections / veterinary
    • Risk Factors
    • Seasons
    • Thoracoscopy / veterinary
    • Trachea / microbiology
    • Trachea / pathology
    • Tracheal Diseases / epidemiology
    • Tracheal Diseases / etiology
    • Tracheal Diseases / veterinary
    • Tracheitis / complications
    • Tracheitis / epidemiology
    • Tracheitis / veterinary

    Citations

    This article has been cited 14 times.
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