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Extensive large colon resection in the pony. II. Digestibility studies and postmortem findings.
Abstract: The nutritional implications and adaptive processes resulting from resection of 75% of the length of the large colon in ponies were investigated. Ten ponies in good physical condition were divided into two groups: six in the experimental group and four in the control group. During the sixth postoperative month, two digestibility studies were conducted, and phosphate fractional renal excretion and serum biochemical profiles were determined in both groups. The ponies (N = 10) were euthanized six months postoperatively, and gross and histopathological examinations were performed. Results of the serum biochemical profiles, phosphate fractional renal extraction and digestibility studies showed no statistically significant difference between groups except for the serum phosphate concentration. However, large colon resection was associated with hypophosphatemia in three of the six ponies and produced an overall significantly lower phosphate concentration in the experimental ponies. This hypophosphatemia suggests that some dietary modifications may be needed postoperatively in ponies or horses undergoing this surgical procedure. Postmortem examination and histopathological examination failed to demonstrate differences between groups. Adaptive mechanisms, specifically mucosal hypertrophy or hyperplasia, were not observed.
Publication Date: 1987-01-01 PubMed ID: 3567754PubMed Central: PMC1255277 The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research paper investigates the effects of removing 75% of a pony’s large colon on their digestion and nutrition, finding that it may significantly lower phosphate levels in the body. The paper suggests dietary adjustments may be required post-surgery.
Study Population and Methodology
- The research involved ten ponies who were in good physical condition. These were divided into two groups – an experimental group of six ponies who underwent large colon resection, and a control group of four who did not undergo any surgery.
- Over six months, researchers conducted two digestibility studies, as well as determining serum biochemical profiles and phosphate fractional renal extraction for both groups.
Results and Findings
- The researchers found no significant statistical difference between the groups in most parameters, except serum phosphate concentration.
- In the ponies who had undergone colon resection, there was an overall significantly lower phosphate concentration, with three out of six experiencing hypophosphatemia, a condition characterized by low phosphate levels that can have numerous detrimental effects on health.
- This outcome implies that dietary modifications may be required in those animals to compensate for this drop in phosphate levels after colon surgery.
Postmortem analysis and Histopathological Examination
- The ponies were euthanized six months after the surgery and both a gross examination and a histopathological examination were performed.
- These examinations showed no differences between the experimental group and the control group.
- Additionally, the expected adaptive mechanisms, such as mucosal hypertrophy or hyperplasia, did not occur. This means that the body did not respond to the loss of a large part of the colon by increasing the size or number of cells in the mucosal lining of the remaining colon.
Cite This Article
APA
Ducharme NG, Burton JH, van Dreumel AA, Horney FD, Baird JD, Arighi M.
(1987).
Extensive large colon resection in the pony. II. Digestibility studies and postmortem findings.
Can J Vet Res, 51(1), 76-82.
Publication
Researcher Affiliations
MeSH Terms
- Abdomen / pathology
- Animal Nutritional Physiological Phenomena
- Animals
- Cecum / pathology
- Colon / pathology
- Colon / surgery
- Digestion
- Female
- Horse Diseases / pathology
- Horses / blood
- Horses / metabolism
- Horses / surgery
- Intestines / pathology
- Phosphates / blood
- Phosphates / metabolism
- Postoperative Complications / veterinary
References
This article includes 15 references
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- Embertson RM, Schneider RK, Granstedt M. Partial resection and anastomosis of the large colon in a horse.. J Am Vet Med Assoc 1982 May 15;180(10):1230-2.
- Lane VM, Merritt AM. Reliability of single-sample phosphorus fractional excretion determination as a measure of daily phosphorus renal clearance in equids.. Am J Vet Res 1983 Mar;44(3):500-2.
- Tate LP Jr, Ralston SL, Koch CM, Everitt JI. Effects of extensive resection of the small intestine in the pony.. Am J Vet Res 1983 Jul;44(7):1187-91.
- Saunders JB, Wodak AD, Williams R. Past experience of advice and treatment for drinking problems of patients with alcoholic liver disease.. Br J Addict 1985 Mar;80(1):51-6.
- Schryver HF, Hintz HF, Craig PH, Hogue DE, Lowe JE. Site of phosphorus absorption from the intestine of the horse.. J Nutr 1972 Jan;102(1):143-7.
Citations
This article has been cited 1 times.- Arighi M, Ducharme NG, Horney FD, Livesey MA. Extension large colon resection in 12 horses. Can Vet J 1987 May;28(5):245-8.
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