Future directions in treatment of joint disease in horses.
Abstract: Osteoarthritis is one of the most economically important diseases facing equine practitioners. The loss of use associated with joint disease is a leading problem in the equine industry. Although osteoarthritis in all species is believed to be a multifactorial disease that is not well understood, significant advances are being made. This article presents areas of research that are relatively well developed but have not made it to commercialization or routine clinical practice and looks at new applications being investigated for peo-ple that may have an equine application.
Publication Date: 2005-11-22 PubMed ID: 16297729DOI: 10.1016/j.cveq.2005.07.001Google Scholar: Lookup
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- Journal Article
- Review
Summary
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This research article explores potential future treatments for joint disease in horses, particularly osteoarthritis, given its significant impact on the equine industry. The researchers focus on promising fields of study that have yet to reach commercial production or daily clinical use, and evaluates interventions used on humans that could potentially be effective in treating equine conditions.
Overview of Joint Disease in Horses
- The paper begins by addressing the prevalent issue of joint disease in horses, which considerably impairs their usage and poses an economic challenge to the equine industry. The primary focus of the article is on osteoarthritis, a complex condition not fully understood yet but is subject to increasing research efforts.
Current Research Directions
- The authors of the study outline areas of research that are relatively well-established but have not yet made the transition into commercial or routine clinical applications. The intention is to highlight these promising therapies and encourage further development and adoption in the treatment of equine osteoarthritis.
Potential Human-to-Equine Applications
- The study also investigates possible therapeutic options that have been successfully implemented in human medicine and could be transferred for use in equine patients. The underlying principle is that successful treatments for human joint diseases may also prove effective in managing similar conditions in horses, which could open up new avenues for treatment strategies in veterinary medicine.
Implications and Future Directions
- While the paper doesn’t propose a specific treatment method, it serves as a resource to stimulate further investigation and exploration of novel treatment methods. The real-world implementation of these methodologies can offer newly improved ways of treating and potentially even preventing equine joint disease like osteoarthritis.
- This review can potentially be instrumental in shaping the future direction of equine healthcare research, contribute to reducing the burden of joint diseases on the equine industry, and enhance the welfare and longevity of horses worldwide.
Cite This Article
APA
Frisbie DD.
(2005).
Future directions in treatment of joint disease in horses.
Vet Clin North Am Equine Pract, 21(3), 713-viii.
https://doi.org/10.1016/j.cveq.2005.07.001 Publication
Researcher Affiliations
- Department of Clinical Sciences, Colorado State University, 2503 Bay Farm Road, Delivery Code 0912, Fort Collins, CO 80523, USA. dfrisbie@colostate.edu
MeSH Terms
- Animals
- Bone Transplantation / methods
- Bone Transplantation / veterinary
- Horse Diseases / diagnosis
- Horse Diseases / surgery
- Horse Diseases / therapy
- Horses
- Joint Diseases / diagnosis
- Joint Diseases / surgery
- Joint Diseases / therapy
- Joint Diseases / veterinary
- Lameness, Animal / etiology
- Lameness, Animal / surgery
- Veterinary Medicine / trends
Citations
This article has been cited 8 times.- Zare R, Tanideh N, Nikahval B, Mirtalebi MS, Ahmadi N, Zarea S, Hosseinabadi OK, Bhimani R, Ashkani-Esfahani S. Are Stem Cells Derived from Synovium and Fat Pad Able to Treat Induced Knee Osteoarthritis in Rats?. Int J Rheumatol 2020;2020:9610261.
- Bertoni L, Branly T, Jacquet S, Desancé M, Desquilbet L, Rivory P, Hartmann DJ, Denoix JM, Audigié F, Galéra P, Demoor M. Intra-Articular Injection of 2 Different Dosages of Autologous and Allogeneic Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells Triggers a Variable Inflammatory Response of the Fetlock Joint on 12 Sound Experimental Horses. Stem Cells Int 2019;2019:9431894.
- Barboni B, Russo V, Berardinelli P, Mauro A, Valbonetti L, Sanyal H, Canciello A, Greco L, Muttini A, Gatta V, Stuppia L, Mattioli M. Placental Stem Cells from Domestic Animals: Translational Potential and Clinical Relevance. Cell Transplant 2018 Jan;27(1):93-116.
- Bembo F, Eraud J, Philandrianos C, Bertrand B, Silvestre A, Veran J, Sabatier F, Magalon G, Magalon J. Combined use of platelet rich plasma & micro-fat in sport and race horses with degenerative joint disease: preliminary clinical study in eight horses. Muscles Ligaments Tendons J 2016 Apr-Jun;6(2):198-204.
- Tessier L, Bienzle D, Williams LB, Koch TG. Phenotypic and immunomodulatory properties of equine cord blood-derived mesenchymal stromal cells. PLoS One 2015;10(4):e0122954.
- Broeckx S, Zimmerman M, Crocetti S, Suls M, Mariën T, Ferguson SJ, Chiers K, Duchateau L, Franco-Obregón A, Wuertz K, Spaas JH. Regenerative therapies for equine degenerative joint disease: a preliminary study. PLoS One 2014;9(1):e85917.
- Colleoni S, Bottani E, Tessaro I, Mari G, Merlo B, Romagnoli N, Spadari A, Galli C, Lazzari G. Isolation, growth and differentiation of equine mesenchymal stem cells: effect of donor, source, amount of tissue and supplementation with basic fibroblast growth factor. Vet Res Commun 2009 Dec;33(8):811-21.
- Koch TG, Heerkens T, Thomsen PD, Betts DH. Isolation of mesenchymal stem cells from equine umbilical cord blood. BMC Biotechnol 2007 May 30;7:26.
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