Harnessing the genetic toolbox for the benefit of the racing Thoroughbred.
Abstract: The understanding and application of genetics have grown extremely quickly since it has become possible to sequence the whole genome of an organism. The human genome sequence was completed in 2001 and that of the horse in 2007. The significance of this is that it makes it more feasible to explain how both genetically simple and complex traits are transmitted from one generation to the next and, therefore, to make informed breeding decisions, modify how horses are managed and trained to minimise the risk of disease and injury, and improve methods of prevention, diagnosis and treatment of many conditions. The science of genetics/genomics will continue to grow internationally, limited only by the funds available. The application of the science to man, horses and other species raises very complex moral and commercial issues. Thoroughbred breeders are perceived by some as resistant to change, but their apparent intransigence is often based on a genuine concern for the integrity of the breed. By taking control of the application of the advances in genetics, the Thoroughbred industry potentially has the opportunity to improve both the health and performance of Thoroughbreds. If, however, the science is applied in an uncoordinated manner, driven by commercial interests with no underlying concern for the horses themselves, there is a very real risk that breeders, the Thoroughbred breed and individual horses will all suffer as a consequence.
© 2011 EVJ Ltd.
Publication Date: 2011-11-06 PubMed ID: 22132854DOI: 10.1111/j.2042-3306.2011.00465.xGoogle Scholar: Lookup
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Summary
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The research article discusses the use of advances in genetics to improve the health and performance of Thoroughbred horses, considering both the potential benefits and risks associated with unregulated commercial interests.
Overview of the Research
- The paper begins by acknowledging how the understanding and application of genetics have expanded since the capability to sequence an entire organism’s genome became possible. This development has led to the complete sequencing of the human genome in 2001 and the horse genome in 2007.
- One of the critical implications of this genetic enhancement is that it allows for a clearer understanding of how traits – both simple and complex – are passed on from the parent horses to the offspring. Such knowledge is beneficial in making better breeding decisions and managing and training horses to minimize disease and injury risks.
- Furthermore, improvements in genetics can facilitate the development of superior prevention methods – as well as more accurate diagnosis and efficient treatment – for various conditions.
Growth of Genetics/Genomics and Associated Limitations
- The researchers highlight that the scientific field of genetics/genomics will continue to grow globally, restricted chiefly by the amounts of available funding.
- There is also an important discussion on the complexity of moral and commercial issues that arise when applying genomic science to humans, horses, and other species.
The Role of Thoroughbred Breeders and The Industry
- The authors state that some people perceive Thoroughbred breeders as resistant to change, often due to their concern regarding the breed’s integrity.
- The article argues that by harnessing the advances in genetics, the Thoroughbred industry has the potential to significantly enhance the health and performance of Thoroughbreds.
Potential Risks
- However, the paper cautions that if the science is applied haphazardly and driven primarily by commercial interests without considering the horses’ welfare, there could be significant adverse consequences.
- Negative impacts could be borne not only by the breeders and the Thoroughbred breed but also by individual horses.
Cite This Article
APA
Webbon P.
(2011).
Harnessing the genetic toolbox for the benefit of the racing Thoroughbred.
Equine Vet J, 44(1), 8-12.
https://doi.org/10.1111/j.2042-3306.2011.00465.x Publication
Researcher Affiliations
- The Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, UK. peter.webbon@aht.org.uk
MeSH Terms
- Animals
- Genetic Predisposition to Disease
- Genome
- Horse Diseases / genetics
- Horses
- Sports
Citations
This article has been cited 1 times.- Lee JR, Hong CP, Moon JW, Jung YD, Kim DS, Kim TH, Gim JA, Bae JH, Choi Y, Eo J, Kwon YJ, Song S, Ko J, Yang YM, Lee HK, Park KD, Ahn K, Do KT, Ha HS, Han K, Yi JM, Cha HJ, Cho BW, Bhak J, Kim HS. Genome-wide analysis of DNA methylation patterns in horse.. BMC Genomics 2014 Jul 15;15(1):598.
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