Has horsepox become extinct?
Abstract: Mystery surrounds the extent to which horsepox virus may have contributed to the vaccinia virus used to eradicate smallpox. With few documented cases of horsepox in recent years it may never be solved, says José Esparza, who seeks to raise awareness of the potential historical and scientific importance of identifying new cases.
Publication Date: 2013-09-24 PubMed ID: 24057497DOI: 10.1136/vr.f5587Google Scholar: Lookup
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- Historical Article
- Journal Article
Summary
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The research article discusses the possibility of the horsepox virus having become extinct and potentially impacting the effectiveness of the previously used vaccinia virus for eradicating smallpox. The scarcity of recent horsepox cases makes this a challenging issue to address.
Horsepox and its impact on the Vaccinia Virus
- The paper begins by addressing an ongoing debate on the role that the horsepox virus might have had on the development of the vaccinia virus, a pivotal tool used to eliminate smallpox. The extent to which horsepox contributed to the efficacy of vaccinia remains a mystery that the author, José Esparza, aims to further examine.
Recent Cases and Potential Extinction
- Esparza observes the lack of documented horsepox cases in recent years, suggesting that this could be an indicator that the virus has become extinct. If this were true, the absence of the horsepox could have implications on our understanding of the vaccinia virus and its successful application.
Potential scientific and historical importance
- Through the article, Esparza raises the alarm on the scientific and historical significance of identifying new cases of horsepox. Documentation and examination of any future horsepox instances could provide valuable insights and data to enhance our comprehension of this virus and its potential relationships to other viruses.
Objective of the Research Article
- In essence, the article’s objective is to trigger a broader scientific awareness and research interest into the horsepox virus. Increasing vigilance towards identifying and scientifically examining future cases of horsepox could be pivotal in understanding the virus’s existence and potential relationship to vaccinia and the eradication of smallpox.
Cite This Article
APA
Esparza J.
(2013).
Has horsepox become extinct?
Vet Rec, 173(11), 272-273.
https://doi.org/10.1136/vr.f5587 Publication
Researcher Affiliations
- Senior Advisor, Global Health (Vaccines), Bill & Melinda Gates Foundation, Seattle, Washington, USA.
MeSH Terms
- Animals
- History, 18th Century
- History, 19th Century
- History, 20th Century
- History, 21st Century
- Horse Diseases / epidemiology
- Horse Diseases / prevention & control
- Horses
- Smallpox / epidemiology
- Smallpox / prevention & control
- Smallpox / veterinary
- Smallpox Vaccine / history
- Vaccination / history
- Vaccination / veterinary
- Vaccinia virus / immunology
- Variola virus / immunology
Citations
This article has been cited 7 times.- Duggan AT, Klunk J, Porter AF, Dhody AN, Hicks R, Smith GL, Humphreys M, McCollum AM, Davidson WB, Wilkins K, Li Y, Burke A, Polasky H, Flanders L, Poinar D, Raphenya AR, Lau TTY, Alcock B, McArthur AG, Golding GB, Holmes EC, Poinar HN. The origins and genomic diversity of American Civil War Era smallpox vaccine strains.. Genome Biol 2020 Jul 20;21(1):175.
- Ehmann R, Brandes K, Antwerpen M, Walter M, V Schlippenbach K, Stegmaier E, Essbauer S, Bugert J, Teifke JP, Meyer H. Molecular and genomic characterization of a novel equine molluscum contagiosum-like virus.. J Gen Virol 2021 Mar;102(3).
- Thiel V. Synthetic viruses-Anything new?. PLoS Pathog 2018 Oct;14(10):e1007019.
- Esparza J, Nitsche A, Damaso CR. Beyond the myths: Novel findings for old paradigms in the history of the smallpox vaccine.. PLoS Pathog 2018 Jul;14(7):e1007082.
- Noyce RS, Lederman S, Evans DH. Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments.. PLoS One 2018;13(1):e0188453.
- Sánchez-Sampedro L, Perdiguero B, Mejías-Pérez E, García-Arriaza J, Di Pilato M, Esteban M. The evolution of poxvirus vaccines.. Viruses 2015 Apr 7;7(4):1726-803.
- Weiss RA, Esparza J. The prevention and eradication of smallpox: a commentary on Sloane (1755) 'An account of inoculation'.. Philos Trans R Soc Lond B Biol Sci 2015 Apr 19;370(1666).
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