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The Veterinary clinics of North America. Equine practice2023; 39(1); 89-98; doi: 10.1016/j.cveq.2022.11.009

Hendra Virus: An Update on Diagnosis, Vaccination, and Biosecurity Protocols for Horses.

Abstract: Hendra virus (HeV) emerged as a zoonotic pathogen in the 1990s, causing low morbidity but high mortality in humans and horses. Pteropid bats are the natural reservoir of HeV and other important zoonotic viruses such as Nipah and Ebola viruses. Equivac HeV, manufactured by Zoetis (Parkville, Victoria, Australia), is the only commercially available vaccine for horses. There is no commercial vaccine for humans. The epidemiology, clinical features, pathology, diagnosis, management, and prevention of HeV will be reviewed.
Publication Date: 2023-02-01 PubMed ID: 36737284DOI: 10.1016/j.cveq.2022.11.009Google Scholar: Lookup
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Summary

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The research paper presents an update on the diagnosis, vaccination, and biosecurity protocols for horses affected by the Hendra virus. This virus, which has pteropid bats as its natural carrier, emerged in the 90s as a pathogen causing significant fatalities in both horses and humans.

Understanding Hendra Virus

  • Hendra virus, or HeV, emerged as a zoonotic pathogen in the 1990s. As a zoonotic pathogen, it can be transmitted from animals to humans. Despite showing a low occurrence rate, or morbidity, it presents a high fatality rate, or mortality, in both horses and humans that do contract it.
  • Pteropid bats, often referred to as flying foxes, are identified as the natural carriers of HeV. They also are reservoirs for other significant zoonotic viruses like Nipah and Ebola viruses.

Commercially Available Vaccine

  • Equivac HeV is the only commercially available vaccine for Hendra virus, intended specifically for horses. This vaccine is produced by Zoetis, a company based in Parkville, Victoria, Australia.
  • There are currently no commercial vaccines available for humans against this virus.

Epidemiology, Clinical Features, and Pathology of HeV

  • The paper also offers an updated review on various aspects related to HeV including its epidemiology, clinical features, and pathology.
  • Epidemiology refers to the incidence, distribution, and control of the Hendra virus in a population, be it humans or horses.
  • Clinical features touch on the symptoms and progression of the virus in an infected individual.
  • Pathology refers to the effects HeV has on the bodies of both horses and humans, potentially damaging tissues and organs.

Diagnosis, Management, and Prevention of HeV

  • The research paper underlines the importance of proper diagnosis, management, and prevention strategies for Hearth virus.
  • Diagnosis would involve identifying signs of the virus, conducting laboratory tests, and confirming the presence of the Hendra virus.
  • Management refers to the healthcare approach after diagnosis – treating the symptoms, monitoring the infected individual, and limiting the spread of the virus.
  • Prevention includes strategies to avoid the spreading of the virus (biosecurity measures), which could involve quarantine measures, sanitation practices, or controlling the virus in its natural reservoir.

Cite This Article

APA
Wang X, Wise JC, Stewart AJ. (2023). Hendra Virus: An Update on Diagnosis, Vaccination, and Biosecurity Protocols for Horses. Vet Clin North Am Equine Pract, 39(1), 89-98. https://doi.org/10.1016/j.cveq.2022.11.009

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 39
Issue: 1
Pages: 89-98

Researcher Affiliations

Wang, Xueli
  • School of Veterinary Science, The University of Queensland, Gatton Campus, Building 8114, Inner Ring Road, Gatton, Queensland 4343, Australia.
Wise, Jessica C
  • School of Veterinary Science, The University of Queensland, Gatton Campus, Building 8114, Inner Ring Road, Gatton, Queensland 4343, Australia.
Stewart, Allison J
  • School of Veterinary Science, The University of Queensland, Gatton Campus, Building 8114, Inner Ring Road, Gatton, Queensland 4343, Australia. Electronic address: allison.stewart@uq.edu.au.

MeSH Terms

  • Humans
  • Animals
  • Horses
  • Hendra Virus
  • Biosecurity
  • Horse Diseases / prevention & control
  • Vaccination / veterinary
  • Vaccines
  • Chiroptera
  • Henipavirus Infections / epidemiology
  • Henipavirus Infections / veterinary

Citations

This article has been cited 6 times.
  1. White J, Thompson K, van den Berg D, O'Neill G, Mendez DH, Talwar J, Degeling C, Forsythe R, Durrheim DN. 'Pretty devastating': exploring horse owner and veterinarian lived experiences of the equine Hendra virus. Front Vet Sci 2025;12:1661615.
    doi: 10.3389/fvets.2025.1661615pubmed: 41357753google scholar: lookup
  2. van den Hurk S, Yondo A, Velayudhan BT. Laboratory Diagnosis of Hendra and Nipah: Two Emerging Zoonotic Diseases with One Health Significance. Viruses 2025 Jul 17;17(7).
    doi: 10.3390/v17071003pubmed: 40733619google scholar: lookup
  3. McNabb L, McMahon A, Woube EG, Agnihotri K, Colling A, Broder CC, Kucinskaite-Kodze I, Petraityte-Burneikiene R, Bowden TR, Halpin K. Development and Validation of a Differentiating Infected from Vaccinated Animals (DIVA) Enzyme-Linked Immunosorbent Assay (ELISA) Strategy for Distinguishing Between Hendra-Infected and Vaccinated Horses. Viruses 2025 Feb 28;17(3).
    doi: 10.3390/v17030354pubmed: 40143282google scholar: lookup
  4. Findlay-Wilson S, Thakur N, Crossley L, Easterbrook L, Salguero FJ, Ruedas-Torres I, Fotheringham S, Kennedy E, Bailey D, Dowall S. Cross-protectivity of henipavirus soluble glycoprotein in an in vivo model of Nipah virus disease. Front Immunol 2025;16:1517244.
    doi: 10.3389/fimmu.2025.1517244pubmed: 40078997google scholar: lookup
  5. Mahdeen AA, Hossain I, Masum MHU, Islam S, Rabbi TMF. Designing novel multiepitope mRNA vaccine targeting Hendra virus (HeV): An integrative approach utilizing immunoinformatics, reverse vaccinology, and molecular dynamics simulation. PLoS One 2024;19(10):e0312239.
    doi: 10.1371/journal.pone.0312239pubmed: 39441880google scholar: lookup
  6. Shapter FM, Granados-Soler JL, Stewart AJ, Bertin FR, Allavena R. Equine Crofton Weed (Ageratina spp.) Pneumotoxicity: What Do We Know and What Do We Need to Know?. Animals (Basel) 2023 Jun 23;13(13).
    doi: 10.3390/ani13132082pubmed: 37443880google scholar: lookup