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Frontiers in veterinary science2019; 6; 9; doi: 10.3389/fvets.2019.00009

Heterologous Wharton’s Jelly Derived Mesenchymal Stem Cells Application on a Large Chronic Skin Wound in a 6-Month-Old Filly.

Abstract: A complex feedback of growth factors, secreted by a variety of cell types, is responsible for the mediation of skin healing. Despite the recent advances in wound healing management, this fails up to 50% and skin wounds can still be considered one of the main causes of morbidity, both in human and veterinary medicine. Regenerative medicine, involving mesenchymal stromal cells (MSCs), is nowadays a promising solution for skin wound healing. Indeed, MSCs are involved in the modulation of the inflammatory local response and cell replacing, by a paracrine mode of action. Local application of equine umbilical cord Wharton's jelly MSCs (WJMSCS) was carried out in a 6-months-old filly with a non-healing skin wound. Heterologous WJMSCs were applied four times using a carboxymethylcellulose (CMC) gel, produced dissolving CMC in autologous plasma. At first application the mean wound area was 7.28 ± 0.2 cm2. Four days after the last application of WJMSCs, the mean wound area was 1.90 ± 0.03 cm2, and the wound regression rate was +74%. No local or systemic side effects were registered after WJMSCs application and no evident exuberant scar was observed after wound healing. At discharge, the mean wound area was 0.38 ± 0.01 cm2 and the total regression rate was +80%. Five days later, the wound was completely healed. In the present clinical case report, the use of WJMSCs led to promising clinical results, paving the way for possible future applications in the treatment of chronic wounds in horses.
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Publication Date: 2019-01-30 PubMed ID: 30761313PubMed Central: PMC6363668DOI: 10.3389/fvets.2019.00009Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigated the use of a specific type of stem cells (Wharton’s Jelly Derived Mesenchymal Stem Cells) to treat a large chronic skin wound in a 6-month-old filly. The findings suggest that these stem cells can significantly improve wound healing rates, reducing wound size by an average of 74% shortly after treatment and by 80% at discharge, with no observed side effects.

Understanding the Research

  • The basis for the study is related to the complex network of growth factors secreted by different types of cells, which influence the healing of skin wounds. Despite advances in the management of wound healing, up to half of these attempts are unsuccessful. Skin wounds remain a significant cause of illness in both human and veterinary medicine.
  • The study argues that regenerative medicine, specifically involving mesenchymal stromal cells (MSCs), might hold potential solutions for skin wound healing. These cells play a role in controlling the local inflammatory response and replacing cells.
  • The researchers used Wharton’s Jelly Mesenchymal Stem Cells (WJMSCs) derived from an equine umbilical cord. These cells were applied to a non-healing skin wound on a 6-month-old filly. These WJMSCs were applied through a carboxymethylcellulose (CMC) gel. This gel was produced by dissolving CMC in the horse’s plasma.

The Experiment and Findings

  • At the start of the experiment, the wound’s average area was 7.28 cm. After the final application of WJMSCs, the wound area decreased to an average of 1.90 cm, signaling a wound regression rate of 74%.
  • The treatment did not result in any local or systemic side effects, and there was no evident excessive scarring after the wound healed. The average wound area was further reduced to 0.38 cm at discharge, accounting for an 80% total regression rate.
  • The wound was completely healed five days after discharge. Therefore, they concluded that the utilization of WJMSCs resulted in promising clinical outcomes, potentially opening up future applications in treating chronic wounds in horses.

Cite This Article

APA
Lanci A, Merlo B, Mariella J, Castagnetti C, Iacono E. (2019). Heterologous Wharton’s Jelly Derived Mesenchymal Stem Cells Application on a Large Chronic Skin Wound in a 6-Month-Old Filly. Front Vet Sci, 6, 9. https://doi.org/10.3389/fvets.2019.00009

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 6
Pages: 9

Researcher Affiliations

Lanci, Aliai
  • Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Merlo, Barbara
  • Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Mariella, Jole
  • Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Castagnetti, Carolina
  • Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Iacono, Eleonora
  • Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.

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Citations

This article has been cited 16 times.
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